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The neocortex is hierarchically organized around three sensory areas and one motor area, but little is known about the developmental mechanisms that regulate this patterning. In this issue, Armentano and colleagues use a cortex-specific deletion of COUP-TFI to show that this transcription factor is required to balance patterning of neocortex into frontal/motor and sensory areas. The cover is a coronal section of newborn mouse brain with anterogradely labeled visual axons in red and somatosensory axons in green. (p 1277)
Mentoring is important to early career success, but is not always available locally. Several new programs are improving the professional prospects of young scientists by matching them with good mentors elsewhere in the world.
Maintaining balance requires the translation of a high-level command—“Keep the body's center of mass over the feet”—to low-level adjustments in individual muscles and joints. A new paper finds that a simple translation between these two levels of control provides a robust explanation for responses to several types of perturbations.
A study in this issue reports that, in mice, embryonic cortical neurons transplanted into injured adult motor cortex can rapidly and accurately reinnervate distant projections. These remarkable results urgently need to be replicated.
Despite the widespread use of functional magnetic resonance imaging, we still do not fully understand what it measures. A new study reports that oxygen-concentration changes and local field potentials are concurrent in time and space.
The identity of the tip link, which converts mechanical force to channel opening in hair cells, has been controversial, with different groups promoting cadherin 23 or protocadherin 15. A new paper in Nature shows that both proteins are involved.