Latest Research

  • Resource |

    By analyzing hundreds of mice treated with a library of neuro- and psychoactive drugs, Wiltschko et al. show that Motion Sequencing can effectively discriminate and categorize drug effects and link molecular targets to behavioral syllables.

    • Alexander B. Wiltschko
    • , Tatsuya Tsukahara
    • , Ayman Zeine
    • , Rockwell Anyoha
    • , Winthrop F. Gillis
    • , Jeffrey E. Markowitz
    • , Ralph E. Peterson
    • , Jesse Katon
    • , Matthew J. Johnson
    •  & Sandeep Robert Datta
  • Technical Report |

    Kuan, Phelps, et al. used synchrotron X-ray imaging and deep learning to map dense neuronal wiring in fly and mouse tissue, enabling examination of individual cells and connectivity in circuits governing motor control and perceptual decision-making.

    • Aaron T. Kuan
    • , Jasper S. Phelps
    • , Logan A. Thomas
    • , Tri M. Nguyen
    • , Julie Han
    • , Chiao-Lin Chen
    • , Anthony W. Azevedo
    • , John C. Tuthill
    • , Jan Funke
    • , Peter Cloetens
    • , Alexandra Pacureanu
    •  & Wei-Chung Allen Lee
  • Resource |

    The ventral hippocampus is central in the processing of emotional information. Here, a combination of viral and sequencing approaches defines the organizational logic of the extended ventral CA1 circuit.

    • Mark M. Gergues
    • , Kasey J. Han
    • , Hye Sun Choi
    • , Brandon Brown
    • , Kelsey J. Clausing
    • , Victoria S. Turner
    • , Ilia D. Vainchtein
    • , Anna V. Molofsky
    •  & Mazen A. Kheirbek
  • Resource |

    Chen et al. define previously unreported zebrafish astrocytes, provide new insights into vertebrate astrocyte development and lay the foundation for studying astrocyte function in the entire nervous system of an intact and behaving animal.

    • Jiakun Chen
    • , Kira E. Poskanzer
    • , Marc R. Freeman
    •  & Kelly R. Monk
  • Article |

    Yamamuro et al. show that juvenile social isolation disrupts prefrontal neurons projecting to the paraventricular thalamus and associated prefrontal somatostatin interneurons, and thereby impairs sociability in adulthood.

    • Kazuhiko Yamamuro
    • , Lucy K. Bicks
    • , Michael B. Leventhal
    • , Daisuke Kato
    • , Susanna Im
    • , Meghan E. Flanigan
    • , Yury Garkun
    • , Kevin J. Norman
    • , Keaven Caro
    • , Masato Sadahiro
    • , Klas Kullander
    • , Schahram Akbarian
    • , Scott J. Russo
    •  & Hirofumi Morishita
  • Brief Communication |

    Toren et al. show that outcomes that are better or worse than expected lengthen or shorten the perceived duration of stimuli, respectively, and that this interaction between teaching signals and time perception occurs in the human striatum.

    • Ido Toren
    • , Kristoffer C. Aberg
    •  & Rony Paz
  • Article |

    Babetto et al. demonstrate an axonal injury-induced glycolytic surge in Schwann cells that supplies perturbed axons with glycolytic energy substrates. Disruption of this metabolic coupling of axons and glial cells promotes axonal degeneration.

    • Elisabetta Babetto
    • , Keit Men Wong
    •  & Bogdan Beirowski
  • Article |

    Parkinson’s disease brain neurons exhibit a widespread epigenetic dysregulation of enhancers that is linked to an upregulation of TET2. Inactivation of TET2 protects against nigral dopaminergic neuronal loss and neuroinflammation.

    • Lee L. Marshall
    • , Bryan A. Killinger
    • , Elizabeth Ensink
    • , Peipei Li
    • , Katie X. Li
    • , Wei Cui
    • , Noah Lubben
    • , Matthew Weiland
    • , Xinhe Wang
    • , Juozas Gordevicius
    • , Gerhard A. Coetzee
    • , Jiyan Ma
    • , Stefan Jovinge
    •  & Viviane Labrie
  • Technical Report |

    This study describes a series of new gene-regulatory sequences that restrict expression of viral transgenes to specific interneuron subtypes, allowing for selective monitoring and manipulation of their activity from mice to humans.

    • Douglas Vormstein-Schneider
    • , Jessica D. Lin
    • , Kenneth A. Pelkey
    • , Ramesh Chittajallu
    • , Baolin Guo
    • , Mario A. Arias-Garcia
    • , Kathryn Allaway
    • , Sofia Sakopoulos
    • , Gates Schneider
    • , Olivia Stevenson
    • , Josselyn Vergara
    • , Jitendra Sharma
    • , Qiangge Zhang
    • , Tom P. Franken
    • , Jared Smith
    • , Leena A. Ibrahim
    • , Kevin J. M astro
    • , Ehsan Sabri
    • , Shuhan Huang
    • , Emilia Favuzzi
    • , Timothy Burbridge
    • , Qing Xu
    • , Lihua Guo
    • , Ian Vogel
    • , Vanessa Sanchez
    • , Giuseppe A. Saldi
    • , Bram L. Gorissen
    • , Xiaoqing Yuan
    • , Kareem A. Zaghloul
    • , Orrin Devinsky
    • , Bernardo L. Sabatini
    • , Renata Batista-Brito
    • , John Reynolds
    • , Guoping Feng
    • , Zhanyan Fu
    • , Chris J. McBain
    • , Gord Fishell
    •  & Jordane Dimidschstein
  • Author Correction |

    • Federico Giovannoni
    • , Irene Bosch
    • , Carolina Manganeli Polonio
    • , María F. Torti
    • , Michael A. Wheeler
    • , Zhaorong Li
    • , Leonardo Romorini
    • , María S. Rodriguez Varela
    • , Veit Rothhammer
    • , Andreia Barroso
    • , Emily C. Tjon
    • , Liliana M. Sanmarco
    • , Maisa C. Takenaka
    • , Seyed Mohamad Sadegh Modaresi
    • , Cristina Gutiérrez-Vázquez
    • , Nágela Ghabdan Zanluqui
    • , Nilton Barreto dos Santos
    • , Carolina Demarchi Munhoz
    • , Zhongyan Wang
    • , Elsa B. Damonte
    • , David Sherr
    • , Lee Gehrke
    • , Jean Pierre Schatzmann Peron
    • , Cybele C. Garcia
    •  & Francisco J. Quintana
  • Article |

    Park et al. demonstrate in tauopathy models that tau disrupts the interaction between neuronal nitric oxide synthase and PSD95, uncoupling glutamatergic synaptic activity from nitric oxide production and dampening the hemodynamic response to activation.

    • Laibaik Park
    • , Karin Hochrainer
    • , Yorito Hattori
    • , Sung Ji Ahn
    • , Antoine Anfray
    • , Gang Wang
    • , Ken Uekawa
    • , James Seo
    • , Victoria Palfini
    • , Ismary Blanco
    • , Diana Acosta
    • , David Eliezer
    • , Ping Zhou
    • , Josef Anrather
    •  & Costantino Iadecola
  • Review Article |

    Busche and Hyman review emerging evidence for an interaction between Aβ and tau during Alzheimer’s disease (AD) progression that challenges the classical linear trajectory model and offers a new perspective on AD pathophysiology and therapy.

    • Marc Aurel Busche
    •  & Bradley T. Hyman
  • Brief Communication |

    This study shows that the dorsal hippocampus is necessary for goal-directed action, but only transiently, during initial learning. Convergently, goal-directed actions also depend transiently on the physical context.

    • Laura A. Bradfield
    • , Beatrice K. Leung
    • , Susan Boldt
    • , Sophia Liang
    •  & Bernard W. Balleine
  • Article |

    The nervous system is hypothesized to calculate reward prediction errors to estimate reward availability in the environment. The authors quantify a robust prediction error signal in the ventral pallidum derived from recently received rewarding outcomes.

    • David J. Ottenheimer
    • , Bilal A. Bari
    • , Elissa Sutlief
    • , Kurt M. Fraser
    • , Tabitha H. Kim
    • , Jocelyn M. Richard
    • , Jeremiah Y. Cohen
    •  & Patricia H. Janak
  • Article |

    The authors showed that the ‘moment of perception’ is causally related to dendritic activity in subcortically projecting layer 5 pyramidal neurons that project to the higher-order thalamus, superior colliculus and striatum.

    • Naoya Takahashi
    • , Christian Ebner
    • , Johanna Sigl-Glöckner
    • , Sara Moberg
    • , Svenja Nierwetberg
    •  & Matthew E. Larkum
  • Article |

    Mazzone and Liang-Guallpa et al. demonstrate that consuming high-fat foods rapidly and durably tunes parallel brain circuits to drive intake of a high-fat diet while devaluing a nutritionally balanced, standard diet even under states of intense hunger.

    • Christopher M. Mazzone
    • , Jing Liang-Guallpa
    • , Chia Li
    • , Nora S. Wolcott
    • , Montana H. Boone
    • , Morgan Southern
    • , Nicholas P. Kobzar
    • , Isabel de Araujo Salgado
    • , Deepa M. Reddy
    • , Fangmiao Sun
    • , Yajun Zhang
    • , Yulong Li
    • , Guohong Cui
    •  & Michael J. Krashes
  • Article |

    Charlet, Grinevich et al. show that social touch between female rats activates parvocellular oxytocin neurons; these neurons control social behavior by coordinating the responses of the much larger population of magnocellular oxytocin neurons.

    • Yan Tang
    • , Diego Benusiglio
    • , Arthur Lefevre
    • , Louis Hilfiger
    • , Ferdinand Althammer
    • , Anna Bludau
    • , Daisuke Hagiwara
    • , Angel Baudon
    • , Pascal Darbon
    • , Jonas Schimmer
    • , Matthew K. Kirchner
    • , Ranjan K. Roy
    • , Shiyi Wang
    • , Marina Eliava
    • , Shlomo Wagner
    • , Martina Oberhuber
    • , Karl K. Conzelmann
    • , Martin Schwarz
    • , Javier E. Stern
    • , Gareth Leng
    • , Inga D. Neumann
    • , Alexandre Charlet
    •  & Valery Grinevich
  • Technical Report |

    Garcia-Marques et al. present CLADES, an innovative approach to study neuronal lineages based on CRISPR. Inspired by synthetic biology, CLADES relies on a system of genetic switches to activate and inactivate reporter genes in a predetermined order.

    • Jorge Garcia-Marques
    • , Isabel Espinosa-Medina
    • , Kai-Yuan Ku
    • , Ching-Po Yang
    • , Minoru Koyama
    • , Hung-Hsiang Yu
    •  & Tzumin Lee
  • Article |

    Yamaguchi et al. identify a little-known amygdalar region, the posterior amygdala, as a key node in male mouse social behaviors. Two largely non-overlapping subpopulations in the posterior amygdala form parallel projections to distinct hypothalamic regions to regulate mating and fighting.

    • Takashi Yamaguchi
    • , Dongyu Wei
    • , Soomin C. Song
    • , Byungkook Lim
    • , Nicolas X. Tritsch
    •  & Dayu Lin
  • Technical Report |

    SPARC is an all-genetic toolkit to express effectors in precise proportions of neurons. This method enables imaging of individual neurons and manipulation of neuronal subpopulations.

    • Jesse Isaacman-Beck
    • , Kristine C. Paik
    • , Carl F. R. Wienecke
    • , Helen H. Yang
    • , Yvette E. Fisher
    • , Irving E. Wang
    • , Itzel G. Ishida
    • , Gaby Maimon
    • , Rachel I. Wilson
    •  & Thomas R. Clandinin
  • Article |

    Tamaki et al. measured MRS changes in sleeping humans trained on a visual task. During NREM sleep, learning gains were associated with enhanced visual cortical plasticity that was also seen independent of learning. REM sleep stabilized plasticity only after pre-sleep learning.

    • Masako Tamaki
    • , Zhiyan Wang
    • , Tyler Barnes-Diana
    • , DeeAnn Guo
    • , Aaron V. Berard
    • , Edward Walsh
    • , Takeo Watanabe
    •  & Yuka Sasaki
  • Article |

    Giovannoni et al. report that the aryl hydrocarbon receptor (AHR) is a novel host factor exploited by Zika virus and dengue virus to evade the immune response. AHR is a candidate target for the treatment of Zika virus congenital syndrome and dengue fever.

    • Federico Giovannoni
    • , Irene Bosch
    • , Carolina Manganeli Polonio
    • , María F. Torti
    • , Michael A. Wheeler
    • , Zhaorong Li
    • , Leonardo Romorini
    • , María S. Rodriguez Varela
    • , Veit Rothhammer
    • , Andreia Barroso
    • , Emily C. Tjon
    • , Liliana M. Sanmarco
    • , Maisa C. Takenaka
    • , Seyed Mohamad Sadegh Modaresi
    • , Cristina Gutiérrez-Vázquez
    • , Nágela Ghabdan Zanluqui
    • , Nilton Barreto dos Santos
    • , Carolina Demarchi Munhoz
    • , Zhongyan Wang
    • , Elsa B. Damonte
    • , David Sherr
    • , Lee Gehrke
    • , Jean Pierre Schatzmann Peron
    • , Cybele C. Garcia
    •  & Francisco J. Quintana
  • Publisher Correction |

    • Elaine T. Lim
    • , Mohammed Uddin
    • , Silvia De Rubeis
    • , Yingleong Chan
    • , Anne S. Kamumbu
    • , Xiaochang Zhang
    • , Alissa M. D’Gama
    • , Sonia N. Kim
    • , Robert Sean Hill
    • , Arthur P. Goldberg
    • , Christopher Poultney
    • , Nancy J. Minshew
    • , Itaru Kushima
    • , Branko Aleksic
    • , Norio Ozaki
    • , Mara Parellada
    • , Celso Arango
    • , Maria J. Penzol
    • , Angel Carracedo
    • , Alexander Kolevzon
    • , Christina M. Hultman
    • , Lauren A. Weiss
    • , Menachem Fromer
    • , Andreas G. Chiocchetti
    • , Christine M. Freitag
    • , George M. Church
    • , Stephen W. Scherer
    • , Joseph D. Buxbaum
    •  & Christopher A. Walsh
  • Article |

    Kelly et al. describe two cerebellum–thalamus–mPFC pathways in mice that regulate social and repetitive behavior. PC activation in Rcrus1 and posterior vermis improved social and reduced repetitive behaviors, respectively, in PC-Tsc1 mutant mice.

    • Elyza Kelly
    • , Fantao Meng
    • , Hirofumi Fujita
    • , Felipe Morgado
    • , Yasaman Kazemi
    • , Laura C. Rice
    • , Chongyu Ren
    • , Christine Ochoa Escamilla
    • , Jennifer M. Gibson
    • , Sanaz Sajadi
    • , Robert J. Pendry
    • , Tommy Tan
    • , Jacob Ellegood
    • , M. Albert Basson
    • , Randy D. Blakely
    • , Scott V. Dindot
    • , Christelle Golzio
    • , Maureen K. Hahn
    • , Nicholas Katsanis
    • , Diane M. Robins
    • , Jill L. Silverman
    • , Karun K. Singh
    • , Rachel Wevrick
    • , Margot J. Taylor
    • , Christopher Hammill
    • , Evdokia Anagnostou
    • , Brad E. Pfeiffer
    • , Catherine J. Stoodley
    • , Jason P. Lerch
    • , Sascha du Lac
    •  & Peter T. Tsai
  • Article |

    Most studies of autism spectrum disorder (ASD) have focused on neuronal mechanisms. Here, the authors describe vascular impairments in a mouse model of 16p11.2 deletion syndrome using physiological and genetic approaches to examine endothelial-dependent phenotypes.

    • Julie Ouellette
    • , Xavier Toussay
    • , Cesar H. Comin
    • , Luciano da F. Costa
    • , Mirabelle Ho
    • , María Lacalle-Aurioles
    • , Moises Freitas-Andrade
    • , Qing Yan Liu
    • , Sonia Leclerc
    • , Youlian Pan
    • , Ziying Liu
    • , Jean-François Thibodeau
    • , Melissa Yin
    • , Micael Carrier
    • , Cameron J. Morse
    • , Peter Van Dyken
    • , Christopher J. Bergin
    • , Sylvain Baillet
    • , Christopher R. Kennedy
    • , Marie-Ève Tremblay
    • , Yannick D. Benoit
    • , William L. Stanford
    • , Dylan Burger
    • , Duncan J. Stewart
    •  & Baptiste Lacoste
  • Technical Report |

    Deschloroclozapine (DCZ) is a broadly useful chemogenetic agonist for studies using nonhuman primates and mice. DCZ rapidly and reversibly activates DREADDs, and its binding can be visualized noninvasively by positron emission tomography.

    • Yuji Nagai
    • , Naohisa Miyakawa
    • , Hiroyuki Takuwa
    • , Yukiko Hori
    • , Kei Oyama
    • , Bin Ji
    • , Manami Takahashi
    • , Xi-Ping Huang
    • , Samuel T. Slocum
    • , Jeffrey F. DiBerto
    • , Yan Xiong
    • , Takuya Urushihata
    • , Toshiyuki Hirabayashi
    • , Atsushi Fujimoto
    • , Koki Mimura
    • , Justin G. English
    • , Jing Liu
    • , Ken-ichi Inoue
    • , Katsushi Kumata
    • , Chie Seki
    • , Maiko Ono
    • , Masafumi Shimojo
    • , Ming-Rong Zhang
    • , Yutaka Tomita
    • , Jin Nakahara
    • , Tetsuya Suhara
    • , Masahiko Takada
    • , Makoto Higuchi
    • , Jian Jin
    • , Bryan L. Roth
    •  & Takafumi Minamimoto
  • Article |

    Laszlovszky et al. demonstrate the presence of two types of cholinergic neurons that differ in cellular physiology, coupling with cortical oscillations, synchrony within each group, behavior performance correlates and anatomical distribution.

    • Tamás Laszlovszky
    • , Dániel Schlingloff
    • , Panna Hegedüs
    • , Tamás F. Freund
    • , Attila Gulyás
    • , Adam Kepecs
    •  & Balázs Hangya
  • Article |

    Lovett-Barron et al. register in situ gene expression to cellular-level neural dynamics in behaving zebrafish and find threat-selective populations spanning multiple hypothalamic peptidergic neuron classes, which converge on brainstem defensive action premotor neurons.

    • Matthew Lovett-Barron
    • , Ritchie Chen
    • , Susanna Bradbury
    • , Aaron S. Andalman
    • , Mahendra Wagle
    • , Su Guo
    •  & Karl Deisseroth
  • Article |

    Barbosa, Stein et al. show that rather than operating independently, PFC persistent activity and ‘activity-silent’ mechanisms interact dynamically to produce serial effects in working memory, consistent with attractor models with synaptic plasticity.

    • Joao Barbosa
    • , Heike Stein
    • , Rebecca L. Martinez
    • , Adrià Galan-Gadea
    • , Sihai Li
    • , Josep Dalmau
    • , Kirsten C. S. Adam
    • , Josep Valls-Solé
    • , Christos Constantinidis
    •  & Albert Compte
  • Article |

    Using data from top neuroscience journals, this study finds that women-led work tends to be undercited relative to expectations. This imbalance is driven largely by the citation practices of men and is increasing over time as the field diversifies.

    • Jordan D. Dworkin
    • , Kristin A. Linn
    • , Erin G. Teich
    • , Perry Zurn
    • , Russell T. Shinohara
    •  & Danielle S. Bassett
  • Review Article |

    Recent studies separately address the neural representation of stimuli and its dynamics in networks that model neural interactions. Ju and Bassett review such recent advances and discuss the integration of neural representations and network models.

    • Harang Ju
    •  & Danielle S. Bassett
  • Article |

    Mice with AD-like pathology and memory impairments surprisingly have memory engrams in their hippocampus. However, interference with novelty-like cells prevents proper recall, erroneously letting mice perceive a previously learned context as novel.

    • Stefanie Poll
    • , Manuel Mittag
    • , Fabrizio Musacchio
    • , Lena C. Justus
    • , Eleonora Ambrad Giovannetti
    • , Julia Steffen
    • , Jens Wagner
    • , Lioba Zohren
    • , Susanne Schoch
    • , Boris Schmidt
    • , Walker S. Jackson
    • , Dan Ehninger
    •  & Martin Fuhrmann
  • Article |

    Andreone, Przybyla et al. used induced pluripotent stem cell-derived human microglia to show that TREM2-dependent phagocytosis and lipid metabolism require the Alzheimer’s risk factor PLCγ2, which can also mediate TREM2-independent inflammatory signaling via Toll-like receptors.

    • Benjamin J. Andreone
    • , Laralynne Przybyla
    • , Ceyda Llapashtica
    • , Anil Rana
    • , Sonnet S. Davis
    • , Bettina van Lengerich
    • , Karin Lin
    • , Ju Shi
    • , Yuan Mei
    • , Giuseppe Astarita
    • , Gilbert Di Paolo
    • , Thomas Sandmann
    • , Kathryn M. Monroe
    •  & Joseph W. Lewcock