Collections

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    Popularization of super-resolution imaging techniques has allowed cell biologists to probe cell structure and function in previously unattainable detail. These methodologies continue to evolve, with new improvements that allow tailoring the available techniques to a particular need and application. This collection showcases primary research articles, reviews and protocols and highlights these recent developments by exemplifying the new, interesting applications of super-resolution microscopy as well as related tool development.

    Image: Bertocchi et al., Nature Cell Biology volume 19, pages 28–37 (2017).
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    Collection of articles from the Nature Research journals covering advances in understanding the gut-brain axis.

    Image: Laura Marshall
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    For several decades, the neuroscience community has endeavored to understand how the brain controls our perception of the world and how we interact with it. The molecular, cellular and circuit-level mechanisms that underlie these processes have been investigated primarily in animal models. Noninvasive methods such as magnetic resonance imaging (MRI), electroencephalography (EEG) and magnetoencephalography (MEG) have allowed neuroscientists to complement these findings with measures of human brain responses to complex stimuli and behaviors. Nature Neuroscience presents a special issue highlighting considerations and recent developments in noninvasive techniques that improve our understanding of neural measurements in humans, bridging the gap between human and animal research in neuroscience.

    Image: Credit: Getty Images/iStockphoto / Thinkstock \ Robert Adrian Hillman
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    The nervous and immune systems communicate and reciprocally influence their functional responses. Nature ImmunologyandNature Neurosciencepresent a joint focus entailing a series of specially commissioned review articles that discuss how the nervous system and immune cells interact during development, homeostasis and in pathogenic disease states.

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    There is an accelerating push towards greater selectivity, sensitivity and power in data collection in neuroscience. This is accompanied by the associated development of sophisticated analyses. Nature Neuroscience is pleased to present a special issue focused on techniques that sit at the forefront of modern neuroscience that present a view of recent advances in technical development, a consideration about how these are best deployed, and large-scale initiatives designed to advance further tool development, with expected parallel advances in neurobiological insight.

    Image: Credit: Getty Images/iStockphoto Thinkstock Images \ Andrey Burmakin
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    Deep understanding in neuroscience comes from the complementary embrace of theory and experiment. This has been the case in the past, and is only going to become truer in the future. The ability to perform increasingly large parallel measurements of neural activity has been one of the more exciting developments in experimental neuroscience. However, the increased data collection necessitates progressively sophisticated computational techniques and theoretical frameworks to inform our understanding. Nature Neuroscience is pleased to present a special issue focused on recent advances in computational and theoretical neuroscience that highlight the current thinking and unanswered questions on topics that include neural networks and coding, memory formation, sensory perception and decision-making, and psychiatric illness.

    Image: Credit: Getty Images/iStockphoto Thinkstock Images \ agsandrew
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    Stress serves an important purpose in maintaining health, but prolonged or severe stress can be harmful, particularly to the central nervous system. Nature Neurosciencepresents a special issue focused on how stress affects brain function, behavior, and the development of psychiatric diseases, via a series of reviews and perspectives written by leaders in the field.

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    Ten years ago, channelrhodopsin-2 was expressed in neurons and shown to control their activity. In this issue, we consider how the field has developed since these early optogenetic experiments.

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    Nature Neurosciencepresents a special focus issue on the topic of Epilepsy which, through a series of reviews and opinionated articles from key leaders in the field, aims to highlight many of the most recent and informative research which has expanded our understanding of the pathogenic events which lead to aberrant brain activity and the molecular and circuit-level mechanisms that regulate neuronal excitability.

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    Big data projects in the neurosciences have been increasing in number in recent years. Nature Neurosciencepresents a collection of Reviews, Perspectives and Commentaries that discuss different kinds of big data in neuroscience, from epigenomics to connectomics and whole-brain activity recordings to big behavioral data. The authors of these pieces tackle tough questions that have come to the forefront during this era of big data, including whether big data will completely change the way neuroscience is done, how much insight will be gained from big data, and what are the best ways to go about conducting such projects.