Review Articles

Filter By:

  • This Review organizes models of cognitive maps into a clear ontology. This ontology reveals parallels between existing empirical results and implies new approaches to understand hippocampal–cortical interactions and beyond.

    • James C. R. Whittington
    • David McCaffary
    • Timothy E. J. Behrens
    Review Article
  • This Review provides a comprehensive overview of presynaptic applications of optogenetic tools, including the associated challenges, current limitations and future directions for this approach.

    • Benjamin R. Rost
    • Jonas Wietek
    • Dietmar Schmitz
    Review Article
  • Eating disorders are prevalent and, in far too many cases, fatal. This review covers advances in genetics, neuroimaging, and animal models, and encourages a more unified science of eating disorders.

    • Cynthia M. Bulik
    • Jonathan R. I. Coleman
    • Gerome Breen
    Review Article
  • Roy, Zhang et al. discuss how modern neuroscience is revealing underappreciated heterogeneity in thalamic cell types, which leads to the idea that ‘thalamic subnetworks’ provide a more appropriate level of functional description than thalamic nuclei.

    • Dheeraj S. Roy
    • Ying Zhang
    • Guoping Feng
    Review Article
  • Neuroscientists can measure activity from more neurons than ever before, garnering new insights and posing challenges to traditional theoretical frameworks. New frameworks may help researchers use these observations to shed light on brain function.

    • Anne E. Urai
    • Brent Doiron
    • Anne K. Churchland
    Review Article
  • This Review discusses evidence from human studies and mouse models that cortical interneurons are involved in the pathophysiology of autism and that parvalbumin cell hypofunction may be a primary driver of circuit dysfunction in autism.

    • Anis Contractor
    • Iryna M. Ethell
    • Carlos Portera-Cailliau
    Review Article
  • Myelin is traditionally perceived as inert and immutable, but this notion is now being challenged. de Faria et al. discuss how myelin changes throughout life and in response to experience, and consider the functional implications of these changes.

    • Omar de Faria Jr
    • Helena Pivonkova
    • Ragnhildur Thóra Káradóttir
    Review Article
  • Multiphoton holographic optogenetics is opening the era of ‘tailored’ optogenetics. The authors review the underlying technology and discuss how it can be used to bridge the gap between experimental and theoretical neuroscience.

    • Hillel Adesnik
    • Lamiae Abdeladim
    Review Article
  • Schaeffer and Iadecola review the anatomical, molecular and functional heterogeneity of the neurovasculature and highlight the coordinated interaction of factors intrinsic and extrinsic to the brain in its dynamic regulation and role in disease.

    • Samantha Schaeffer
    • Costantino Iadecola
    Review Article
  • Gene-based therapies offer the promise of long-lasting clinical benefit for both genetic and sporadic neurodegenerative diseases. Sun and Roy highlight recent successes and caveats, offering a prospective glimpse into this rapidly emerging arena.

    • Jichao Sun
    • Subhojit Roy
    Review Article
  • This Review discusses two high-throughput techniques—massively parallel reporter assays (MPRAs) and CRISPR screens—focusing on their potential to validate non-coding genetic risk variants in human stem cell models of complex brain disorders.

    • Kayla G. Townsley
    • Kristen J. Brennand
    • Laura M. Huckins
    Review Article
  • Gangopadhyay, Chawla et al. examine the neural bases of social decision-making at different processing stages and across humans, non-human primates and rodents. These examinations underscore the importance of the medial prefrontal–amygdala pathways.

    • Prabaha Gangopadhyay
    • Megha Chawla
    • Steve W. C. Chang
    Review Article
  • Behavioral quantification is changing neuroscience. Pereira et al. provide an overview of the latest advances in motion tracking and behavior prediction and discuss how these methods are used to understand the brain in ways not previously possible.

    • Talmo D. Pereira
    • Joshua W. Shaevitz
    • Mala Murthy
    Review Article