Articles

  • Article |

    Lau et al. find that α-synuclein strains initiate distinct diseases when injected into mice, which provides a potential molecular explanation for the clinical and pathological differences between Parkinson’s disease and related neurodegenerative disorders.

    • Angus Lau
    • , Raphaella W. L. So
    • , Heather H. C. Lau
    • , Jason C. Sang
    • , Alejandro Ruiz-Riquelme
    • , Shelaine C. Fleck
    • , Erica Stuart
    • , Sindhu Menon
    • , Naomi P. Visanji
    • , Georg Meisl
    • , Rania Faidi
    • , Maria M. Marano
    • , Cian Schmitt-Ulms
    • , Zhilan Wang
    • , Paul E. Fraser
    • , Anurag Tandon
    • , Bradley T. Hyman
    • , Holger Wille
    • , Martin Ingelsson
    • , David Klenerman
    •  & Joel C. Watts
  • Article |

    Using samples from the Danish Neonatal Screening Biobank, children with ASD and children with ADHD were found to have similar, significantly increased rates of rare protein-truncating variants in evolutionarily constrained genes.

    • F. Kyle Satterstrom
    • , Raymond K. Walters
    • , Tarjinder Singh
    • , Emilie M. Wigdor
    • , Francesco Lescai
    • , Ditte Demontis
    • , Jack A. Kosmicki
    • , Jakob Grove
    • , Christine Stevens
    • , Jonas Bybjerg-Grauholm
    • , Marie Bækvad-Hansen
    • , Duncan S. Palmer
    • , Julian B. Maller
    • , Merete Nordentoft
    • , Ole Mors
    • , Elise B. Robinson
    • , David M. Hougaard
    • , Thomas M. Werge
    • , Preben Bo Mortensen
    • , Benjamin M. Neale
    • , Anders D. Børglum
    •  & Mark J. Daly
  • Article |

    Animals compose behaviors from both sensory cues and internal states. Calhoun et al. develop an unsupervised modeling framework to identify the dynamic internal states that shape social interactions in Drosophila and use the model to identify neurons that modulate the male’s internal state.

    • Adam J. Calhoun
    • , Jonathan W. Pillow
    •  & Mala Murthy
  • Article |

    This study shows that mouse prefrontal neurons differentially categorize social and nonsocial olfactory cues. Social cue representations are refined with experience and are disrupted in a mouse model of autism with elevated cortical noise.

    • Dana Rubi Levy
    • , Tal Tamir
    • , Maya Kaufman
    • , Ana Parabucki
    • , Aharon Weissbrod
    • , Elad Schneidman
    •  & Ofer Yizhar
  • Article |

    The authors show that spatiotemporal spike sequences across neurons in the primate amygdala serve as a coding mechanism and might aid memory formation via the rehearsal of a recently experienced aversive or pleasant tone–odor association.

    • Tamar Reitich-Stolero
    •  & Rony Paz
  • Article |

    DNA sequencing of 3,864 individuals with ALS and 7,839 controls identified a novel disease gene, DNAJC7, which encodes a heat-shock protein. As DNAJC7 is an essential part of cell maintenance, mutations in DNAJC7 may lead to neurodegeneration.

    • Sali M. K. Farhan
    • , Daniel P. Howrigan
    • , Liam E. Abbott
    • , Joseph R. Klim
    • , Simon D. Topp
    • , Andrea E. Byrnes
    • , Claire Churchhouse
    • , Hemali Phatnani
    • , Bradley N. Smith
    • , Evadnie Rampersaud
    • , Gang Wu
    • , Joanne Wuu
    • , Aleksey Shatunov
    • , Alfredo Iacoangeli
    • , Ahmad Al Khleifat
    • , Daniel A. Mordes
    • , Sulagna Ghosh
    • , Kevin Eggan
    • , Rosa Rademakers
    • , Jacob L. McCauley
    • , Rebecca Schüle
    • , Stephan Züchner
    • , Michael Benatar
    • , J. Paul Taylor
    • , Michael Nalls
    • , Marc Gotkine
    • , Pamela J. Shaw
    • , Karen E. Morrison
    • , Ammar Al-Chalabi
    • , Bryan Traynor
    • , Christopher E. Shaw
    • , David B. Goldstein
    • , Matthew B. Harms
    • , Mark J. Daly
    •  & Benjamin M. Neale
  • Article |

    Walking requires continual integrated information about the dynamic internal and external environment. This study reveals a pathway whereby the somatosensory cortex directly influences motor behavior based on integrated spatiotemporal information.

    • Spyridon K. Karadimas
    • , Kajana Satkunendrarajah
    • , Alex M. Laliberte
    • , Dene Ringuette
    • , Iliya Weisspapir
    • , Lijun Li
    • , Simon Gosgnach
    •  & Michael G. Fehlings
  • Article |

    Zhou et al. show that the reward and context information of cocaine-associated memory is stored in selectively strengthened inter-engram connections from the ventral CA1 to the nucleus accumbens core, forming an ‘engram circuit’ that mediates memory recall.

    • Yiming Zhou
    • , Huiwen Zhu
    • , Zhiyuan Liu
    • , Xi Chen
    • , XiuJuan Su
    • , Chaonan Ma
    • , Zhen Tian
    • , Bing Huang
    • , Enhui Yan
    • , Xing Liu
    •  & Lan Ma
  • Article |

    Hartley et al. report the bidirectional remodeling of a basolateral amygdala-to-central amygdala neural circuit, where input onto corticotropin-releasing factor (CRF)-expressing and CRF-negative neurons is shaped by the acquisition and extinction of fear memory.

    • Nolan D. Hartley
    • , Andrew D. Gaulden
    • , Rita Báldi
    • , Nathan D. Winters
    • , Gregory J. Salimando
    • , Luis Eduardo Rosas-Vidal
    • , Alexis Jameson
    • , Danny G. Winder
    •  & Sachin Patel
  • Article |

    Qasim et al. describe neurons in the human entorhinal cortex that activate near the locations in space that a person is cued to recall during a memory task. These results show one way in which the cognitive map shifts according to memory demands.

    • Salman E. Qasim
    • , Jonathan Miller
    • , Cory S. Inman
    • , Robert E. Gross
    • , Jon T. Willie
    • , Bradley Lega
    • , Jui-Jui Lin
    • , Ashwini Sharan
    • , Chengyuan Wu
    • , Michael R. Sperling
    • , Sameer A. Sheth
    • , Guy M. McKhann
    • , Elliot H. Smith
    • , Catherine Schevon
    • , Joel M. Stein
    •  & Joshua Jacobs
  • Article |

    The authors develop a deep learning approach that enables an efficient search of the input space to find the best stimuli for modeled neurons. When tested, these stimuli are most effective at driving their matching cells in the brain.

    • Edgar Y. Walker
    • , Fabian H. Sinz
    • , Erick Cobos
    • , Taliah Muhammad
    • , Emmanouil Froudarakis
    • , Paul G. Fahey
    • , Alexander S. Ecker
    • , Jacob Reimer
    • , Xaq Pitkow
    •  & Andreas S. Tolias
  • Article |

    Forkosh, Karamihalev and colleagues present a framework for inferring stable traits from a broad range of behavioral readouts and apply it to capture biologically relevant individual differences in mice.

    • Oren Forkosh
    • , Stoyo Karamihalev
    • , Simone Roeh
    • , Uri Alon
    • , Sergey Anpilov
    • , Chadi Touma
    • , Markus Nussbaumer
    • , Cornelia Flachskamm
    • , Paul M. Kaplick
    • , Yair Shemesh
    •  & Alon Chen
  • Article |

    The Drosophila neuropeptide leucokinin mediates hunger- and thirst-dependent expression of learned behaviors. State-relevant selection of appropriate memory emerges from competition between leucokinin and other modulators onto dopaminergic neurons.

    • Bhagyashree Senapati
    • , Chang-Hui Tsao
    • , Yi-An Juan
    • , Tai-Hsiang Chiu
    • , Chia-Lin Wu
    • , Scott Waddell
    •  & Suewei Lin
  • Article |

    Chow et al. show that high blood levels of insulin in prediabetic conditions are linked to saturated insulin levels in the brain. Chronic insulin exposure leads to insulin resistance, cell cycle reentry and premature aging, corresponding to senescence-like pathological changes in neurons.

    • Hei-Man Chow
    • , Meng Shi
    • , Aifang Cheng
    • , Yuehong Gao
    • , Guimiao Chen
    • , Xuan Song
    • , Raphaella Wai Lam So
    • , Jie Zhang
    •  & Karl Herrup
  • Article |

    Krabbe, Paradiso et al. show that amygdala VIP interneurons are activated by instructive cues for associative learning. These interneurons provide a mandatory disinhibitory signal permitting plasticity in response to unexpected salient events.

    • Sabine Krabbe
    • , Enrica Paradiso
    • , Simon d’Aquin
    • , Yael Bitterman
    • , Julien Courtin
    • , Chun Xu
    • , Keisuke Yonehara
    • , Milica Markovic
    • , Christian Müller
    • , Tobias Eichlisberger
    • , Jan Gründemann
    • , Francesco Ferraguti
    •  & Andreas Lüthi
  • Article |

    Liu et al. show that microglial process surveillance is restrained in awake mice, and that reduced neuronal activity due to anesthesia, sensory deprivation or optogenetic inhibition increases microglial dynamics via norepinephrine signaling.

    • Yong U. Liu
    • , Yanlu Ying
    • , Yujiao Li
    • , Ukpong B. Eyo
    • , Tingjun Chen
    • , Jiaying Zheng
    • , Anthony D. Umpierre
    • , Jia Zhu
    • , Dale B. Bosco
    • , Hailong Dong
    •  & Long-Jun Wu
  • Article |

    Stowell, Sipe et al. describe how norepinephrine signaling to microglia during wakefulness influences the dynamic movement of microglial processes, affecting both microglial interactions with neurons and experience-dependent plasticity.

    • Rianne D. Stowell
    • , Grayson O. Sipe
    • , Ryan P. Dawes
    • , Hanna N. Batchelor
    • , Katheryn A. Lordy
    • , Brendan S. Whitelaw
    • , Mark B. Stoessel
    • , Jean M. Bidlack
    • , Edward Brown
    • , Mriganka Sur
    •  & Ania K. Majewska
  • Article |

    In offspring exposed to THC in utero, molecular, synaptic and circuit reorganizations lead to a hyperdopaminergic phenotype and behavioral susceptibility. The neurosteroid pregnenolone restores both dopamine function and abnormal behavior.

    • Roberto Frau
    • , Vivien Miczán
    • , Francesco Traccis
    • , Sonia Aroni
    • , Csaba I. Pongor
    • , Pierluigi Saba
    • , Valeria Serra
    • , Claudia Sagheddu
    • , Silvia Fanni
    • , Mauro Congiu
    • , Paola Devoto
    • , Joseph F. Cheer
    • , István Katona
    •  & Miriam Melis
  • Article |

    The authors found that activity of the same ventral tegmental area dopaminergic axons in basal amygdala increased following learned cues predicting either food rewards or punishments, in a manner consistent with signaling of motivational salience.

    • Andrew Lutas
    • , Hakan Kucukdereli
    • , Osama Alturkistani
    • , Crista Carty
    • , Arthur U. Sugden
    • , Kayla Fernando
    • , Veronica Diaz
    • , Vanessa Flores-Maldonado
    •  & Mark L. Andermann
  • Article |

    The authors report that the ALS-associated gene FUS stimulates transcription of acetylcholine receptor subunit genes in subsynaptic myonuclei. ALS mutations distort this mechanism, inducing muscle-intrinsic toxicity that may contribute to dying-back motor neuronopathy.

    • Gina Picchiarelli
    • , Maria Demestre
    • , Amila Zuko
    • , Marije Been
    • , Julia Higelin
    • , Stéphane Dieterlé
    • , Marc-Antoine Goy
    • , Moushami Mallik
    • , Chantal Sellier
    • , Jelena Scekic-Zahirovic
    • , Li Zhang
    • , Angela Rosenbohm
    • , Céline Sijlmans
    • , Amr Aly
    • , Sina Mersmann
    • , Inmaculada Sanjuan-Ruiz
    • , Annemarie Hübers
    • , Nadia Messaddeq
    • , Marina Wagner
    • , Nick van Bakel
    • , Anne-Laurence Boutillier
    • , Albert Ludolph
    • , Clotilde Lagier-Tourenne
    • , Tobias M. Boeckers
    • , Luc Dupuis
    •  & Erik Storkebaum
  • Article |

    Control of movements can be understood in terms of the interplay between a controller, a simulator and an estimator. Egger et. al. show that cortical neurons establish the same building blocks to control cognitive states in the absence of movement.

    • Seth W. Egger
    • , Evan D. Remington
    • , Chia-Jung Chang
    •  & Mehrdad Jazayeri
  • Article |

    Using intracranial recordings in humans, the authors found decision conflict-related effects on firing rate in the dorsal anterior cingulate cortex (dACC), on spike-phase coupling in the dACC, and on spike-field coherence in the dorsolateral prefrontal cortex.

    • Elliot H. Smith
    • , Guillermo Horga
    • , Mark J. Yates
    • , Charles B. Mikell
    • , Garrett P. Banks
    • , Yagna J. Pathak
    • , Catherine A. Schevon
    • , Guy M. McKhann II
    • , Benjamin Y. Hayden
    • , Matthew M. Botvinick
    •  & Sameer A. Sheth
  • Article |

    The authors use a linear model to reveal how neural activity patterns are related to cognition or movements. They find that uninstructed movements dominate single-cell and population activity throughout the brain, outpacing task-related activity.

    • Simon Musall
    • , Matthew T. Kaufman
    • , Ashley L. Juavinett
    • , Steven Gluf
    •  & Anne K. Churchland
  • Article |

    By developing layer-specific functional MRI techniques for a high-order cognitive brain area, Finn et al. dissociate activity in superficial and deeper cortical layers during different periods of a working memory task in human dorsolateral prefrontal cortex.

    • Emily S. Finn
    • , Laurentius Huber
    • , David C. Jangraw
    • , Peter J. Molfese
    •  & Peter A. Bandettini
  • Article |

    Microglia and astrocytes propagate neurodegeneration by releasing fragmented and dysfunctional mitochondria into the neuronal milieu. Inhibiting pathological fragmentation of glial mitochondria blunts neuroinflammation and increases neuroprotection.

    • Amit U. Joshi
    • , Paras S. Minhas
    • , Shane A. Liddelow
    • , Bereketeab Haileselassie
    • , Katrin I. Andreasson
    • , Gerald W. Dorn II
    •  & Daria Mochly-Rosen
  • Article |

    In leukocyte transcriptomes from toddlers with ASD, Gazestani et al. find a perturbed gene network that is involved in fetal brain development and lies downstream of ASD risk genes, and whose dysregulation level correlates with ASD symptom severity.

    • Vahid H. Gazestani
    • , Tiziano Pramparo
    • , Srinivasa Nalabolu
    • , Benjamin P. Kellman
    • , Sarah Murray
    • , Linda Lopez
    • , Karen Pierce
    • , Eric Courchesne
    •  & Nathan E. Lewis
  • Article |

    Sun and Jin et al. report that a population of neurons in the subiculum form a pathway for visual information to reach the hippocampus and impact place-specific activity. Activation of these neurons promotes the formation of object-location memories.

    • Yanjun Sun
    • , Suoqin Jin
    • , Xiaoxiao Lin
    • , Lujia Chen
    • , Xin Qiao
    • , Li Jiang
    • , Pengcheng Zhou
    • , Kevin G. Johnston
    • , Peyman Golshani
    • , Qing Nie
    • , Todd C. Holmes
    • , Douglas A. Nitz
    •  & Xiangmin Xu
  • Article |

    Huang and colleagues functionally map a brain circuit connecting the amygdala and the spinal cord that is altered after nerve injury and contributes to chronic pain.

    • Junting Huang
    • , Vinicius M. Gadotti
    • , Lina Chen
    • , Ivana A. Souza
    • , Shuo Huang
    • , Decheng Wang
    • , Charu Ramakrishnan
    • , Karl Deisseroth
    • , Zizhen Zhang
    •  & Gerald W. Zamponi
  • Article |

    Gehrlach et al. show how the posterior insular cortex processes and modulates diverse internally and externally generated aversive states, and they dissect the functional contribution of segregated projections mediating inhibition of ongoing behaviors.

    • Daniel A. Gehrlach
    • , Nejc Dolensek
    • , Alexandra S. Klein
    • , Ritu Roy Chowdhury
    • , Arthur Matthys
    • , Michaela Junghänel
    • , Thomas N. Gaitanos
    • , Alja Podgornik
    • , Thomas D. Black
    • , Narasimha Reddy Vaka
    • , Karl-Klaus Conzelmann
    •  & Nadine Gogolla
  • Article |

    Breen et al. map RNA editing profiles in cortical samples from individuals with schizophrenia and controls, and find links between altered RNA editing in glutamatergic and postsynaptic density genes and schizophrenia genetic risk architecture.

    • Michael S. Breen
    • , Amanda Dobbyn
    • , Qin Li
    • , Panos Roussos
    • , Gabriel E. Hoffman
    • , Eli Stahl
    • , Andrew Chess
    • , Pamela Sklar
    • , Jin Billy Li
    • , Bernie Devlin
    • , Joseph D. Buxbaum
    • , Schahram Akbarian
    • , Jaroslav Bendl
    • , Kristen Brennand
    • , Leanne Brown
    • , Andrew Browne
    • , Alexander Charney
    • , Lizette Couto
    • , Greg Crawford
    • , Olivia Devillers
    • , Enrico Domenici
    • , Michele Filosi
    • , Elie Flatow
    • , Nancy Francoeur
    • , John F. Fullard
    • , Sergio Espeso Gil
    • , Kiran Girdhar
    • , Attila Gulyás-Kovács
    • , Raquel Gur
    • , Chang-Gyu Hahn
    • , Vahram Haroutunian
    • , Mads Engel Hauberg
    • , Laura Huckins
    • , Rivky Jacobov
    • , Yan Jiang
    • , Jessica S. Johnson
    • , Bibi Kassim
    • , Yungil Kim
    • , Lambertus Klei
    • , Robin Kramer
    • , Mario Lauria
    • , Thomas Lehner
    • , David A. Lewis
    • , Barbara K. Lipska
    • , Stefano Marenco
    • , Lara M. Mangravite
    • , Kelsey Montgomery
    • , Royce Park
    • , Thanneer Malai Perumal
    • , Mette A. Peters
    • , Chaggai Rosenbluh
    • , Douglas M. Ruderfer
    • , Geetha Senthil
    • , Hardik R. Shah
    • , Solveig K. Sieberts
    • , Laura Sloofman
    • , Lingyun Song
    • , Patrick Sullivan
    • , Roberto Visintainer
    • , Jiebiao Wang
    • , Ying-Chih Wang
    • , Jennifer Wiseman
    • , Eva Xia
    • , Wen Zhang
    •  & Elizabeth Zharovsky
  • Article |

    Zhou et al. report a novel 5-HT circuit from the dorsal raphe nucleus to somatostatin-expressing neurons in the central nucleus of the amygdala that partially mediates depressive-like behavior in a mouse model of chronic pain.

    • Wenjie Zhou
    • , Yan Jin
    • , Qian Meng
    • , Xia Zhu
    • , Tongjian Bai
    • , Yanghua Tian
    • , Yu Mao
    • , Likui Wang
    • , Wen Xie
    • , Hui Zhong
    • , Na Zhang
    • , Min-Hua Luo
    • , Wenjuan Tao
    • , Haitao Wang
    • , Jie Li
    • , Juan Li
    • , Ben-Sheng Qiu
    • , Jiang-Ning Zhou
    • , Xiangyao Li
    • , Han Xu
    • , Kai Wang
    • , Xiaochu Zhang
    • , Yong Liu
    • , Gal Richter-Levin
    • , Lin Xu
    •  & Zhi Zhang
  • Article |

    Researchers identify a transcriptional network engaged in stress-resilient mice that is regulated by a previously unstudied transcription factor, Zfp189, and elucidate molecular mechanisms controlling this network and resilience behavior.

    • Zachary S. Lorsch
    • , Peter J. Hamilton
    • , Aarthi Ramakrishnan
    • , Eric M. Parise
    • , Marine Salery
    • , William J. Wright
    • , Ashley E. Lepack
    • , Philipp Mews
    • , Orna Issler
    • , Andrew McKenzie
    • , Xianxiao Zhou
    • , Lyonna F. Parise
    • , Stephen T. Pirpinias
    • , Idelisse Ortiz Torres
    • , Hope G. Kronman
    • , Sarah E. Montgomery
    • , Yong-Hwee Eddie Loh
    • , Benoit Labonté
    • , Andrew Conkey
    • , Ann E. Symonds
    • , Rachael L. Neve
    • , Gustavo Turecki
    • , Ian Maze
    • , Yan Dong
    • , Bin Zhang
    • , Li Shen
    • , Rosemary C. Bagot
    •  & Eric J. Nestler
  • Article |

    Neural populations often encode unknown variables. Chaudhuri et al. develop a method to decode unknown variables by finding shapes in neural data. They show that a mammalian brain circuit of thousands of neurons constructs a navigational compass with only a one-dimensional ring of stable activity states.

    • Rishidev Chaudhuri
    • , Berk Gerçek
    • , Biraj Pandey
    • , Adrien Peyrache
    •  & Ila Fiete
  • Article |

    Using data from rats and humans, the authors study the time it takes to make sensory judgments. The authors define the new regularity as the time–intensity equivalence in discrimination (TIED), which provides a mechanistic basis of Weber’s law.

    • Jose L. Pardo-Vazquez
    • , Juan R. Castiñeiras-de Saa
    • , Mafalda Valente
    • , Iris Damião
    • , Tiago Costa
    • , M. Inês Vicente
    • , André G. Mendonça
    • , Zachary F. Mainen
    •  & Alfonso Renart
  • Article |

    Like humans, songbirds learn to communicate vocally early in life. Moore and Woolley taught birds the songs of a different species to identify how vocal experience and auditory tuning mechanisms create neural representations of communication sounds.

    • Jordan M. Moore
    •  & Sarah M. N. Woolley
  • Article |

    Everyday decisions require choosing among multiple options. This work derives the optimal decision policy and shows how it can be approximated by a biologically plausible neural circuit and how this circuit can reproduce observed behavior.

    • Satohiro Tajima
    • , Jan Drugowitsch
    • , Nisheet Patel
    •  & Alexandre Pouget
  • Article |

    This study identifies eight significant genetic associations with intrusive reexperiencing of trauma in post-traumatic stress disorder (PTSD) from the Million Veteran Program (MVP), a large biobank focused on US veterans.

    • Joel Gelernter
    • , Ning Sun
    • , Renato Polimanti
    • , Robert. Pietrzak
    • , Daniel F. Levey
    • , Julien Bryois
    • , Qiongshi Lu
    • , Yiming Hu
    • , Boyang Li
    • , Krishnan Radhakrishnan
    • , Mihaela Aslan
    • , Kei-Hoi Cheung
    • , Yuli Li
    • , Nallakkandi Rajeevan
    • , Frederick Sayward
    • , Kelly Harrington
    • , Quan Chen
    • , Kelly Cho
    • , Saiju Pyarajan
    • , Patrick F. Sullivan
    • , Rachel Quaden
    • , Yunling Shi
    • , Haley Hunter-Zinck
    • , J. Michael Gaziano
    • , John Concato
    • , Hongyu Zhao
    •  & Murray B. Stein
  • Article |

    Detecting and responding to noxious stimuli is essential for survival. Wee et al. show that noxious stimuli elicit intense and widespread activity in zebrafish oxytocin neurons, which promote defensive behavior by activating hindbrain premotor neurons.

    • Caroline L. Wee
    • , Maxim Nikitchenko
    • , Wei-Chun Wang
    • , Sasha J. Luks-Morgan
    • , Erin Song
    • , James A. Gagnon
    • , Owen Randlett
    • , Isaac H. Bianco
    • , Alix M. B. Lacoste
    • , Elena Glushenkova
    • , Joshua P. Barrios
    • , Alexander F. Schier
    • , Samuel Kunes
    • , Florian Engert
    •  & Adam D. Douglass
  • Article |

    Henderson et al. use quantitative pathology mapping and network modeling to show that α-synuclein pathology spreads through a neuroanatomically connected network, guided by selective vulnerability and genetic risk factors.

    • Michael X. Henderson
    • , Eli J. Cornblath
    • , Adam Darwich
    • , Bin Zhang
    • , Hannah Brown
    • , Ronald J. Gathagan
    • , Raizel M. Sandler
    • , Danielle S. Bassett
    • , John Q. Trojanowski
    •  & Virginia M. Y. Lee
  • Article |

    Guo et al. show that synaptic alterations in ACC pyramidal neurons underlie social impairments in Shank3 mutant mice and that selective activation of ACC pyramidal neurons or enhancing AMPAR function improves social behavior in these mice.

    • Baolin Guo
    • , Jing Chen
    • , Qian Chen
    • , Keke Ren
    • , Dayun Feng
    • , Honghui Mao
    • , Han Yao
    • , Jing Yang
    • , Haiying Liu
    • , Yingying Liu
    • , Fan Jia
    • , Chuchu Qi
    • , Taylor Lynn-Jones
    • , Hailan Hu
    • , Zhanyan Fu
    • , Guoping Feng
    • , Wenting Wang
    •  & Shengxi Wu
  • Article |

    Green et al. find that, when their internal heading estimate is rotated via neural stimulation, flies turn their body in a direction that aims to return their heading estimate back to its previous value. This suggests the heading estimate is compared with an internal goal to guide navigation.

    • Jonathan Green
    • , Vikram Vijayan
    • , Peter Mussells Pires
    • , Atsuko Adachi
    •  & Gaby Maimon
  • Article |

    Laboy-Juárez et al. show that barrel cortex neurons in mice are tuned for elementary multi-whisker sequences that represent tactile motion, using a computation similar to motion direction selectivity in vision. These findings provide a novel view of columnar organization.

    • Keven J. Laboy-Juárez
    • , Tomer Langberg
    • , Seoiyoung Ahn
    •  & Daniel E. Feldman
  • Article |

    The authors find that olfactory bulb inputs and outputs sample overlapping but distinct odor subspaces. Physical–chemical properties used to characterize odorants are not well represented in bulb activity, urging further search for better descriptors of odor space.

    • Honggoo Chae
    • , Daniel R. Kepple
    • , Walter G. Bast
    • , Venkatesh N. Murthy
    • , Alexei A. Koulakov
    •  & Dinu F. Albeanu
  • Article |

    SFRP1, an ADAM10 inhibitor, is elevated in the brains of patients with Alzheimer’s disease (AD). Antibody-mediated neutralization of its activity stalls brain alterations and cognitive loss in AD-like mice, supporting SFRP1 as a potential target for disease therapy.

    • Pilar Esteve
    • , Javier Rueda-Carrasco
    • , María Inés Mateo
    • , María Jesús Martin-Bermejo
    • , Jonathan Draffin
    • , Guadalupe Pereyra
    • , África Sandonís
    • , Inmaculada Crespo
    • , Inmaculada Moreno
    • , Ester Aso
    • , Paula Garcia-Esparcia
    • , Estrella Gomez-Tortosa
    • , Alberto Rábano
    • , Juan Fortea
    • , Daniel Alcolea
    • , Alberto Lleo
    • , Michael T. Heneka
    • , José M. Valpuesta
    • , José A. Esteban
    • , Isidro Ferrer
    • , Mercedes Domínguez
    •  & Paola Bovolenta