Articles

  • Article |

    Shen et al. report that prolonged obesity is associated with cerebrovascular dysfunction and Tak1 activation in brainstem microglia. Pharmacological inhibition or genetic depletion of Tak1 restores cerebrovascular function in obese mice.

    • Qing Shen
    • , Zhuo Chen
    • , Faming Zhao
    • , Susu Pan
    • , Tingting Zhang
    • , Xueer Cheng
    • , Lei Zhang
    • , Shanshan Zhang
    • , Junxia Qi
    • , Juxue Li
    • , Dongsheng Cai
    •  & Guo Zhang
  • Article |

    Precisely timed motor learning promotes remyelination in the motor cortex by enhancing oligodendrogenesis and stimulating mature oligodendrocytes to generate new myelin, presenting mature oligodendrocytes as new targets in remyelinating therapies.

    • Clara M. Bacmeister
    • , Helena J. Barr
    • , Crystal R. McClain
    • , Michael A. Thornton
    • , Dailey Nettles
    • , Cristin G. Welle
    •  & Ethan G. Hughes
  • Article |

    Hua and Chen et al. show that general anesthesia activates a distinct population of central amygdala neurons and that these neurons can potently suppress pain responses through their widespread projections to many pain-processing centers in the brain.

    • Thuy Hua
    • , Bin Chen
    • , Dongye Lu
    • , Katsuyasu Sakurai
    • , Shengli Zhao
    • , Bao-Xia Han
    • , Jiwoo Kim
    • , Luping Yin
    • , Yong Chen
    • , Jinghao Lu
    •  & Fan Wang
  • Article |

    Medulloblastomas lacking p53 do not express surface class I major histocompatibility complex (MHC-I) and are resistant to immune rejection. Tumor necrosis factor rescues MHC-I expression and synergizes with immune checkpoint inhibitors to promote rejection.

    • Alexandra Garancher
    • , Hiromichi Suzuki
    • , Svasti Haricharan
    • , Lianne Q. Chau
    • , Meher Beigi Masihi
    • , Jessica M. Rusert
    • , Paula S. Norris
    • , Florent Carrette
    • , Megan M. Romero
    • , Sorana A. Morrissy
    • , Patryk Skowron
    • , Florence M. G. Cavalli
    • , Hamza Farooq
    • , Vijay Ramaswamy
    • , Steven J. M. Jones
    • , Richard A. Moore
    • , Andrew J. Mungall
    • , Yussanne Ma
    • , Nina Thiessen
    • , Yisu Li
    • , Alaide Morcavallo
    • , Lin Qi
    • , Mari Kogiso
    • , Yuchen Du
    • , Patricia Baxter
    • , Jacob J. Henderson
    • , John R. Crawford
    • , Michael L. Levy
    • , James M. Olson
    • , Yoon-Jae Cho
    • , Aniruddha J. Deshpande
    • , Xiao-Nan Li
    • , Louis Chesler
    • , Marco A. Marra
    • , Harald Wajant
    • , Oren J. Becher
    • , Linda M. Bradley
    • , Carl F. Ware
    • , Michael D. Taylor
    •  & Robert J. Wechsler-Reya
  • Article |

    Cregg et al. find that a specific population of brainstem neurons act to control left–right turning of locomotor movements in mammals through distinct axial- and limb-based mechanisms. This turning pathway is the dominant system for natural directional movements.

    • Jared M. Cregg
    • , Roberto Leiras
    • , Alexia Montalant
    • , Paulina Wanken
    • , Ian R. Wickersham
    •  & Ole Kiehn
  • Article |

    The authors establish the claustrum-Cre transgenic mouse line and demonstrate that the claustrum orchestrates cortical slow-wave activity by synchronously driving the inhibitory interneurons in widespread cortical areas.

    • Kimiya Narikiyo
    • , Rumiko Mizuguchi
    • , Ayako Ajima
    • , Momoko Shiozaki
    • , Hiroki Hamanaka
    • , Joshua P. Johansen
    • , Kensaku Mori
    •  & Yoshihiro Yoshihara
  • Article |

    Marshall et al. show that regions of the genome adopt a noncanonical Z-DNA state in the prefrontal cortex in response to fear learning and that binding of Adar1 reduces Z-DNA during extinction learning, which is required for memory flexibility.

    • Paul R. Marshall
    • , Qiongyi Zhao
    • , Xiang Li
    • , Wei Wei
    • , Ambika Periyakaruppiah
    • , Esmi L. Zajaczkowski
    • , Laura J. Leighton
    • , Sachithrani U. Madugalle
    • , Dean Basic
    • , Ziqi Wang
    • , Jiayu Yin
    • , Wei-Siang Liau
    • , Ankita Gupte
    • , Carl R. Walkley
    •  & Timothy W. Bredy
  • Article |

    The authors describe a thalamic population, innervated by multimodal brainstem inputs, that forms a CS–US association prior to the lateral amygdala. Its fast and plastic signal defines an amygdala activity pattern necessary for adaptive fear learning.

    • Boglárka Barsy
    • , Kinga Kocsis
    • , Aletta Magyar
    • , Ákos Babiczky
    • , Mónika Szabó
    • , Judit M. Veres
    • , Dániel Hillier
    • , István Ulbert
    • , Ofer Yizhar
    •  & Ferenc Mátyás
  • Article |

    Flanigan et al. show that activation of inhibitory neurons in the lateral habenula by the neuropeptide orexin (hypocretin) promotes both inter-male aggression and conditioned place preference for contexts associated with winning aggressive contests.

    • Meghan E. Flanigan
    • , Hossein Aleyasin
    • , Long Li
    • , C. Joseph Burnett
    • , Kenny L. Chan
    • , Katherine B. LeClair
    • , Elizabeth K. Lucas
    • , Bridget Matikainen-Ankney
    • , Romain Durand-de Cuttoli
    • , Aki Takahashi
    • , Caroline Menard
    • , Madeline L. Pfau
    • , Sam A. Golden
    • , Sylvain Bouchard
    • , Erin S. Calipari
    • , Eric J. Nestler
    • , Ralph J. DiLeone
    • , Akihiro Yamanaka
    • , George W. Huntley
    • , Roger L. Clem
    •  & Scott J. Russo
  • Article |

    Lopez-Persem et al. used intracranial recordings in people with epilepsy to uncover key functional properties of neural value signals that might explain irrational choice behavior.

    • Alizée Lopez-Persem
    • , Julien Bastin
    • , Mathilde Petton
    • , Raphaëlle Abitbol
    • , Katia Lehongre
    • , Claude Adam
    • , Vincent Navarro
    • , Sylvain Rheims
    • , Philippe Kahane
    • , Philippe Domenech
    •  & Mathias Pessiglione
  • Article |

    The most common genetic cause of ALS and frontal temporal dementia—hexanucleotide repeat expansion in C9orf72—is shown to provoke disease via synergy of gain of toxicity(ies) from repeat-encoded RNAs/dipeptide repeat proteins and reduction in the C9ORF72 protein.

    • Qiang Zhu
    • , Jie Jiang
    • , Tania F. Gendron
    • , Melissa McAlonis-Downes
    • , Lulin Jiang
    • , Amy Taylor
    • , Sandra Diaz Garcia
    • , Somasish Ghosh Dastidar
    • , Maria J. Rodriguez
    • , Patrick King
    • , Yongjie Zhang
    • , Albert R. La Spada
    • , Huaxi Xu
    • , Leonard Petrucelli
    • , John Ravits
    • , Sandrine Da Cruz
    • , Clotilde Lagier-Tourenne
    •  & Don W. Cleveland
  • Article |

    Hippocampal neurons track events as abstract units of episodic experience. These event representations can be transferred between different experiences and are separately manipulable from hippocampal representations of continuous changes in space.

    • Chen Sun
    • , Wannan Yang
    • , Jared Martin
    •  & Susumu Tonegawa
  • Article |

    Eschbach, Fushiki et al. combine synaptic-resolution circuit mapping, functional analyses and modeling to reveal circuit motifs that regulate dopaminergic neuron activity and may increase associative learning task performance and flexibility.

    • Claire Eschbach
    • , Akira Fushiki
    • , Michael Winding
    • , Casey M. Schneider-Mizell
    • , Mei Shao
    • , Rebecca Arruda
    • , Katharina Eichler
    • , Javier Valdes-Aleman
    • , Tomoko Ohyama
    • , Andreas S. Thum
    • , Bertram Gerber
    • , Richard D. Fetter
    • , James W. Truman
    • , Ashok Litwin-Kumar
    • , Albert Cardona
    •  & Marta Zlatic
  • Article |

    Jaffe et al. profile the granule cell layer of the human hippocampus and find unique molecular associations for aging and genetic variation, as well as diagnosis with schizophrenia and its genetic risk, that were previously undiscovered in homogenate tissue.

    • Andrew E. Jaffe
    • , Daniel J. Hoeppner
    • , Takeshi Saito
    • , Lou Blanpain
    • , Joy Ukaigwe
    • , Emily E. Burke
    • , Leonardo Collado-Torres
    • , Ran Tao
    • , Katsunori Tajinda
    • , Kristen R. Maynard
    • , Matthew N. Tran
    • , Keri Martinowich
    • , Amy Deep-Soboslay
    • , Joo Heon Shin
    • , Joel E. Kleinman
    • , Daniel R. Weinberger
    • , Mitsuyuki Matsumoto
    •  & Thomas M. Hyde
  • Article |

    A new spatial transcriptomic approach reveals astrocyte heterogeneity across layers of the mammalian cerebral cortex. Astrocytes diversify into superficial-, mid- and deep-layer subtypes distinct from neuronal laminae, yet instructed by neuronal cues.

    • Omer Ali Bayraktar
    • , Theresa Bartels
    • , Staffan Holmqvist
    • , Vitalii Kleshchevnikov
    • , Araks Martirosyan
    • , Damon Polioudakis
    • , Lucile Ben Haim
    • , Adam M. H. Young
    • , Mykhailo Y. Batiuk
    • , Kirti Prakash
    • , Alexander Brown
    • , Kenny Roberts
    • , Mercedes F. Paredes
    • , Riki Kawaguchi
    • , John H. Stockley
    • , Khalida Sabeur
    • , Sandra M. Chang
    • , Eric Huang
    • , Peter Hutchinson
    • , Erik M. Ullian
    • , Martin Hemberg
    • , Giovanni Coppola
    • , Matthew G. Holt
    • , Daniel H. Geschwind
    •  & David H. Rowitch
  • Article |

    Mohammad et al. show that prenatal alcohol exposure increases Kcnn2 activity in the mouse cerebral cortex. Blockade of Kcnn2 improves learning deficits in a mouse model of fetal alcohol spectrum disorders.

    • Shahid Mohammad
    • , Stephen J. Page
    • , Li Wang
    • , Seiji Ishii
    • , Peijun Li
    • , Toru Sasaki
    • , Aiesha Basha
    • , Anna Salzberg
    • , Zenaide Quezado
    • , Fumiaki Imamura
    • , Hirotaka Nishi
    • , Keiichi Isaka
    • , Joshua G. Corbin
    • , Judy S. Liu
    • , Yuka Imamura Kawasawa
    • , Masaaki Torii
    •  & Kazue Hashimoto-Torii
  • Article |

    Chen, Deister et al. show that Shank3B-knockout mice display hypersensitivity to tactile sensory stimulation and that dysfunction of interneurons in somatosensory cortex contributes to the sensory hyper-reactivity in this mouse model of autism.

    • Qian Chen
    • , Christopher A. Deister
    • , Xian Gao
    • , Baolin Guo
    • , Taylor Lynn-Jones
    • , Naiyan Chen
    • , Michael F. Wells
    • , Runpeng Liu
    • , Michael J. Goard
    • , Jordane Dimidschstein
    • , Shijing Feng
    • , Yiwu Shi
    • , Weiping Liao
    • , Zhonghua Lu
    • , Gord Fishell
    • , Christopher I. Moore
    •  & Guoping Feng
  • Article |

    Zhou et al. unveil a novel role for activated microglia and macrophages during wound healing after CNS injury. Microglia promote corralling and form a protective barrier at the injury penumbra via the axon guidance receptor Plexin-B2.

    • Xiang Zhou
    • , Shalaka Wahane
    • , Marie-Sophie Friedl
    • , Michael Kluge
    • , Caroline C. Friedel
    • , Kleopatra Avrampou
    • , Venetia Zachariou
    • , Lei Guo
    • , Bin Zhang
    • , Xijing He
    • , Roland H. Friedel
    •  & Hongyan Zou
  • Article |

    Prior stressful experience affects subsequent behavior even in different situations. Daviu et al. demonstrate that CRHPVN neurons encode stress controllability and contribute to shifts between active and passive innate defensive strategies.

    • Núria Daviu
    • , Tamás Füzesi
    • , David G. Rosenegger
    • , Neilen P. Rasiah
    • , Toni-Lee Sterley
    • , Govind Peringod
    •  & Jaideep S. Bains
  • Article |

    Alpha-synuclein fibrils can disrupt the enteric nervous system, which is mitigated by peripheral GBA1 gene transfer via systemic AAVs. Aging increases susceptibility to α-synuclein pathology progression from the gut to the brain.

    • Collin Challis
    • , Acacia Hori
    • , Timothy R. Sampson
    • , Bryan B. Yoo
    • , Rosemary C. Challis
    • , Adam M. Hamilton
    • , Sarkis K. Mazmanian
    • , Laura A. Volpicelli-Daley
    •  & Viviana Gradinaru
  • Article |

    Rodriguez et al. define a native role for RAN translation and CGG repeats in regulating mGluR-dependent fragile X protein (FMRP) synthesis. RAN-blocking antisense oligonucleotides increase FMRP and improve survival of neurons from patients with repeat expansions.

    • Caitlin M. Rodriguez
    • , Shannon E. Wright
    • , Michael G. Kearse
    • , Jill M. Haenfler
    • , Brittany N. Flores
    • , Yu Liu
    • , Marius F. Ifrim
    • , Mary R. Glineburg
    • , Amy Krans
    • , Paymaan Jafar-Nejad
    • , Michael A. Sutton
    • , Gary J. Bassell
    • , Jack M. Parent
    • , Frank Rigo
    • , Sami J. Barmada
    •  & Peter K. Todd
  • Article |

    Oligodendrocyte precursor cells divide or differentiate in response to external stimuli to control their numbers and to form new myelin. Using zebrafish, we show that these two functions are accomplished by distinct subgroups of cells.

    • Roberta Marisca
    • , Tobias Hoche
    • , Eneritz Agirre
    • , Laura Jane Hoodless
    • , Wenke Barkey
    • , Franziska Auer
    • , Gonçalo Castelo-Branco
    •  & Tim Czopka
  • Article |

    Fear learning induces myelin formation. In the absence of new myelination, remote fear memory and neurophysiology of fear memory circuits are impaired. Conversely, administration of the pro-myelinating drug clemastine enhances remote fear memory.

    • Simon Pan
    • , Sonia R. Mayoral
    • , Hye Sun Choi
    • , Jonah R. Chan
    •  & Mazen A. Kheirbek
  • Article |

    The authors establish inducible Cxcr4-CreER-based fate mapping as a universal means to identify bone-marrow-derived myeloid cells in the injured brain and demonstrate that Cxcr4 deficiency affects the innate immune response and outcome after stroke.

    • Yves Werner
    • , Elvira Mass
    • , Praveen Ashok Kumar
    • , Thomas Ulas
    • , Kristian Händler
    • , Arik Horne
    • , Kathrin Klee
    • , Amelie Lupp
    • , Dagmar Schütz
    • , Friederike Saaber
    • , Christoph Redecker
    • , Joachim L. Schultze
    • , Frederic Geissmann
    •  & Ralf Stumm
  • Article |

    The authors identify an impaired myelination signature from the brains of mouse models of Pitt–Hopkins syndrome and show that it is shared in the postmortem brains of people with autism.

    • BaDoi N. Phan
    • , Joseph F. Bohlen
    • , Brittany A. Davis
    • , Zengyou Ye
    • , Huei-Ying Chen
    • , Brent Mayfield
    • , Srinidhi Rao Sripathy
    • , Stephanie Cerceo Page
    • , Morganne N. Campbell
    • , Hannah L. Smith
    • , Danisha Gallop
    • , Hyojin Kim
    • , Courtney L. Thaxton
    • , Jeremy M. Simon
    • , Emily E. Burke
    • , Joo Heon Shin
    • , Andrew J. Kennedy
    • , J. David Sweatt
    • , Benjamin D. Philpot
    • , Andrew E. Jaffe
    •  & Brady J. Maher
  • Article |

    Microglia in the aging hippocampus accumulate lipid droplets, and are functionally impaired and inflamed. Lipid droplet formation in microglia is regulated by genes linked to neurodegeneration such as progranulin.

    • Julia Marschallinger
    • , Tal Iram
    • , Macy Zardeneta
    • , Song E. Lee
    • , Benoit Lehallier
    • , Michael S. Haney
    • , John V. Pluvinage
    • , Vidhu Mathur
    • , Oliver Hahn
    • , David W. Morgens
    • , Justin Kim
    • , Julia Tevini
    • , Thomas K. Felder
    • , Heimo Wolinski
    • , Carolyn R. Bertozzi
    • , Michael C. Bassik
    • , Ludwig Aigner
    •  & Tony Wyss-Coray
  • Article |

    High concentrations of sodium are normally unpalatable. This study shows a neural population in the brainstem that suppresses appetite for sodium. Reducing the activity of these neurons can drive ingestion of high concentrations of sodium.

    • Seahyung Park
    • , Kevin W. Williams
    • , Chen Liu
    •  & Jong-Woo Sohn
  • Article |

    The authors measure evoked activity and perform dense reconstruction of the olfactory bulb wiring diagram in a zebrafish larva, uncovering a mechanism for whitening, a computation that decorrelates activity for pattern classification by memory networks.

    • Adrian A. Wanner
    •  & Rainer W. Friedrich
  • Article |

    Rees et al. show that de novo mutations in the gene SLC6A1, and more broadly across evolutionary constrained genes and genes implicated in neurodevelopmental disorders, increase the risk for developing schizophrenia.

    • Elliott Rees
    • , Jun Han
    • , Joanne Morgan
    • , Noa Carrera
    • , Valentina Escott-Price
    • , Andrew J. Pocklington
    • , Madeleine Duffield
    • , Lynsey S. Hall
    • , Sophie E. Legge
    • , Antonio F. Pardiñas
    • , Alexander L. Richards
    • , Julian Roth
    • , Tatyana Lezheiko
    • , Nikolay Kondratyev
    • , Vasilii Kaleda
    • , Vera Golimbet
    • , Mara Parellada
    • , Javier González-Peñas
    • , Celso Arango
    • , Behrooz Z. Alizadeh
    • , Therese van Amelsvoort
    • , Richard Bruggeman
    • , Wiepke Cahn
    • , Lieuwe de Haan
    • , Jurjen J. Luykx
    • , Bart P. F. Rutten
    • , Jim van Os
    • , Ruud van Winkel
    • , Micha Gawlik
    • , George Kirov
    • , James T. R. Walters
    • , Peter Holmans
    • , Michael C. O’Donovan
    •  & Michael J. Owen
  • Article |

    Gao et al. provide evidence that two major classes of neurons exist in the paraventricular thalamus. One of these, termed type II PVT neurons, belongs to a previously ignored cell population that relays arousal information to the infralimbic cortex.

    • Claire Gao
    • , Yan Leng
    • , Jun Ma
    • , Victoria Rooke
    • , Shakira Rodriguez-Gonzalez
    • , Charu Ramakrishnan
    • , Karl Deisseroth
    •  & Mario A. Penzo
  • Article |

    In this study of protein-coding de novo mutations in schizophrenia, researchers found only a small contribution toward overall risk, coming predominantly from genes under negative selection and highly expressed in the brain.

    • Daniel P. Howrigan
    • , Samuel A. Rose
    • , Kaitlin E. Samocha
    • , Menachem Fromer
    • , Felecia Cerrato
    • , Wei J. Chen
    • , Claire Churchhouse
    • , Kimberly Chambert
    • , Sharon D. Chandler
    • , Mark J. Daly
    • , Ashley Dumont
    • , Giulio Genovese
    • , Hai-Gwo Hwu
    • , Nan Laird
    • , Jack A. Kosmicki
    • , Jennifer L. Moran
    • , Cheryl Roe
    • , Tarjinder Singh
    • , Shi-Heng Wang
    • , Stephen V. Faraone
    • , Stephen J. Glatt
    • , Steven A. McCarroll
    • , Ming Tsuang
    •  & Benjamin M. Neale
  • Article |

    In mice that have undergone Pavlovian reward conditioning, dopaminergic neurons regulate conditioned movements in a temporally restricted manner, consistent with a primary contribution to associative learning rather than online movement generation.

    • Kwang Lee
    • , Leslie D. Claar
    • , Ayaka Hachisuka
    • , Konstantin I. Bakhurin
    • , Jacquelyn Nguyen
    • , Jeremy M. Trott
    • , Jay L. Gill
    •  & Sotiris C. Masmanidis
  • Article |

    Munn et al. provide evidence that medial entorhinal speed signals scale to reflect the geometry of the environment, whereas entorhinal head direction signals reflect learned information about the geometric symmetry of the environment.

    • Robert G. K. Munn
    • , Caitlin S. Mallory
    • , Kiah Hardcastle
    • , Dane M. Chetkovich
    •  & Lisa M. Giocomo
  • Article |

    Shuman et al. report that epileptic mice harbor desynchronized hippocampal interneuron activity and unstable spatial representations, revealing that precise intrahippocampal synchronization is critical for spatial coding.

    • Tristan Shuman
    • , Daniel Aharoni
    • , Denise J. Cai
    • , Christopher R. Lee
    • , Spyridon Chavlis
    • , Lucia Page-Harley
    • , Lauren M. Vetere
    • , Yu Feng
    • , Chen Yi Yang
    • , Irene Mollinedo-Gajate
    • , Lingxuan Chen
    • , Zachary T. Pennington
    • , Jiannis Taxidis
    • , Sergio E. Flores
    • , Kevin Cheng
    • , Milad Javaherian
    • , Christina C. Kaba
    • , Naina Rao
    • , Mimi La-Vu
    • , Ioanna Pandi
    • , Matthew Shtrahman
    • , Konstantin I. Bakhurin
    • , Sotiris C. Masmanidis
    • , Baljit S. Khakh
    • , Panayiota Poirazi
    • , Alcino J. Silva
    •  & Peyman Golshani
  • Article |

    Yoo and colleagues find that while pursuing virtual prey, monkeys predict the prey’s upcoming movements, and neurons in the dorsal anterior cingulate cortex tracked prey position, velocity and acceleration to facilitate these predictions.

    • Seng Bum Michael Yoo
    • , Jiaxin Cindy Tu
    • , Steven T. Piantadosi
    •  & Benjamin Yost Hayden
  • Article |

    Gallego, Perich et al. report that latent dynamics in the neural manifold across three cortical areas are stable throughout years of consistent behavior. The authors posit that these dynamics are fundamental building blocks of learned behavior.

    • Juan A. Gallego
    • , Matthew G. Perich
    • , Raeed H. Chowdhury
    • , Sara A. Solla
    •  & Lee E. Miller
  • Article |

    Although Bayesian models provide good accounts of perceptual decisions, it is unclear how their components are represented in the brain. This paper addresses this question by showing that uncertainty decoded from visual cortex helps predict behavior.

    • Edgar Y. Walker
    • , R. James Cotton
    • , Wei Ji Ma
    •  & Andreas S. Tolias
  • Article |

    Gulli et al. record neurons in the monkey hippocampus during multiple tasks in a virtual reality environment and find that spatial coding is task-dependent. Their analyses reveal rich nonspatial sensory and mnemonic coding of task-related features.

    • Roberto A. Gulli
    • , Lyndon R. Duong
    • , Benjamin W. Corrigan
    • , Guillaume Doucet
    • , Sylvain Williams
    • , Stefano Fusi
    •  & Julio C. Martinez-Trujillo
  • Article |

    Kappes et al. report a new confirmation bias mechanism. When faced with disagreement, a reduction in the neural sensitivity to the confidence of others is observed leading to a subsequent failure to use others’ confidence to alter one’s own.

    • Andreas Kappes
    • , Ann H. Harvey
    • , Terry Lohrenz
    • , P. Read Montague
    •  & Tali Sharot
  • Article |

    Scheggia et al. show that a specific subpopulation of cortical neurons expressing somatostatin in the prefrontal cortex has a primary role in orchestrating the ability of mice to discriminate positive and negative affective states in others.

    • Diego Scheggia
    • , Francesca Managò
    • , Federica Maltese
    • , Stefania Bruni
    • , Marco Nigro
    • , Daniel Dautan
    • , Patrick Latuske
    • , Gabriella Contarini
    • , Marta Gomez-Gonzalo
    • , Linda Maria Requie
    • , Valentina Ferretti
    • , Giulia Castellani
    • , Daniele Mauro
    • , Alessandra Bonavia
    • , Giorgio Carmignoto
    • , Ofer Yizhar
    •  & Francesco Papaleo
  • Article |

    Cummings and Clem demonstrate that cue-related activation and plasticity of prefrontal interneurons cause disinhibition of a distributed brain network that underlies fear memory.

    • Kirstie A. Cummings
    •  & Roger L. Clem
  • Article |

    Cocaine-generated silent synapses dictate the encoding, consolidation, retrieval-induced destabilization and reconsolidation of cocaine memories, and these syapses can be targeted to reduce drug seeking and relapse.

    • William J. Wright
    • , Nicholas M. Graziane
    • , Peter A. Neumann
    • , Peter J. Hamilton
    • , Hannah M. Cates
    • , Lauren Fuerst
    • , Alexander Spenceley
    • , Natalie MacKinnon-Booth
    • , Kartik Iyer
    • , Yanhua H. Huang
    • , Yavin Shaham
    • , Oliver M. Schlüter
    • , Eric J. Nestler
    •  & Yan Dong