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  • After spinal cord injury, stromal fibroblasts originate from pericytes and perivascular fibroblasts, with pericytes more prevalent in gray matter and fibroblasts in white matter. Holl et al. show that both cell types respond to injury and inflammation, are activated, and transcriptionally converge on scar formation after injury, paving the way for therapeutic possibilities.

    • Vittorio Gallo
    • Panagiotis Kratimenos
    News & Views
  • To celebrate Pride month in the USA, Nature Neuroscience is having conversations with LGBTQIA+ scientists across multiple career stages to discuss their personal and professional experiences in research. In this Q&A, we are talking to Aniruddha Das, an associate professor at Columbia University, New York, USA. Das’s research uses macaque models to explore the cognitive basis of visual processing, attention, and motivation.

    • George Inglis
    Q&A
  • To celebrate Pride month in the USA, Nature Neuroscience is having conversations with LGBTQIA+ scientists across multiple career stages to discuss their personal and professional experiences in research. In this Q&A, we are talking to Laura Huckins, an associate professor at Yale University School of Medicine, New Haven, USA. Huckins’ research focuses primarily on the genetics of eating disorders and post-traumatic stress disorder, as well as the development of statistical and multi-omic methods for use in genome-wide association studies (GWASs).

    • George Inglis
    Q&A
  • To celebrate Pride month in the USA, Nature Neuroscience is having conversations with LGBTQIA+ scientists across multiple career stages to discuss their personal and professional experiences in research. In this Q&A, we are talking to Alexandra Keinath, an assistant professor at the University of Illinois, Chicago, USA. Keinath’s research uses both rodent and human models to investigate the neural representations of spatial memory and navigation.

    • George Inglis
    Q&A
  • Here the authors show that ventrally derived oligodendrocytes (OLs) can myelinate areas usually populated by dorsally derived OLs but cannot functionally compensate, as animals populated only by ventrally derived OLs show locomotor and cognitive deficits.

    • Sarah Foerster
    • Elisa M. Floriddia
    • Robin J. M. Franklin
    ArticleOpen Access
  • Specifically mutating the neurofibromatosis type 1 gene (NF1) in oligodendrocyte precursor cells (OPCs) impairs their adaptive response to neuronal activity and their differentiation into mature oligodendrocytes, as well as promoting focal regions of OPC hyperdensity. These defects delay oligodendroglial development and impede adaptive oligodendrogenesis, which are important for motor learning.

    Research Briefing
  • BrainTF is the largest study to date that directly measures transcription factor (TF) binding in human postmortem brain, demonstrating improved measurements of TF activity and nominating TFs whose occupancy is enriched for risk variants of neuropsychiatric disorders.

    • Jacob M. Loupe
    • Ashlyn G. Anderson
    • Richard M. Myers
    Resource