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  • Brain connections modulated by 534 deep-brain-stimulation electrodes revealed a gradient of circuits involved in dystonia, Parkinson’s disease, Tourette’s syndrome and obsessive-compulsive disorder. Together, these circuits begin to describe the human ‘dysfunctome’, a library of dysfunctional circuits that lead to various brain disorders.

    Research Briefing
  • Long COVID has remained an on-going public health issue in the years following the global pandemic. Here, we report blood–brain barrier disruption in patients with acute SARS-CoV-2 infection and brain fog, and patients presenting with long COVID, brain fog and cognitive decline, compared to those with long COVID without any neurological symptoms.

    Research Briefing
  • Hollunder et al. identify networks where deep brain stimulation reduces symptoms for Parkinson’s disease, Tourette’s syndrome, dystonia and obsessive-compulsive disorder. This revealed a fronto-rostral topography that segregates the frontal cortex.

    • Barbara Hollunder
    • Jill L. Ostrem
    • Andreas Horn
    ArticleOpen Access
  • The Sehgal lab presents data showing that the non-cell autonomous pathway of glial lipid droplet formation occurs during sleep and helps to resolve neuronal reactive oxygen species (ROS). This promotes neuronal function after an active day. Hence, this pathway has an important physiological function beyond its previously described role in ROS-associated diseases, including Alzheimer’s disease.

    • Lindsey D. Goodman
    • Matthew J. Moulton
    • Hugo J. Bellen
    News & Views
  • Both caloric restriction and obesity affect autoimmune diseases. The activation of brainstem neurons in the ventrolateral medulla (VLM) with fasting suppresses experimental autoimmune diseases. Stimulation of VLM neurons alters T cell traffic by redistributing immune cells to bone marrow and reduces inflammatory cytokine production, thus providing therapy of experimental autoimmunity.

    • Noga Or-Geva
    • Lawrence Steinman
    News & Views
  • Muller et al. demonstrate that reward signals recorded from the frontal cortex of nonhuman primates exhibit a population-based scheme for learning probability distributions over reward values. This study provides evidence that neural signals outside of the midbrain reflect the principles of distributional reinforcement-learning theory.

    • Tao Hong
    • William R. Stauffer
    News & Views
  • As Nature Neuroscience celebrates its 25th anniversary, we are having conversations with both established leaders in the field and those earlier in their careers to discuss how the field has evolved and where it is heading. This month we are talking to Nancy Ip, Morningside Professor of Life Science and president of the Hong Kong University of Science and Technology. We discussed her path from academia to industry and back, her experiences as a working mother and how she has helped scientific research in Hong Kong to flourish.

    • Shari Wiseman
    Q&A
  • Minakuchi et al. find that separable inhibitory inputs to a critical hypothalamic aggression-control node can influence the evolution of an aggressive state by independently modulating either the motivational phase or the action phase.

    • Tomohito Minakuchi
    • Eartha Mae Guthman
    • Annegret L. Falkner
    Article