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  • Astrocytes have important roles in the repair of the CNS. However, the underlying mechanisms involved remain incompletely understood. O’Shea et al. report that the functional reprogramming of astrocytes at the borders of traumatic lesions contributes to the re-establishment of CNS integrity by separating the parenchyma from stromal and immune cells.

    • Hong-Gyun Lee
    • Francisco J. Quintana
    News & Views
  • This theoretical study shows that dopaminergic reward prediction error neurons encode experienced rewards efficiently, which explains four major aspects of the neural population. This efficient code can be learned with local updates for each neuron.

    • Heiko H. Schütt
    • Dongjae Kim
    • Wei Ji Ma
    Article
  • After spinal cord injury, stromal fibroblasts originate from pericytes and perivascular fibroblasts, with pericytes more prevalent in gray matter and fibroblasts in white matter. Holl et al. show that both cell types respond to injury and inflammation, are activated, and transcriptionally converge on scar formation after injury, paving the way for therapeutic possibilities.

    • Vittorio Gallo
    • Panagiotis Kratimenos
    News & Views
  • To celebrate Pride month in the USA, Nature Neuroscience is having conversations with LGBTQIA+ scientists across multiple career stages to discuss their personal and professional experiences in research. In this Q&A, we are talking to Aniruddha Das, an associate professor at Columbia University, New York, USA. Das’s research uses macaque models to explore the cognitive basis of visual processing, attention, and motivation.

    • George Inglis
    Q&A
  • To celebrate Pride month in the USA, Nature Neuroscience is having conversations with LGBTQIA+ scientists across multiple career stages to discuss their personal and professional experiences in research. In this Q&A, we are talking to Laura Huckins, an associate professor at Yale University School of Medicine, New Haven, USA. Huckins’ research focuses primarily on the genetics of eating disorders and post-traumatic stress disorder, as well as the development of statistical and multi-omic methods for use in genome-wide association studies (GWASs).

    • George Inglis
    Q&A
  • To celebrate Pride month in the USA, Nature Neuroscience is having conversations with LGBTQIA+ scientists across multiple career stages to discuss their personal and professional experiences in research. In this Q&A, we are talking to Alexandra Keinath, an assistant professor at the University of Illinois, Chicago, USA. Keinath’s research uses both rodent and human models to investigate the neural representations of spatial memory and navigation.

    • George Inglis
    Q&A
  • Here the authors show that ventrally derived oligodendrocytes (OLs) can myelinate areas usually populated by dorsally derived OLs but cannot functionally compensate, as animals populated only by ventrally derived OLs show locomotor and cognitive deficits.

    • Sarah Foerster
    • Elisa M. Floriddia
    • Robin J. M. Franklin
    ArticleOpen Access