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In 2022, we began a pilot to facilitate data sharing for manuscripts submitted to Nature Neuroscience. Here, we analyze its effects on research data availability and reflect on the importance of facilitating open science.
Perl et al. show that in PTSD, hippocampal representations of autobiographical memories are similar across people with similar semantic content only for sad but not traumatic memories, pointing to altered brain state during traumatic memory recall.
Benisty, Barson et al. show that motor behaviors are represented by fast changes in the activity magnitude and functional connectivity across the mouse neocortex, which provides insight into the relationship between neural signals and behavior.
Griggs, Norman et al. demonstrate a closed-loop ultrasound-based brain–machine interface (BMI) in rhesus macaques. The ultrasound BMI is capable of controlling eight independent movement directions and is stable across months without retraining.
Li et al. developed a base-editing system to edit mutations linked to autism. Targeting a mutation in Mef2c restored Mef2c protein levels in several brain regions and reversed behavioral changes in Mef2c-mutant mice.
We show that genetic disruption of TFEB- and vacuolar ATPase-mediated lysosomal signaling leads to increased tau pathology and defective microglia activation. Our findings demonstrate an essential role of the lysosome in regulating microglia activity in tauopathy and Alzheimer’s disease.
We discovered expression of SYNGAP1, which encodes the ‘synaptic’ protein SYNGAP1, within human cortical progenitors. In an organoid model of SYNGAP1 haploinsufficiency, cortical neurogenesis and neuronal network activity were disrupted. This finding reveals an unknown function for SYNGAP1 at early stages of development, providing a new framework for understanding the pathophysiology of autism spectrum disorder.
Recent discoveries highlight the skull bone marrow, linked to the CNS via osseous channels, as a key neuroimmune compartment. Here, the authors discuss the anatomy, functions and implications of this immune reservoir on CNS health and disease.
The authors identify a cluster of ~160 peptidergic neurons in the mouse brainstem whose activity is necessary and sufficient for producing sound and controlling sound volume. These neurons form the final common pathway for vocalization.
The ENIGMA-ORIGINs group presents a large and globally diverse pediatric neuroimaging dataset from birth to age 6. They use this resource to study the effects of sociodemographics and adverse birth outcomes on trajectories of brain volumes and cognition.
