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  • Christenson et al. describe hue-selective neurons in the fruit fly optic lobe. Using a connectomics-constrained model combined with genetic manipulations of the circuit, they show that recurrent connections are critical for hue selectivity.

    • Matthias P. Christenson
    • Alvaro Sanz Diez
    • Rudy Behnia
    ArticleOpen Access
  • It has been widely believed that a key function of sleep is to actively clear metabolites and toxins from the brain. Miao, Luo et al. show in mice that brain clearance is markedly reduced—not increased—during sleep and anesthesia.

    • Andawei Miao
    • Tianyuan Luo
    • Nicholas P. Franks
    Brief CommunicationOpen Access
  • The subcommissural organ (SCO) is a gland in the brain, and relatively little is known about its function. Zhang et al. genetically ablated SCO cells and observed severe hydrocephalus and neuronal defects. The reintroduction of SCO-derived peptides into SCO-ablated brain substantially rescued developmental defects.

    • Tingting Zhang
    • Daosheng Ai
    • Woo-ping Ge
  • Neural activity does not always lie in a low-dimensional subspace. The authors extend this classic view to show that task-relevant information is distributed across multiple covariability classes and propose a new method, sliceTCA, to disentangle them.

    • Arthur Pellegrino
    • Heike Stein
    • N. Alex Cayco-Gajic
    Technical ReportOpen Access
  • This paper shows that compulsive-like grooming in Sapap3-knockout mice can be reduced by closed-loop optogenetic stimulation of striatal interneurons based on grooming onset prediction, suggesting that adaptive stimulation may have therapeutic potential in obsessive–compulsive disorder.

    • Sirenia Lizbeth Mondragón-González
    • Christiane Schreiweis
    • Eric Burguière
    ArticleOpen Access
  • The layout of cortical systems varies across people, which is assumed to be largely due to border shifts between nearby systems. Dworetsky et al. reveal a qualitatively different variation in systems that occurs at a distance from expected locations.

    • Ally Dworetsky
    • Benjamin A. Seitzman
    • Caterina Gratton
  • Charlton and Goris developed a new perceptual decision-making task for macaque monkeys and found that prefrontal circuits involved in action selection are also used for the deliberation of abstract propositions divorced from a specific motor plan.

    • Julie A. Charlton
    • Robbe L. T. Goris
    ArticleOpen Access
  • Effective science communication is necessary for engaging the public in scientific discourse and ensuring equitable access to knowledge. Training doctoral students in science communication will instill principles of accessibility, accountability, and adaptability in the next generation of scientific leaders, who are poised to expand science’s reach, generate public support for research funding, and counter misinformation. To this aim, we provide a guide for implementing formal science communication training for doctoral students.

    • Christina Maher
    • Trevonn Gyles
    • Daniela Schiller
  • Gene expression in the human cortex is shown to exhibit a generalizable three-component architecture that reflects neuronal, metabolic, and immune programmes of healthy brain development. The three components have distinct associations with autism spectrum disorder and schizophrenia, revealing connections between previously unrelated results from studies of case–control neuroimaging, differential gene expression, and genetic risk.

    Research Briefing
  • As Nature Neuroscience celebrates its 25th anniversary, we are having conversations with both established leaders in the field and those earlier in their careers to discuss how the field has evolved and where it is heading. This month we are talking to Fernando de Castro Soubriet, principal investigator at the Instituto Cajal (Spain). He is a neurodevelopmental biologist who is actively involved in championing the history of neuroscience. He is among the group of Spanish scientists who ensured that the Archives of Santiago Ramón y Cajal and the Spanish Neurohistological School are registered as World Heritage with UNESCO (United Nations Educational, Scientific and Cultural Organization). Here, we discuss science and the legacy of the Spanish Neurohistological School.

    • Elisa Floriddia