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Resource |
Molecular characterization of selectively vulnerable neurons in Alzheimer’s disease
Leng et al. uncover the molecular signature of neuronal subpopulations that are selectively vulnerable to tau aggregation and death early in Alzheimer’s disease in the human entorhinal cortex and other brain regions, validating RORB as a marker.
- Kun Leng
- , Emmy Li
- , Rana Eser
- , Antonia Piergies
- , Rene Sit
- , Michelle Tan
- , Norma Neff
- , Song Hua Li
- , Roberta Diehl Rodriguez
- , Claudia Kimie Suemoto
- , Renata Elaine Paraizo Leite
- , Alexander J. Ehrenberg
- , Carlos A. Pasqualucci
- , William W. Seeley
- , Salvatore Spina
- , Helmut Heinsen
- , Lea T. Grinberg
- & Martin Kampmann
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Article |
Machine learning reveals bilateral distribution of somatic L1 insertions in human neurons and glia
Zhu et al. discover that in human brain there is widespread anatomic distribution of low-frequency somatic, mosaic L1 insertions, using deep whole-genome sequencing of neuronal and glial fractions and machine-learning analysis.
- Xiaowei Zhu
- , Bo Zhou
- , Reenal Pattni
- , Kelly Gleason
- , Chunfeng Tan
- , Agnieszka Kalinowski
- , Steven Sloan
- , Anna-Sophie Fiston-Lavier
- , Jessica Mariani
- , Dmitri Petrov
- , Ben A. Barres
- , Laramie Duncan
- , Alexej Abyzov
- , Hannes Vogel
- , Xiaowei Zhu
- , Bo Zhou
- , Alexander Urban
- , Christopher Walsh
- , Javier Ganz
- , Mollie Woodworth
- , Pengpeng Li
- , Rachel Rodin
- , Robert Hill
- , Sara Bizzotto
- , Zinan Zhou
- , Alice Lee
- , Alissa D’Gama
- , Alon Galor
- , Craig Bohrson
- , Daniel Kwon
- , Doga Gulhan
- , Elaine Lim
- , Isidro Cortes
- , Joe Luquette
- , Maxwell Sherman
- , Michael Coulter
- , Michael Lodato
- , Peter Park
- , Rebeca Monroy
- , Sonia Kim
- , Yanmei Dou
- , Andrew Chess
- , Attila Jones
- , Chaggai Rosenbluh
- , Schahram Akbarian
- , Ben Langmead
- , Jeremy Thorpe
- , Jonathan Pevsner
- , Rob Scharpf
- , Sean Cho
- , Flora Vaccarino
- , Liana Fasching
- , Simone Tomasi
- , Nenad Sestan
- , Sirisha Pochareddy
- , Andrew Jaffe
- , Apua Paquola
- , Daniel Weinberger
- , Jennifer Erwin
- , Jooheon Shin
- , Richard Straub
- , Rujuta Narurkar
- , Anjene Addington
- , David Panchision
- , Doug Meinecke
- , Geetha Senthil
- , Lora Bingaman
- , Tara Dutka
- , Thomas Lehner
- , Alexej Abyzov
- , Taejeong Bae
- , Laura Saucedo-Cuevas
- , Tara Conniff
- , Diane A. Flasch
- , Trenton J. Frisbie
- , Jeffrey M. Kidd
- , Mandy M. Lam
- , John B. Moldovan
- , John V. Moran
- , Kenneth Y. Kwan
- , Ryan E. Mills
- , Sarah Emery
- , Weichen Zhou
- , Yifan Wang
- , Kenneth Daily
- , Mette Peters
- , Fred Gage
- , Meiyan Wang
- , Patrick Reed
- , Sara Linker
- , Ani Sarkar
- , Aitor Serres
- , David Juan
- , Inna Povolotskaya
- , Irene Lobon
- , Manuel Solis
- , Raquel Garcia
- , Tomas Marques-Bonet
- , Gary Mathern
- , Eric Courchesne
- , Jing Gu
- , Joseph Gleeson
- , Laurel Ball
- , Renee George
- , Tiziano Pramparo
- , Aakrosh Ratan
- , Mike J. McConnell
- , John V. Moran
- , Flora M. Vaccarino
- , Carol A. Tamminga
- , Douglas F. Levinson
- & Alexander E. Urban
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Article |
The landscape of somatic mutation in cerebral cortex of autistic and neurotypical individuals revealed by ultra-deep whole-genome sequencing
Rodin and Dou et al. characterized genome-wide somatic mutation in autistic and control brains, revealing that even unaffected individuals may possess dozens of brain somatic mutations and providing insight into the role of somatic mutation in autism.
- Rachel E. Rodin
- , Yanmei Dou
- , Minseok Kwon
- , Maxwell A. Sherman
- , Alissa M. D’Gama
- , Ryan N. Doan
- , Lariza M. Rento
- , Kelly M. Girskis
- , Craig L. Bohrson
- , Sonia N. Kim
- , Ajay Nadig
- , Lovelace J. Luquette
- , Doga C. Gulhan
- , Christopher A. Walsh
- , Javier Ganz
- , Mollie B. Woodworth
- , Pengpeng Li
- , Rachel E. Rodin
- , Robert S. Hill
- , Sara Bizzotto
- , Zinan Zhou
- , Eunjung A. Lee
- , Alison R. Barton
- , Alissa M. D’Gama
- , Alon Galor
- , Craig L. Bohrson
- , Daniel Kwon
- , Doga C. Gulhan
- , Elaine T. Lim
- , Isidro Ciriano Cortes
- , Lovelace J. Luquette
- , Maxwell A. Sherman
- , Michael E. Coulter
- , Michael A. Lodato
- , Peter J. Park
- , Rebeca B. Monroy
- , Sonia N. Kim
- , Yanmei Dou
- , Andrew Chess
- , Attila Gulyás-Kovács
- , Chaggai Rosenbluh
- , Schahram Akbarian
- , Ben Langmead
- , Jeremy Thorpe
- , Jonathan Pevsner
- , Soonweng Cho
- , Andrew E. Jaffe
- , Apua Paquola
- , Daniel R. Weinberger
- , Jennifer A. Erwin
- , Jooheon H. Shin
- , Richard E. Straub
- , Rujuta Narurkar
- , Alexej S. Abyzov
- , Taejeong Bae
- , Anjene Addington
- , David Panchision
- , Doug Meinecke
- , Geetha Senthil
- , Lora Bingaman
- , Tara Dutka
- , Thomas Lehner
- , Laura Saucedo-Cuevas
- , Tara Conniff
- , Kenneth Daily
- , Mette Peters
- , Fred H. Gage
- , Meiyan Wang
- , Patrick J. Reed
- , Sara B. Linker
- , Alex E. Urban
- , Bo Zhou
- , Xiaowei Zhu
- , Aitor Serres
- , David Juan
- , Inna Povolotskaya
- , Irene Lobón
- , Manuel Solis-Moruno
- , Raquel García-Pérez
- , Tomas Marquès-Bonet
- , Gary W. Mathern
- , Eric Courchesne
- , Jing Gu
- , Joseph G. Gleeson
- , Laurel L. Ball
- , Renee D. George
- , Tiziano Pramparo
- , Diane A. Flasch
- , Trenton J. Frisbie
- , Jeffrey M. Kidd
- , John B. Moldovan
- , John V. Moran
- , Kenneth Y. Kwan
- , Ryan E. Mills
- , Sarah B. Emery
- , Weichen Zhou
- , Yifan Wang
- , Aakrosh Ratan
- , Michael J. McConnell
- , Flora M. Vaccarino
- , Gianfilippo Coppola
- , Jessica B. Lennington
- , Liana Fasching
- , Nenad Sestan
- , Sirisha Pochareddy
- , Peter J. Park
- & Christopher A. Walsh
-
Author Correction |
Author Correction: Hippocampal neurons represent events as transferable units of experience
- Chen Sun
- , Wannan Yang
- , Jared Martin
- & Susumu Tonegawa
-
Publisher Correction |
Publisher Correction: Diversity and dynamism in the cerebellum
- Chris I. De Zeeuw
- , Stephen G. Lisberger
- & Jennifer L. Raymond
-
News & Views |
Inflammation stresses out brain development
A new study reveals that maternal immune activation promotes sex-biased activation of the integrated stress response in the developing mouse brain and that this mechanistically contributes to the onset of autism-related behaviors uniquely in male offspring.
- Kristine E. Zengeler
- & John R. Lukens
-
Article |
Maternal immune activation in mice disrupts proteostasis in the fetal brain
This paper shows that maternal immune activation in mice induces changes in the mRNA translation machinery in the fetal brain and activates the integrated stress response in male fetuses, which mediates neurobehavioral abnormalities.
- Brian T. Kalish
- , Eunha Kim
- , Benjamin Finander
- , Erin E. Duffy
- , Hyunju Kim
- , Casey K. Gilman
- , Yeong Shin Yim
- , Lilin Tong
- , Randal J. Kaufman
- , Eric C. Griffith
- , Gloria B. Choi
- , Michael E. Greenberg
- & Jun R. Huh
-
Article |
Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice
Overexpression of complement C4A is associated with schizophrenia risk. Using a novel mouse model, Yilmaz et al. find that increased expression of C4A leads to abnormal synaptic pruning and behavior, suggesting its importance as a therapeutic target.
- Melis Yilmaz
- , Esra Yalcin
- , Jessy Presumey
- , Ernest Aw
- , Minghe Ma
- , Christopher W. Whelan
- , Beth Stevens
- , Steven A. McCarroll
- & Michael C. Carroll
-
Article |
Long-term self-renewing stem cells in the adult mouse hippocampus identified by intravital imaging
Neurons are generated throughout life in the mammalian hippocampus. Bottes et al. used intravital imaging and comparative single-cell transcriptomics to identify long-term self-renewing neural stem cells in the adult mouse hippocampus.
- Sara Bottes
- , Baptiste N. Jaeger
- , Gregor-Alexander Pilz
- , David J. Jörg
- , John Darby Cole
- , Merit Kruse
- , Lachlan Harris
- , Vladislav I. Korobeynyk
- , Izaskun Mallona
- , Fritjof Helmchen
- , François Guillemot
- , Benjamin D. Simons
- & Sebastian Jessberger
-
Article |
Vector trace cells in the subiculum of the hippocampal formation
Poulter et al. report on vector trace cells (VTCs) in the hippocampal subiculum. VTCs support vector coding for previously encountered, now absent, objects and boundaries, potentially facilitating navigation to remembered goals.
- Steven Poulter
- , Sang Ah Lee
- , James Dachtler
- , Thomas J. Wills
- & Colin Lever
-
Article |
Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis
Efficient repair of demyelinated CNS lesions involves the resolution of inflammation and induction of remyelination. Berghoff et al. show that sterol synthesis in microglia is key to both processes, which can be supported by squalene therapy.
- Stefan A. Berghoff
- , Lena Spieth
- , Ting Sun
- , Leon Hosang
- , Lennart Schlaphoff
- , Constanze Depp
- , Tim Düking
- , Jan Winchenbach
- , Jonathan Neuber
- , David Ewers
- , Patricia Scholz
- , Franziska van der Meer
- , Ludovico Cantuti-Castelvetri
- , Andrew O. Sasmita
- , Martin Meschkat
- , Torben Ruhwedel
- , Wiebke Möbius
- , Roman Sankowski
- , Marco Prinz
- , Inge Huitinga
- , Michael W. Sereda
- , Francesca Odoardi
- , Till Ischebeck
- , Mikael Simons
- , Christine Stadelmann-Nessler
- , Julia M. Edgar
- , Klaus-Armin Nave
- & Gesine Saher
-
Article |
Transcriptomic organization of the human brain in post-traumatic stress disorder
A transcriptome-wide characterization of the molecular pathology of post-traumatic stress disorder (PTSD) postmortem brains provides a comprehensive resource for mechanistic insight and therapeutic development.
- Matthew J. Girgenti
- , Jiawei Wang
- , Dingjue Ji
- , Dianne A. Cruz
- , Victor E. Alvarez
- , David Benedek
- , Christopher Brady
- , David A. Davis
- , Paul E. Holtzheimer
- , Terence M. Keane
- , Neil Kowell
- , Mark W. Logue
- , Ann McKee
- , Brian Marx
- , Deborah Mash
- , Mark W. Miller
- , William K. Scott
- , Thor Stein
- , Robert Ursano
- , Erika J. Wolf
- , Murray B. Stein
- , Joel Gelernter
- , Keith A. Young
- , Bertrand R. Huber
- , Douglas E. Williamson
- , Matthew J. Friedman
- , John H. Krystal
- , Hongyu Zhao
- & Ronald S. Duman
-
Article |
The S1 protein of SARS-CoV-2 crosses the blood–brain barrier in mice
Rhea at al. show that intravenously injected, radiolabeled SARS-CoV-2 spike 1 protein crosses the mouse blood–brain barrier, likely through the mechanism of adsorptive transcytosis and is also taken up by peripheral tissues.
- Elizabeth M. Rhea
- , Aric F. Logsdon
- , Kim M. Hansen
- , Lindsey M. Williams
- , May J. Reed
- , Kristen K. Baumann
- , Sarah J. Holden
- , Jacob Raber
- , William A. Banks
- & Michelle A. Erickson
-
Author Correction |
Author Correction: Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration
- Amit U. Joshi
- , Paras S. Minhas
- , Shane A. Liddelow
- , Bereketeab Haileselassie
- , Katrin I. Andreasson
- , Gerald W. Dorn II
- & Daria Mochly-Rosen
-
Brief Communication |
Microglial Gi-dependent dynamics regulate brain network hyperexcitability
Merlini, Rafalski et al. show that dynamic microglial brain surveillance prevents hyperexcitability and seizures by Gi-dependent microglia–neuron interactions in response to evoked neuronal activity to maintain physiological network synchronization.
- Mario Merlini
- , Victoria A. Rafalski
- , Keran Ma
- , Keun-Young Kim
- , Eric A. Bushong
- , Pamela E. Rios Coronado
- , Zhaoqi Yan
- , Andrew S. Mendiola
- , Elif G. Sozmen
- , Jae Kyu Ryu
- , Matthias G. Haberl
- , Matthew Madany
- , Daniel Naranjo Sampson
- , Mark A. Petersen
- , Sophia Bardehle
- , Reshmi Tognatta
- , Terry Dean Jr
- , Rosa Meza Acevedo
- , Belinda Cabriga
- , Reuben Thomas
- , Shaun R. Coughlin
- , Mark H. Ellisman
- , Jorge J. Palop
- & Katerina Akassoglou
-
News & Views |
Revealing the complexity of the gut’s brain
A new study proposes an exciting new model of neuronal diversification in the developing enteric nervous system (ENS) and establishes a detailed molecular taxonomy for enteric neurons. Their findings open new horizons for ENS research and for developing cell-based therapies for ENS disorders.
- Julia Ganz
-
Perspective |
Diversity and dynamism in the cerebellum
Recent research has discovered new connections between cerebellar neurons, revealed abundant inputs related to reward, demonstrated a cellular solution for the temporal credit assignment problem and restructured theories of cerebellar learning.
- Chris I. De Zeeuw
- , Stephen G. Lisberger
- & Jennifer L. Raymond
-
Article |
GABAergic signaling to astrocytes in the prefrontal cortex sustains goal-directed behaviors
Mederos et al. show that GABAB receptor signaling in astrocytes regulates prefrontal cortex activity to impact goal-directed behaviors. Thus, the coordinated activity of GABAergic neurons and astrocytes helps decision-making.
- Sara Mederos
- , Cristina Sánchez-Puelles
- , Julio Esparza
- , Manuel Valero
- , Alexey Ponomarenko
- & Gertrudis Perea
-
Article |
Diversification of molecularly defined myenteric neuron classes revealed by single-cell RNA sequencing
Imaging and transcriptomic approaches to investigate mouse enteric nervous system diversity and development reveal a new classification of intestinal myenteric neurons and a novel principle of neuronal diversification by postmitotic transitions.
- Khomgrit Morarach
- , Anastassia Mikhailova
- , Viktoria Knoflach
- , Fatima Memic
- , Rakesh Kumar
- , Wei Li
- , Patrik Ernfors
- & Ulrika Marklund
-
Article |
Strong inhibitory signaling underlies stable temporal dynamics and working memory in spiking neural networks
By analyzing computational models and neural data from the primate prefrontal cortex, the authors show that inhibitory-to-inhibitory signaling is critical for the stable temporal dynamics required for performing working memory tasks.
- Robert Kim
- & Terrence J. Sejnowski
-
Article |
USH2A is a Meissner’s corpuscle protein necessary for normal vibration sensing in mice and humans
Schwaller et al. show that the USH2A protein, present in Meissner’s corpuscles, is necessary in humans and mice to perceive tiny vibrations. USH2A may facilitate force transfer to mechanoreceptors as the fingertip probes rough surfaces.
- Fred Schwaller
- , Valérie Bégay
- , Gema García-García
- , Francisco J. Taberner
- , Rabih Moshourab
- , Brennan McDonald
- , Trevor Docter
- , Johannes Kühnemund
- , Julia Ojeda-Alonso
- , Ricardo Paricio-Montesinos
- , Stefan G. Lechner
- , James F. A. Poulet
- , Jose M. Millan
- & Gary R. Lewin
-
Publisher Correction |
Publisher Correction: A community-based transcriptomics classification and nomenclature of neocortical cell types
- Rafael Yuste
- , Michael Hawrylycz
- , Nadia Aalling
- , Argel Aguilar-Valles
- , Detlev Arendt
- , Ruben Armananzas Arnedillo
- , Giorgio A. Ascoli
- , Concha Bielza
- , Vahid Bokharaie
- , Tobias Borgtoft Bergmann
- , Irina Bystron
- , Marco Capogna
- , Yoonjeung Chang
- , Ann Clemens
- , Christiaan P. J. de Kock
- , Javier DeFelipe
- , Sandra Esmeralda Dos Santos
- , Keagan Dunville
- , Dirk Feldmeyer
- , Richárd Fiáth
- , Gordon James Fishell
- , Angelica Foggetti
- , Xuefan Gao
- , Parviz Ghaderi
- , Natalia A. Goriounova
- , Onur Güntürkün
- , Kenta Hagihara
- , Vanessa Jane Hall
- , Moritz Helmstaedter
- , Suzana Herculano
- , Markus M. Hilscher
- , Hajime Hirase
- , Jens Hjerling-Leffler
- , Rebecca Hodge
- , Josh Huang
- , Rafiq Huda
- , Konstantin Khodosevich
- , Ole Kiehn
- , Henner Koch
- , Eric S. Kuebler
- , Malte Kühnemund
- , Pedro Larrañaga
- , Boudewijn Lelieveldt
- , Emma Louise Louth
- , Jan H. Lui
- , Huibert D. Mansvelder
- , Oscar Marin
- , Julio Martinez-Trujillo
- , Homeira Moradi Chameh
- , Alok Nath
- , Maiken Nedergaard
- , Pavel Němec
- , Netanel Ofer
- , Ulrich Gottfried Pfisterer
- , Samuel Pontes
- , William Redmond
- , Jean Rossier
- , Joshua R. Sanes
- , Richard Scheuermann
- , Esther Serrano-Saiz
- , Jochen F. Steiger
- , Peter Somogyi
- , Gábor Tamás
- , Andreas Savas Tolias
- , Maria Antonietta Tosches
- , Miguel Turrero García
- , Hermany Munguba Vieira
- , Christian Wozny
- , Thomas V. Wuttke
- , Liu Yong
- , Juan Yuan
- , Hongkui Zeng
- & Ed Lein
-
News & Views |
Natural killers of cognition
One of the mechanisms driving aging and neurodegenerative diseases is the accumulation of senescent cells, while their elimination mitigates age-related decline. A new report details how, with aging, changes in the dentate gyrus microenvironment lead to natural-killer-cell-mediated clearance of neurogenic senescent cells, resulting in cognitive decline.
- Nurit Papismadov
- & Valery Krizhanovsky
-
Article |
Neuroblast senescence in the aged brain augments natural killer cell cytotoxicity leading to impaired neurogenesis and cognition
Jin et al. discover the accumulation of natural killer (NK) cells in the aged brains of humans and mice. Neuroblast senescence in the dentate gyrus augments NK cell cytotoxicity that impairs neurogenesis and cognition during normal brain aging.
- Wei-Na Jin
- , Kaibin Shi
- , Wenyan He
- , Jun-Hong Sun
- , Luc Van Kaer
- , Fu-Dong Shi
- & Qiang Liu
-
Article |
Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19
The authors demonstrate the presence of SARS-CoV-2 in the nasopharynx and brain, suggesting that the virus is present in the CNS and may enter through the olfactory mucosa, exploiting the close vicinity of olfactory mucosal, endothelial and nervous tissue.
- Jenny Meinhardt
- , Josefine Radke
- , Carsten Dittmayer
- , Jonas Franz
- , Carolina Thomas
- , Ronja Mothes
- , Michael Laue
- , Julia Schneider
- , Sebastian Brünink
- , Selina Greuel
- , Malte Lehmann
- , Olga Hassan
- , Tom Aschman
- , Elisa Schumann
- , Robert Lorenz Chua
- , Christian Conrad
- , Roland Eils
- , Werner Stenzel
- , Marc Windgassen
- , Larissa Rößler
- , Hans-Hilmar Goebel
- , Hans R. Gelderblom
- , Hubert Martin
- , Andreas Nitsche
- , Walter J. Schulz-Schaeffer
- , Samy Hakroush
- , Martin S. Winkler
- , Björn Tampe
- , Franziska Scheibe
- , Péter Körtvélyessy
- , Dirk Reinhold
- , Britta Siegmund
- , Anja A. Kühl
- , Sefer Elezkurtaj
- , David Horst
- , Lars Oesterhelweg
- , Michael Tsokos
- , Barbara Ingold-Heppner
- , Christine Stadelmann
- , Christian Drosten
- , Victor Max Corman
- , Helena Radbruch
- & Frank L. Heppner
-
Editorial |
Focus on neuroscience methods
In this special issue, we present a series of reviews, perspectives and commentaries that highlight advances in methods and analytical approaches and provide guidelines and best practices in various areas of neuroscience.
-
Article |
Acute social isolation evokes midbrain craving responses similar to hunger
When people are isolated, they crave social interactions. Midbrain craving regions were activated by food in hungry people, and by social interactions in people mandated to be isolated.
- Livia Tomova
- , Kimberly L. Wang
- , Todd Thompson
- , Gillian A. Matthews
- , Atsushi Takahashi
- , Kay M. Tye
- & Rebecca Saxe
-
Article |
An offset ON–OFF receptive field is created by gap junctions between distinct types of retinal ganglion cells
Cooler and Schwartz describe a retinal ganglion cell type with receptive field properties generated by asymmetric morphology and an electrical connection, via gap junctions, to a different type of retinal ganglion cell.
- Sam Cooler
- & Gregory W. Schwartz
-
Article |
Auditory activity is diverse and widespread throughout the central brain of Drosophila
Pacheco et al. present new methods for the unbiased recording and cataloging of sensory activity throughout the Drosophila brain and across trials and individuals. They find auditory activity is temporally diverse but present in neurons throughout nearly all central brain regions.
- Diego A. Pacheco
- , Stephan Y. Thiberge
- , Eftychios Pnevmatikakis
- & Mala Murthy
-
Article |
Neuronal correlates of strategic cooperation in monkeys
Ong et al. analyzed behavior, gaze patterns and neuronal activity of monkeys playing the game ‘chicken’. Monkeys seemed to develop models of the behavior of the partner, and neurons in the mSTS and the ACCg signaled strategic information to guide their decisions.
- Wei Song Ong
- , Seth Madlon-Kay
- & Michael L. Platt
-
Technical Report |
Parameterizing neural power spectra into periodic and aperiodic components
A method for parameterizing electrophysiological neural power spectra into periodic and aperiodic components is introduced, addressing limitations of common approaches. The method is validated in simulation and demonstrated on real data applications.
- Thomas Donoghue
- , Matar Haller
- , Erik J. Peterson
- , Paroma Varma
- , Priyadarshini Sebastian
- , Richard Gao
- , Torben Noto
- , Antonio H. Lara
- , Joni D. Wallis
- , Robert T. Knight
- , Avgusta Shestyuk
- & Bradley Voytek
-
Author Correction |
Author Correction: Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion
- Yubin Huang
- , Zhen Xu
- , Shanshan Xiong
- , Fangfang Sun
- , Guangrong Qin
- , Guanglei Hu
- , Jingjing Wang
- , Lei Zhao
- , Yu-Xiang Liang
- , Tianzhun Wu
- , Zhonghua Lu
- , Mark S. Humayun
- , Kwok-Fai So
- , Yihang Pan
- , Ningning Li
- , Ti-Fei Yuan
- , Yanxia Rao
- & Bo Peng
-
Article |
Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer’s disease via H2O2− production
Chun et al. find that a severe model of reactive astrocytes overproduces hydrogen peroxide, leading to the development of Alzheimer’s disease-like pathologies, including neurodegeneration, tauopathy and memory impairment.
- Heejung Chun
- , Hyeonjoo Im
- , You Jung Kang
- , Yunha Kim
- , Jin Hee Shin
- , Woojin Won
- , Jiwoon Lim
- , Yeonha Ju
- , Yongmin Mason Park
- , Sunpil Kim
- , Seung Eun Lee
- , Jaekwang Lee
- , Junsung Woo
- , Yujin Hwang
- , Hyesun Cho
- , Seonmi Jo
- , Jong-Hyun Park
- , Daesoo Kim
- , Doo Yeon Kim
- , Jeong-Sun Seo
- , Byoung Joo Gwag
- , Young Soo Kim
- , Ki Duk Park
- , Bong-Kiun Kaang
- , Hansang Cho
- , Hoon Ryu
- & C. Justin Lee
-
Review Article |
Massively parallel techniques for cataloguing the regulome of the human brain
This Review discusses two high-throughput techniques—massively parallel reporter assays (MPRAs) and CRISPR screens—focusing on their potential to validate non-coding genetic risk variants in human stem cell models of complex brain disorders.
- Kayla G. Townsley
- , Kristen J. Brennand
- & Laura M. Huckins
-
Review Article |
Recent advances in neurotechnologies with broad potential for neuroscience research
This review summarizes advances in electrical, optical and microfluidic neural interfaces with characteristics that suggest near-term potential for broad deployment to the neuroscience community.
- Abraham Vázquez-Guardado
- , Yiyuan Yang
- , Amay J. Bandodkar
- & John A. Rogers
-
Article |
Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life
Uhlmann et al. show that the preclinical phase of Alzheimer’s disease may in fact be a relatively late manifestation of a much earlier pathogenic and targetable process of seed formation and propagation.
- Ruth E. Uhlmann
- , Christine Rother
- , Jay Rasmussen
- , Juliane Schelle
- , Carina Bergmann
- , Emily M. Ullrich Gavilanes
- , Sarah K. Fritschi
- , Anika Buehler
- , Frank Baumann
- , Angelos Skodras
- , Rawaa Al-Shaana
- , Natalie Beschorner
- , Lan Ye
- , Stephan A. Kaeser
- , Ulrike Obermüller
- , Søren Christensen
- , Fredrik Kartberg
- , Jeffrey B. Stavenhagen
- , Jens-Ulrich Rahfeld
- , Holger Cynis
- , Fang Qian
- , Paul H. Weinreb
- , Thierry Bussiere
- , Lary C. Walker
- , Matthias Staufenbiel
- & Mathias Jucker
-
Publisher Correction |
Publisher Correction: Schwann cell energy to die for
- Amelia Trimarco
- & Carla Taveggia
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Article |
Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer’s disease
Alzheimer’s disease is often considered a disease of neurons. This study reveals that astrocytes are also impaired by the disease and that these cells contribute more to memory deterioration than previously thought.
- Kevin Richetin
- , Pascal Steullet
- , Mathieu Pachoud
- , Romain Perbet
- , Enea Parietti
- , Mathischan Maheswaran
- , Sabiha Eddarkaoui
- , Séverine Bégard
- , Catherine Pythoud
- , Maria Rey
- , Raphaëlle Caillierez
- , Kim Q Do
- , Sophie Halliez
- , Paola Bezzi
- , Luc Buée
- , Geneviève Leuba
- , Morvane Colin
- , Nicolas Toni
- & Nicole Déglon
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Technical Report |
Modeling behaviorally relevant neural dynamics enabled by preferential subspace identification
This work develops PSID, a dynamic modeling method to dissociate and prioritize neural dynamics relevant to a given behavior.
- Omid G. Sani
- , Hamidreza Abbaspourazad
- , Yan T. Wong
- , Bijan Pesaran
- & Maryam M. Shanechi
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Review Article |
Prefrontal–amygdala circuits in social decision-making
Gangopadhyay, Chawla et al. examine the neural bases of social decision-making at different processing stages and across humans, non-human primates and rodents. These examinations underscore the importance of the medial prefrontal–amygdala pathways.
- Prabaha Gangopadhyay
- , Megha Chawla
- , Olga Dal Monte
- & Steve W. C. Chang
-
Review Article |
Quantifying behavior to understand the brain
Behavioral quantification is changing neuroscience. Pereira et al. provide an overview of the latest advances in motion tracking and behavior prediction and discuss how these methods are used to understand the brain in ways not previously possible.
- Talmo D. Pereira
- , Joshua W. Shaevitz
- & Mala Murthy
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Brief Communication |
A cerebello-olivary signal for negative prediction error is sufficient to cause extinction of associative motor learning
Learning to suppress maladaptive behaviors is critical for good mental health. Kim et al. show that mice can be taught to suppress previously acquired motor responses by selective and properly timed stimulation of the cerebello-olivary pathway.
- Olivia A. Kim
- , Shogo Ohmae
- & Javier F. Medina
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News & Views |
An ‘edgy’ new look
Network neuroscientists envision the brain as a network of nodes (regions) linked via edges (connections). A long-held assumption is that node-centric interactions are the primary phenomena of interest. Faskowitz et al. introduce a novel edge-centric framework with the potential to usher in a new era of discovery in connectomics research.
- Lucina Q. Uddin
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Review Article |
Brain organoids for the study of human neurobiology at the interface of in vitro and in vivo
Chiaradia and Lancaster review applications and limitations of brain organoids, placing them in context with other technologies and describing how these methods are heavily informed by in vivo development.
- Ilaria Chiaradia
- & Madeline A. Lancaster
-
Article |
Mesophasic organization of GABAA receptors in hippocampal inhibitory synapses
Using cryo-electron tomography to detect individual GABAA receptors in hippocampal synapses, we discovered a hierarchical and mesophasic organization of inhibitory postsynaptic density proteins that enables efficient synaptic transmission.
- Yun-Tao Liu
- , Chang-Lu Tao
- , Xiaokang Zhang
- , Wenjun Xia
- , Dong-Qing Shi
- , Lei Qi
- , Cheng Xu
- , Rong Sun
- , Xiao-Wei Li
- , Pak-Ming Lau
- , Z. Hong Zhou
- & Guo-Qiang Bi
-
Review Article |
Challenges and future directions for representations of functional brain organization
In this Primer article, Bijsterbosch and colleagues provide an accessible discussion of the challenges faced in analytical representations of functional brain organization and provide clear recommendations to unite a fractionated field.
- Janine Bijsterbosch
- , Samuel J. Harrison
- , Saad Jbabdi
- , Mark Woolrich
- , Christian Beckmann
- , Stephen Smith
- & Eugene P. Duff
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Article |
Activated microglia cause metabolic disruptions in developmental cortical interneurons that persist in interneurons from individuals with schizophrenia
When co-cultured with activated microglia, iPSC-derived interneurons from individuals with schizophrenia and from healthy controls show defects in metabolic pathways, but only the interneurons from individuals with schizophrenia showed prolonged metabolic deficits.
- Gun-Hoo Park
- , Haneul Noh
- , Zhicheng Shao
- , Peiyan Ni
- , Yiren Qin
- , Dongxin Liu
- , Cameron P. Beaudreault
- , Joy S. Park
- , Chiderah P. Abani
- , James M. Park
- , Derek T. Le
- , Sasha Z. Gonzalez
- , Youxin Guan
- , Bruce M. Cohen
- , Donna L. McPhie
- , Joseph T. Coyle
- , Thomas A. Lanz
- , Hualin S. Xi
- , Changhong Yin
- , Weihua Huang
- , Hae-Young Kim
- & Sangmi Chung
-
News & Views |
Help from peripheral macrophages in ALS?
Chiot and colleagues investigated whether peripheral macrophages play a role in amyotrophic lateral sclerosis (ALS) pathology, finding that macrophages along peripheral motor neuron axons react to neurodegeneration. Modifying reactive oxygen species (ROS) signaling in peripheral macrophages, using bone marrow cell replacement, reduces both macrophage and microglia inflammatory response, delays pathology and increases survival in ALS mouse models.
- P. Hande Özdinler
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Technical Report |
Edge-centric functional network representations of human cerebral cortex reveal overlapping system-level architecture
The authors present an edge-centric model of brain connectivity. Edge networks are stable across datasets, and their structure can be modulated by sensory input. When clustered, edge networks yield pervasively overlapping functional modules.
- Joshua Faskowitz
- , Farnaz Zamani Esfahlani
- , Youngheun Jo
- , Olaf Sporns
- & Richard F. Betzel