Browse Articles

Filters ​

  • Publisher Correction |

    • Rafael Yuste
    • , Michael Hawrylycz
    • , Nadia Aalling
    • , Argel Aguilar-Valles
    • , Detlev Arendt
    • , Ruben Armananzas Arnedillo
    • , Giorgio A. Ascoli
    • , Concha Bielza
    • , Vahid Bokharaie
    • , Tobias Borgtoft Bergmann
    • , Irina Bystron
    • , Marco Capogna
    • , Yoonjeung Chang
    • , Ann Clemens
    • , Christiaan P. J. de Kock
    • , Javier DeFelipe
    • , Sandra Esmeralda Dos Santos
    • , Keagan Dunville
    • , Dirk Feldmeyer
    • , Richárd Fiáth
    • , Gordon James Fishell
    • , Angelica Foggetti
    • , Xuefan Gao
    • , Parviz Ghaderi
    • , Natalia A. Goriounova
    • , Onur Güntürkün
    • , Kenta Hagihara
    • , Vanessa Jane Hall
    • , Moritz Helmstaedter
    • , Suzana Herculano
    • , Markus M. Hilscher
    • , Hajime Hirase
    • , Jens Hjerling-Leffler
    • , Rebecca Hodge
    • , Josh Huang
    • , Rafiq Huda
    • , Konstantin Khodosevich
    • , Ole Kiehn
    • , Henner Koch
    • , Eric S. Kuebler
    • , Malte Kühnemund
    • , Pedro Larrañaga
    • , Boudewijn Lelieveldt
    • , Emma Louise Louth
    • , Jan H. Lui
    • , Huibert D. Mansvelder
    • , Oscar Marin
    • , Julio Martinez-Trujillo
    • , Homeira Moradi Chameh
    • , Alok Nath
    • , Maiken Nedergaard
    • , Pavel Němec
    • , Netanel Ofer
    • , Ulrich Gottfried Pfisterer
    • , Samuel Pontes
    • , William Redmond
    • , Jean Rossier
    • , Joshua R. Sanes
    • , Richard Scheuermann
    • , Esther Serrano-Saiz
    • , Jochen F. Steiger
    • , Peter Somogyi
    • , Gábor Tamás
    • , Andreas Savas Tolias
    • , Maria Antonietta Tosches
    • , Miguel Turrero García
    • , Hermany Munguba Vieira
    • , Christian Wozny
    • , Thomas V. Wuttke
    • , Liu Yong
    • , Juan Yuan
    • , Hongkui Zeng
    •  & Ed Lein

  • News & Views |

    One of the mechanisms driving aging and neurodegenerative diseases is the accumulation of senescent cells, while their elimination mitigates age-related decline. A new report details how, with aging, changes in the dentate gyrus microenvironment lead to natural-killer-cell-mediated clearance of neurogenic senescent cells, resulting in cognitive decline.

    • Nurit Papismadov
    •  & Valery Krizhanovsky

  • Article |

    The authors demonstrate the presence of SARS-CoV-2 in the nasopharynx and brain, suggesting that the virus is present in the CNS and may enter through the olfactory mucosa, exploiting the close vicinity of olfactory mucosal, endothelial and nervous tissue.

    • Jenny Meinhardt
    • , Josefine Radke
    • , Carsten Dittmayer
    • , Jonas Franz
    • , Carolina Thomas
    • , Ronja Mothes
    • , Michael Laue
    • , Julia Schneider
    • , Sebastian Brünink
    • , Selina Greuel
    • , Malte Lehmann
    • , Olga Hassan
    • , Tom Aschman
    • , Elisa Schumann
    • , Robert Lorenz Chua
    • , Christian Conrad
    • , Roland Eils
    • , Werner Stenzel
    • , Marc Windgassen
    • , Larissa Rößler
    • , Hans-Hilmar Goebel
    • , Hans R. Gelderblom
    • , Hubert Martin
    • , Andreas Nitsche
    • , Walter J. Schulz-Schaeffer
    • , Samy Hakroush
    • , Martin S. Winkler
    • , Björn Tampe
    • , Franziska Scheibe
    • , Péter Körtvélyessy
    • , Dirk Reinhold
    • , Britta Siegmund
    • , Anja A. Kühl
    • , Sefer Elezkurtaj
    • , David Horst
    • , Lars Oesterhelweg
    • , Michael Tsokos
    • , Barbara Ingold-Heppner
    • , Christine Stadelmann
    • , Christian Drosten
    • , Victor Max Corman
    • , Helena Radbruch
    •  & Frank L. Heppner

  • Editorial |

    In this special issue, we present a series of reviews, perspectives and commentaries that highlight advances in methods and analytical approaches and provide guidelines and best practices in various areas of neuroscience.

  • Article |

    When people are isolated, they crave social interactions. Midbrain craving regions were activated by food in hungry people, and by social interactions in people mandated to be isolated.

    • Livia Tomova
    • , Kimberly L. Wang
    • , Todd Thompson
    • , Gillian A. Matthews
    • , Atsushi Takahashi
    • , Kay M. Tye
    •  & Rebecca Saxe

  • Article |

    Pacheco et al. present new methods for the unbiased recording and cataloging of sensory activity throughout the Drosophila brain and across trials and individuals. They find auditory activity is temporally diverse but present in neurons throughout nearly all central brain regions.

    • Diego A. Pacheco
    • , Stephan Y. Thiberge
    • , Eftychios Pnevmatikakis
    •  & Mala Murthy

  • Article |

    Ong et al. analyzed behavior, gaze patterns and neuronal activity of monkeys playing the game ‘chicken’. Monkeys seemed to develop models of the behavior of the partner, and neurons in the mSTS and the ACCg signaled strategic information to guide their decisions.

    • Wei Song Ong
    • , Seth Madlon-Kay
    •  & Michael L. Platt

  • Technical Report |

    A method for parameterizing electrophysiological neural power spectra into periodic and aperiodic components is introduced, addressing limitations of common approaches. The method is validated in simulation and demonstrated on real data applications.

    • Thomas Donoghue
    • , Matar Haller
    • , Erik J. Peterson
    • , Paroma Varma
    • , Priyadarshini Sebastian
    • , Richard Gao
    • , Torben Noto
    • , Antonio H. Lara
    • , Joni D. Wallis
    • , Robert T. Knight
    • , Avgusta Shestyuk
    •  & Bradley Voytek

  • Article |

    Chun et al. find that a severe model of reactive astrocytes overproduces hydrogen peroxide, leading to the development of Alzheimer’s disease-like pathologies, including neurodegeneration, tauopathy and memory impairment.

    • Heejung Chun
    • , Hyeonjoo Im
    • , You Jung Kang
    • , Yunha Kim
    • , Jin Hee Shin
    • , Woojin Won
    • , Jiwoon Lim
    • , Yeonha Ju
    • , Yongmin Mason Park
    • , Sunpil Kim
    • , Seung Eun Lee
    • , Jaekwang Lee
    • , Junsung Woo
    • , Yujin Hwang
    • , Hyesun Cho
    • , Seonmi Jo
    • , Jong-Hyun Park
    • , Daesoo Kim
    • , Doo Yeon Kim
    • , Jeong-Sun Seo
    • , Byoung Joo Gwag
    • , Young Soo Kim
    • , Ki Duk Park
    • , Bong-Kiun Kaang
    • , Hansang Cho
    • , Hoon Ryu
    •  & C. Justin Lee

  • Review Article |

    This Review discusses two high-throughput techniques—massively parallel reporter assays (MPRAs) and CRISPR screens—focusing on their potential to validate non-coding genetic risk variants in human stem cell models of complex brain disorders.

    • Kayla G. Townsley
    • , Kristen J. Brennand
    •  & Laura M. Huckins

  • Article |

    Uhlmann et al. show that the preclinical phase of Alzheimer’s disease may in fact be a relatively late manifestation of a much earlier pathogenic and targetable process of seed formation and propagation.

    • Ruth E. Uhlmann
    • , Christine Rother
    • , Jay Rasmussen
    • , Juliane Schelle
    • , Carina Bergmann
    • , Emily M. Ullrich Gavilanes
    • , Sarah K. Fritschi
    • , Anika Buehler
    • , Frank Baumann
    • , Angelos Skodras
    • , Rawaa Al-Shaana
    • , Natalie Beschorner
    • , Lan Ye
    • , Stephan A. Kaeser
    • , Ulrike Obermüller
    • , Søren Christensen
    • , Fredrik Kartberg
    • , Jeffrey B. Stavenhagen
    • , Jens-Ulrich Rahfeld
    • , Holger Cynis
    • , Fang Qian
    • , Paul H. Weinreb
    • , Thierry Bussiere
    • , Lary C. Walker
    • , Matthias Staufenbiel
    •  & Mathias Jucker

  • Article |

    Alzheimer’s disease is often considered a disease of neurons. This study reveals that astrocytes are also impaired by the disease and that these cells contribute more to memory deterioration than previously thought.

    • Kevin Richetin
    • , Pascal Steullet
    • , Mathieu Pachoud
    • , Romain Perbet
    • , Enea Parietti
    • , Mathischan Maheswaran
    • , Sabiha Eddarkaoui
    • , Séverine Bégard
    • , Catherine Pythoud
    • , Maria Rey
    • , Raphaëlle Caillierez
    • , Kim Q Do
    • , Sophie Halliez
    • , Paola Bezzi
    • , Luc Buée
    • , Geneviève Leuba
    • , Morvane Colin
    • , Nicolas Toni
    •  & Nicole Déglon

  • Review Article |

    Gangopadhyay, Chawla et al. examine the neural bases of social decision-making at different processing stages and across humans, non-human primates and rodents. These examinations underscore the importance of the medial prefrontal–amygdala pathways.

    • Prabaha Gangopadhyay
    • , Megha Chawla
    • , Olga Dal Monte
    •  & Steve W. C. Chang

  • Review Article |

    Behavioral quantification is changing neuroscience. Pereira et al. provide an overview of the latest advances in motion tracking and behavior prediction and discuss how these methods are used to understand the brain in ways not previously possible.

    • Talmo D. Pereira
    • , Joshua W. Shaevitz
    •  & Mala Murthy

  • News & Views |

    Network neuroscientists envision the brain as a network of nodes (regions) linked via edges (connections). A long-held assumption is that node-centric interactions are the primary phenomena of interest. Faskowitz et al. introduce a novel edge-centric framework with the potential to usher in a new era of discovery in connectomics research.

    • Lucina Q. Uddin

  • Article |

    Using cryo-electron tomography to detect individual GABAA receptors in hippocampal synapses, we discovered a hierarchical and mesophasic organization of inhibitory postsynaptic density proteins that enables efficient synaptic transmission.

    • Yun-Tao Liu
    • , Chang-Lu Tao
    • , Xiaokang Zhang
    • , Wenjun Xia
    • , Dong-Qing Shi
    • , Lei Qi
    • , Cheng Xu
    • , Rong Sun
    • , Xiao-Wei Li
    • , Pak-Ming Lau
    • , Z. Hong Zhou
    •  & Guo-Qiang Bi

  • Review Article |

    In this Primer article, Bijsterbosch and colleagues provide an accessible discussion of the challenges faced in analytical representations of functional brain organization and provide clear recommendations to unite a fractionated field.

    • Janine Bijsterbosch
    • , Samuel J. Harrison
    • , Saad Jbabdi
    • , Mark Woolrich
    • , Christian Beckmann
    • , Stephen Smith
    •  & Eugene P. Duff

  • Article |

    When co-cultured with activated microglia, iPSC-derived interneurons from individuals with schizophrenia and from healthy controls show defects in metabolic pathways, but only the interneurons from individuals with schizophrenia showed prolonged metabolic deficits.

    • Gun-Hoo Park
    • , Haneul Noh
    • , Zhicheng Shao
    • , Peiyan Ni
    • , Yiren Qin
    • , Dongxin Liu
    • , Cameron P. Beaudreault
    • , Joy S. Park
    • , Chiderah P. Abani
    • , James M. Park
    • , Derek T. Le
    • , Sasha Z. Gonzalez
    • , Youxin Guan
    • , Bruce M. Cohen
    • , Donna L. McPhie
    • , Joseph T. Coyle
    • , Thomas A. Lanz
    • , Hualin S. Xi
    • , Changhong Yin
    • , Weihua Huang
    • , Hae-Young Kim
    •  & Sangmi Chung

  • News & Views |

    Chiot and colleagues investigated whether peripheral macrophages play a role in amyotrophic lateral sclerosis (ALS) pathology, finding that macrophages along peripheral motor neuron axons react to neurodegeneration. Modifying reactive oxygen species (ROS) signaling in peripheral macrophages, using bone marrow cell replacement, reduces both macrophage and microglia inflammatory response, delays pathology and increases survival in ALS mouse models.

    • P. Hande Özdinler

  • Article |

    Peripheral macrophages located along motor axons react differently to neurodegeneration compared to CNS microglia in ALS mice. Modifying peripheral macrophages suppresses proinflammatory microglial responses, shifting them toward neuronal support.

    • Aude Chiot
    • , Sakina Zaïdi
    • , Charlène Iltis
    • , Matthieu Ribon
    • , Félix Berriat
    • , Lorenzo Schiaffino
    • , Ariane Jolly
    • , Pierre de la Grange
    • , Michel Mallat
    • , Delphine Bohl
    • , Stéphanie Millecamps
    • , Danielle Seilhean
    • , Christian S. Lobsiger
    •  & Séverine Boillée

  • Article |

    Donegan et al. show that hippocampal CA2 neurons contribute to social memory by encoding social novelty. Abnormal CA2 coding and social memory in a mouse model of the 22q11.2 microdeletion are rescued by blocking elevated CA2 TREK-1 K+ current.

    • Macayla L. Donegan
    • , Fabio Stefanini
    • , Torcato Meira
    • , Joshua A. Gordon
    • , Stefano Fusi
    •  & Steven A. Siegelbaum

  • Review Article |

    Aggression is an instinctive behavior supported by hardwired neural circuits. Julieta Lischinsky and Dayu Lin review our current understanding of the neural circuits of aggression across species and their modulation by internal state.

    • Julieta E. Lischinsky
    •  & Dayu Lin

  • Resource |

    The authors show that a coordinated epigenetic priming event during memory encoding and consolidation facilitates promoter–enhancer interactions that are vital for the unique transcriptional output of reactivated engram neurons.

    • Asaf Marco
    • , Hiruy S. Meharena
    • , Vishnu Dileep
    • , Ravikiran M. Raju
    • , Jose Davila-Velderrain
    • , Amy Letao Zhang
    • , Chinnakkaruppan Adaikkan
    • , Jennie Z. Young
    • , Fan Gao
    • , Manolis Kellis
    •  & Li-Huei Tsai

  • Article |

    Kohro et al. identify a population of astrocytes located in the superficial dorsal horn of adult spinal cord (genetically defined by Hes5) that acts as a gate for locus coeruleus descending noradrenergic control of mechanosensory hypersensitivity.

    • Yuta Kohro
    • , Tsuyoshi Matsuda
    • , Kohei Yoshihara
    • , Keita Kohno
    • , Keisuke Koga
    • , Ryuichi Katsuragi
    • , Takaaki Oka
    • , Ryoichi Tashima
    • , Sho Muneta
    • , Takuya Yamane
    • , Shota Okada
    • , Kazuya Momokino
    • , Aogu Furusho
    • , Kenji Hamase
    • , Takumi Oti
    • , Hirotaka Sakamoto
    • , Kenichiro Hayashida
    • , Ryosuke Kobayashi
    • , Takuro Horii
    • , Izuho Hatada
    • , Hidetoshi Tozaki-Saitoh
    • , Katsuhiko Mikoshiba
    • , Verdon Taylor
    • , Kazuhide Inoue
    •  & Makoto Tsuda

  • News & Views |

    By building a richer behavioral vocabulary, Wiltschko et al. tease apart subtle differences in how pharmacological agents affect animal behavior, mapping on- and off-target effects of drugs with improved precision.

    • Ann Kennedy

  • News & Views |

    Abrupt spatial changes in anatomic and functional properties of the brain demarcate boundaries between discrete functional areas. While previous work has identified these boundaries in cortex, a new study by Tian et al. applies this approach for the first time to subcortical structures within the in vivo human brain.

    • Evan M. Gordon

  • Article |

    This study demonstrates that basal ganglia functional topography is maintained across and downstream of its output nuclei, and in closed loops. Focal stimulation of distinct striatal subregions induces distinct action, supporting a model of parallel behavioral control.

    • Jaeeon Lee
    • , Wengang Wang
    •  & Bernardo L. Sabatini

  • Article |

    Kusick et al. capture snapshots of synaptic vesicle docking and fusion using a new time-resolved electron microscopy technique. They find that vesicles are replaced milliseconds after they fuse, which may contribute to short-term synaptic plasticity.

    • Grant F. Kusick
    • , Morven Chin
    • , Sumana Raychaudhuri
    • , Kristina Lippmann
    • , Kadidia P. Adula
    • , Edward J. Hujber
    • , Thien Vu
    • , M. Wayne Davis
    • , Erik M. Jorgensen
    •  & Shigeki Watanabe

  • Resource |

    By analyzing hundreds of mice treated with a library of neuro- and psychoactive drugs, Wiltschko et al. show that Motion Sequencing can effectively discriminate and categorize drug effects and link molecular targets to behavioral syllables.

    • Alexander B. Wiltschko
    • , Tatsuya Tsukahara
    • , Ayman Zeine
    • , Rockwell Anyoha
    • , Winthrop F. Gillis
    • , Jeffrey E. Markowitz
    • , Ralph E. Peterson
    • , Jesse Katon
    • , Matthew J. Johnson
    •  & Sandeep Robert Datta

  • Technical Report |

    Kuan, Phelps, et al. used synchrotron X-ray imaging and deep learning to map dense neuronal wiring in fly and mouse tissue, enabling examination of individual cells and connectivity in circuits governing motor control and perceptual decision-making.

    • Aaron T. Kuan
    • , Jasper S. Phelps
    • , Logan A. Thomas
    • , Tri M. Nguyen
    • , Julie Han
    • , Chiao-Lin Chen
    • , Anthony W. Azevedo
    • , John C. Tuthill
    • , Jan Funke
    • , Peter Cloetens
    • , Alexandra Pacureanu
    •  & Wei-Chung Allen Lee

  • Resource |

    The ventral hippocampus is central in the processing of emotional information. Here, a combination of viral and sequencing approaches defines the organizational logic of the extended ventral CA1 circuit.

    • Mark M. Gergues
    • , Kasey J. Han
    • , Hye Sun Choi
    • , Brandon Brown
    • , Kelsey J. Clausing
    • , Victoria S. Turner
    • , Ilia D. Vainchtein
    • , Anna V. Molofsky
    •  & Mazen A. Kheirbek

  • News & Views |

    A new study shows that, immediately after axon injury, glycolysis is increased in Schwann cells to provide axons with energy and prevent them from degenerating. The authors also identify possible therapeutic targets that could be modulated to promote axonal protection.

    • Amelia Trimarco
    •  & Carla Taveggia

  • Obituary |

    Horace Basil Barlow, Fellow of the Royal Society, winner of the Australia Prize, the Royal Medal of the Royal Society and the Schwartz Prize of the Society for Neuroscience, died on 5 July 2020 at the age of 98, 10 days after suffering a stroke. As news spread among his former students and collaborators, one phrase recurred again and again in the messages of nostalgic reflection: ‘the end of an era’.

    • Colin Blakemore

  • Resource |

    Chen et al. define previously unreported zebrafish astrocytes, provide new insights into vertebrate astrocyte development and lay the foundation for studying astrocyte function in the entire nervous system of an intact and behaving animal.

    • Jiakun Chen
    • , Kira E. Poskanzer
    • , Marc R. Freeman
    •  & Kelly R. Monk