Jennie Vallis

Special focus on Learning and Memory

Latest Research

  • Article |

    Stowell, Sipe et al. describe how norepinephrine signaling to microglia during wakefulness influences the dynamic movement of microglial processes, affecting both microglial interactions with neurons and experience-dependent plasticity.

    • Rianne D. Stowell
    • , Grayson O. Sipe
    • , Ryan P. Dawes
    • , Hanna N. Batchelor
    • , Katheryn A. Lordy
    • , Brendan S. Whitelaw
    • , Mark B. Stoessel
    • , Jean M. Bidlack
    • , Edward Brown
    • , Mriganka Sur
    •  & Ania K. Majewska
  • Article |

    Chow et al. show that high blood levels of insulin in prediabetic conditions are linked to saturated insulin levels in the brain. Chronic insulin exposure leads to insulin resistance, cell cycle reentry and premature aging, corresponding to senescence-like pathological changes in neurons.

    • Hei-Man Chow
    • , Meng Shi
    • , Aifang Cheng
    • , Yuehong Gao
    • , Guimiao Chen
    • , Xuan Song
    • , Raphaella Wai Lam So
    • , Jie Zhang
    •  & Karl Herrup
  • Article |

    Krabbe, Paradiso et al. show that amygdala VIP interneurons are activated by instructive cues for associative learning. These interneurons provide a mandatory disinhibitory signal permitting plasticity in response to unexpected salient events.

    • Sabine Krabbe
    • , Enrica Paradiso
    • , Simon d’Aquin
    • , Yael Bitterman
    • , Julien Courtin
    • , Chun Xu
    • , Keisuke Yonehara
    • , Milica Markovic
    • , Christian Müller
    • , Tobias Eichlisberger
    • , Jan Gründemann
    • , Francesco Ferraguti
    •  & Andreas Lüthi
  • Article |

    Liu et al. show that microglial process surveillance is restrained in awake mice, and that reduced neuronal activity due to anesthesia, sensory deprivation or optogenetic inhibition increases microglial dynamics via norepinephrine signaling.

    • Yong U. Liu
    • , Yanlu Ying
    • , Yujiao Li
    • , Ukpong B. Eyo
    • , Tingjun Chen
    • , Jiaying Zheng
    • , Anthony D. Umpierre
    • , Jia Zhu
    • , Dale B. Bosco
    • , Hailong Dong
    •  & Long-Jun Wu
  • Article |

    In offspring exposed to THC in utero, molecular, synaptic and circuit reorganizations lead to a hyperdopaminergic phenotype and behavioral susceptibility. The neurosteroid pregnenolone restores both dopamine function and abnormal behavior.

    • Roberto Frau
    • , Vivien Miczán
    • , Francesco Traccis
    • , Sonia Aroni
    • , Csaba I. Pongor
    • , Pierluigi Saba
    • , Valeria Serra
    • , Claudia Sagheddu
    • , Silvia Fanni
    • , Mauro Congiu
    • , Paola Devoto
    • , Joseph F. Cheer
    • , István Katona
    •  & Miriam Melis
  • Resource |

    Munji et al. analyzed the transcriptomes of endothelial cells from multiple organs and in neural tissue of neurological disease models. They identified a blood–brain barrier dysfunction module in seizure, multiple sclerosis, stroke and brain trauma.

    • Roeben Nocon Munji
    • , Allison Luen Soung
    • , Geoffrey Aaron Weiner
    • , Fabien Sohet
    • , Bridgette Deanne Semple
    • , Alpa Trivedi
    • , Kayleen Gimlin
    • , Masakazu Kotoda
    • , Masaaki Korai
    • , Sidar Aydin
    • , Austin Batugal
    • , Anne Christelle Cabangcala
    • , Patrick Georg Schupp
    • , Michael Clark Oldham
    • , Tomoki Hashimoto
    • , Linda J. Noble-Haeusslein
    •  & Richard Daneman

News & Comment

  • News & Views |

    Unexpected experiences often lead to strong memories. A new study by Krabbe and Paradiso et al. shows that vasoactive intestinal peptide (VIP)-expressing interneurons of the basolateral amygdala control associative learning and memory formation by gating aversive stimuli scaled by their unexpectedness.

    • Panna Hegedüs
    • , Sergio Martínez-Bellver
    •  & Balázs Hangya
  • News & Views |

    Two new studies demonstrate the importance of awake imaging to investigate microglia–neuron interactions. These studies show that microglial dynamics are influenced by neuronal activity, and they provide evidence that norepinergic signaling plays an important role in this effect.

    • Dilek Mercan
    •  & Michael T. Heneka
  • News & Views |

    Astrocytes are crucial contributors to brain homeostasis. Yet the lack of ad hoc analysis tools has prevented in-depth characterization of astrocyte-derived signals. In a new study, the authors present an image-analysis toolbox that captures the complexity of astrocyte activity and enables our understanding of astrocytic physiology.

    • Jennifer Romanos
    • , Laetitia Thieren
    •  & Mirko Santello
  • News & Views |

    Using data from 45,615 people, Kaufmann et al. compare the gaps between brain age and chronological age in a number of brain disorders and study the relationship of these gaps with genetics. Their research shows that the brains of individuals with a range of different brain disorders, such as dementia and schizophrenia, are aging faster than normal.

    • Janine Bijsterbosch
  • News & Views |

    We express decisions through movements, but not all movements matter to the outcome. For example, fidgeting is a common yet ‘nonessential’ behavior we exhibit. New evidence suggests that this non-task-related movement profoundly shapes neural activity in expert mice performing tasks.

    • Mackenzie Weygandt Mathis
  • Editorial |

    In this special issue of Nature Neuroscience, we feature an assortment of reviews and perspectives that explore the topic of learning and memory.

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