Perl et al. show that in PTSD, hippocampal representations of autobiographical memories are similar across people with similar semantic content only for sad but not traumatic memories, pointing to altered brain state during traumatic memory recall.

Benisty, Barson et al. show that motor behaviors are represented by fast changes in the activity magnitude and functional connectivity across the mouse neocortex, which provides insight into the relationship between neural signals and behavior.

The ENIGMA-ORIGINs group presents a large and globally diverse pediatric neuroimaging dataset from birth to age 6. They use this resource to study the effects of sociodemographics and adverse birth outcomes on trajectories of brain volumes and cognition.

Recent discoveries highlight the skull bone marrow, linked to the CNS via osseous channels, as a key neuroimmune compartment. Here, the authors discuss the anatomy, functions and implications of this immune reservoir on CNS health and disease.

Hypertension can lead to cognitive impairment. However, the underlying mechanisms are unclear. Here, the authors show that meningeal T cell-produced interleukin-17 activates border-associated macrophages, affecting neurovascular and cognitive functions in a mouse model of hypertension.

Perl et al. show that in PTSD, hippocampal representations of autobiographical memories are similar across people with similar semantic content only for sad but not traumatic memories, pointing to altered brain state during traumatic memory recall.

Benisty, Barson et al. show that motor behaviors are represented by fast changes in the activity magnitude and functional connectivity across the mouse neocortex, which provides insight into the relationship between neural signals and behavior.

Griggs, Norman et al. demonstrate a closed-loop ultrasound-based brain–machine interface (BMI) in rhesus macaques. The ultrasound BMI is capable of controlling eight independent movement directions and is stable across months without retraining.

Li et al. developed a base-editing system to edit mutations linked to autism. Targeting a mutation in Mef2c restored Mef2c protein levels in several brain regions and reversed behavioral changes in Mef2c-mutant mice.

The authors identify a cluster of ~160 peptidergic neurons in the mouse brainstem whose activity is necessary and sufficient for producing sound and controlling sound volume. These neurons form the final common pathway for vocalization.

As Nature Neuroscience celebrates its 25th anniversary, we are having conversations with both established leaders in the field and those earlier in their careers to discuss how the field has evolved, and where it is heading. This month, we are talking to Ukpong Eyo (Associate Professor of Neuroscience at the University of Virginia, USA), a glial biologist interested in the role of microglia in neurodevelopment, health and disease, about science, family, and the benefits of finding your balance.

As Nature Neuroscience celebrates its 25th anniversary, we are having conversations with both established leaders in the field and those earlier in their careers to discuss how the field has evolved and where it is heading. This month we are talking to Kelsey Martin, Executive Vice President of Autism and Neuroscience at the Simons Foundation and Professor in the Department of Biological Chemistry at the University of California, Los Angeles (UCLA), where she previously served as the Dean of the David Geffen School of Medicine. We discussed the pleasures of studying neuronal cell biology and her leadership roles.

In 2022, we began a pilot to facilitate data sharing for manuscripts submitted to Nature Neuroscience. Here, we analyze its effects on research data availability and reflect on the importance of facilitating open science.