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    • The authors summarize changes in circuits after spinal cord injury and current strategies to target these circuits in order to improve recovery, but also advocate for new concepts of reorganizing circuits informed by multi-omic single-cell atlases.

      • Mark A. Anderson
      • Jordan W. Squair
      • Grégoire Courtine
      Review Article
    • Scheggia et al.1 have established a behavioral paradigm to explore preferences for ‘altruistic’ or ‘selfish’ choice behavior in mice. The results suggest that altruistic behavior develops through reinforcement learning driven by social rewards, which is controlled by interactions between the basolateral amygdala and prelimbic cortex.

      • Hee-Sup Shin
      News & Views
    • Psychedelics are serotonergic drugs that have therapeutic potential. This Review article provides an integrative perspective on the basic neurobiology underlying the actions of psychedelics and highlights open questions in the field.

      • Alex C. Kwan
      • David E. Olson
      • Bryan L. Roth
      Review Article
    • How genetic and environmental risk factors interact to trigger the development of post-traumatic stress disorder (PTSD) remains largely unknown. Seah et al. model stress hypersensitivity as a potential mechanism by examining transcriptomic responses to glucocorticoids in neurons derived from individuals with PTSD.

      • Siwei Zhang
      • Alan R. Sanders
      • Jubao Duan
      News & Views
    • Learning requires new oligodendrogenesis, but how myelin patterns change during learning is unclear. Bacmeister et al. show that motor learning induces phase-specific changes in myelination on behaviorally activated axons that correlate with motor performance, suggesting myelin remodeling is involved in learning.

      • Wendy Xin
      • Jonah R. Chan
      News & Views
  • Neuroscientists may wish to remain above the fray. But, when policy-makers and judges are deciding on matters that could be informed by their research, neuroscientists must lend their voices to the discussion.

    Editorial
  • In the case that led the Supreme Court to overturn Roe vs Wade, the State of Mississippi made the strong claim that fetuses can feel pain. We argue that critical biological evidence used to support this claim was misinterpreted and that the State’s argument conflated pain and nociception. Abortion policy has profound moral and ethical consequences and therefore needs to be grounded in the most accurate scientific arguments, as well as a clear understanding of what we mean when we use the term pain.

    • T. V. Salomons
    • G. D. Iannetti
    Comment
  • By integrating ongoing bioethical collaboration, neuroscientists can create a positive effect on their research and the knowledge it produces. To this end, we offer our experiences with an interdisciplinary model for the ethical advancement of a promising area of neuroscience — human neural organoid research.

    • Insoo Hyun
    • J. C. Scharf-Deering
    • Jeantine E. Lunshof
    Comment

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