Han Yao, Baolin Guo, Wenting Wang and Shengxi Wu

Network analysis predicts spread of α-synuclein pathology

Latest Research

  • Article |

    Researchers identify a transcriptional network engaged in stress-resilient mice that is regulated by a previously unstudied transcription factor, Zfp189, and elucidate molecular mechanisms controlling this network and resilience behavior.

    • Zachary S. Lorsch
    • , Peter J. Hamilton
    • , Aarthi Ramakrishnan
    • , Eric M. Parise
    • , Marine Salery
    • , William J. Wright
    • , Ashley E. Lepack
    • , Philipp Mews
    • , Orna Issler
    • , Andrew McKenzie
    • , Xianxiao Zhou
    • , Lyonna F. Parise
    • , Stephen T. Pirpinias
    • , Idelisse Ortiz Torres
    • , Hope G. Kronman
    • , Sarah E. Montgomery
    • , Yong-Hwee Eddie Loh
    • , Benoit Labonté
    • , Andrew Conkey
    • , Ann E. Symonds
    • , Rachael L. Neve
    • , Gustavo Turecki
    • , Ian Maze
    • , Yan Dong
    • , Bin Zhang
    • , Li Shen
    • , Rosemary C. Bagot
    •  & Eric J. Nestler
  • Article |

    Neural populations often encode unknown variables. Chaudhuri et al. develop a method to decode unknown variables by finding shapes in neural data. They show that a mammalian brain circuit of thousands of neurons constructs a navigational compass with only a one-dimensional ring of stable activity states.

    • Rishidev Chaudhuri
    • , Berk Gerçek
    • , Biraj Pandey
    • , Adrien Peyrache
    •  & Ila Fiete
  • Article |

    Using data from rats and humans, the authors study the time it takes to make sensory judgments. The authors define the new regularity as the time–intensity equivalence in discrimination (TIED), which provides a mechanistic basis of Weber’s law.

    • Jose L. Pardo-Vazquez
    • , Juan R. Castiñeiras-de Saa
    • , Mafalda Valente
    • , Iris Damião
    • , Tiago Costa
    • , M. Inês Vicente
    • , André G. Mendonça
    • , Zachary F. Mainen
    •  & Alfonso Renart
  • Article |

    Like humans, songbirds learn to communicate vocally early in life. Moore and Woolley taught birds the songs of a different species to identify how vocal experience and auditory tuning mechanisms create neural representations of communication sounds.

    • Jordan M. Moore
    •  & Sarah M. N. Woolley
  • Article |

    Everyday decisions require choosing among multiple options. This work derives the optimal decision policy and shows how it can be approximated by a biologically plausible neural circuit and how this circuit can reproduce observed behavior.

    • Satohiro Tajima
    • , Jan Drugowitsch
    • , Nisheet Patel
    •  & Alexandre Pouget

News & Comment

  • News & Views |

    Repeat-associated non-AUG (RAN) translation generates toxic repeat proteins from pathological repeat expansions found in certain neurodegenerative disorders, including amyotrophic lateral sclerosis and frontotemporal dementia. How to suppress RAN translation has so far been unknown. A new study now reports a selective regulator of RAN translation identified in a genetic screen in yeast.

    • Saskia Hutten
    •  & Dorothee Dormann
  • News & Views |

    Misfolded protein aggregates are a classical hallmark of many neurodegenerative diseases. By combining a mouse model of misfolded protein injection and a brain network model of misfolded protein diffusion, a study now finds a strong link between the stereotypical spreading patterns of neurodegeneration, protein expression and anatomical connectivity.

    • Ellen Kuhl
  • News & Views |

    Mosquito-borne virus infections, such as West Nile and Zika, have debilitating cognitive effects that persist despite recovery from encephalitis. Garber et al. identify mechanisms by which antiviral T cell persistence after recovery from infection leads to impairments in cognition via virus-specific mediation of microglial synapse elimination.

    • Karen Krukowski
    •  & Susanna Rosi
  • Q&A |

    There is disagreement on how best to define and investigate fear. Nature Neuroscience asked Dean Mobbs to lead experts from the fields of human and animal affective neuroscience to discuss their viewpoints on how to define fear and how to move forward with the study of fear.

    • Dean Mobbs
    • , Ralph Adolphs
    • , Michael S. Fanselow
    • , Lisa Feldman Barrett
    • , Joseph E. LeDoux
    • , Kerry Ressler
    •  & Kay M. Tye
  • Obituary |

    On April 13, the neuroscience community lost a remarkable scientist and true humanitarian. Paul Greengard, co-recipient of the Nobel Prize in Physiology or Medicine in 2000, Vincent Astor Professor and head of the Laboratory of Molecular and Cellular Neuroscience at the Rockefeller University in New York City, died of an apparent heart attack at age 93. Paul will be remembered for his seminal contributions to neuroscience, for pioneering the field of neuronal signal transduction and for training hundreds of neuroscientists. For anyone who knew Paul it will come as no surprise that up until a few hours before his death, Paul was doing what he liked the best: working on a scientific manuscript.

    • Helen S. Bateup
    • , Myriam Heiman
    •  & Anne Schaefer
  • News & Views |

    The creation of a murine Cre driver specific to CNS capillary pericytes has opened a major bottleneck in brain microvascular research. Using this tool, pericyte loss in the adult brain is shown to induce neuronal loss due to concurrent microcirculatory failure and depletion of the protective trophic factor pleiotrophin.

    • Andrée-Anne Berthiaume
    •  & Andy Y. Shih

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