Han Yao, Baolin Guo, Wenting Wang and Shengxi Wu

Network analysis predicts spread of α-synuclein pathology

Latest Research

  • Article |

    Neural populations often encode unknown variables. Chaudhuri et al. develop a method to decode unknown variables by finding shapes in neural data. They show that a mammalian brain circuit of thousands of neurons constructs a navigational compass with only a one-dimensional ring of stable activity states.

    • Rishidev Chaudhuri
    • , Berk Gerçek
    • , Biraj Pandey
    • , Adrien Peyrache
    •  & Ila Fiete
  • Article |

    Using data from rats and humans, the authors study the time it takes to make sensory judgments. The authors define the new regularity as the time–intensity equivalence in discrimination (TIED), which provides a mechanistic basis of Weber’s law.

    • Jose L. Pardo-Vazquez
    • , Juan R. Castiñeiras-de Saa
    • , Mafalda Valente
    • , Iris Damião
    • , Tiago Costa
    • , M. Inês Vicente
    • , André G. Mendonça
    • , Zachary F. Mainen
    •  & Alfonso Renart
  • Article |

    Like humans, songbirds learn to communicate vocally early in life. Moore and Woolley taught birds the songs of a different species to identify how vocal experience and auditory tuning mechanisms create neural representations of communication sounds.

    • Jordan M. Moore
    •  & Sarah M. N. Woolley
  • Article |

    Everyday decisions require choosing among multiple options. This work derives the optimal decision policy and shows how it can be approximated by a biologically plausible neural circuit and how this circuit can reproduce observed behavior.

    • Satohiro Tajima
    • , Jan Drugowitsch
    • , Nisheet Patel
    •  & Alexandre Pouget
  • Article |

    This study identifies eight significant genetic associations with intrusive reexperiencing of trauma in post-traumatic stress disorder (PTSD) from the Million Veteran Program (MVP), a large biobank focused on US veterans.

    • Joel Gelernter
    • , Ning Sun
    • , Renato Polimanti
    • , Robert. Pietrzak
    • , Daniel F. Levey
    • , Julien Bryois
    • , Qiongshi Lu
    • , Yiming Hu
    • , Boyang Li
    • , Krishnan Radhakrishnan
    • , Mihaela Aslan
    • , Kei-Hoi Cheung
    • , Yuli Li
    • , Nallakkandi Rajeevan
    • , Frederick Sayward
    • , Kelly Harrington
    • , Quan Chen
    • , Kelly Cho
    • , Saiju Pyarajan
    • , Patrick F. Sullivan
    • , Rachel Quaden
    • , Yunling Shi
    • , Haley Hunter-Zinck
    • , J. Michael Gaziano
    • , John Concato
    • , Hongyu Zhao
    •  & Murray B. Stein
  • Brief Communication |

    Tost et al. show that urban green space exposure improves well-being, particularly in people dwelling in relatively deprived areas and showing less prefrontal activity during emotion processing, a neural signature that is linked to mental health risk.

    • Heike Tost
    • , Markus Reichert
    • , Urs Braun
    • , Iris Reinhard
    • , Robin Peters
    • , Sven Lautenbach
    • , Andreas Hoell
    • , Emanuel Schwarz
    • , Ulrich Ebner-Priemer
    • , Alexander Zipf
    •  & Andreas Meyer-Lindenberg

News & Comment

  • News & Views |

    Misfolded protein aggregates are a classical hallmark of many neurodegenerative diseases. By combining a mouse model of misfolded protein injection and a brain network model of misfolded protein diffusion, a study now finds a strong link between the stereotypical spreading patterns of neurodegeneration, protein expression and anatomical connectivity.

    • Ellen Kuhl
  • News & Views |

    Mosquito-borne virus infections, such as West Nile and Zika, have debilitating cognitive effects that persist despite recovery from encephalitis. Garber et al. identify mechanisms by which antiviral T cell persistence after recovery from infection leads to impairments in cognition via virus-specific mediation of microglial synapse elimination.

    • Karen Krukowski
    •  & Susanna Rosi
  • Q&A |

    There is disagreement on how best to define and investigate fear. Nature Neuroscience asked Dean Mobbs to lead experts from the fields of human and animal affective neuroscience to discuss their viewpoints on how to define fear and how to move forward with the study of fear.

    • Dean Mobbs
    • , Ralph Adolphs
    • , Michael S. Fanselow
    • , Lisa Feldman Barrett
    • , Joseph E. LeDoux
    • , Kerry Ressler
    •  & Kay M. Tye
  • Obituary |

    On April 13, the neuroscience community lost a remarkable scientist and true humanitarian. Paul Greengard, co-recipient of the Nobel Prize in Physiology or Medicine in 2000, Vincent Astor Professor and head of the Laboratory of Molecular and Cellular Neuroscience at the Rockefeller University in New York City, died of an apparent heart attack at age 93. Paul will be remembered for his seminal contributions to neuroscience, for pioneering the field of neuronal signal transduction and for training hundreds of neuroscientists. For anyone who knew Paul it will come as no surprise that up until a few hours before his death, Paul was doing what he liked the best: working on a scientific manuscript.

    • Helen S. Bateup
    • , Myriam Heiman
    •  & Anne Schaefer
  • News & Views |

    The creation of a murine Cre driver specific to CNS capillary pericytes has opened a major bottleneck in brain microvascular research. Using this tool, pericyte loss in the adult brain is shown to induce neuronal loss due to concurrent microcirculatory failure and depletion of the protective trophic factor pleiotrophin.

    • Andrée-Anne Berthiaume
    •  & Andy Y. Shih
  • News & Views |

    Shahmoradian and colleagues report that the structure of Lewy bodies in Parkinson’s disease consists of α-synuclein and lipid vesicle clusters instead of the long-assumed amyloid fibril core. This finding has implications for our understanding of the underlying pathogenesis of synucleinopathies.

    • Tim Bartels

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