Meningeal lymphatics govern neuroinflammation

Latest Research

  • Article |

    The authors report that impaired hippocampal synchrony in a mouse model of schizophrenia is due to parvalbumin interneuron hypoexcitability. Rescuing interneuron excitability during adulthood restores wild-type-like network dynamics and behavior.

    • Thomas Marissal
    • , Rodrigo F. Salazar
    • , Cristina Bertollini
    • , Sophie Mutel
    • , Mathias De Roo
    • , Ivan Rodriguez
    • , Dominique Müller
    •  & Alan Carleton
  • Resource |

    The BRAINcode consortium found that tens of thousands of transcribed noncoding elements (TNEs) from the ‘dark matter’ of our genome are active in dopamine neurons. They may be linked to schizophrenia, Parkinson’s disease, and addiction.

    • Xianjun Dong
    • , Zhixiang Liao
    • , David Gritsch
    • , Yavor Hadzhiev
    • , Yunfei Bai
    • , Joseph J. Locascio
    • , Boris Guennewig
    • , Ganqiang Liu
    • , Cornelis Blauwendraat
    • , Tao Wang
    • , Charles H. Adler
    • , John C. Hedreen
    • , Richard L. M. Faull
    • , Matthew P. Frosch
    • , Peter T. Nelson
    • , Patrizia Rizzu
    • , Antony A. Cooper
    • , Peter Heutink
    • , Thomas G. Beach
    • , John S. Mattick
    • , Ferenc Müller
    •  & Clemens R. Scherzer
  • Article |

    Applying a social Pavlovian conditioning procedure for macaques, this study shows that medial prefrontal neurons selectively monitor self-reward or other-reward information and that dopamine neurons integrate this information into subjective value.

    • Atsushi Noritake
    • , Taihei Ninomiya
    •  & Masaki Isoda
  • Article |

    Louveau et al. demonstrate that meningeal lymphatics drain CSF-derived macromolecules and immune cells and play a key role in regulating neuroinflammation. Meningeal lymphatics may represent a new therapeutic target for multiple sclerosis.

    • Antoine Louveau
    • , Jasmin Herz
    • , Maria Nordheim Alme
    • , Andrea Francesca Salvador
    • , Michael Q. Dong
    • , Kenneth E. Viar
    • , S. Grace Herod
    • , James Knopp
    • , Joshua C. Setliff
    • , Alexander L. Lupi
    • , Sandro Da Mesquita
    • , Elizabeth L. Frost
    • , Alban Gaultier
    • , Tajie H. Harris
    • , Rui Cao
    • , Song Hu
    • , John R. Lukens
    • , Igor Smirnov
    • , Christopher C. Overall
    • , Guillermo Oliver
    •  & Jonathan Kipnis
  • Article |

    Mongillo et al. use theoretical modeling to link structure & activity in a cortical network. They find that activity patterns are predominantly controlled by inhibitory connections, making the network robust to ongoing changes in excitatory synapses.

    • Gianluigi Mongillo
    • , Simon Rumpel
    •  & Yonatan Loewenstein
  • Article |

    Behavior is the result of a Bayesian computation that weights past experience and current sensory information by their reliabilities. Here single-neuron activity in eye movement cortex exemplifies how the brain implements a Bayesian computation.

    • Timothy R. Darlington
    • , Jeffrey M. Beck
    •  & Stephen G. Lisberger

News & Comment

  • News & Views |

    How we value our own rewards depends on what others have. A new study shows that neurons in the medial prefrontal cortex selectively monitor the value of rewards received by oneself or by another individual, whereas midbrain dopaminergic neurons integrate these values to generate social subjective reward values.

    • Olga Dal Monte
    • , Siqi Fan
    •  & Steve W. C. Chang
  • News & Views |

    The surge in single-cell and single-nucleus RNA-sequencing has raised the question of the value of bulk tissue transcriptomics. Kelley et al. describe an analysis framework by which existing bulk transcriptomic data can be reanalyzed using cell-type-specific data to yield insights into cell-type variation across brain regions and diseases.

    • Vilas Menon
  • News & Views |

    Twenty years ago, 2 studies showed that behavioral experience affects proliferation & survival of newborn neurons in adult hippocampus, suggesting adult neurogenesis as a form of experience-dependent neuroplasticity relevant to memory, emotion, & mental health.

    • Michael R. Drew
    •  & Christine A. Denny
  • News & Views |

    A study has found that young male mice with a mutation of the autism-associated gene Chd8 show abnormal behaviors and elevated neuronal activation in several brain areas under stressful conditions, while female mice with the same mutation have reduced baseline neuronal activity, which may protect them from developing these abnormal phenotypes.

    • Laura C. Andreae
    •  & M. Albert Basson
  • News & Views |

    A deep-learning-based software package called DeepLabCut rapidly and easily enables video-based motion tracking in any animal species. Such tracking technology is bound to revolutionize movement science and behavioral tracking in the laboratory and is also poised to find many applications in the real world.

    • Kunlin Wei
    •  & Konrad Paul Kording
  • News & Views |

    Phenotypic diversity confers the benefits of adaptation to an evolving species. Random perturbations in our genetic structure may result in new functions required for some change in our environment, and we can survive outside of our happy niche for generations. But where are the limits on this sort of diversity?

    • Rosalyn J. Moran

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