Latest Research

  • Perspective
    | Open Access

    In this Perspective, the authors review the different applications for mobile phone data to support COVID-19 pandemic response, the relevance of these applications for infectious disease transmission and control, and potential sources and implications of selection bias in mobile phone data.

    • Kyra H. Grantz
    • , Hannah R. Meredith
    • , Derek A. T. Cummings
    • , C. Jessica E. Metcalf
    • , Bryan T. Grenfell
    • , John R. Giles
    • , Shruti Mehta
    • , Sunil Solomon
    • , Alain Labrique
    • , Nishant Kishore
    • , Caroline O. Buckee
    •  & Amy Wesolowski
  • Article
    | Open Access

    Transcription factor TFIIIC plays roles in Pol III transcription and in chromatin organization. CryoEM structure of the yeast TFIIIC subcomplex τA, a negative stain reconstruction of τA bound to the TFIIIB subunits Brf1 and TBP and accompanying biochemistry suggest how τA achieves positioning of TFIIIB upstream of the TSS and remodeling of the TFIIIC complex during assembly of TFIIIB.

    • Matthias K. Vorländer
    • , Anna Jungblut
    • , Kai Karius
    • , Florence Baudin
    • , Helga Grötsch
    • , Jan Kosinski
    •  & Christoph W. Müller
  • Article
    | Open Access

    The extracellular matrix (ECM) can influence tumor growth and its response to therapy. Here, the authors develop a fibrinogen and thrombin based artificial ECM that can starve tumours and prevent dissemination of cancer cells.

    • Di-Wei Zheng
    • , Sheng Hong
    • , Qiu-Ling Zhang
    • , Xue Dong
    • , Pei Pan
    • , Wen-Fang Song
    • , Wen Song
    • , Si-Xue Cheng
    •  & Xian-Zheng Zhang
  • Article
    | Open Access

    Halogen bonding (HB) catalysis is rapidly gaining momentum, however, cases of XB activation for challenging bonds formation are rare. Here, the authors show a robust XB catalyzed 2-deoxyglycosylation with broad scope and featuring a quantum tunneling phenomenon in the proton transfer rate determining step.

    • Chunfa Xu
    • , V. U. Bhaskara Rao
    • , Julia Weigen
    •  & Charles C. J. Loh
  • Article
    | Open Access

    The application of STING agonists and the blockade of the SIRPα–CD47 signaling axis are emerging immunotherapeutic strategies. Here the authors show that hybrid cellular membrane nanovesicles loaded with a STING agonist or overexpressing high-affinity SIRPα variants can be exploited to promote anti-tumor immune responses.

    • Lang Rao
    • , Lei Wu
    • , Zhida Liu
    • , Rui Tian
    • , Guocan Yu
    • , Zijian Zhou
    • , Kuikun Yang
    • , Hong-Gang Xiong
    • , Anli Zhang
    • , Guang-Tao Yu
    • , Wenjing Sun
    • , Han Xu
    • , Jingya Guo
    • , Andrew Li
    • , Hongmin Chen
    • , Zhi-Jun Sun
    • , Yang-Xin Fu
    •  & Xiaoyuan Chen
  • Article
    | Open Access

    Mechanistic inference following GWAS is hampered by the lack of tissue-specific transcriptomic resources. Here the authors combine genetic variants predisposing to type 2 diabetes with human pancreatic islet RNA-seq data. They identify 7741 islet expression quantitative trait loci (eQTLs), providing a resource for functional interpretation of association signals mapping to non-coding sequence.

    • Ana Viñuela
    • , Arushi Varshney
    • , Martijn van de Bunt
    • , Rashmi B. Prasad
    • , Olof Asplund
    • , Amanda Bennett
    • , Michael Boehnke
    • , Andrew A. Brown
    • , Michael R. Erdos
    • , João Fadista
    • , Ola Hansson
    • , Gad Hatem
    • , Cédric Howald
    • , Apoorva K. Iyengar
    • , Paul Johnson
    • , Ulrika Krus
    • , Patrick E. MacDonald
    • , Anubha Mahajan
    • , Jocelyn E. Manning Fox
    • , Narisu Narisu
    • , Vibe Nylander
    • , Peter Orchard
    • , Nikolay Oskolkov
    • , Nikolaos I. Panousis
    • , Anthony Payne
    • , Michael L. Stitzel
    • , Swarooparani Vadlamudi
    • , Ryan Welch
    • , Francis S. Collins
    • , Karen L. Mohlke
    • , Anna L. Gloyn
    • , Laura J. Scott
    • , Emmanouil T. Dermitzakis
    • , Leif Groop
    • , Stephen C. J. Parker
    •  & Mark I. McCarthy
  • Article
    | Open Access

    There are gaps in international efforts to monitor the wildlife trade, with many species potentially being undetected by the established monitoring groups. Here the authors use an automated web search to document the sale of reptiles online, revealing over 36% of all known reptile species are in trade, including many missing from official databases.

    • Benjamin M. Marshall
    • , Colin Strine
    •  & Alice C. Hughes
  • Article
    | Open Access

    Extinctions of megafauna can have cascading effects on their ecological communities. Here, Lim et al. investigate the relationships of historical and current mammalian frugivore body size with palm fruit size, then project how further mammal extinctions are likely to affect palm communities.

    • Jun Ying Lim
    • , Jens-Christian Svenning
    • , Bastian Göldel
    • , Søren Faurby
    •  & W. Daniel Kissling
  • Article
    | Open Access

    Coherent twin boundaries in nickel-based superalloys are vulnerable sites for alloy failure in demanding environments. Here, the authors show that the abnormal γ″ precipitation mechanism at twin boundaries is responsible for pronounced strain localisation and subsequent failure.

    • Zhenbo Zhang
    • , Zhibiao Yang
    • , Song Lu
    • , Allan Harte
    • , Roberto Morana
    •  & Michael Preuss
  • Article
    | Open Access

    Myelination is a highly regulated phenomenon. Here, the authors show that demyelination induced by the loss of a single oligodendrocyte triggers replenishment of a specific fraction the original myelin and myelination of previously unmyelinated axons in the mouse cortex.

    • Nicolas Snaidero
    • , Martina Schifferer
    • , Aleksandra Mezydlo
    • , Bernard Zalc
    • , Martin Kerschensteiner
    •  & Thomas Misgeld
  • Article
    | Open Access

    Observation of a strain-gradient-induced piezoresponse at domain walls remains a challenge. Here, the authors find the piezoelectric response to be enhanced in the ferroelastic domain walls of centrosymmetric tungsten trioxide thin films due to a large strain gradient over a wide width of the wall.

    • Shinhee Yun
    • , Kyung Song
    • , Kanghyun Chu
    • , Soo-Yoon Hwang
    • , Gi-Yeop Kim
    • , Jeongdae Seo
    • , Chang-Su Woo
    • , Si-Young Choi
    •  & Chan-Ho Yang
  • Article
    | Open Access

    Coastal river delta regions are particularly impacted by the effects of climate change, yet though these regions are densely inhabited, robust estimates of population are lacking. Here the authors use global datasets to predict the number of people and regions most threatened by flooding and extreme weather.

    • Douglas A. Edmonds
    • , Rebecca L. Caldwell
    • , Eduardo S. Brondizio
    •  & Sacha M. O. Siani
  • Article
    | Open Access

    Mercury has a global dayside exosphere that is very tenuous and does not extend far from the planet. Here, the authors show enhancement of neutral densities at high altitudes inferred from pickup ions that is most likely caused by the impact of a meteroid.

    • Jamie M. Jasinski
    • , Leonardo H. Regoli
    • , Timothy A. Cassidy
    • , Ryan M. Dewey
    • , Jim M. Raines
    • , James A. Slavin
    • , Andrew J. Coates
    • , Daniel J. Gershman
    • , Tom A. Nordheim
    •  & Neil Murphy
  • Article
    | Open Access

    The origin of the covalent H–H bond is understood to be driven by kinetic energy lowering. Here the authors show this is not the case for bonds between heavier elements likely due to the presence of core electrons, and that constructive quantum interference instead drives bond formation.

    • Daniel S. Levine
    •  & Martin Head-Gordon
  • Article
    | Open Access

    The contribution of satellite glia to peripheral nerve regeneration is unclear. Here, the authors show that satellite glia are transcriptionally distinct from Schwann cells, share similarities with astrocytes, and, upon injury, they contribute to axon regeneration via Fasn-PPARα signalling pathway.

    • Oshri Avraham
    • , Pan-Yue Deng
    • , Sara Jones
    • , Rejji Kuruvilla
    • , Clay F. Semenkovich
    • , Vitaly A. Klyachko
    •  & Valeria Cavalli
  • Article
    | Open Access

    CRISPR/Cas9 technology has revolutionised the ability of scientists to make genetically modified cells and animal models. Here, the authors make a Tet-On genetically modified mouse using the Streptococcus pyogenes Cas9 and demonstrate that it can be used for generation of mice with lung cancer.

    • Anders Lundin
    • , Michelle J. Porritt
    • , Himjyot Jaiswal
    • , Frank Seeliger
    • , Camilla Johansson
    • , Abdel Wahad Bidar
    • , Lukas Badertscher
    • , Sandra Wimberger
    • , Emma J. Davies
    • , Elizabeth Hardaker
    • , Carla P. Martins
    • , Emily James
    • , Therese Admyre
    • , Amir Taheri-Ghahfarokhi
    • , Jenna Bradley
    • , Anna Schantz
    • , Babak Alaeimahabadi
    • , Maryam Clausen
    • , Xiufeng Xu
    • , Lorenz M. Mayr
    • , Roberto Nitsch
    • , Mohammad Bohlooly-Y
    • , Simon T. Barry
    •  & Marcello Maresca
  • Article
    | Open Access

    Mechanisms and consequences of the acclimation of soil respiration to warming are unclear. Here, the authors combine soil respiration, metagenomics, and functional gene results from a 7-year grassland warming experiment to a microbial-enzyme decomposition model, showing functional gene information to lower uncertainty and improve fit.

    • Xue Guo
    • , Qun Gao
    • , Mengting Yuan
    • , Gangsheng Wang
    • , Xishu Zhou
    • , Jiajie Feng
    • , Zhou Shi
    • , Lauren Hale
    • , Linwei Wu
    • , Aifen Zhou
    • , Renmao Tian
    • , Feifei Liu
    • , Bo Wu
    • , Lijun Chen
    • , Chang Gyo Jung
    • , Shuli Niu
    • , Dejun Li
    • , Xia Xu
    • , Lifen Jiang
    • , Arthur Escalas
    • , Liyou Wu
    • , Zhili He
    • , Joy D. Van Nostrand
    • , Daliang Ning
    • , Xueduan Liu
    • , Yunfeng Yang
    • , Edward. A. G. Schuur
    • , Konstantinos T. Konstantinidis
    • , James R. Cole
    • , C. Ryan Penton
    • , Yiqi Luo
    • , James M. Tiedje
    •  & Jizhong Zhou
  • Article
    | Open Access

    Here the authors use chemical proteomics to identify the herpes simplex virus 1 encoded proteome in infected cells. Functional characterization of one of the nine identified proteins, designated piUL49, shows that it acts as neurovirulence factor in mice by regulating a virally encoded dUTPase.

    • Akihisa Kato
    • , Shungo Adachi
    • , Shuichi Kawano
    • , Kousuke Takeshima
    • , Mizuki Watanabe
    • , Shinobu Kitazume
    • , Ryota Sato
    • , Hideo Kusano
    • , Naoto Koyanagi
    • , Yuhei Maruzuru
    • , Jun Arii
    • , Tomohisa Hatta
    • , Tohru Natsume
    •  & Yasushi Kawaguchi
  • Article
    | Open Access

    Natural biomolecules such as peptides and DNA can dynamically self-organize into diverse hierarchical structures. Here the authors report experiments and simulations on the dynamic network self-assembly and subsequent collapse of the synthetic homopolymer poly(propylene sulfone).

    • Fanfan Du
    • , Baofu Qiao
    • , Trung Dac Nguyen
    • , Michael P. Vincent
    • , Sharan Bobbala
    • , Sijia Yi
    • , Chamille Lescott
    • , Vinayak P. Dravid
    • , Monica Olvera de la Cruz
    •  & Evan Alexander Scott
  • Article
    | Open Access

    Dryness stresses vegetation and can lead to declines in productivity, increased emission of carbon, and plant mortality, but the drivers of this stress remain unclear. Here the authors show that soil moisture plays a dominant role relative to atmospheric water demand over most global land vegetated areas.

    • Laibao Liu
    • , Lukas Gudmundsson
    • , Mathias Hauser
    • , Dahe Qin
    • , Shuangcheng Li
    •  & Sonia I. Seneviratne
  • Article
    | Open Access

    Chemical production of amino acids from renewable carbon sources in an energy-saving manner is highly desirable. Here, the authors report visible-light-driven, CdS nanosheets-promoted synthesis of amino acids from biomass-based feedstock and NH3 under mild reaction conditions.

    • Song Song
    • , Jiafu Qu
    • , Peijie Han
    • , Max J. Hülsey
    • , Guping Zhang
    • , Yunzhu Wang
    • , Shuai Wang
    • , Dongyun Chen
    • , Jianmei Lu
    •  & Ning Yan
  • Article
    | Open Access

    Most driver models were designed for specific scenario. Here, the authors developed a driver behaviour model that can be applied to multiple scenarios and show that human-like driving behaviour emerges when the Driver’s Risk Field is coupled to a controller that maintains the perceived risk below a threshold level.

    • Sarvesh Kolekar
    • , Joost de Winter
    •  & David Abbink
  • Article
    | Open Access

    Living cells and tissues experience various complex modes of forces but how different force modes impact gene expression is elusive. Here authors apply forces via magnetic beads to integrins on a cell surface and observe force-mode dependent chromatin stretching and gene upregulation in cells and identify underlying mechanisms.

    • Fuxiang Wei
    • , Xiangyu Xu
    • , Cunyu Zhang
    • , Yawen Liao
    • , Baohua Ji
    •  & Ning Wang
  • Author Correction
    | Open Access

    • Noreen Eder
    • , Federico Roncaroli
    • , Marie-Charlotte Domart
    • , Stuart Horswell
    • , Felipe Andreiuolo
    • , Helen R. Flynn
    • , Andre T. Lopes
    • , Suzanne Claxton
    • , John-Paul Kilday
    • , Lucy Collinson
    • , Jun-Hao Mao
    • , Torsten Pietsch
    • , Barry Thompson
    • , Ambrosius P. Snijders
    •  & Sila K. Ultanir
  • Article
    | Open Access

    Deterministic generation of photonic multi-partite entangled states has previously been achieved for specific states using ad-hoc devices. Here, the authors present a single superconducting circuit device to deterministically generate a variety of states, namely W, GHZ, and cluster states.

    • Jean-Claude Besse
    • , Kevin Reuer
    • , Michele C. Collodo
    • , Arne Wulff
    • , Lucien Wernli
    • , Adrian Copetudo
    • , Daniel Malz
    • , Paul Magnard
    • , Abdulkadir Akin
    • , Mihai Gabureac
    • , Graham J. Norris
    • , J. Ignacio Cirac
    • , Andreas Wallraff
    •  & Christopher Eichler
  • Article
    | Open Access

    The ecological niche of a given microbe is difficult to define, but can be approximated from the range of biochemical reactions encoded by its genome. Here the authors use these genomic data and analyze them using manifold learning, which generates a diffusion map of the metabolic niche space of over 2500 bacteria.

    • Ashkaan K. Fahimipour
    •  & Thilo Gross
  • Article
    | Open Access

    Pulmonary sarcomatoid carcinoma (PSC) is a rare subtype of lung cancer with poor prognosis. Here the authors performed multi-omics analysis of human samples to investigate the mutational landscape of PSC and show three subgroups of PSC with distinct biology, prognosis and potential therapeutic strategies.

    • Zhenlin Yang
    • , Jiachen Xu
    • , Lin Li
    • , Renda Li
    • , Yalong Wang
    • , Yanhua Tian
    • , Wei Guo
    • , Zhijie Wang
    • , Fengwei Tan
    • , Jianming Ying
    • , Yuchen Jiao
    • , Shugeng Gao
    • , Jie Wang
    • , Yibo Gao
    •  & Jie He
  • Article
    | Open Access

    DNA damage sensors DDB2 and XPC are fundamental factors to initiate global genome nucleotide excision repair and protect DNA from mutagenesis. Here the authors reveal that ubiquitin and TFIIH-stimulated DDB2 dissociation promotes DNA damage handover to XPC in nucleotide excision repair.

    • Cristina Ribeiro-Silva
    • , Mariangela Sabatella
    • , Angela Helfricht
    • , Jurgen A. Marteijn
    • , Arjan F. Theil
    • , Wim Vermeulen
    •  & Hannes Lans
  • Article
    | Open Access

    CLR01 is a molecular tweezer that inhibits protein aggregation. Here the authors show that CLR01 protects dopaminergic neurons in vitro and in vivo in human neurons and in mouse models showing potential as a disease-modifying therapy for Parkinson’s disease.

    • Nora Bengoa-Vergniory
    • , Emilie Faggiani
    • , Paula Ramos-Gonzalez
    • , Ecem Kirkiz
    • , Natalie Connor-Robson
    • , Liam V. Brown
    • , Ibrar Siddique
    • , Zizheng Li
    • , Siv Vingill
    • , Milena Cioroch
    • , Fabio Cavaliere
    • , Sarah Threlfell
    • , Bradley Roberts
    • , Thomas Schrader
    • , Frank-Gerrit Klärner
    • , Stephanie Cragg
    • , Benjamin Dehay
    • , Gal Bitan
    • , Carlos Matute
    • , Erwan Bezard
    •  & Richard Wade-Martins
  • Article
    | Open Access

    Early stages of the novel coronavirus disease (COVID-19) have been associated with silent hypoxia and poor oxygenation despite relatively small fractions of afflicted lung. Here, the authors present a mathematical model which reproduces the vascular pulmonary mechanisms observed in patients with early COVID-19.

    • Jacob Herrmann
    • , Vitor Mori
    • , Jason H. T. Bates
    •  & Béla Suki
  • Article
    | Open Access

    Calreticulin del52 and ins5 mutations induce two phenotypically distinct myeloproliferative neoplasms in patients. Here the authors show that modeling these mutations in knock-in mice recapitulate the two diseases and highlight how they impact the different hematopoietic compartments.

    • Camélia Benlabiod
    • , Maira da Costa Cacemiro
    • , Audrey Nédélec
    • , Valérie Edmond
    • , Delphine Muller
    • , Philippe Rameau
    • , Laure Touchard
    • , Patrick Gonin
    • , Stefan N. Constantinescu
    • , Hana Raslova
    • , Jean-Luc Villeval
    • , William Vainchenker
    • , Isabelle Plo
    •  & Caroline Marty
  • Article
    | Open Access

    Current gene drive strategies are restricted to sexually reproducing species. Here the authors develop a gene drive in herpesviruses that allows the spread of an engineered trait through a viral population.

    • Marius Walter
    •  & Eric Verdin
  • Article
    | Open Access

    Imaging methods, such as CT or MRI, cannot provide accurate diagnosis between malignant thymomas and other thymic abnormalities. Here the authors show that the levels of IL-8 in circulating naive T cells are elevated in patients with thymoma compared with other thymic masses, proposing IL-8 as a candidate biomarker for thymoma diagnosis and recurrence surveillance.

    • Shilin Gao
    • , Jiahao Jiang
    • , Chun Jin
    • , Jian Gao
    • , Dian Xiong
    • , Pengjie Yang
    • , Shuzhong Cui
    • , Wenhao Yang
    • , Qibin Leng
    • , Jihong Dong
    • , Gang Chen
    • , Junzhen Liu
    • , Li Wang
    • , Aiwu Ke
    • , Haikun Wang
    •  & Jianyong Ding
  • Article
    | Open Access

    BATF is a transcription factor that is needed for IL-9 production by T helper 9 cells. Here the authors show that STAT5 is needed at the Il9 locus to enable BATF to function in this manner and that this interaction can reprogram other T helper subsets into IL-9 producing cells, thus regulating the immune response to disease.

    • Yongyao Fu
    • , Jocelyn Wang
    • , Gayathri Panangipalli
    • , Benjamin J. Ulrich
    • , Byunghee Koh
    • , Chengxian Xu
    • , Rakshin Kharwadkar
    • , Xiaona Chu
    • , Yue Wang
    • , Hongyu Gao
    • , Wenting Wu
    • , Jie Sun
    • , Robert S. Tepper
    • , Baohua Zhou
    • , Sarath Chandra Janga
    • , Kai Yang
    •  & Mark H. Kaplan
  • Article
    | Open Access

    Formation of tertiary C(sp3)-C bonds is a formidable challenge due to steric interactions and low barriers for isomerization of intermediates. Here, the authors show a Ni-catalyzed migratory 3,3-difluoroallylation of unactivated alkyl bromides at remote tertiary carbon centers.

    • Chuan Zhu
    • , Ze-Yao Liu
    • , Luning Tang
    • , Heng Zhang
    • , Yu-Feng Zhang
    • , Patrick J. Walsh
    •  & Chao Feng
  • Article
    | Open Access

    Integration of III-V semiconductor microlasers into modern Si or Si3N4 based photonic integrated circuits remains a challenge. Here, the authors demonstrate a perovskite vortex microlaser with highly directional outputs and well-controlled topological charges that is highly compatible with most materials.

    • Wenzhao Sun
    • , Yilin Liu
    • , Geyang Qu
    • , Yubin Fan
    • , Wei Dai
    • , Yuhan Wang
    • , Qinghai Song
    • , Jiecai Han
    •  & Shumin Xiao
  • Article
    | Open Access

    Thioglycoligases have proved useful for bonding carbohydrates to non-sugar acceptors, however, the scope of these biocatalysts is usually limited. Here, the authors engineer a xylosidase into a thioglycoligase with the ability to form O-, N-, S- and Se- glycosides together with sugar esters and phosphoesters.

    • Manuel Nieto-Domínguez
    • , Beatriz Fernández de Toro
    • , Laura I. de Eugenio
    • , Andrés G. Santana
    • , Lara Bejarano-Muñoz
    • , Zach Armstrong
    • , Juan Antonio Méndez-Líter
    • , Juan Luis Asensio
    • , Alicia Prieto
    • , Stephen G. Withers
    • , Francisco Javier Cañada
    •  & María Jesús Martínez
  • Article
    | Open Access

    Poly(ADP-ribose) glycohydrolase (PARG) is involved in different cellular processes including DNA repair. Here the authors reveal a role for PARG in regulating meiotic DNA double strand break induction and repair in Caenorhabditis elegans.

    • Eva Janisiw
    • , Marilina Raices
    • , Fabiola Balmir
    • , Luis F. Paulin
    • , Antoine Baudrimont
    • , Arndt von Haeseler
    • , Judith L. Yanowitz
    • , Verena Jantsch
    •  & Nicola Silva
  • Article
    | Open Access

    The atypical chemokine receptor 3 (ACKR3) is known to regulate cell migration, but the underlying mechanisms are unclear. Here, the authors show, from an interactome analysis, ACKR3 association with the gap junction protein Connexin 43 in vivo and ACKR3-mediated inhibition of astrocyte gap junctional communication.

    • Amos Fumagalli
    • , Joyce Heuninck
    • , Anne Pizzoccaro
    • , Enora Moutin
    • , Joyce Koenen
    • , Martial Séveno
    • , Thierry Durroux
    • , Marie-Pierre Junier
    • , Géraldine Schlecht-Louf
    • , Francoise Bachelerie
    • , Dagmar Schütz
    • , Ralf Stumm
    • , Martine J. Smit
    • , Nathalie C. Guérineau
    • , Séverine Chaumont-Dubel
    •  & Philippe Marin
  • Article
    | Open Access

    In metabolic engineering, mechanistic models require prior metabolism knowledge of the chassis strain, whereas machine learning models need ample training data. Here, the authors combine the mechanistic and machine learning models to improve prediction performance of tryptophan metabolism in baker’s yeast.

    • Jie Zhang
    • , Søren D. Petersen
    • , Tijana Radivojevic
    • , Andrés Ramirez
    • , Andrés Pérez-Manríquez
    • , Eduardo Abeliuk
    • , Benjamín J. Sánchez
    • , Zak Costello
    • , Yu Chen
    • , Michael J. Fero
    • , Hector Garcia Martin
    • , Jens Nielsen
    • , Jay D. Keasling
    •  & Michael K. Jensen
  • Article
    | Open Access

    Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired social interactions with repetitive and restrictive behaviours. Here the authors integrate mRNA expression, miRNA expression, DNA methylation, and histone acetylation datasets from a collection of post mortem brain tissues and identify a convergent molecular subtype of ASD.

    • Gokul Ramaswami
    • , Hyejung Won
    • , Michael J. Gandal
    • , Jillian Haney
    • , Jerry C. Wang
    • , Chloe C. Y. Wong
    • , Wenjie Sun
    • , Shyam Prabhakar
    • , Jonathan Mill
    •  & Daniel H. Geschwind
  • Article
    | Open Access

    Current methods of neuronal network imaging cannot be used for continuous, long-term functional recordings. Here, the authors present a dual-mode high-density microelectrode array, which can simultaneously record in full-frame and high-signal-to-noise modes for label-free electrophysiological measurements.

    • Xinyue Yuan
    • , Manuel Schröter
    • , Marie Engelene J. Obien
    • , Michele Fiscella
    • , Wei Gong
    • , Tetsuhiro Kikuchi
    • , Aoi Odawara
    • , Shuhei Noji
    • , Ikuro Suzuki
    • , Jun Takahashi
    • , Andreas Hierlemann
    •  & Urs Frey
  • Article
    | Open Access

    Synthetic Biology often lacks the predictive power needed for efficient bioengineering. Here the authors present ART, a machine learning and probabilistic predictive tool to guide synthetic biology design in a systematic fashion.

    • Tijana Radivojević
    • , Zak Costello
    • , Kenneth Workman
    •  & Hector Garcia Martin
  • Article
    | Open Access

    Tumours are made up of heterogeneous subclones. Here, the authors show using breast cancer imaging and gene expression datasets that these subclones can be inferred by the deconvolution of gene expression data, mapped to MRI derived radiogenomic signatures and used to estimate prognosis.

    • Ming Fan
    • , Pingping Xia
    • , Robert Clarke
    • , Yue Wang
    •  & Lihua Li