Latest Research

  • Article | | open

    Urinary tract infections are a common side effect of urethral catheters. Here, the authors report on the development of antibiotic loaded NPs with functional polymer coatings which attach too and are removed by motile bacteria to trigger the release of antibiotic.

    • Shengtao Lu
    • , Wuguo Bi
    • , Quanchao Du
    • , Sheetal Sinha
    • , Xiangyang Wu
    • , Arnold Subrata
    • , Surajit Bhattacharjya
    • , Bengang Xing
    •  & Edwin K. L. Yeow
  • Article | | open

    Listeria monocytogenes causes meningitis in newborns. Here, Pägelow et al. present a mouse model of neonatal cerebral listeriosis, and show that nasal inoculation, but not intragastric administration, leads to early brain infection in the absence of bacteraemia during the neonatal period.

    • Dennis Pägelow
    • , Chintan Chhatbar
    • , Andreas Beineke
    • , Xiaokun Liu
    • , Andreas Nerlich
    • , Kira van Vorst
    • , Manfred Rohde
    • , Ulrich Kalinke
    • , Reinhold Förster
    • , Stephan Halle
    • , Peter Valentin-Weigand
    • , Mathias W. Hornef
    •  & Marcus Fulde
  • Article | | open

    Progressive diseases tend to be heterogeneous in their underlying aetiology mechanism, disease manifestation, and disease time course. Here, Young and colleagues devise a computational method to account for both phenotypic heterogeneity and temporal heterogeneity, and demonstrate it using two neurodegenerative disease cohorts.

    • Alexandra L Young
    • , Razvan V Marinescu
    • , Neil P Oxtoby
    • , Martina Bocchetta
    • , Keir Yong
    • , Nicholas C Firth
    • , David M Cash
    • , David L Thomas
    • , Katrina M Dick
    • , Jorge Cardoso
    • , John van Swieten
    • , Barbara Borroni
    • , Daniela Galimberti
    • , Mario Masellis
    • , Maria Carmela Tartaglia
    • , James B Rowe
    • , Caroline Graff
    • , Fabrizio Tagliavini
    • , Giovanni B Frisoni
    • , Robert Laforce Jr
    • , Elizabeth Finger
    • , Alexandre de Mendonça
    • , Sandro Sorbi
    • , Jason D Warren
    • , Sebastian Crutch
    • , Nick C Fox
    • , Sebastien Ourselin
    • , Jonathan M Schott
    • , Jonathan D Rohrer
    • , Daniel C Alexander
    • , Christin Andersson
    • , Silvana Archetti
    • , Andrea Arighi
    • , Luisa Benussi
    • , Giuliano Binetti
    • , Sandra Black
    • , Maura Cosseddu
    • , Marie Fallström
    • , Carlos Ferreira
    • , Chiara Fenoglio
    • , Morris Freedman
    • , Giorgio G Fumagalli
    • , Stefano Gazzina
    • , Roberta Ghidoni
    • , Marina Grisoli
    • , Vesna Jelic
    • , Lize Jiskoot
    • , Ron Keren
    • , Gemma Lombardi
    • , Carolina Maruta
    • , Lieke Meeter
    • , Simon Mead
    • , Rick van Minkelen
    • , Benedetta Nacmias
    • , Linn Öijerstedt
    • , Alessandro Padovani
    • , Jessica Panman
    • , Michela Pievani
    • , Cristina Polito
    • , Enrico Premi
    • , Sara Prioni
    • , Rosa Rademakers
    • , Veronica Redaelli
    • , Ekaterina Rogaeva
    • , Giacomina Rossi
    • , Martin Rossor
    • , Elio Scarpini
    • , David Tang-Wai
    • , Hakan Thonberg
    • , Pietro Tiraboschi
    • , Ana Verdelho
    • , Michael W Weiner
    • , Paul Aisen
    • , Ronald Petersen
    • , Clifford R Jack
    • , William Jagust
    • , John Q Trojanowki
    • , Arthur W Toga
    • , Laurel Beckett
    • , Robert C Green
    • , Andrew J Saykin
    • , John Morris
    • , Leslie M Shaw
    • , Zaven Khachaturian
    • , Greg Sorensen
    • , Lew Kuller
    • , Marc Raichle
    • , Steven Paul
    • , Peter Davies
    • , Howard Fillit
    • , Franz Hefti
    • , Davie Holtzman
    • , M Marcel Mesulam
    • , William Potter
    • , Peter Snyder
    • , Adam Schwartz
    • , Tom Montine
    • , Ronald G Thomas
    • , Michael Donohue
    • , Sarah Walter
    • , Devon Gessert
    • , Tamie Sather
    • , Gus Jiminez
    • , Danielle Harvey
    • , Matthew Bernstein
    • , Paul Thompson
    • , Norbert Schuff
    • , Bret Borowski
    • , Jeff Gunter
    • , Matt Senjem
    • , Prashanthi Vemuri
    • , David Jones
    • , Kejal Kantarci
    • , Chad Ward
    • , Robert A Koeppe
    • , Norm Foster
    • , Eric M Reiman
    • , Kewei Chen
    • , Chet Mathis
    • , Susan Landau
    • , Nigel J Cairns
    • , Erin Householder
    • , Lisa Taylor-Reinwald
    • , Virginia Lee
    • , Magdalena Korecka
    • , Michal Figurski
    • , Karen Crawford
    • , Scott Neu
    • , Tatiana M Foroud
    • , Steven Potkin
    • , Li Shen
    • , Kelley Faber
    • , Sungeun Kim
    • , Kwangsik Nho
    • , Leon Thal
    • , Neil Buckholtz
    • , Marylyn Albert
    • , Richard Frank
    • , John Hsiao
    • , Jeffrey Kaye
    • , Joseph Quinn
    • , Betty Lind
    • , Raina Carter
    • , Sara Dolen
    • , Lon S Schneider
    • , Sonia Pawluczyk
    • , Mauricio Beccera
    • , Liberty Teodoro
    • , Bryan M Spann
    • , James Brewer
    • , Helen Vanderswag
    • , Adam Fleisher
    • , Judith L Heidebrink
    • , Joanne L Lord
    • , Sara S Mason
    • , Colleen S Albers
    • , David Knopman
    • , Kris Johnson
    • , Rachelle S Doody
    • , Javier Villanueva-Meyer
    • , Munir Chowdhury
    • , Susan Rountree
    • , Mimi Dang
    • , Yaakov Stern
    • , Lawrence S Honig
    • , Karen L Bell
    • , Beau Ances
    • , Maria Carroll
    • , Sue Leon
    • , Mark A Mintun
    • , Stacy Schneider
    • , Angela Oliver
    • , Daniel Marson
    • , Randall Griffith
    • , David Clark
    • , David Geldmacher
    • , John Brockington
    • , Erik Roberson
    • , Hillel Grossman
    • , Effie Mitsis
    • , Leyla de Toledo-Morrell
    • , Raj C Shah
    • , Ranjan Duara
    • , Daniel Varon
    • , Maria T Greig
    • , Peggy Roberts
    • , Marilyn Albert
    • , Chiadi Onyike
    • , Daniel D’Agostino
    • , Stephanie Kielb
    • , James E Galvin
    • , Brittany Cerbone
    • , Christina A Michel
    • , Henry Rusinek
    • , Mony J de Leon
    • , Lidia Glodzik
    • , Susan De Santi
    • , P Murali Doraiswamy
    • , Jeffrey R Petrella
    • , Terence Z Wong
    • , Steven E Arnold
    • , Jason H Karlawish
    • , David Wolk
    • , Charles D Smith
    • , Greg Jicha
    • , Peter Hardy
    • , Partha Sinha
    • , Elizabeth Oates
    • , Gary Conrad
    • , Oscar L Lopez
    • , MaryAnn Oakley
    • , Donna M Simpson
    • , Anton P Porsteinsson
    • , Bonnie S Goldstein
    • , Kim Martin
    • , Kelly M Makino
    • , M Saleem Ismail
    • , Connie Brand
    • , Ruth A Mulnard
    • , Gaby Thai
    • , Catherine Mc-Adams-Ortiz
    • , Kyle Womack
    • , Dana Mathews
    • , Mary Quiceno
    • , Ramon Diaz-Arrastia
    • , Richard King
    • , Myron Weiner
    • , Kristen Martin-Cook
    • , Michael DeVous
    • , Allan I Levey
    • , James J Lah
    • , Janet S Cellar
    • , Jeffrey M Burns
    • , Heather S Anderson
    • , Russell H Swerdlow
    • , Liana Apostolova
    • , Kathleen Tingus
    • , Ellen Woo
    • , Daniel Hs Silverman
    • , Po H Lu
    • , George Bartzokis
    • , Neill R Graff-Radford
    • , Francine Parfitt
    • , Tracy Kendall
    • , Heather Johnson
    • , Martin R Farlow
    • , Ann Marie Hake
    • , Brandy R Matthews
    • , Scott Herring
    • , Cynthia Hunt
    • , Christopher H van Dyck
    • , Richard E Carson
    • , Martha G MacAvoy
    • , Howard Chertkow
    • , Howard Bergman
    • , Chris Hosein
    • , Bojana Stefanovic
    • , Curtis Caldwell
    • , Ging-Yuek Robin Hsiung
    • , Howard Feldman
    • , Benita Mudge
    • , Michele Assaly
    • , Andrew Kertesz
    • , John Rogers
    • , Charles Bernick
    • , Donna Munic
    • , Diana Kerwin
    • , Marek-Marsel Mesulam
    • , Kristine Lipowski
    • , Chuang-Kuo Wu
    • , Nancy Johnson
    • , Carl Sadowsky
    • , Walter Martinez
    • , Teresa Villena
    • , Raymond Scott Turner
    • , Kathleen Johnson
    • , Brigid Reynolds
    • , Reisa A Sperling
    • , Keith A Johnson
    • , Gad Marshall
    • , Meghan Frey
    • , Barton Lane
    • , Allyson Rosen
    • , Jared Tinklenberg
    • , Marwan N Sabbagh
    • , Christine M Belden
    • , Sandra A Jacobson
    • , Sherye A Sirrel
    • , Neil Kowall
    • , Ronald Killiany
    • , Andrew E Budson
    • , Alexander Norbash
    • , Patricia Lynn Johnson
    • , Joanne Allard
    • , Alan Lerner
    • , Paula Ogrocki
    • , Leon Hudson
    • , Evan Fletcher
    • , Owen Carmichael
    • , John Olichney
    • , Charles DeCarli
    • , Smita Kittur
    • , Michael Borrie
    • , T-Y Lee
    • , Rob Bartha
    • , Sterling Johnson
    • , Sanjay Asthana
    • , Cynthia M Carlsson
    • , Steven G Potkin
    • , Adrian Preda
    • , Dana Nguyen
    • , Pierre Tariot
    • , Stephanie Reeder
    • , Vernice Bates
    • , Horacio Capote
    • , Michelle Rainka
    • , Douglas W Scharre
    • , Maria Kataki
    • , Anahita Adeli
    • , Earl A Zimmerman
    • , Dzintra Celmins
    • , Alice D Brown
    • , Godfrey D Pearlson
    • , Karen Blank
    • , Karen Anderson
    • , Robert B Santulli
    • , Tamar J Kitzmiller
    • , Eben S Schwartz
    • , Kaycee M Sink
    • , Jeff D Williamson
    • , Pradeep Garg
    • , Franklin Watkins
    • , Brian R Ott
    • , Henry Querfurth
    • , Geoffrey Tremont
    • , Stephen Salloway
    • , Paul Malloy
    • , Stephen Correia
    • , Howard J Rosen
    • , Bruce L Miller
    • , Jacobo Mintzer
    • , Kenneth Spicer
    • , David Bachman
    • , Stephen Pasternak
    • , Irina Rachinsky
    • , Dick Drost
    • , Nunzio Pomara
    • , Raymundo Hernando
    • , Antero Sarrael
    • , Susan K Schultz
    • , Laura L Boles Ponto
    • , Hyungsub Shim
    • , Karen Elizabeth Smith
    • , Norman Relkin
    • , Gloria Chaing
    • , Lisa Raudin
    • , Amanda Smith
    • , Kristin Fargher
    • , Balebail Ashok Raj
    • , Thomas Neylan
    • , Jordan Grafman
    • , Melissa Davis
    • , Rosemary Morrison
    • , Jacqueline Hayes
    • , Shannon Finley
    • , Karl Friedl
    • , Debra Fleischman
    • , Konstantinos Arfanakis
    • , Olga James
    • , Dino Massoglia
    • , J Jay Fruehling
    • , Sandra Harding
    • , Elaine R Peskind
    • , Eric C Petrie
    • , Gail Li
    • , Jerome A Yesavage
    • , Joy L Taylor
    •  & Ansgar J Furst
  • Article | | open

    Resistance to anti-HER2 therapy in breast cancer remains a major obstacle in the clinic. Here the authors performed a CRISPR-selective vulnerability screen to identify transaldoloase as a target that is synthetically lethal with HER2 inhibition in breast cancer cells.

    • Yi Ding
    • , Chang Gong
    • , De Huang
    • , Rui Chen
    • , Pinpin Sui
    • , Kevin H. Lin
    • , Gehao Liang
    • , Lifeng Yuan
    • , Handan Xiang
    • , Junying Chen
    • , Tao Yin
    • , Peter B. Alexander
    • , Qian-Fei Wang
    • , Er-Wei Song
    • , Qi-Jing Li
    • , Kris C. Wood
    •  & Xiao-Fan Wang
  • Article | | open

    Cognitive decline in Huntington’s disease (HD) may be due to impaired hippocampal synaptic plasticity. In this study the authors show that AMPA receptor surface diffusion, a key player in synaptic plasticity, is deregulated in multiple HD mouse models as a result of impaired BDNF signalling that underlies the memory deficits, and can be pharmacologically rescued.

    • Hongyu Zhang
    • , Chunlei Zhang
    • , Jean Vincent
    • , Diana Zala
    • , Caroline Benstaali
    • , Matthieu Sainlos
    • , Dolors Grillo-Bosch
    • , Sophie Daburon
    • , Françoise Coussen
    • , Yoon Cho
    • , Denis J. David
    • , Frederic Saudou
    • , Yann Humeau
    •  & Daniel Choquet
  • Article | | open

    Enabling concurrent, high throughput analysis of single nano particles would greatly increase the capacity to study size, composition and inter and intra particle population variance. Here, the authors present a comprehensive platform for single particle automated Raman trapping analysis without any target modification.

    • Jelle Penders
    • , Isaac J. Pence
    • , Conor C. Horgan
    • , Mads S. Bergholt
    • , Christopher S. Wood
    • , Adrian Najer
    • , Ulrike Kauscher
    • , Anika Nagelkerke
    •  & Molly M. Stevens
  • Article | | open

    Phagocytic cells of the innate immune system play critical roles in defence against invading pathogens including the opportunistic pathogen Candida albicans. Here the authors show that C. albicans derived Candidalysin in addition to being a cell-damaging toxin to mononuclear phagocytes is a trigger of NLRP3 inflammasome activation in these cells.

    • Lydia Kasper
    • , Annika König
    • , Paul-Albert Koenig
    • , Mark S. Gresnigt
    • , Johannes Westman
    • , Rebecca A. Drummond
    • , Michail S. Lionakis
    • , Olaf Groß
    • , Jürgen Ruland
    • , Julian R. Naglik
    •  & Bernhard Hube
  • Article | | open

    Whether DNA viruses contact specific regions of host genomes or make random contacts is unclear. Here, the authors use Hi-C and show that HBV cccDNA and Ad5 DNA contact preferentially active chromatin at CpG islands for the former and at transcription start sites and enhancers for the latter.

    • Pierrick Moreau
    • , Axel Cournac
    • , Gianna Aurora Palumbo
    • , Martial Marbouty
    • , Shogofa Mortaza
    • , Agnes Thierry
    • , Stefano Cairo
    • , Marc Lavigne
    • , Romain Koszul
    •  & Christine Neuveut
  • Article | | open

    Similar to cancers, somatic mutations might lead to neurodegenerative diseases. Here, the authors perform ultra-deep sequencing of 102 genes in 173 adult human brains, detect somatic mutations in 54 brains, and develop a mathematical model to estimate the frequency of mutated foci in human brains.

    • Michael J. Keogh
    • , Wei Wei
    • , Juvid Aryaman
    • , Lauren Walker
    • , Jelle van den Ameele
    • , Jon Coxhead
    • , Ian Wilson
    • , Matthew Bashton
    • , Jon Beck
    • , John West
    • , Richard Chen
    • , Christian Haudenschild
    • , Gabor Bartha
    • , Shujun Luo
    • , Chris M. Morris
    • , Nick S. Jones
    • , Johannes Attems
    •  & Patrick F. Chinnery
  • Article | | open

    Advancing phenological timing is a risk for migratory birds, particularly in the Arctic where change is most rapid. Here, the authors show that bar-tailed godwits can adjust for phenological shifts by fuelling faster at staging areas to arrive at breeding sites in time.

    • Eldar Rakhimberdiev
    • , Sjoerd Duijns
    • , Julia Karagicheva
    • , Cornelis J. Camphuysen
    • , Anne Dekinga
    • , Rob Dekker
    • , Anatoly Gavrilov
    • , Job ten Horn
    • , Joop Jukema
    • , Anatoly Saveliev
    • , Mikhail Soloviev
    • , T. Lee Tibbitts
    • , Jan A. van Gils
    • , Theunis Piersma
    • , Andre van Loon
    • , Arnold Wijker
    • , Guido Keijl
    • , Henk Levering
    • , Jan Visser
    • , Leo Heemskerk
    • , Luc Knijnsberg
    • , Marc van Roomen
    • , Paul Ruiters
    • , Piet Admiraal
    • , Piet Veldt
    • , Richard Reijnders
    •  & Walter Beentjes
  • Article | | open

    The degree to which species diversity is bounded by limited niche space is under debate. Here, Larcombe and colleagues show that bounded and unbounded processes contribute more-or-less equally to conifer diversification, and that it may be niche dimensionality that facilitates these opposing forces.

    • Matthew J. Larcombe
    • , Gregory J. Jordan
    • , David Bryant
    •  & Steven I. Higgins
  • Article | | open

    Predicting the response to chemotherapy is a major goal of cancer research. Here the authors use CRISPR knockout screens in pancreatic ductal adenocarcinoma cells to identify deletions synergistic with MEK inhibitors.

    • Karol Szlachta
    • , Cem Kuscu
    • , Turan Tufan
    • , Sara J. Adair
    • , Stephen Shang
    • , Alex D. Michaels
    • , Matthew G. Mullen
    • , Natasha Lopes Fischer
    • , Jiekun Yang
    • , Limin Liu
    • , Prasad Trivedi
    • , Edward B. Stelow
    • , P. Todd Stukenberg
    • , J. Thomas Parsons
    • , Todd W. Bauer
    •  & Mazhar Adli
  • Article | | open

    The origin of Fc receptor-based phagocytosis is unknown, although plasma lipid redistribution after solid structure binding induces similar phagocytic signaling. Here, Mu et al. show that PIP2 accumulation from plasma membrane deformation recruits Moesin to trigger receptor-independent phagocytosis.

    • Libing Mu
    • , Zhongyuan Tu
    • , Lin Miao
    • , Hefei Ruan
    • , Ning Kang
    • , Yongzhen Hei
    • , Jiahuan Chen
    • , Wei Wei
    • , Fangling Gong
    • , Bingjie Wang
    • , Yanan Du
    • , Guanghui Ma
    • , Matthias W. Amerein
    • , Tie Xia
    •  & Yan Shi
  • Article | | open

    Barrett’s oesophagus is associated with an increased risk of oseophageal cancer, but its cell of origin is unclear. Here the authors show, using single-cell RNA sequencing of biopsies from six patients and two unaffected subjects, that cells in Barrett’s oesophagus show a transcriptional profile that is similar to that of cells in oesophageal submucosal glands.

    • Richard Peter Owen
    • , Michael Joseph White
    • , David Tyler Severson
    • , Barbara Braden
    • , Adam Bailey
    • , Robert Goldin
    • , Lai Mun Wang
    • , Carlos Ruiz-Puig
    • , Nicholas David Maynard
    • , Angie Green
    • , Paolo Piazza
    • , David Buck
    • , Mark Ross Middleton
    • , Chris Paul Ponting
    • , Benjamin Schuster-Böckler
    •  & Xin Lu
  • Article | | open

    Incorporation of triboelectric nanogenerators into textiles is attractive for self-powered wearable electronics. Here the authors employ black phosphorus with a hydrophobic coating in a durable, washable, and air permeable textile-based device that converts biomechanical motion into electricity.

    • Jiaqing Xiong
    • , Peng Cui
    • , Xiaoliang Chen
    • , Jiangxin Wang
    • , Kaushik Parida
    • , Meng-Fang Lin
    •  & Pooi See Lee
  • Article | | open

    The HIV Tat protein recruits a host elongation factor from the cellular 7SK complex to the viral TAR RNA to ensure transcriptional elongation. Here, Pham et al. solve the structures of both 7SK and TAR RNAs in complex with Tat’s RNA binding domain and gain mechanistic insights into the process.

    • Vincent V. Pham
    • , Carolina Salguero
    • , Shamsun Nahar Khan
    • , Jennifer L. Meagher
    • , W. Clay Brown
    • , Nicolas Humbert
    • , Hugues de Rocquigny
    • , Janet L. Smith
    •  & Victoria M. D’Souza
  • Article | | open

    T-acute lymphoblastic leukemia is an aggressive cancer. Here the authors provide insights into the functional role of SHQ1, an H/ACA snoRNP assembly factor involved in snRNA pseudouridylation, in T-lymphoblastic leukemia cell survival through regulating the maturation of MYC mRNA.

    • Hexiu Su
    • , Juncheng Hu
    • , Liang Huang
    • , Yang Yang
    • , Morgan Thenoz
    • , Anna Kuchmiy
    • , Yufeng Hu
    • , Peng Li
    • , Hui Feng
    • , Yu Zhou
    • , Tom Taghon
    • , Pieter Van Vlierberghe
    • , Guoliang Qing
    • , Zhichao Chen
    •  & Hudan Liu
  • Article | | open

    Analysis of bioluminescence images of bacterial distributions in living animals is mostly manual and semiquantitative. Here, the authors present an analysis platform featuring an animal mold, a probabilistic organ atlas, and a mirror gantry to perform automatic in vivo bioluminescence quantification.

    • Alexander D. Klose
    •  & Neal Paragas
  • Article | | open

    Methane- and ammonia-oxidizing bacteria use the integral membrane, copper-dependent enzymes particulate methane monooxygenase (pMMO) and ammonia monooxygenase (AMO) to oxidize methane and ammonia. Here the authors structurally characterize the copper-binding protein PmoD, which contains an unusual CuA site and their genetic analyses strongly support a pMMO and AMO related function of PmoD.

    • Oriana S. Fisher
    • , Grace E. Kenney
    • , Matthew O. Ross
    • , Soo Y. Ro
    • , Betelehem E. Lemma
    • , Sharon Batelu
    • , Paul M. Thomas
    • , Victoria C. Sosnowski
    • , Caroline J. DeHart
    • , Neil L. Kelleher
    • , Timothy L. Stemmler
    • , Brian M. Hoffman
    •  & Amy C. Rosenzweig
  • Article | | open

    Genetic loci linked to susceptibility for the common skin cancer cutaneous squamous cell carcinoma (cSCC) have been identified by genome wide association studies (GWAS). Here, the authors impute gene expression levels from GWAS data to perform a transcriptome wide association study (TWAS), identifying five novel genetic loci linked to cSCC susceptibility.

    • Nilah M. Ioannidis
    • , Wei Wang
    • , Nicholas A. Furlotte
    • , David A. Hinds
    • , Michelle Agee
    • , Babak Alipanahi
    • , Adam Auton
    • , Robert K. Bell
    • , Katarzyna Bryc
    • , Sarah L. Elson
    • , Pierre Fontanillas
    • , Karen E. Huber
    • , Aaron Kleinman
    • , Nadia K. Litterman
    • , Jennifer C. McCreight
    • , Matthew H. McIntyre
    • , Joanna L. Mountain
    • , Elizabeth S. Noblin
    • , Carrie A. M. Northover
    • , Steven J. Pitts
    • , J. Fah Sathirapongsasuti
    • , Olga V. Sazonova
    • , Janie F. Shelton
    • , Suyash Shringarpure
    • , Chao Tian
    • , Joyce Y. Tung
    • , Vladimir Vacic
    • , Catherine H. Wilson
    • , Carlos D. Bustamante
    • , Eric Jorgenson
    • , Maryam M. Asgari
    •  & Alice S. Whittemore
  • Article | | open

    Existing n-type colloidal quantum dot materials easily lose their doping polarity in air. Here Song et al. passivate the reactive covalent surface of indium arsenide quantum dots to gain the energy-level tunability and show p–n junction type solar cells with 7.92% certified efficiency.

    • Jung Hoon Song
    • , Hyekyoung Choi
    • , Hien Thu Pham
    •  & Sohee Jeong
  • Article | | open

    The CD1d pathway present lipid antigens resulting in the activation of iNKT cells but the complete pathway remains to be fully elucidated. Here, Chandra et al. use an siRNA screen and identify Mrp1 as crucial for CD1d lipid presentation and activation of iNKT in the context of Streptococcus pneumoniae infection.

    • Shilpi Chandra
    • , James Gray
    • , William B. Kiosses
    • , Archana Khurana
    • , Kaori Hitomi
    • , Catherine M. Crosby
    • , Ashu Chawla
    • , Zheng Fu
    • , Meng Zhao
    • , Natacha Veerapen
    • , Stewart K. Richardson
    • , Steven A. Porcelli
    • , Gurdyal Besra
    • , Amy R. Howell
    • , Sonia Sharma
    • , Bjoern Peters
    •  & Mitchell Kronenberg
  • Article | | open

    In a dynamic environment old evidence could be outdated. Here, the authors investigate the ability of rats to integrate and discount evidence provided by auditory clicks to infer a hidden, dynamic, state of the world and model the consequence of sensory noise to explain the source of errors.

    • Alex T. Piet
    • , Ahmed El Hady
    •  & Carlos D. Brody
  • Article | | open

    The authors compare human fecal viromes from three isolated villages of the Amazon rain forest with those from city dwellers. They report that the diversity of human viruses is not reduced in isolated villages, suggesting frequent viral introductions or increased susceptibility to enteric infections.

    • Juliana D. Siqueira
    • , Maria Gloria Dominguez-Bello
    • , Monica Contreras
    • , Orlana Lander
    • , Hortensia Caballero-Arias
    • , Deng Xutao
    • , Oscar Noya-Alarcon
    •  & Eric Delwart
  • Article | | open

    Molecular capsules typically bind only guests with volumes smaller than their cavities. Here, the authors find that a polyaromatic capsule accommodates linear amphiphilic oligomers in a length-dependent manner, whereas short chains are fully crammed into the cavity, long chains can be incorporated into the capsule in a threaded fashion.

    • Masahiro Yamashina
    • , Shunsuke Kusaba
    • , Munetaka Akita
    • , Takashi Kikuchi
    •  & Michito Yoshizawa
  • Article | | open

    Astrocytes have been shown to regulate glutamatergic transmission in the brain. Here, the authors show that astrocytes also detect and modulate GABAergic transmission from somatostatin but not parvalbumin-positive interneurons, thus regulating dendritic inhibition via a feedback loop.

    • Marco Matos
    • , Anthony Bosson
    • , Ilse Riebe
    • , Clare Reynell
    • , Joanne Vallée
    • , Isabel Laplante
    • , Aude Panatier
    • , Richard Robitaille
    •  & Jean-Claude Lacaille
  • Article | | open

    “Conventional chemotherapy-photothermal therapy combination has limited efficacy in drug resistant cancers. Here they develop Copper-palladium tetrapod nanoparticles to overcome these challenges and show them to work in synergy with autophagy inhibitors to treat drug resistant cancers”

    • Yunjiao Zhang
    • , Rui Sha
    • , Lan Zhang
    • , Wenbin Zhang
    • , Peipei Jin
    • , Weiguo Xu
    • , Jianxun Ding
    • , Jun Lin
    • , Jing Qian
    • , Guangyu Yao
    • , Rui Zhang
    • , Fanchen Luo
    • , Jie Zeng
    • , Jie Cao
    •  & Long-ping Wen
  • Article | | open

    The tracking and targeted release of multi-agents to cooperatively treat cancer is a developing and evolving field. Here, the authors demonstrate the anticancer effects of cubic Pd hydride nanocrystals with photoacoustic imaging properties that can release hydrogen under an NIR trigger and have photothermal effects.

    • Penghe Zhao
    • , Zhaokui Jin
    • , Qian Chen
    • , Tian Yang
    • , Danyang Chen
    • , Jin Meng
    • , Xifeng Lu
    • , Zhen Gu
    •  & Qianjun He
  • Article | | open

    The atmospheric response to subseasonal variability of Tibetan Plateau snow cover has been largely ignored. Here the authors show that the fast subseasonal variability of Tibetan Plateau snow cover is closely related to the subsequent East Asian atmospheric circulation at medium-range time scales.

    • Wenkai Li
    • , Weidong Guo
    • , Bo Qiu
    • , Yongkang Xue
    • , Pang-Chi Hsu
    •  & Jiangfeng Wei
  • Article | | open

    Loss of the transcription factor Myogenin in mice reduces skeletal myogenesis and leads to perinatal death but how Myogenin regulates muscle formation is unclear. Here, the authors show that zebrafish Myogenin enhances Myomaker expression, muscle cell fusion and myotome size, yet decreases fast muscle fibre number.

    • Massimo Ganassi
    • , Sara Badodi
    • , Huascar Pedro Ortuste Quiroga
    • , Peter S. Zammit
    • , Yaniv Hinits
    •  & Simon M. Hughes
  • Article | | open

    Genetic variants in ACTB and ACTG1 have been associated with Baraitser-Winter Cerebrofrontofacial syndrome. Here, the authors report of a syndromic thrombocytopenia caused by variants in ACTB exons 5 or 6 that compromise the organization and coupling of the cytoskeleton, leading to impaired platelet maturation.

    • Sharissa L. Latham
    • , Nadja Ehmke
    • , Patrick Y. A. Reinke
    • , Manuel H. Taft
    • , Dorothee Eicke
    • , Theresia Reindl
    • , Werner Stenzel
    • , Michael J. Lyons
    • , Michael J. Friez
    • , Jennifer A. Lee
    • , Ramona Hecker
    • , Michael C. Frühwald
    • , Kerstin Becker
    • , Teresa M. Neuhann
    • , Denise Horn
    • , Evelin Schrock
    • , Indra Niehaus
    • , Katharina Sarnow
    • , Konrad Grützmann
    • , Luzie Gawehn
    • , Barbara Klink
    • , Andreas Rump
    • , Christine Chaponnier
    • , Constanca Figueiredo
    • , Ralf Knöfler
    • , Dietmar J. Manstein
    •  & Nataliya Di Donato
  • Article | | open

    Meiotic drive elements are selfish genetic elements that mediate a skew in their sexual transmission from parent to offspring. Here, the authors sequence and analyze large and complex genomic regions associated with meiotic drive elements in the fungus Neurospora intermedia.

    • Jesper Svedberg
    • , Sara Hosseini
    • , Jun Chen
    • , Aaron A. Vogan
    • , Iva Mozgova
    • , Lars Hennig
    • , Pennapa Manitchotpisit
    • , Anna Abusharekh
    • , Thomas M. Hammond
    • , Martin Lascoux
    •  & Hanna Johannesson
  • Article | | open

    T helper 2 (Th2) cells and type 2 innate lymphoid cells (ILC2) respond differently to interleukin-33 (IL-33) stimulation. Here the authors show that a phosphatase, Dusp10, is expressed in Th2, but not ILC2, to dephosphorylate p38 kinase, reduce GATA3 transcription factor activity, and suppress the induction of IL-5 in response to IL-33.

    • Takeshi Yamamoto
    • , Yusuke Endo
    • , Atsushi Onodera
    • , Kiyoshi Hirahara
    • , Hikari K. Asou
    • , Takahiro Nakajima
    • , Toshio Kanno
    • , Yasuo Ouchi
    • , Satoshi Uematsu
    • , Hiroshi Nishimasu
    • , Osamu Nureki
    • , Damon J. Tumes
    • , Naoki Shimojo
    •  & Toshinori Nakayama
  • Article | | open

    Targeting noncoding nucleic acids with small molecules represents an important and significant challenge in chemical biology and drug discovery. Here the authors characterize DC-34, a small molecule that exhibits selective binding to specific G4 structures, and provide a structural basis for its selectivity

    • David R. Calabrese
    • , Xiang Chen
    • , Elena C. Leon
    • , Snehal M. Gaikwad
    • , Zaw Phyo
    • , William M. Hewitt
    • , Stephanie Alden
    • , Thomas A. Hilimire
    • , Fahu He
    • , Aleksandra M. Michalowski
    • , John K. Simmons
    • , Lindsey B. Saunders
    • , Shuling Zhang
    • , Daniel Connors
    • , Kylie J. Walters
    • , Beverly A. Mock
    •  & John S. Schneekloth Jr.
  • Article | | open

    The central circadian clock in Drosophila is made up of ~ 150 anatomically distributed neurons; the circuits underlying photoentrainment is unclear. This study describes ex vivo patch-clamp recording of the eye-mediated light response of all known circadian clock neurons, and shows that they are organized in parallel circuits centered around a hub.

    • Meng-Tong Li
    • , Li-Hui Cao
    • , Na Xiao
    • , Min Tang
    • , Bowen Deng
    • , Tian Yang
    • , Taishi Yoshii
    •  & Dong-Gen Luo
  • Article | | open

    Drivers of crop yield variability require quantification, and historical records can help in improving understanding. Here, Webber et al. report that drought stress will remain a key driver of yield losses in wheat and maize across Europe, and benefits from CO2 will be limited in low-yielding years.

    • Heidi Webber
    • , Frank Ewert
    • , Jørgen E. Olesen
    • , Christoph Müller
    • , Stefan Fronzek
    • , Alex C. Ruane
    • , Maryse Bourgault
    • , Pierre Martre
    • , Behnam Ababaei
    • , Marco Bindi
    • , Roberto Ferrise
    • , Robert Finger
    • , Nándor Fodor
    • , Clara Gabaldón-Leal
    • , Thomas Gaiser
    • , Mohamed Jabloun
    • , Kurt-Christian Kersebaum
    • , Jon I. Lizaso
    • , Ignacio J. Lorite
    • , Loic Manceau
    • , Marco Moriondo
    • , Claas Nendel
    • , Alfredo Rodríguez
    • , Margarita Ruiz-Ramos
    • , Mikhail A. Semenov
    • , Stefan Siebert
    • , Tommaso Stella
    • , Pierre Stratonovitch
    • , Giacomo Trombi
    •  & Daniel Wallach
  • Article | | open

    Motor cortical neurons enable performance of a wide range of movements. Here, the authors report that dominant population activity patterns, the neural modes, are largely preserved across various tasks, with many displaying consistent temporal dynamics and reliably mapping onto muscle activity.

    • Juan A. Gallego
    • , Matthew G. Perich
    • , Stephanie N. Naufel
    • , Christian Ethier
    • , Sara A. Solla
    •  & Lee E. Miller
  • Article | | open

    Due to the limited proliferation capacity of adult mammalian cardiomyocytes, the human heart has negligible regenerative capacity after injury. Here the authors show that a Hedgehog-Gli1-Mycn signaling cascade regulates cardiomyocyte proliferation and cardiac regeneration from amphibians to mammals.

    • Bhairab N. Singh
    • , Naoko Koyano-Nakagawa
    • , Wuming Gong
    • , Ivan P. Moskowitz
    • , Cyprian V. Weaver
    • , Elizabeth Braunlin
    • , Satyabrata Das
    • , Jop H. van Berlo
    • , Mary G. Garry
    •  & Daniel J. Garry
  • Article | | open

    It is important to establish a baseline for natural climate variability under relatively warm conditions. Here we show that the Last Interglacial in the North Atlantic and southern Europe was characterized by enhanced climate instability relative to the pre-industrial Holocene.

    • P. C. Tzedakis
    • , R. N. Drysdale
    • , V. Margari
    • , L. C. Skinner
    • , L. Menviel
    • , R. H. Rhodes
    • , A. S. Taschetto
    • , D. A. Hodell
    • , S. J. Crowhurst
    • , J. C. Hellstrom
    • , A. E. Fallick
    • , J. O. Grimalt
    • , J. F. McManus
    • , B. Martrat
    • , Z. Mokeddem
    • , F. Parrenin
    • , E. Regattieri
    • , K. Roe
    •  & G. Zanchetta
  • Article | | open

    Understanding the tunable range of radiative thermal load for a given colour is important for thermal management of outdoor structures. Here, the authors theoretically and experimentally highlighted all mechanisms through which one can control the radiative thermal load of coloured objects.

    • Wei Li
    • , Yu Shi
    • , Zhen Chen
    •  & Shanhui Fan
  • Article | | open

    Hyperpolarization methods play a crucial role in the in vivo observation of molecular metabolism by MRI techniques. Here, the authors develop NHC-containing iridium complexes which improve the NMR detectability of 1H, 13C and 15N nuclei via transfer of latent magnetism of para-hydrogen into a substrate.

    • Peter J. Rayner
    • , Philip Norcott
    • , Kate M. Appleby
    • , Wissam Iali
    • , Richard O. John
    • , Sam J. Hart
    • , Adrian C. Whitwood
    •  & Simon B. Duckett
  • Article | | open

    Membrane bilayers are made up of a myriad of different lipids that affect membrane proteins, but identifying those specific lipid requirements remains a challenge. Here authors present an engineered thermal-shift screen which reveals specific lipid preferences of eukaryotic and prokaryotic membrane proteins.

    • Emmanuel Nji
    • , Yurie Chatzikyriakidou
    • , Michael Landreh
    •  & David Drew
  • Article | | open

    Autophagic clearance of aggregates, aggrephagy, is essential for cellular homeostasis but tools to induce and monitor it are limited. Here the authors present a fluorescence-based aggrephagy induction assay to study spatiotemporal dynamics and control mechanisms driving protein aggregate clearance.

    • Anne F. J. Janssen
    • , Eugene A. Katrukha
    • , Wendy van Straaten
    • , Pauline Verlhac
    • , Fulvio Reggiori
    •  & Lukas C. Kapitein
  • Article | | open

    Measuring precise protein turnover rates in animals is technically challenging at the proteomic level. Here, Fornasiero and colleagues use isotopic labeling with mass spectrometry and mathematical modeling to accurately determine protein lifetimes in the mouse brain

    • Eugenio F. Fornasiero
    • , Sunit Mandad
    • , Hanna Wildhagen
    • , Mihai Alevra
    • , Burkhard Rammner
    • , Sarva Keihani
    • , Felipe Opazo
    • , Inga Urban
    • , Till Ischebeck
    • , M. Sadman Sakib
    • , Maryam K. Fard
    • , Koray Kirli
    • , Tonatiuh Pena Centeno
    • , Ramon O. Vidal
    • , Raza-Ur Rahman
    • , Eva Benito
    • , André Fischer
    • , Sven Dennerlein
    • , Peter Rehling
    • , Ivo Feussner
    • , Stefan Bonn
    • , Mikael Simons
    • , Henning Urlaub
    •  & Silvio O. Rizzoli