Latest Research

  • Article | | open

    Mutations in the mechanotransduction channel component TMC1/2 cause deafness. Here, the authors use a synthetic AAV to replace TMC1 and 2 in the inner ear and show restoration of cochlear and vestibular function, of neuronal reponses in the auditory cortex and of hearing and balance in mice.

    • Carl A. Nist-Lund
    • , Bifeng Pan
    • , Amy Patterson
    • , Yukako Asai
    • , Tianwen Chen
    • , Wu Zhou
    • , Hong Zhu
    • , Sandra Romero
    • , Jennifer Resnik
    • , Daniel B. Polley
    • , Gwenaelle S. Géléoc
    •  & Jeffrey R. Holt
  • Article | | open

    The Cas12b family of CRISPR nucleases has been underutilized in mammalian cells due to the high temperature requirement of known members. Here the authors engineer BhCas12b to overcome this limitation for robust and specific genome editing applications in human cells.

    • Jonathan Strecker
    • , Sara Jones
    • , Balwina Koopal
    • , Jonathan Schmid-Burgk
    • , Bernd Zetsche
    • , Linyi Gao
    • , Kira S. Makarova
    • , Eugene V. Koonin
    •  & Feng Zhang
  • Article | | open

    While hydrogen offers a potential carbon neutral fuel, its production from water using earth-abundant, heterogeneous materials has proven challenging to understand. Here, authors present a series of molecular electrocatalysts based on molybdenum, sulphur, and oxygen for aqueous hydrogen evolution.

    • James McAllister
    • , Nuno A. G. Bandeira
    • , Jessica C. McGlynn
    • , Alexey Y. Ganin
    • , Yu-Fei Song
    • , Carles Bo
    •  & Haralampos N. Miras
  • Article | | open

    Plasmodium vivax biology is not well understood, due to a lack of in vitro culture systems and difficulties associated with studying clinical blood samples. Here, Kim et al. use gene expression profiles from P. vivax infected patient blood and show stage-specific chloroquine response and differential regulation of male and female gametocytes.

    • Adam Kim
    • , Jean Popovici
    • , Didier Menard
    •  & David Serre
  • Article | | open

    GWAS have identified more than 500 genetic loci associated with blood lipid levels. Here, the authors report a genome-wide analysis of interactions between genetic markers and physical activity, and find that physical activity modifies the effects of four genetic loci on HDL or LDL cholesterol.

    • Tuomas O. Kilpeläinen
    • , Amy R. Bentley
    • , Raymond Noordam
    • , Yun Ju Sung
    • , Karen Schwander
    • , Thomas W. Winkler
    • , Hermina Jakupović
    • , Daniel I. Chasman
    • , Alisa Manning
    • , Ioanna Ntalla
    • , Hugues Aschard
    • , Michael R. Brown
    • , Lisa de las Fuentes
    • , Nora Franceschini
    • , Xiuqing Guo
    • , Dina Vojinovic
    • , Stella Aslibekyan
    • , Mary F. Feitosa
    • , Minjung Kho
    • , Solomon K. Musani
    • , Melissa Richard
    • , Heming Wang
    • , Zhe Wang
    • , Traci M. Bartz
    • , Lawrence F. Bielak
    • , Archie Campbell
    • , Rajkumar Dorajoo
    • , Virginia Fisher
    • , Fernando P. Hartwig
    • , Andrea R. V. R. Horimoto
    • , Changwei Li
    • , Kurt K. Lohman
    • , Jonathan Marten
    • , Xueling Sim
    • , Albert V. Smith
    • , Salman M. Tajuddin
    • , Maris Alver
    • , Marzyeh Amini
    • , Mathilde Boissel
    • , Jin Fang Chai
    • , Xu Chen
    • , Jasmin Divers
    • , Evangelos Evangelou
    • , Chuan Gao
    • , Mariaelisa Graff
    • , Sarah E. Harris
    • , Meian He
    • , Fang-Chi Hsu
    • , Anne U. Jackson
    • , Jing Hua Zhao
    • , Aldi T. Kraja
    • , Brigitte Kühnel
    • , Federica Laguzzi
    • , Leo-Pekka Lyytikäinen
    • , Ilja M. Nolte
    • , Rainer Rauramaa
    • , Muhammad Riaz
    • , Antonietta Robino
    • , Rico Rueedi
    • , Heather M. Stringham
    • , Fumihiko Takeuchi
    • , Peter J. van der Most
    • , Tibor V. Varga
    • , Niek Verweij
    • , Erin B. Ware
    • , Wanqing Wen
    • , Xiaoyin Li
    • , Lisa R. Yanek
    • , Najaf Amin
    • , Donna K. Arnett
    • , Eric Boerwinkle
    • , Marco Brumat
    • , Brian Cade
    • , Mickaël Canouil
    • , Yii-Der Ida Chen
    • , Maria Pina Concas
    • , John Connell
    • , Renée de Mutsert
    • , H. Janaka de Silva
    • , Paul S. de Vries
    • , Ayşe Demirkan
    • , Jingzhong Ding
    • , Charles B. Eaton
    • , Jessica D. Faul
    • , Yechiel Friedlander
    • , Kelley P. Gabriel
    • , Mohsen Ghanbari
    • , Franco Giulianini
    • , Chi Charles Gu
    • , Dongfeng Gu
    • , Tamara B. Harris
    • , Jiang He
    • , Sami Heikkinen
    • , Chew-Kiat Heng
    • , Steven C. Hunt
    • , M. Arfan Ikram
    • , Jost B. Jonas
    • , Woon-Puay Koh
    • , Pirjo Komulainen
    • , Jose E. Krieger
    • , Stephen B. Kritchevsky
    • , Zoltán Kutalik
    • , Johanna Kuusisto
    • , Carl D. Langefeld
    • , Claudia Langenberg
    • , Lenore J. Launer
    • , Karin Leander
    • , Rozenn N. Lemaitre
    • , Cora E. Lewis
    • , Jingjing Liang
    • , Behrooz Z. Alizadeh
    • , H. Marike Boezen
    • , Lude Franke
    • , Gerjan Navis
    • , Marianne Rots
    • , Morris Swertz
    • , Bruce H. R. Wolffenbuttel
    • , Cisca Wijmenga
    • , Jianjun Liu
    • , Reedik Mägi
    • , Ani Manichaikul
    • , Thomas Meitinger
    • , Andres Metspalu
    • , Yuri Milaneschi
    • , Karen L. Mohlke
    • , Thomas H. Mosley Jr.
    • , Alison D. Murray
    • , Mike A. Nalls
    • , Ei-Ei Khaing Nang
    • , Christopher P. Nelson
    • , Sotoodehnia Nona
    • , Jill M. Norris
    • , Chiamaka Vivian Nwuba
    • , Jeff O’Connell
    • , Nicholette D. Palmer
    • , George J. Papanicolau
    • , Raha Pazoki
    • , Nancy L. Pedersen
    • , Annette Peters
    • , Patricia A. Peyser
    • , Ozren Polasek
    • , David J. Porteous
    • , Alaitz Poveda
    • , Olli T. Raitakari
    • , Stephen S. Rich
    • , Neil Risch
    • , Jennifer G. Robinson
    • , Lynda M. Rose
    • , Igor Rudan
    • , Pamela J. Schreiner
    • , Robert A. Scott
    • , Stephen S. Sidney
    • , Mario Sims
    • , Jennifer A. Smith
    • , Harold Snieder
    • , Tamar Sofer
    • , John M. Starr
    • , Barbara Sternfeld
    • , Konstantin Strauch
    • , Hua Tang
    • , Kent D. Taylor
    • , Michael Y. Tsai
    • , Jaakko Tuomilehto
    • , André G. Uitterlinden
    • , M. Yldau van der Ende
    • , Diana van Heemst
    • , Trudy Voortman
    • , Melanie Waldenberger
    • , Patrik Wennberg
    • , Gregory Wilson
    • , Yong-Bing Xiang
    • , Jie Yao
    • , Caizheng Yu
    • , Jian-Min Yuan
    • , Wei Zhao
    • , Alan B. Zonderman
    • , Diane M. Becker
    • , Michael Boehnke
    • , Donald W. Bowden
    • , Ulf de Faire
    • , Ian J. Deary
    • , Paul Elliott
    • , Tõnu Esko
    • , Barry I. Freedman
    • , Philippe Froguel
    • , Paolo Gasparini
    • , Christian Gieger
    • , Norihiro Kato
    • , Markku Laakso
    • , Timo A. Lakka
    • , Terho Lehtimäki
    • , Patrik K. E. Magnusson
    • , Albertine J. Oldehinkel
    • , Brenda W. J. H. Penninx
    • , Nilesh J. Samani
    • , Xiao-Ou Shu
    • , Pim van der Harst
    • , Jana V. Van Vliet-Ostaptchouk
    • , Peter Vollenweider
    • , Lynne E. Wagenknecht
    • , Ya X. Wang
    • , Nicholas J. Wareham
    • , David R. Weir
    • , Tangchun Wu
    • , Wei Zheng
    • , Xiaofeng Zhu
    • , Michele K. Evans
    • , Paul W. Franks
    • , Vilmundur Gudnason
    • , Caroline Hayward
    • , Bernardo L. Horta
    • , Tanika N. Kelly
    • , Yongmei Liu
    • , Kari E. North
    • , Alexandre C. Pereira
    • , Paul M. Ridker
    • , E. Shyong Tai
    • , Rob M. van Dam
    • , Ervin R. Fox
    • , Sharon L. R. Kardia
    • , Ching-Ti Liu
    • , Dennis O. Mook-Kanamori
    • , Michael A. Province
    • , Susan Redline
    • , Cornelia M. van Duijn
    • , Jerome I. Rotter
    • , Charles B. Kooperberg
    • , W. James Gauderman
    • , Bruce M. Psaty
    • , Kenneth Rice
    • , Patricia B. Munroe
    • , Myriam Fornage
    • , L. Adrienne Cupples
    • , Charles N. Rotimi
    • , Alanna C. Morrison
    • , Dabeeru C. Rao
    •  & Ruth J. F. Loos
  • Article | | open

    A computationally efficient description of ice-water systems at the mesoscopic scale is challenging due to system size and timescale limitations. Here the authors develop a machine-learned coarse-grained water model to elucidate the ice nucleation process much more efficiently than previous models.

    • Henry Chan
    • , Mathew J. Cherukara
    • , Badri Narayanan
    • , Troy D. Loeffler
    • , Chris Benmore
    • , Stephen K. Gray
    •  & Subramanian K. R. S. Sankaranarayanan
  • Article | | open

    Obesity is linked to increased cancer risk but the impact of body size versus weight distribution in determining the increased risk is unclear. Here the authors examined body mass index, waist circumference, and waist to hip ratio in relation to all-cancer incidence and incidence of seven individual cancers in a population of approximately 26,000 individual and conclude that central adiposity appears to be a stronger predictor of all-cancer risk than body size.

    • Amanda M. Barberio
    • , Asalah Alareeki
    • , Benjamin Viner
    • , Joy Pader
    • , Jennifer E. Vena
    • , Paul Arora
    • , Christine M. Friedenreich
    •  & Darren R. Brenner
  • Article | | open

    The utility of UV vision for visualizing habitat structure is poorly known. Here, the authors use optical models and multispectral imaging to show that UV vision reveals sharp visual contrasts between leaf surfaces, potentially an advantage in navigating forest environments.

    • Cynthia Tedore
    •  & Dan-Eric Nilsson
  • Article | | open

    Spin-orbit coupling is interesting for fundamental understanding of spin transport and quench dynamics. Here the authors demonstrate spin-current generation and its relaxation in spin-orbit-coupled Bose-Einstein condensates of Rb atoms in different spin states.

    • Chuan-Hsun Li
    • , Chunlei Qu
    • , Robert J. Niffenegger
    • , Su-Ju Wang
    • , Mingyuan He
    • , David B. Blasing
    • , Abraham J. Olson
    • , Chris H. Greene
    • , Yuli Lyanda-Geller
    • , Qi Zhou
    • , Chuanwei Zhang
    •  & Yong P. Chen
  • Article | | open

    Somatic alterations in the exonuclease domain of DNA polymerase ɛ have been linked to the development of highly mutated cancers. Here, the authors report that a major consequence of the most common cancer-associated Polɛ variant is a dramatically increased DNA polymerase activity.

    • Xuanxuan Xing
    • , Daniel P. Kane
    • , Chelsea R. Bulock
    • , Elizabeth A. Moore
    • , Sushma Sharma
    • , Andrei Chabes
    •  & Polina V. Shcherbakova
  • Article | | open

    The circadian clock can affect pathogen replication, but underlying molecular mechanisms are unclear. Here the authors demonstrate that the circadian components BMAL1 and REV-ERBα affect entry of hepatitis C virus (HCV) into hepatocytes and genome replication of HCV and related flaviviruses dengue and zika.

    • Xiaodong Zhuang
    • , Andrea Magri
    • , Michelle Hill
    • , Alvina G. Lai
    • , Abhinav Kumar
    • , Srinivasa Bhargav Rambhatla
    • , Claire L. Donald
    • , Andrea F. Lopez-Clavijo
    • , Simon Rudge
    • , Katherine Pinnick
    • , Wai Hoong Chang
    • , Peter A. C. Wing
    • , Ryan Brown
    • , Ximing Qin
    • , Peter Simmonds
    • , Thomas F. Baumert
    • , David Ray
    • , Andrew Loudon
    • , Peter Balfe
    • , Michael Wakelam
    • , Sam Butterworth
    • , Alain Kohl
    • , Catherine L. Jopling
    • , Nicole Zitzmann
    •  & Jane A. McKeating
  • Article | | open

    Transport in quantum systems is complex and can be suppressed by coherent superposition of the involved states. Here, the authors find all-electronic suppression of transport in a carbon nanotube originating from coherent population trapping and give criteria for the presence of such a dark state.

    • Andrea Donarini
    • , Michael Niklas
    • , Michael Schafberger
    • , Nicola Paradiso
    • , Christoph Strunk
    •  & Milena Grifoni
  • Article | | open

    Bulk tissue RNA-seq data reveals transcriptomic profiles but masks the contributions of different cell types. Here, the authors develop a new method for estimating cell type proportions from bulk tissue RNA-seq data guided by multi-subject single-cell expression reference.

    • Xuran Wang
    • , Jihwan Park
    • , Katalin Susztak
    • , Nancy R. Zhang
    •  & Mingyao Li
  • Article | | open

    While direct N2 reduction using electrochemistry offers an appealing method to obtain usable nitrogen, materials typically show poor activities and efficiencies. Here, authors demonstrate a single-atom catalyst, iron on N-doped carbon, to have dramatically enhanced N2 reduction efficiencies.

    • Mengfan Wang
    • , Sisi Liu
    • , Tao Qian
    • , Jie Liu
    • , Jinqiu Zhou
    • , Haoqing Ji
    • , Jie Xiong
    • , Jun Zhong
    •  & Chenglin Yan
  • Author Correction | | open

    • Jayaram Vijayakrishnan
    • , James Studd
    • , Peter Broderick
    • , Ben Kinnersley
    • , Amy Holroyd
    • , Philip J. Law
    • , Rajiv Kumar
    • , James M. Allan
    • , Christine J. Harrison
    • , Anthony V. Moorman
    • , Ajay Vora
    • , Eve Roman
    • , Sivaramakrishna Rachakonda
    • , Sally E. Kinsey
    • , Eamonn Sheridan
    • , Pamela D. Thompson
    • , Julie A. Irving
    • , Rolf Koehler
    • , Per Hoffmann
    • , Markus M. Nöthen
    • , Stefanie Heilmann-Heimbach
    • , Karl-Heinz Jöckel
    • , Douglas F. Easton
    • , Paul D. P. Pharaoh
    • , Alison M. Dunning
    • , Julian Peto
    • , Frederico Canzian
    • , Anthony Swerdlow
    • , Rosalind A. Eeles
    • , Zsofia Kote-Jarai
    • , Kenneth Muir
    • , Nora Pashayan
    • , Brian E. Henderson
    • , Christopher A. Haiman
    • , Sara Benlloch
    • , Fredrick R. Schumacher
    • , Ali Amin Al Olama
    • , Sonja I. Berndt
    • , David V. Conti
    • , Fredrik Wiklund
    • , Stephen Chanock
    • , Victoria L. Stevens
    • , Catherine M. Tangen
    • , Jyotsna Batra
    • , Judith Clements
    • , Henrik Gronberg
    • , Johanna Schleutker
    • , Demetrius Albanes
    • , Stephanie Weinstein
    • , Alicja Wolk
    • , Catharine West
    • , Lorelei Mucci
    • , Géraldine Cancel-Tassin
    • , Stella Koutros
    • , Karina Dalsgaard Sorensen
    • , Lovise Maehle
    • , David E. Neal
    • , Ruth C. Travis
    • , Robert J. Hamilton
    • , Sue Ann Ingles
    • , Barry Rosenstein
    • , Yong-Jie Lu
    • , Graham G. Giles
    • , Adam S. Kibel
    • , Ana Vega
    • , Manolis Kogevinas
    • , Kathryn L. Penney
    • , Jong Y. Park
    • , Janet L. Stanford
    • , Cezary Cybulski
    • , Børge G. Nordestgaard
    • , Hermann Brenner
    • , Christiane Maier
    • , Jeri Kim
    • , Esther M. John
    • , Manuel R. Teixeira
    • , Susan L. Neuhausen
    • , Kim De Ruyck
    • , Azad Razack
    • , Lisa F. Newcomb
    • , Davor Lessel
    • , Radka Kaneva
    • , Nawaid Usmani
    • , Frank Claessens
    • , Paul A. Townsend
    • , Manuela Gago-Dominguez
    • , Monique J. Roobol
    • , Florence Menegaux
    • , Mel Greaves
    • , Martin Zimmerman
    • , Claus R. Bartram
    • , Martin Schrappe
    • , Martin Stanulla
    • , Kari Hemminki
    •  & Richard S. Houlston
  • Article | | open

    Current treatments for age-related neovascular macular degeneration (nAMD) suffer from limited efficacy. Here, Zhao et al. show that pharmacological inhibition or genetic deletion of the mineralocorticoid receptor (MR) limits choroidal neovascularisation in rodents, and show in a pilot clinical study that targeting the MR pathway may provide clinical benefits in nAMD patiens.

    • Min Zhao
    • , Irmela Mantel
    • , Emmanuelle Gelize
    • , Xinxin Li
    • , Xiaoyue Xie
    • , Alejandro Arboleda
    • , Marie Seminel
    • , Rinath Levy-Boukris
    • , Marilyn Dernigoghossian
    • , Andrea Prunotto
    • , Charlotte Andrieu-Soler
    • , Carlo Rivolta
    • , Jérémie Canonica
    • , Marie-Christine Naud
    • , Sebastian Lechner
    • , Nicolette Farman
    • , Irene Bravo-Osuna
    • , Rocio Herrero-Vanrell
    • , Frederic Jaisser
    •  & Francine Behar-Cohen
  • Article | | open

    The mid-Pleistocene transition is recognized as a shift in paleoclimatic periodicity from 41- to 100-kyr cycles. Here the authors present a unique mid-Pleistocene transition of coupled monsoon-vegetation changes from 23- to 100-kyr cycles, which indicates varied sensitivity of past climate to astronomical and ice/CO2 forcing.

    • Youbin Sun
    • , Qiuzhen Yin
    • , Michel Crucifix
    • , Steven C. Clemens
    • , Pablo Araya-Melo
    • , Weiguo Liu
    • , Xiaoke Qiang
    • , Qingsong Liu
    • , Hui Zhao
    • , Lianji Liang
    • , Hongyun Chen
    • , Ying Li
    • , Li Zhang
    • , Guocheng Dong
    • , Ming Li
    • , Weijian Zhou
    • , Andre Berger
    •  & Zhisheng An
  • Article | | open

    Enhanced Wnt receptor activity is a major cause of cancer development. Here the authors identify camelid single-domain antibody fragments (VHHs) that bind to the Wnt receptor LRP5/6 ectodomain, determine the crystal structures and show that these VHHs selectively inhibit Wnt3- mediated cellular responses and block the growth of mutant Wnt-hypersensitive intestinal tumor organoids.

    • Nicola Fenderico
    • , Revina C. van Scherpenzeel
    • , Michael Goldflam
    • , Davide Proverbio
    • , Ingrid Jordens
    • , Tomica Kralj
    • , Sarah Stryeck
    • , Tarek Z. Bass
    • , Guy Hermans
    • , Christopher Ullman
    • , Teodor Aastrup
    • , Piet Gros
    •  & Madelon M. Maurice
  • Article | | open

    Obesity and the distribution of fat within the body are risk factors for cardiometabolic diseases. Here, Rask-Andersen et al. perform GWAS for bio-electrical impedance measurements in UK Biobank participants and identify 29 novel independent loci for fat distribution and a high degree of sex-heterogeneity.

    • Mathias Rask-Andersen
    • , Torgny Karlsson
    • , Weronica E. Ek
    •  & Åsa Johansson
  • Article | | open

    Electron correlation normally makes electrons less mobile, but it is still not clear when correlation becomes very strong in Dirac semimetals. Here, Fujioka et al. report a very high electron mobility exceeding 60,000 cm2V−1s−1 in correlated Dirac semimetal of perovskite CaIrO3, due to the enhanced electron correlation nearby the Mott transition.

    • J. Fujioka
    • , R. Yamada
    • , M. Kawamura
    • , S. Sakai
    • , M. Hirayama
    • , R. Arita
    • , T. Okawa
    • , D. Hashizume
    • , M. Hoshino
    •  & Y. Tokura
  • Article | | open

    Size and shape of the brain are, among others, influenced by the dimensions of the skull. Here, the authors report genome-wide association studies for head circumference and intracranial volume in children and adults and the identification of nine common or low-frequency variants associated with these traits.

    • Simon Haworth
    • , Chin Yang Shapland
    • , Caroline Hayward
    • , Bram P. Prins
    • , Janine F. Felix
    • , Carolina Medina-Gomez
    • , Fernando Rivadeneira
    • , Carol Wang
    • , Tarunveer S. Ahluwalia
    • , Martine Vrijheid
    • , Mònica Guxens
    • , Jordi Sunyer
    • , Ioanna Tachmazidou
    • , Klaudia Walter
    • , Valentina Iotchkova
    • , Andrew Jackson
    • , Louise Cleal
    • , Jennifer Huffmann
    • , Josine L. Min
    • , Lærke Sass
    • , Paul R. H. J. Timmers
    • , Saeed Al Turki
    • , Carl A. Anderson
    • , Richard Anney
    • , Dinu Antony
    • , María Soler Artigas
    • , Muhammad Ayub
    • , Senduran Bala
    • , Jeffrey C. Barrett
    • , Inês Barroso
    • , Phil Beales
    • , Jamie Bentham
    • , Shoumo Bhattacharya
    • , Ewan Birney
    • , Douglas Blackwood
    • , Martin Bobrow
    • , Elena Bochukova
    • , Patrick F. Bolton
    • , Rebecca Bounds
    • , Chris Boustred
    • , Gerome Breen
    • , Mattia Calissano
    • , Keren Carss
    • , Ruth Charlton
    • , Krishna Chatterjee
    • , Lu Chen
    • , Antonio Ciampi
    • , Sebahattin Cirak
    • , Peter Clapham
    • , Gail Clement
    • , Guy Coates
    • , Massimiliano Cocca
    • , David A. Collier
    • , Catherine Cosgrove
    • , Tony Cox
    • , Nick Craddock
    • , Lucy Crooks
    • , Sarah Curran
    • , David Curtis
    • , Allan Daly
    • , Petr Danecek
    • , Ian N. M. Day
    • , Aaron Day-Williams
    • , Anna Dominiczak
    • , Thomas Down
    • , Yuanping Du
    • , Ian Dunham
    • , Richard Durbin
    • , Sarah Edkins
    • , Rosemary Ekong
    • , Peter Ellis
    • , David M. Evans
    • , I. Sadaf Farooqi
    • , David R. Fitzpatrick
    • , Paul Flicek
    • , James Floyd
    • , A. Reghan Foley
    • , Christopher S. Franklin
    • , Marta Futema
    • , Louise Gallagher
    • , Tom R. Gaunt
    • , Matthias Geihs
    • , Daniel Geschwind
    • , Celia M. T. Greenwood
    • , Heather Griffin
    • , Detelina Grozeva
    • , Xiaosen Guo
    • , Xueqin Guo
    • , Hugh Gurling
    • , Deborah Hart
    • , Audrey E. Hendricks
    • , Peter Holmans
    • , Bryan Howie
    • , Jie Huang
    • , Liren Huang
    • , Tim Hubbard
    • , Steve E. Humphries
    • , Matthew E. Hurles
    • , Pirro Hysi
    • , David K. Jackson
    • , Yalda Jamshidi
    • , Chris Joyce
    • , Konrad J. Karczewski
    • , Jane Kaye
    • , Thomas Keane
    • , John P. Kemp
    • , Karen Kennedy
    • , Alastair Kent
    • , Julia Keogh
    • , Farrah Khawaja
    • , Margriet van Kogelenberg
    • , Anja Kolb-Kokocinski
    • , Genevieve Lachance
    • , Cordelia Langford
    • , Daniel Lawson
    • , Irene Lee
    • , Monkol Lek
    • , Rui Li
    • , Yingrui Li
    • , Jieqin Liang
    • , Hong Lin
    • , Ryan Liu
    • , Jouko Lönnqvist
    • , Luis R. Lopes
    • , Margarida Lopes
    • , Daniel G. MacArthur
    • , Massimo Mangino
    • , Jonathan Marchini
    • , Gaëlle Marenne
    • , John Maslen
    • , Iain Mathieson
    • , Shane McCarthy
    • , Peter McGuffin
    • , Andrew M. McIntosh
    • , Andrew G. McKechanie
    • , Andrew McQuillin
    • , Yasin Memari
    • , Sarah Metrustry
    • , Nicola Migone
    • , Hannah M. Mitchison
    • , Alireza Moayyeri
    • , Andrew Morris
    • , James Morris
    • , Dawn Muddyman
    • , Francesco Muntoni
    • , Kate Northstone
    • , Michael C. O’Donovan
    • , Stephen O’Rahilly
    • , Alexandros Onoufriadis
    • , Karim Oualkacha
    • , Michael J. Owen
    • , Aarno Palotie
    • , Kalliope Panoutsopoulou
    • , Victoria Parker
    • , Jeremy R. Parr
    • , Lavinia Paternoster
    • , Tiina Paunio
    • , Felicity Payne
    • , Stewart J. Payne
    • , John R. B. Perry
    • , Olli Pietilainen
    • , Vincent Plagnol
    • , Rebecca C. Pollitt
    • , David J. Porteous
    • , Sue Povey
    • , Michael A. Quail
    • , Lydia Quaye
    • , F. Lucy Raymond
    • , Karola Rehnström
    • , J. Brent Richards
    • , Cheryl K. Ridout
    • , Susan Ring
    • , Graham R. S. Ritchie
    • , Nicola Roberts
    • , Rachel L. Robinson
    • , David B. Savage
    • , Peter Scambler
    • , Stephan Schiffels
    • , Miriam Schmidts
    • , Nadia Schoenmakers
    • , Richard H. Scott
    • , Robert K. Semple
    • , Eva Serra
    • , Sally I. Sharp
    • , Adam Shaw
    • , Hashem A. Shihab
    • , So-Youn Shin
    • , David Skuse
    • , Kerrin S. Small
    • , Carol Smee
    • , Blair H. Smith
    • , Nicole Soranzo
    • , Lorraine Southam
    • , Olivera Spasic-Boskovic
    • , Timothy D. Spector
    • , David St Clair
    • , Jim Stalker
    • , Elizabeth Stevens
    • , Jianping Sun
    • , Gabriela Surdulescu
    • , Jaana Suvisaari
    • , Petros Syrris
    • , Rohan Taylor
    • , Jing Tian
    • , Martin D. Tobin
    • , Ana M. Valdes
    • , Anthony M. Vandersteen
    • , Parthiban Vijayarangakannan
    • , Peter M. Visscher
    • , Louise V. Wain
    • , James T. R. Walters
    • , Guangbiao Wang
    • , Jun Wang
    • , Yu Wang
    • , Kirsten Ward
    • , Eleanor Wheeler
    • , Tamieka Whyte
    • , Hywel J. Williams
    • , Kathleen A. Williamson
    • , Crispian Wilson
    • , Scott G. Wilson
    • , Kim Wong
    • , ChangJiang Xu
    • , Jian Yang
    • , Feng Zhang
    • , Pingbo Zhang
    • , Hou-Feng Zheng
    • , George Davey Smith
    • , Simon E. Fisher
    • , James F. Wilson
    • , Tim J. Cole
    • , Dietmar Fernandez-Orth
    • , Klaus Bønnelykke
    • , Hans Bisgaard
    • , Craig E. Pennell
    • , Vincent W. V. Jaddoe
    • , George Dedoussis
    • , Nicholas Timpson
    • , Eleftheria Zeggini
    • , Veronique Vitart
    •  & Beate St Pourcain
  • Article | | open

    Acinic cell carcinoma (AciCC) is a rare salivary gland carcinoma that is poorly understood. Here the authors perform genomic, transcriptomic and epigenomic profiling of AciCC and find highly recurrent and specific rearrangements [t(4;9)(q13;q31)], which lead to enhancer hijacking that activates oncogenic transcription factor NR4A3.

    • Florian Haller
    • , Matthias Bieg
    • , Rainer Will
    • , Cindy Körner
    • , Dieter Weichenhan
    • , Alexander Bott
    • , Naveed Ishaque
    • , Pavlo Lutsik
    • , Evgeny A. Moskalev
    • , Sarina K. Mueller
    • , Marion Bähr
    • , Angelika Woerner
    • , Birgit Kaiser
    • , Claudia Scherl
    • , Marlen Haderlein
    • , Kortine Kleinheinz
    • , Rainer Fietkau
    • , Heinrich Iro
    • , Roland Eils
    • , Arndt Hartmann
    • , Christoph Plass
    • , Stefan Wiemann
    •  & Abbas Agaimy
  • Article | | open

    Thermonuclear fusion of nuclei of deuterium and tritium may provide the energy for the future and spin polarization is a potential mechanism for enhancing the nuclear reaction. Here the authors predict the enhanced DT fusion rate using chiral effective field theory and ab initio calculations.

    • Guillaume Hupin
    • , Sofia Quaglioni
    •  & Petr Navrátil
  • Article | | open

    The transcription factor Foxp3 and Stat5 modulate lineage stability and function of regulatory T (Treg) cells to promote immune homeostasis. Here the authors show that O-GlcNAcylation of Foxp3 and Stat5, mediated by O-GlcNAc transferase (OGT), is essential for Treg-mediate immune balance, with Treg-specific deficiency of OGT leading to severe autoimmunity.

    • Bing Liu
    • , Oscar C. Salgado
    • , Sangya Singh
    • , Keli L. Hippen
    • , Jason C. Maynard
    • , Alma L. Burlingame
    • , Lauren E. Ball
    • , Bruce R. Blazar
    • , Michael A. Farrar
    • , Kristin A. Hogquist
    •  & Hai-Bin Ruan
  • Article | | open

    In Drosophila, the Calypso–ASX complex catalyzes H2A deubiquitination and aids Polycomb in transcriptional silencing. Here the authors show that the orthologous complex, BAP1.com, promotes gene activation by counteracting PRC1-mediated gene silencing.

    • Antoine Campagne
    • , Ming-Kang Lee
    • , Dina Zielinski
    • , Audrey Michaud
    • , Stéphanie Le Corre
    • , Florent Dingli
    • , Hong Chen
    • , Lara Z. Shahidian
    • , Ivaylo Vassilev
    • , Nicolas Servant
    • , Damarys Loew
    • , Eric Pasmant
    • , Sophie Postel-Vinay
    • , Michel Wassef
    •  & Raphaël Margueron
  • Article | | open

    Pigmentation variation in humans is influenced by complex genetic architecture in different populations. Here, the authors perform a genome-wide association analysis involving > 6,000 Latin Americans for pigmentation of skin and eyes, and identify known and novel genetic associations.

    • Kaustubh Adhikari
    • , Javier Mendoza-Revilla
    • , Anood Sohail
    • , Macarena Fuentes-Guajardo
    • , Jodie Lampert
    • , Juan Camilo Chacón-Duque
    • , Malena Hurtado
    • , Valeria Villegas
    • , Vanessa Granja
    • , Victor Acuña-Alonzo
    • , Claudia Jaramillo
    • , William Arias
    • , Rodrigo Barquera Lozano
    • , Paola Everardo
    • , Jorge Gómez-Valdés
    • , Hugo Villamil-Ramírez
    • , Caio C. Silva de Cerqueira
    • , Tábita Hunemeier
    • , Virginia Ramallo
    • , Lavinia Schuler-Faccini
    • , Francisco M. Salzano
    • , Rolando Gonzalez-José
    • , Maria-Cátira Bortolini
    • , Samuel Canizales-Quinteros
    • , Carla Gallo
    • , Giovanni Poletti
    • , Gabriel Bedoya
    • , Francisco Rothhammer
    • , Desmond J. Tobin
    • , Matteo Fumagalli
    • , David Balding
    •  & Andrés Ruiz-Linares
  • Article | | open

    Polarization-insensitive metasurfaces implies limiting the choice of constituent elements to isotropic nanostructures. Here, the authors demonstrate a polarization-insensitive metalens using anisotropic nanofins, allowing achromatic and polarization-insensitive behaviour across the entire visible.

    • Wei Ting Chen
    • , Alexander Y. Zhu
    • , Jared Sisler
    • , Zameer Bharwani
    •  & Federico Capasso
  • Article | | open

    While the Chern number is used to characterize topological states in both electronic and photonic systems, its direct physical meaning in photonics has not yet been established. Here, Silveirinha shows that the photonic Chern number can be understood as a quantum of the optical angular momentum.

    • Mário G. Silveirinha
  • Article | | open

    Mucosal melanoma is a rare melanoma subtype that is poorly characterised. Here, the authors sequenced human, canine, and equine melanoma samples and performed a cross-species analysis, which revealed candidate driver genes, recurrent copy number alterations in regions syntenic between species, extensive intra-tumour heterogeneity and potential germline predisposing alleles

    • Kim Wong
    • , Louise van der Weyden
    • , Courtney R. Schott
    • , Alastair Foote
    • , Fernando Constantino-Casas
    • , Sionagh Smith
    • , Jane M. Dobson
    • , Elizabeth P. Murchison
    • , Hong Wu
    • , Iwei Yeh
    • , Douglas R. Fullen
    • , Nancy Joseph
    • , Boris C. Bastian
    • , Rajiv M. Patel
    • , Inigo Martincorena
    • , Carla Daniela Robles-Espinoza
    • , Vivek Iyer
    • , Marieke L. Kuijjer
    • , Mark J. Arends
    • , Thomas Brenn
    • , Paul W. Harms
    • , Geoffrey A. Wood
    •  & David J. Adams
  • Article | | open

    Cells divide within a given size range and can scale across differing cell sizes but mechanisms and function remain unclear. Here the authors show, despite the current dogma of fission yeast maintaining constant width, some fission yeast can scale their width and length, impacting the positioning of the cell division site.

    • Ying Gu
    •  & Snezhana Oliferenko
  • Article | | open

    Myelodyplastic hematopoietic stem cells (MDS HSC) have eluded in vivo modeling. Here the authors present a highly efficient MDS patient-derived xenotransplantation model in cytokine-humanized mice with replication of the donors’ genetic complexity and myeloid, erythroid, and megakaryocytic lineage dysplasia.

    • Yuanbin Song
    • , Anthony Rongvaux
    • , Ashley Taylor
    • , Tingting Jiang
    • , Toma Tebaldi
    • , Kunthavai Balasubramanian
    • , Arun Bagale
    • , Yunus Kasim Terzi
    • , Rana Gbyli
    • , Xiaman Wang
    • , Xiaoying Fu
    • , Yimeng Gao
    • , Jun Zhao
    • , Nikolai Podoltsev
    • , Mina Xu
    • , Natalia Neparidze
    • , Ellice Wong
    • , Richard Torres
    • , Emanuela M. Bruscia
    • , Yuval Kluger
    • , Markus G. Manz
    • , Richard A. Flavell
    •  & Stephanie Halene
  • Article | | open

    Single-cell transcriptomic profiling allows the exploration of cellular heterogeneity but commonly focuses on the 3′-end of the transcript. Here the authors introduce C1 CAGE, which detects the 5′ transcript end in a multiplexed microfluidic system.

    • Tsukasa Kouno
    • , Jonathan Moody
    • , Andrew Tae-Jun Kwon
    • , Youtaro Shibayama
    • , Sachi Kato
    • , Yi Huang
    • , Michael Böttcher
    • , Efthymios Motakis
    • , Mickaël Mendez
    • , Jessica Severin
    • , Joachim Luginbühl
    • , Imad Abugessaisa
    • , Akira Hasegawa
    • , Satoshi Takizawa
    • , Takahiro Arakawa
    • , Masaaki Furuno
    • , Naveen Ramalingam
    • , Jay West
    • , Harukazu Suzuki
    • , Takeya Kasukawa
    • , Timo Lassmann
    • , Chung-Chau Hon
    • , Erik Arner
    • , Piero Carninci
    • , Charles Plessy
    •  & Jay W. Shin
  • Article | | open

    Early human embryonic development involves extensive changes in chromatin structure and transcriptional activity. Here the authors present LiCAT-seq, a method enabling simultaneous profiling of chromatin accessibility and gene expression with ultra-low input of cells and map chromatin accessibility and transcriptome landscapes for human pre-implantation embryos.

    • Longqi Liu
    • , Lizhi Leng
    • , Chuanyu Liu
    • , Changfu Lu
    • , Yue Yuan
    • , Liang Wu
    • , Fei Gong
    • , Shuoping Zhang
    • , Xiaoyu Wei
    • , Mingyue Wang
    • , Lei Zhao
    • , Liang Hu
    • , Jian Wang
    • , Huanming Yang
    • , Shida Zhu
    • , Fang Chen
    • , Guangxiu Lu
    • , Zhouchun Shang
    •  & Ge Lin
  • Article | | open

    Plant-inspired osmotic actuation has been proposed as a competitive actuation strategy yet reversibility is still an open issue hampering its implementation in soft robotics. Here the authors show a low input voltage reversible osmotic actuation strategy based on the electrosorption of ions on flexible electrodes.

    • Indrek Must
    • , Edoardo Sinibaldi
    •  & Barbara Mazzolai
  • Article | | open

    The architecture of functional TNTs is still under debate. Here, the authors combine correlative FIB-SEM, light- and cryo-electron microscopy approaches to elucidate the structure of TNTs in neuronal cells, showing that they form structures that are distinct form other membrane protrusions.

    • Anna Sartori-Rupp
    • , Diégo Cordero Cervantes
    • , Anna Pepe
    • , Karine Gousset
    • , Elise Delage
    • , Simon Corroyer-Dulmont
    • , Christine Schmitt
    • , Jacomina Krijnse-Locker
    •  & Chiara Zurzolo
  • Article | | open

    The Pacific white shrimp Litopenaeus vannamei is an important aquaculture species and a promising model for crustacean biology. Here, the authors provide a reference genome assembly, and show that gene expansion is involved in the regulation of frequent molting as well as benthic adaptation of the shrimp.

    • Xiaojun Zhang
    • , Jianbo Yuan
    • , Yamin Sun
    • , Shihao Li
    • , Yi Gao
    • , Yang Yu
    • , Chengzhang Liu
    • , Quanchao Wang
    • , Xinjia Lv
    • , Xiaoxi Zhang
    • , Ka Yan Ma
    • , Xiaobo Wang
    • , Wenchao Lin
    • , Long Wang
    • , Xueli Zhu
    • , Chengsong Zhang
    • , Jiquan Zhang
    • , Songjun Jin
    • , Kuijie Yu
    • , Jie Kong
    • , Peng Xu
    • , Jack Chen
    • , Hongbin Zhang
    • , Patrick Sorgeloos
    • , Amir Sagi
    • , Acacia Alcivar-Warren
    • , Zhanjiang Liu
    • , Lei Wang
    • , Jue Ruan
    • , Ka Hou Chu
    • , Bin Liu
    • , Fuhua Li
    •  & Jianhai Xiang
  • Article | | open

    Giardia lamblia express a dense coat of variant-specific surface proteins (VSPs) on trophozoites that protects the parasite inside the host´s intestine. Here the authors show that stability and immunomodulatory properties of VSPs can be exploited to both protect and adjuvant vaccine antigens for oral administration.

    • Marianela C. Serradell
    • , Lucía L. Rupil
    • , Román A. Martino
    • , César G. Prucca
    • , Pedro G. Carranza
    • , Alicia Saura
    • , Elmer A. Fernández
    • , Pablo R. Gargantini
    • , Albano H. Tenaglia
    • , Juan P. Petiti
    • , Renata R. Tonelli
    • , Nicolás Reinoso-Vizcaino
    • , José Echenique
    • , Luciana Berod
    • , Eliane Piaggio
    • , Bertrand Bellier
    • , Tim Sparwasser
    • , David Klatzmann
    •  & Hugo D. Luján
  • Article | | open

    Prion-forming proteins have been found in animals, plants, fungi, and bacteria. Here, Nan et al. report that a baculovirus-encoded protein behaves as prion in a yeast system and forms aggregates at high multiplicity of infection in insect cells that affect baculovirus replication.

    • Hao Nan
    • , Hongying Chen
    • , Mick F. Tuite
    •  & Xiaodong Xu
  • Article | | open

    Exploring the ground state of two-dimensional (2D) magnetic systems enriches the fundamental understanding of magnetism and boosts the applications. The authors here show the suppression of magnetic order and 2D XY behavior in XXZ-type antiferromagnet NiPS3 when approaching the monolayer limit by Raman spectroscopy.

    • Kangwon Kim
    • , Soo Yeon Lim
    • , Jae-Ung Lee
    • , Sungmin Lee
    • , Tae Yun Kim
    • , Kisoo Park
    • , Gun Sang Jeon
    • , Cheol-Hwan Park
    • , Je-Geun Park
    •  & Hyeonsik Cheong
  • Article | | open

    Serotonin is released throughout the brain from diverse projections of neurons in the dorsal raphe nucleus. Here, the authors use optogenetics and fMRI mediated mapping of the mouse brain-wide serotonin network in response to acute stress and treatment with SSRI.

    • Joanes Grandjean
    • , Alberto Corcoba
    • , Martin C. Kahn
    • , A. Louise Upton
    • , Evan S. Deneris
    • , Erich Seifritz
    • , Fritjof Helmchen
    • , Edward O. Mann
    • , Markus Rudin
    •  & Bechara J. Saab
  • Article | | open

    Tolerance and other side effects are important limitations to the use of opioids as analgesics. In this study, the authors generated mice lacking phosphorylation sites on the µ-opioid receptor to assess their contribution to the analgesic, tolerance and side effect profile of opioid analgesics.

    • A. Kliewer
    • , F. Schmiedel
    • , S. Sianati
    • , A. Bailey
    • , J. T. Bateman
    • , E. S. Levitt
    • , J. T. Williams
    • , M. J. Christie
    •  & S. Schulz
  • Article | | open

    While many processes in biological cells can be understood in terms of molecular logic gates that process information sequentially and combinationally, the design and construction of such devices in the laboratory are unknown. Here the authors achieve this by the reversibly-controlled capture and release of guest molecules from host containers.

    • Brian Daly
    • , Thomas S. Moody
    • , Allen J. M. Huxley
    • , Chaoyi Yao
    • , Benjamin Schazmann
    • , Andre Alves-Areias
    • , John F. Malone
    • , H. Q. Nimal Gunaratne
    • , Peter Nockemann
    •  & A. Prasanna de Silva
  • Article | | open

    Label-free, spatio-temporal imaging of cellular physiological responses is challenging. Here the authors combine digital holographic microscopy with a millifluidic chip and mathematical modelling to quantify cell volume, mass and cell uptake under changing environmental conditions.

    • Daniel Midtvedt
    • , Erik Olsén
    • , Fredrik Höök
    •  & Gavin D. M. Jeffries
  • Article | | open

    The interactions of lignin with polysaccharides in plant secondary cell walls are not well understood. Here the authors employ solid-state NMR measurements to analyse intact stems of maize, Arabidopsis, switchgrass and rice and observe that lignin self-aggregates and forms highly hydrophobic microdomains that make extensive surface contacts to xylan.

    • Xue Kang
    • , Alex Kirui
    • , Malitha C. Dickwella Widanage
    • , Frederic Mentink-Vigier
    • , Daniel J. Cosgrove
    •  & Tuo Wang
  • Article | | open

    Understanding the structural dynamics of flexible metal-organic frameworks at a thin-film level is key if they are to be implemented in devices. Here, Fischer and colleagues anchor flexible MOF crystallites onto substrates and identify a structural responsiveness that is distinct to that of the bulk.

    • Suttipong Wannapaiboon
    • , Andreas Schneemann
    • , Inke Hante
    • , Min Tu
    • , Konstantin Epp
    • , Anna Lisa Semrau
    • , Christian Sternemann
    • , Michael Paulus
    • , Samuel J. Baxter
    • , Gregor Kieslich
    •  & Roland A. Fischer
  • Article | | open

    There are distinct hypermethylation patterns in gene promoters in hepatocellular carcinomas (HCCs). Here, the authors show that the enhancer of C/EBPβ is recurrently hypomethylated in human HCCs, recapitulating this in a transgenic murine model and linking aberrant enhancer hypomethylation to hepatocarcinogenesis.

    • Lei Xiong
    • , Feng Wu
    • , Qiong Wu
    • , Liangliang Xu
    • , Otto K. Cheung
    • , Wei Kang
    • , Myth T. Mok
    • , Lemuel L. M. Szeto
    • , Cheuk-Yin Lun
    • , Raymond W. Lung
    • , Jinglin Zhang
    • , Ken H. Yu
    • , Sau-Dan Lee
    • , Guangcun Huang
    • , Chiou-Miin Wang
    • , Joseph Liu
    • , Zhuo Yu
    • , Dae-Yeul Yu
    • , Jian-Liang Chou
    • , Wan-Hong Huang
    • , Bo Feng
    • , Yue-Sun Cheung
    • , Paul B. Lai
    • , Patrick Tan
    • , Nathalie Wong
    • , Michael W. Chan
    • , Tim H. Huang
    • , Kevin Y. Yip
    • , Alfred S. Cheng
    •  & Ka-Fai To
  • Article | | open

    Immune recognition of Influenza B virus (IBV) is poorly understood. Here, Liu et al. use flow cytometry to characterize IBV-specific memory B cell responses following seasonal vaccination and show that elicited cross-reactive antibodies can protect against infection, providing a platform for vaccine design.

    • Yi Liu
    • , Hyon-Xhi Tan
    • , Marios Koutsakos
    • , Sinthujan Jegaskanda
    • , Robyn Esterbauer
    • , Danielle Tilmanis
    • , Malet Aban
    • , Katherine Kedzierska
    • , Aeron C. Hurt
    • , Stephen J. Kent
    •  & Adam K. Wheatley
  • Article | | open

    Medulloblastoma is one of the most prevalent malignant brain tumors in children and has very poor prognosis. In this study, the authors show, using a mouse model of medulloblastoma, that Gfi1 promotes tumor growth by recruiting Lsd1, that this interaction inhibits genes involved in neuronal differentiation, and that Lsd1 may be a therapeutic target in Gfi1-activated tumors.

    • Catherine Lee
    • , Vasilisa A. Rudneva
    • , Serap Erkek
    • , Marc Zapatka
    • , Lianne Q. Chau
    • , Silvia K. Tacheva-Grigorova
    • , Alexandra Garancher
    • , Jessica M. Rusert
    • , Ozlem Aksoy
    • , Robin Lea
    • , Helai P. Mohammad
    • , Jianxun Wang
    • , William A. Weiss
    • , H. Leighton Grimes
    • , Stefan M. Pfister
    • , Paul A. Northcott
    •  & Robert J. Wechsler-Reya