Research articles

The authors combine ab-initio density functional theory with tight-binding calculations to investigate the optical absorption resonances of armchair carbon nanotubes and zigzag graphene nanoribbons, and show that an atlas of carbon nanotubes optical transitions can be mapped to an atlas of optical resonances of zigzag graphene nanoribbons.

Designing low power consumption and fast operation electronic phase-change devices remains a challenge. Here, the authors demonstrate the reversible displacive transformation in polycrystalline MnTe films to enable resistive switching via fast Joule heating for fast nonvolatile memory applications.

Scientific complementary metal-oxide semiconductor (sCMOS) cameras have advanced the imaging field, but they often suffer from additional noise compared to CCD sensors. Here the authors present a content-adaptive algorithm for the automatic correction of sCMOS-related noise for fluorescence microscopy.

The axon initial segment (AIS) is a specialized location in neurons with clustered ion channels which regulates the distribution of neuronal materials. Here, the authors use proximity biotinylation to examine the AIS proteome and better define its molecular organization.

A robust platform to study modular polyketide synthases (PKSs) in vitro is still unavailable. Here, the authors report the reconstitution of the venemycin PKS, engineer hybrid venemycin/pikromycin PKSs, and obtain much improved yields through employing the updated module boundaries.

New World arenaviruses utilize the cellular transferrin receptor 1 (TfR1) to enter host cells. Here, the authors develop a TfR1-mimetic immunoadhesin, Arenacept, that targets viral spike complexes and exerts effective pan-reactive neutralization against pathogenic mammarenaviruses.

Here, the authors report ultrasensitive negative capacitance phototransistors based on MoS₂ regulated by a layer of ferroelectric hafnium zirconium oxide film to demonstrate a hysteresis-free ultra-steep subthreshold slope of 17.64 mV/dec and specific detectivity of 4.75 × 10¹⁴ cm Hz^1/2 W⁻¹ at room temperature.

Relapse is a limitation for the efficacy of the anaplastic lymphoma kinase (ALK)-inhibitor alectinib in ALK-rearranged lung cancer. Here, the authors show that YAP1 activation upon alectinib treatment leads to therapy resistance and that inhibiting both YAP1 and ALK leads to longer tumor remission in mice.

The existence of regular decadal or longer climate oscillations has been the subject of intensive discussion. Here, statistical analysis of observational data and a large ensemble of model simulations show no evidence for longer-term internal oscillations that are distinguishable from climatic noise.

Long-chain alcohols synthesis from syngas conversion is a promising route for the production of high-value chemicals. Here the authors show that a heterogeneous Fe₅C₂/Cu catalyst derived from layered double hydroxides precursor exhibits excellent performance with a space time yield of 0.101 g g_cat⁻¹ h⁻¹ at a low pressure of 1 MPa.

In Arabidopsis, LZY proteins are involved in specifying the angle of root growth relative to the direction of gravity. Here the authors identify RLD1, a LZY-interacting protein that is recruited to the plasma membrane in a polar manner and is required to establish asymmetric auxin transport and set root angles.

Cancers arising from the gastric squamous-columnar junction have high incidence and are characterized by a poor prognosis. Here, the authors use genetic mouse models to show that loss of p53 and Rb1 expression results in preferential tumour development at the gastric squamous-columnar junction that contains a large pool of osteopontin responsive Lgr5-CD44+ cells.

It is challenging to realize doping and surface passivation simultaneously in colloidal quantum dot inks. Here Choi et al. employ a cascade surface modification approach to solve the problem and obtain record high efficiency of 13.3% for bulk homojunction solar cells based on these inks.

High quality hit identification remains a considerable challenge in de novo drug design. Here, the authors train a generative adversarial network with transcriptome profiles induced by a large set of compounds, enabling it to design molecules that are likely to induce desired expression profiles.

Here the authors report a simple method to create a solid electrolyte interphase that is tightly anchored onto the surface of lithium metal anode. This artificial structure suppresses dead and dendrite Li and stores Li via formation of alloys, enabling impressive battery performance.

Polymorphic mimicry in Papilio swallowtail butterflies is thought to have had multiple independent origins. Here, the authors show that the gene doublesex controls mimicry across multiple species, but with distinct alleles that may have originated from an ancestral polymorphism.

RNA-sequencing is mostly used to assess gene expression; however, it can also give information about genetic variants. Here, the authors present CaSpER, a statistical framework that utilises RNA-sequencing reads to identify and visualise CNV events by integrating transcriptome-wide expression and allelic shift profiles.

Higher-order topological phenomenologies are usually observed separately, with each system giving rise to a specific type of topological insulator. Here, the authors realise a nonsymmorphic acoustic metacrystal where the first and the second band gap host dipole and quadrupole topology respectively.

Damaged mitochondria are known to cause neuronal death, suggesting clearance as a potential therapy. Here, Moskal et al. show that ROCK inhibitors promote Parkin recruitment and mitophagy and have neuroprotective effects in fruit flies challenged with a toxin that induces mitochondrial damage.

It is important to analyse the local resolution of cryo-EM maps. Here the authors present MonoDir, a fully automatic and parameter free method for the directional local resolution analysis of cryo-EM maps that requires only the final map as input and they also propose indicators for assessing map quality.