Articles in 2019

  • Article | | open

    In vivo decorporation of U(VI) from bones is an unsolved challenge because of the formation of stable uranium phosphate complexes. Here, the authors develop a hydroxypyridonone-based ligand with strong uranium complexation and low cytotoxicity. They find this ligand effectively removes uranium from kidney and bones in mice, and is suitable for oral administration.

    • Xiaomei Wang
    • , Xing Dai
    • , Cen Shi
    • , Jianmei Wan
    • , Mark A. Silver
    • , Linjuan Zhang
    • , Lanhua Chen
    • , Xuan Yi
    • , Bizheng Chen
    • , Duo Zhang
    • , Kai Yang
    • , Juan Diwu
    • , Jianqiang Wang
    • , Yujie Xu
    • , Ruhong Zhou
    • , Zhifang Chai
    •  & Shuao Wang
  • Article | | open

    Engineering the coordination mode of atom or ion onto the substrate remains challenging. Here, guided by theoretical calculation, the authors prepare stacked-nanosheet MOF based catalyst with precisely controlled coordination sites on the surface and enhanced catalytic reactivity and structural robustness.

    • Chuanhui Huang
    • , Juncai Dong
    • , Weiming Sun
    • , Zhenjie Xue
    • , Jun Ma
    • , Lirong Zheng
    • , Cong Liu
    • , Xiao Li
    • , Kang Zhou
    • , Xuezhi Qiao
    • , Qian Song
    • , Wende Ma
    • , Lan Zhang
    • , Zhenyu Lin
    •  & Tie Wang
  • Article | | open

    Cyanide is thought to be crucial for the origin of life. Here, the authors showed that iron cyanocarbonyl complexes are present in meteorites and propose that these compounds were a source of free cyanide on early Earth and served as precursors to the active sites of ancient hydrogenases.

    • Karen E. Smith
    • , Christopher H. House
    • , Ricardo D. Arevalo Jr.
    • , Jason P. Dworkin
    •  & Michael P. Callahan
  • Article | | open

    Activation of Ca2+/calmodulin-dependent kinase II (CaMKII) in dendritic spines is a key step of long-term potentiation (LTP) induction, yet the exact biochemical steps of CaMKIIα activation in dendritic spines remained elusive. In this study, the authors developed a novel imaging approach to monitor CaM interactions CaMKIIα in cultured hippocampal neurons after uncaging of glutamate. This allowed the authors to model the kinetics of CaMKIIα activation in single dendritic spines.

    • Jui-Yun Chang
    • , Yoshihisa Nakahata
    • , Yuki Hayano
    •  & Ryohei Yasuda
  • Article | | open

    Spatial distribution has been rarely studied in global disaster risk models. Here the authors address damaged networked infrastructure at the asset level for a wider range of hazards and reveal a global Expected Annual Damages ranging from $3.1 to 22 billion with a particular vulnerability of transport infrastructure in Small Island Developing States.

    • E. E. Koks
    • , J. Rozenberg
    • , C. Zorn
    • , M. Tariverdi
    • , M. Vousdoukas
    • , S. A. Fraser
    • , J. W. Hall
    •  & S. Hallegatte
  • Article | | open

    FTO is an m6A demethylase. Here, the authors show that FTO promotes melanoma tumorigenicity and contributes to resistance to anti-PD1 blockade, while FTO inhibition sensitizes melanoma to anti-PD1 blockade.

    • Seungwon Yang
    • , Jiangbo Wei
    • , Yan-Hong Cui
    • , Gayoung Park
    • , Palak Shah
    • , Yu Deng
    • , Andrew E. Aplin
    • , Zhike Lu
    • , Seungmin Hwang
    • , Chuan He
    •  & Yu-Ying He
  • Article | | open

    Sensory drive theory predicts that vocal signalling coevolves with auditory sensitivity, but empirical evidence is limited. Here, Charlton et al. show that vocal characteristics and hearing have coevolved in forest mammals, due to constraints imposed by the local signalling environment.

    • Benjamin D. Charlton
    • , Megan A. Owen
    •  & Ronald R. Swaisgood
  • Article | | open

    The left hemisphere of the brain is especially involved in processing social vocalizations and (in humans) language, but the mechanisms of this lateralization of function are unclear. Here, the authors compared left and right auditory cortex in mice and show lateralized, experience-dependent circuit-motifs.

    • Robert B. Levy
    • , Tiemo Marquarding
    • , Ashlan P. Reid
    • , Christopher M. Pun
    • , Nicolas Renier
    •  & Hysell V. Oviedo
  • Article | | open

    Quantifying entanglement in a large quantum system requires an intractable number of measurements. Here, the authors demonstrate a method for certifying entanglement from extremely undersampled data by combining a new quantitative entanglement witness with an adaptive sampling procedure.

    • James Schneeloch
    • , Christopher C. Tison
    • , Michael L. Fanto
    • , Paul M. Alsing
    •  & Gregory A. Howland
  • Article | | open

    Outer radial glial cells (oRGs) are undifferentiated cells that divide in the subventricular zone during neurodevelopment, but the underlying mechanisms are not fully understood. Here the authors show that Lzts1 positively controls both neuronal delamination and generation of oRG-like cell types.

    • T. Kawaue
    • , A. Shitamukai
    • , A. Nagasaka
    • , Y. Tsunekawa
    • , T. Shinoda
    • , K. Saito
    • , R. Terada
    • , M. Bilgic
    • , T. Miyata
    • , F. Matsuzaki
    •  & A. Kawaguchi
  • Article | | open

    Standard DNA-based analyses of microbial communities cannot distinguish between active microbes and dead or dormant cells. Here, Couradeau et al. use BONCAT (bioorthogonal non-canonical amino acid tagging), flow cytometry, and 16S rRNA gene amplicon sequencing to identify active microbial cells in soils.

    • Estelle Couradeau
    • , Joelle Sasse
    • , Danielle Goudeau
    • , Nandita Nath
    • , Terry C. Hazen
    • , Ben P. Bowen
    • , Romy Chakraborty
    • , Rex R. Malmstrom
    •  & Trent R. Northen
  • Article | | open

    Cerebral cavernous malformation is a vascular disease characterized by capillary-venous cavernomas in the central nervous system. Here the authors show that cavernomas display benign tumor characteristics and originate from the clonal expansion of mutated endothelial progenitors which can attract surrounding wild-type cells, inducing their mesenchymal transition and leading to growth of the cavernoma.

    • Matteo Malinverno
    • , Claudio Maderna
    • , Abdallah Abu Taha
    • , Monica Corada
    • , Fabrizio Orsenigo
    • , Mariaelena Valentino
    • , Federica Pisati
    • , Carmela Fusco
    • , Paolo Graziano
    • , Monica Giannotta
    • , Qing Cissy Yu
    • , Yi Arial Zeng
    • , Maria Grazia Lampugnani
    • , Peetra U. Magnusson
    •  & Elisabetta Dejana
  • Article | | open

    PGC-1α is activated by exercise and promotes resistance to fatigue in muscles. Here, the authors show that PGC-1α activates the malate-aspartate shuttle, and allows muscle to utilise kynurenine, leading to more efficient glucose oxidation and mitochondrial respiration.

    • Leandro Z. Agudelo
    • , Duarte M. S. Ferreira
    • , Shamim Dadvar
    • , Igor Cervenka
    • , Lars Ketscher
    • , Manizheh Izadi
    • , Liu Zhengye
    • , Regula Furrer
    • , Christoph Handschin
    • , Tomas Venckunas
    • , Marius Brazaitis
    • , Sigitas Kamandulis
    • , Johanna T. Lanner
    •  & Jorge L. Ruas
  • Article | | open

    Future energy demand maybe induced by climate change and subject to uncertainties arising from different extent of climate change and socioeconomic development. Here the authors follow a top-down approach and combined the recently developed socio-economic and climate scenarios and found that across 210 scenarios, moderate warming increases global climate-exposed energy demand before adaptation by 25–58% between 2010 and 2050.

    • Bas J. van Ruijven
    • , Enrica De Cian
    •  & Ian Sue Wing
  • Article | | open

    The role of gene expression noise in the evolution of drug resistance in mammalian cells is unclear. Here, by uncoupling noise from mean expression of a drug resistance gene in CHO cells the authors show that noisy expression aids adaptation to high drug levels, but delays it at low drug levels.

    • Kevin S. Farquhar
    • , Daniel A. Charlebois
    • , Mariola Szenk
    • , Joseph Cohen
    • , Dmitry Nevozhay
    •  & Gábor Balázsi
  • Article | | open

    Two-dimensional electron systems in oxide heterostructures have complex interactions that, once well understood, are expected to result in a powerful platform for electronic devices. Luo et al. show how near-field optical microscopy can perform high-resolution imaging of conducting regions in LaAlO3/SrTiO3 interfaces.

    • Weiwei Luo
    • , Margherita Boselli
    • , Jean-Marie Poumirol
    • , Ivan Ardizzone
    • , Jérémie Teyssier
    • , Dirk van der Marel
    • , Stefano Gariglio
    • , Jean-Marc Triscone
    •  & Alexey B. Kuzmenko
  • Article | | open

    Existing methods for protein polymer engineering suffer from low efficiency especially for synthesis large size polyproteins. Here, Deng et al. construct homo-polymer and co-polymer up to decamer by stepwise ligation and cleavage validated by atomic force microscopy-based single-molecule force spectroscopy.

    • Yibing Deng
    • , Tao Wu
    • , Mengdi Wang
    • , Shengchao Shi
    • , Guodong Yuan
    • , Xi Li
    • , Hanchung Chong
    • , Bin Wu
    •  & Peng Zheng
  • Article | | open

    Dental caries and periodontitis are among the most common medical conditions. Here, the authors report a GWAS for measures of oral health that reveals 47 risk loci for caries, find genetic correlation with 31 other complex traits and use Mendelian randomization analyses to explore potential causal relationships.

    • Dmitry Shungin
    • , Simon Haworth
    • , Kimon Divaris
    • , Cary S. Agler
    • , Yoichiro Kamatani
    • , Myoung Keun Lee
    • , Kelsey Grinde
    • , George Hindy
    • , Viivi Alaraudanjoki
    • , Paula Pesonen
    • , Alexander Teumer
    • , Birte Holtfreter
    • , Saori Sakaue
    • , Jun Hirata
    • , Yau-Hua Yu
    • , Paul M. Ridker
    • , Franco Giulianini
    • , Daniel I. Chasman
    • , Patrik K. E. Magnusson
    • , Takeaki Sudo
    • , Yukinori Okada
    • , Uwe Völker
    • , Thomas Kocher
    • , Vuokko Anttonen
    • , Marja-Liisa Laitala
    • , Marju Orho-Melander
    • , Tamar Sofer
    • , John R. Shaffer
    • , Alexandre Vieira
    • , Mary L. Marazita
    • , Michiaki Kubo
    • , Yasushi Furuichi
    • , Kari E. North
    • , Steve Offenbacher
    • , Erik Ingelsson
    • , Paul W. Franks
    • , Nicholas J. Timpson
    •  & Ingegerd Johansson
  • Article | | open

    The hippocampus represents an allocentric map of space, however, motor movements used for navigation are defined in an egocentric framework. Here, the authors report that dorsomedial striatal neurons exhibit an egocentric representation of the boundaries in the environment.

    • James R. Hinman
    • , G. William Chapman
    •  & Michael E. Hasselmo
  • Article | | open

    Antibodies are generated through remote genomic interactions involving immunoglobulin variable (VH), diversity (DH) and joining (JH) gene segments. Here the authors develop a strategy to track VH-DHJH motion in B-lymphocytes and provide evidence that chromosome organisation near the sol-gel phase transition dictates the timing of genomic interactions to orchestrate gene expression and somatic recombination.

    • Nimish Khanna
    • , Yaojun Zhang
    • , Joseph S. Lucas
    • , Olga K. Dudko
    •  & Cornelis Murre
  • Article | | open

    Acinetobacter baumannii is generally considered an opportunistic pathogen. Here, Di Venanzio et al. develop a mouse model of catheter-associated urinary tract infection and show that a plasmid confers niche specificity to an A. baumannii urinary isolate by regulating the expression of chromosomal genes.

    • Gisela Di Venanzio
    • , Ana L. Flores-Mireles
    • , Juan J. Calix
    • , M. Florencia Haurat
    • , Nichollas E. Scott
    • , Lauren D. Palmer
    • , Robert F. Potter
    • , Michael E. Hibbing
    • , Laura Friedman
    • , Bin Wang
    • , Gautam Dantas
    • , Eric P. Skaar
    • , Scott J. Hultgren
    •  & Mario F. Feldman
  • Article | | open

    Anaplastic thyroid cancer (ATC) and advanced differentiated thyroid cancers (DTCs) come with a dismal prognosis. Here, Yoo and colleagues reveal the genomic and transcriptomic landscape of ATC and DTC, highlighting potential therapeutic vulnerabilities.

    • Seong-Keun Yoo
    • , Young Shin Song
    • , Eun Kyung Lee
    • , Jinha Hwang
    • , Hwan Hee Kim
    • , Gyeongseo Jung
    • , Young A Kim
    • , Su-jin Kim
    • , Sun Wook Cho
    • , Jae-Kyung Won
    • , Eun-Jae Chung
    • , Jong-Yeon Shin
    • , Kyu Eun Lee
    • , Jong-Il Kim
    • , Young Joo Park
    •  & Jeong-Sun Seo
  • Article | | open

    The genetic and pathogenetic basis of heart failure is incompletely understood. Here, the authors present a high-fidelity tissue collection from rapidly preserved failing and non-failing control hearts which are used for eQTL mapping and network analysis, resulting in the prioritization of PPP1R3A as a heart failure gene.

    • Pablo Cordero
    • , Victoria N. Parikh
    • , Elizabeth T. Chin
    • , Ayca Erbilgin
    • , Michael J. Gloudemans
    • , Ching Shang
    • , Yong Huang
    • , Alex C. Chang
    • , Kevin S. Smith
    • , Frederick Dewey
    • , Kathia Zaleta
    • , Michael Morley
    • , Jeff Brandimarto
    • , Nicole Glazer
    • , Daryl Waggott
    • , Aleksandra Pavlovic
    • , Mingming Zhao
    • , Christine S. Moravec
    • , W. H. Wilson Tang
    • , Jamie Skreen
    • , Christine Malloy
    • , Sridhar Hannenhalli
    • , Hongzhe Li
    • , Scott Ritter
    • , Mingyao Li
    • , Daniel Bernstein
    • , Andrew Connolly
    • , Hakon Hakonarson
    • , Aldons J. Lusis
    • , Kenneth B. Margulies
    • , Anna A. Depaoli-Roach
    • , Stephen B. Montgomery
    • , Matthew T. Wheeler
    • , Thomas Cappola
    •  & Euan A. Ashley
  • Article | | open

    G protein-coupled receptors (GPCRs), such as GABAB, can integrate extracellular signals via allosteric interactions within dimers and oligomers. Here authors use crosslinking and identify two transmembrane interfaces in GABAB which undergo a concerted rearrangement upon agonist activation.

    • Li Xue
    • , Qian Sun
    • , Han Zhao
    • , Xavier Rovira
    • , Siyu Gai
    • , Qianwen He
    • , Jean-Philippe Pin
    • , Jianfeng Liu
    •  & Philippe Rondard
  • Article | | open

    The superconducting proximity effect on the surface state of a topological insulator is promising to generate topological superconductivity. Here, Yasuda et al. reported enhanced nonreciprocal charge transport in a Bi2Te3/FeTe heterostructure with an emerging superconducting order parameter.

    • Kenji Yasuda
    • , Hironori Yasuda
    • , Tian Liang
    • , Ryutaro Yoshimi
    • , Atsushi Tsukazaki
    • , Kei S. Takahashi
    • , Naoto Nagaosa
    • , Masashi Kawasaki
    •  & Yoshinori Tokura
  • Article | | open

    Chlamydia trachomatis forms membrane-bound inclusions inside the host cell that are decorated with IncA, a SNARE-like protein that promotes the fusion of inclusions. Here, Cingolani et al. show that the protein folds into a non-canonical four-helix bundle and identify an intramolecular clamp required for membrane fusion.

    • Gino Cingolani
    • , Michael McCauley
    • , Anna Lobley
    • , Alexander J. Bryer
    • , Jordan Wesolowski
    • , Deanna L. Greco
    • , Ravi K. Lokareddy
    • , Erik Ronzone
    • , Juan R. Perilla
    •  & Fabienne Paumet
  • Article | | open

    Lugdunin is a peptide antibiotic produced by the skin commensal Staphylococcus lugdunensis. Here, the authors show that lugdunin reduces Staphylococcus aureus colonization in human keratinocytes and mouse skin by inducing the expression of human LL-37 and recruitment of monocytes and neutrophils.

    • Katharina Bitschar
    • , Birgit Sauer
    • , Jule Focken
    • , Hanna Dehmer
    • , Sonja Moos
    • , Martin Konnerth
    • , Nadine A. Schilling
    • , Stephanie Grond
    • , Hubert Kalbacher
    • , Florian C. Kurschus
    • , Friedrich Götz
    • , Bernhard Krismer
    • , Andreas Peschel
    •  & Birgit Schittek
  • Article | | open

    The understanding of relaxor ferroelectrics is hindered by the complexity of nanoscale perturbations of their structure. Here, a data set of independent techniques treated on common footing provides a multiscale description of atomic order which reconciles conflicting models derived from single methods.

    • M. Eremenko
    • , V. Krayzman
    • , A. Bosak
    • , H. Y. Playford
    • , K. W. Chapman
    • , J. C. Woicik
    • , B. Ravel
    •  & I. Levin
  • Article | | open

    Continuous real-time measurement of biomarker levels in body fluids offers many exciting possibilities. Here, the authors develop an integrated wearable droplet microfluidic sensor that combines continuous sampling of tissue fluid with in situ analysis using wet-chemical assays.

    • Adrian M. Nightingale
    • , Chi Leng Leong
    • , Rachel A. Burnish
    • , Sammer-ul Hassan
    • , Yu Zhang
    • , Geraldine F. Clough
    • , Martyn G. Boutelle
    • , David Voegeli
    •  & Xize Niu
  • Article | | open

    Light emitters can be induced in transition metal dichalcogenides by defect engineering, but challenges remain in their controlled spatial positioning. Here, the authors irradiate monolayer MoS2 with a sub-nm focused helium ion beam to deterministically create defects, and obtain spectrally narrow emission lines that produce photons in the visible spectral range

    • J. Klein
    • , M. Lorke
    • , M. Florian
    • , F. Sigger
    • , L. Sigl
    • , S. Rey
    • , J. Wierzbowski
    • , J. Cerne
    • , K. Müller
    • , E. Mitterreiter
    • , P. Zimmermann
    • , T. Taniguchi
    • , K. Watanabe
    • , U. Wurstbauer
    • , M. Kaniber
    • , M. Knap
    • , R. Schmidt
    • , J. J. Finley
    •  & A. W. Holleitner
  • Article | | open

    Intense electromagnetic impulses induced by Jupiter’s lightning can produce both low-frequency dispersed whistler emissions and non-dispersed radio pulses. Here, the authors show Jupiter dispersed pulses associated with Jovian lightning that are evidence of low density holes in Jupiter’s ionosphere.

    • Masafumi Imai
    • , Ivana Kolmašová
    • , William S. Kurth
    • , Ondřej Santolík
    • , George B. Hospodarsky
    • , Donald A. Gurnett
    • , Shannon T. Brown
    • , Scott J. Bolton
    • , John E. P. Connerney
    •  & Steven M. Levin
  • Article | | open

    Flight loss has occurred numerous times in bird evolution. Here, the authors examine convergent sites in the exonic and intronic sequences of 48 bird genomes, finding amino-acid changes in two genes, ATGL and ACOT7, with potential implications for a change in metabolism rather than anatomy.

    • Shengkai Pan
    • , Yi Lin
    • , Qiong Liu
    • , Jinzhi Duan
    • , Zhenzhen Lin
    • , Yusong Wang
    • , Xueli Wang
    • , Sin Man Lam
    • , Zhen Zou
    • , Guanghou Shui
    • , Yu Zhang
    • , Zhengwang Zhang
    •  & Xiangjiang Zhan
  • Article | | open

    Characterizing host-pathogen protein interactions can help elucidate the molecular basis of bacterial infections. Here, the authors use an integrative proteomics approach to generate a quantitative map of protein interactions between Streptococcus pyogenes and human saliva and plasma.

    • Lotta Happonen
    • , Simon Hauri
    • , Gabriel Svensson Birkedal
    • , Christofer Karlsson
    • , Therese de Neergaard
    • , Hamed Khakzad
    • , Pontus Nordenfelt
    • , Mats Wikström
    • , Magdalena Wisniewska
    • , Lars Björck
    • , Lars Malmström
    •  & Johan Malmström
  • Article | | open

    The understanding of how superconductivity emerges from a complex normal state remains elusive in unconventional superconductors. Here, Pelc et al. report exponential temperature dependence of the diamagnetic response in the normal state with a characteristic temperature scale, universally existing in three classes of oxide superconductors.

    • D. Pelc
    • , Z. Anderson
    • , B. Yu
    • , C. Leighton
    •  & M. Greven
  • Article | | open

    The dynamics of HIV-1 DNA sequences early after HIV-1 transmission remains poorly characterized. Here, the authors perform a longitudinal evaluation of HIV-1 DNA sequences in subtype C-infected individuals during acute infection, providing a landscape of the nature and evolution of the very early viral genome.

    • Guinevere Q. Lee
    • , Kavidha Reddy
    • , Kevin B. Einkauf
    • , Kamini Gounder
    • , Joshua M. Chevalier
    • , Krista L. Dong
    • , Bruce D. Walker
    • , Xu G. Yu
    • , Thumbi Ndung’u
    •  & Mathias Lichterfeld
  • Article | | open

    Thioredoxin reductase (TrxR) plays a crucial part in regulating cellular redox homeostasis. Here, the authors developed a fluorescent probe composed of a five-membered disulphide, a coumarin fluorophore and a urea linker that detects TrxR activity with fast response and high selectivity.

    • Xinming Li
    • , Baoxin Zhang
    • , Chaoxian Yan
    • , Jin Li
    • , Song Wang
    • , Xiangxu Wei
    • , Xiaoyan Jiang
    • , Panpan Zhou
    •  & Jianguo Fang
  • Article | | open

    Immature excitatory neurons in the human amygdala persist throughout life and could be a substrate for plasticity. Here the authors find evidence that the maturation of these cells may be accelerated during puberty.

    • Shawn F. Sorrells
    • , Mercedes F. Paredes
    • , Dmitry Velmeshev
    • , Vicente Herranz-Pérez
    • , Kadellyn Sandoval
    • , Simone Mayer
    • , Edward F. Chang
    • , Ricardo Insausti
    • , Arnold R. Kriegstein
    • , John L. Rubenstein
    • , Jose Manuel Garcia-Verdugo
    • , Eric J. Huang
    •  & Arturo Alvarez-Buylla
  • Article | | open

    Developing planar phononic circuits analogous to photonic circuits are of interest to provide scalable advantages and complex manipulation of phonons. Here, the authors realize a phononic integrated circuit with a Gallium Nitride-on-sapphire platform, which provides strong confinement and control of phonons.

    • Wei Fu
    • , Zhen Shen
    • , Yuntao Xu
    • , Chang-Ling Zou
    • , Risheng Cheng
    • , Xu Han
    •  & Hong X. Tang
  • Article | | open

    Antibiotics targeting cell wall synthesis display an unexplained gap between in vivo efficacy and in vitro binding affinity for their target. Here, Piepenbreier et al. develop a model for bacterial cell wall biosynthesis, show how it is affected by antibiotics, and use it to predict in vivo efficacy of antibiotics.

    • Hannah Piepenbreier
    • , Angelika Diehl
    •  & Georg Fritz
  • Article | | open

    Hydrogel emulsions enable facile loading of bioactive compounds but fabrication methods which allow upscaling and low cytotoxicity are scarce. Here, the authors report a thermally triggered low energy gelation mechanism based on the interaction between a nontoxic Pluronic and nanoemulsion droplets.

    • Seyed Meysam Hashemnejad
    • , Abu Zayed Md Badruddoza
    • , Brady Zarket
    • , Carlos Ricardo Castaneda
    •  & Patrick S. Doyle
  • Article | | open

    The biogenesis of eukaryotic ribosomes is a multi-step process involving the action of more than 200 different ribosome assembly factors. Here the authors show that Rps20 acts as a conduit to coordinate maturation steps across the head domain of the nascent small ribosomal subunit.

    • Valentin Mitterer
    • , Ramtin Shayan
    • , Sébastien Ferreira-Cerca
    • , Guillaume Murat
    • , Tanja Enne
    • , Dana Rinaldi
    • , Sarah Weigl
    • , Hajrija Omanic
    • , Pierre-Emmanuel Gleizes
    • , Dieter Kressler
    • , Celia Plisson-Chastang
    •  & Brigitte Pertschy
  • Article | | open

    Composition and function of immune populations at barrier surfaces is crucial for response to infection. Here, the authors identify a population of dendritic cells in human epidermis, abundant in anogenital epithelia and distinct from Langerhans cells by surface phenotype and by high capacity for HIV infection and transmission.

    • Kirstie M. Bertram
    • , Rachel A. Botting
    • , Heeva Baharlou
    • , Jake W. Rhodes
    • , Hafsa Rana
    • , J. Dinny Graham
    • , Ellis Patrick
    • , James Fletcher
    • , Toby M. Plasto
    • , Naomi R. Truong
    • , Caroline Royle
    • , Chloe M. Doyle
    • , Orion Tong
    • , Najla Nasr
    • , Laith Barnouti
    • , Mark P. Kohout
    • , Andrew J. Brooks
    • , Michael P. Wines
    • , Peter Haertsch
    • , Jake Lim
    • , Martijn P. Gosselink
    • , Grahame Ctercteko
    • , Jacob D. Estes
    • , Melissa J. Churchill
    • , Paul U. Cameron
    • , Eric Hunter
    • , Muzlifah A. Haniffa
    • , Anthony L. Cunningham
    •  & Andrew N. Harman
  • Article | | open

    Volume electron microscopy data of brain tissue can tell us much about neural circuits, but increasingly large data sets demand automation of analysis. Here, the authors introduce cellular morphology neural networks and successfully automate a range of morphological analysis tasks.

    • Philipp J. Schubert
    • , Sven Dorkenwald
    • , Michał Januszewski
    • , Viren Jain
    •  & Joergen Kornfeld
  • Article | | open

    Mast cells within the tumor microenvironment have controversial roles. Here, the authors show, using genetic mouse models, that in gastric cancer, mast cells at the periphery of the tumors are activated via cancer cell produced-IL33 and promote tumorigenesis by recruiting macrophages within the tumors.

    • Moritz F. Eissmann
    • , Christine Dijkstra
    • , Andrew Jarnicki
    • , Toby Phesse
    • , Jamina Brunnberg
    • , Ashleigh R. Poh
    • , Nima Etemadi
    • , Evelyn Tsantikos
    • , Stefan Thiem
    • , Nicholas D. Huntington
    • , Margaret L. Hibbs
    • , Alex Boussioutas
    • , Michele A. Grimbaldeston
    • , Michael Buchert
    • , Robert J. J. O’Donoghue
    • , Frederick Masson
    •  & Matthias Ernst
  • Perspective | | open

    There are several lines of evidence for interactions between the two membrane leaflets in cells. In this review the authors discuss the transmembrane coupling of lipids, the involvement of phosphatidyl serine species PS 18:0/18:1, and their importance for various cellular processes.

    • Tore Skotland
    •  & Kirsten Sandvig