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  • Negative emission technologies are central to avoiding catastrophic climate change. Deploying engineered solutions such as direct air capture requires a policy sequencing strategy that focuses on “incentives + mandates” in early adopters, while creating positive spillovers that incentivize follower countries to take policy action.

    • Jonas Meckling
    • Eric Biber
    Perspective Open Access
  • Endocrine therapy has been the mainstay for hormone responsive breast cancer treatment. Here, Garcia-Martinez and colleagues discuss epigenetic mechanisms regulating ER + breast cancer and endocrine therapy resistance, and highlight approaches to rewire the cancer epigenome to improve targeted therapies for this cancer.

    • Liliana Garcia-Martinez
    • Yusheng Zhang
    • Lluis Morey
    Perspective Open Access
  • Current developments in synthetic biology are not immediately applicable outside of the controlled laboratory environment. In this Perspective, the authors outline the advances and challenges the field faces in operating in resource limited and off-the-grid scenarios.

    • Sierra M. Brooks
    • Hal S. Alper
    Perspective Open Access
  • Pain management is an extremely important topic both medically and socio-economically. Here the authors offer an overview of the use of degrading polymeric materials for delivery of pharmaceutical agents for pain management and offer a perspective of the future directions of the field.

    • Natasha C. Brigham
    • Ru-Rong Ji
    • Matthew L. Becker
    Perspective Open Access
  • Enantioselective functionalization of ubiquitous C(sp3)–H bonds via radical species has witnessed a renaissance in the past years. Here, the authors summarize the main achievements in the field by identifying two main reaction pathways determining the stereochemistry and give an outlook on future challenges and opportunities.

    • Chi Zhang
    • Zhong-Liang Li
    • Xin-Yuan Liu
    Perspective Open Access
  • Synthetic biology engineering principles enable two-way communication between living and inanimate substrates. Here the authors consider the development of this bio-informational exchange and propose cyber-physical architectures and applications.

    • Thomas A. Dixon
    • Thomas C. Williams
    • Isak S. Pretorius
    Perspective Open Access
  • Ketamine is associated with rapid antidepressant effects and temporary dissociative experiences, and this review examines whether these dissociative symptoms are necessary for antidepressant efficacy. Although the current literature does not support this relationship, further work is needed to explore possible associations at the molecular, biomarker, and psychological levels.

    • Elizabeth D. Ballard
    • Carlos A. Zarate Jr.
    Perspective Open Access
  • A key security challenge with biosecurity threats is determining the responsible actor. In this Perspective, the authors review recent developments in using genetic sequence to assign a lab-of-origin and the potential protection it provides against misuse of synthetic biology.

    • Gregory Lewis
    • Jacob L. Jordan
    • Thomas V. Inglesby
    Perspective Open Access
  • Many fluid biomarker findings have had low reproducibility despite initially promising results. Here, the authors review possible sources for low reproducibility of studies on fluid biomarkers for neurodegenerative diseases and suggest guidelines for the biomarker community to agree on and implement.

    • Niklas Mattsson-Carlgren
    • Sebastian Palmqvist
    • Oskar Hansson
    Perspective Open Access
  • Advances in our ability to manipulate genetics leads to deeper understanding of biological systems. In this Perspective, the authors argue that synthetic genomics facilitates complex modifications that open up new areas of research.

    • Alessandro L. V. Coradini
    • Cara B. Hull
    • Ian M. Ehrenreich
    Perspective Open Access
  • The IMEx consortium provides one of the largest resources of curated, experimentally verified molecular interaction data. Here, the authors review how IMEx evolved into a fundamental resource for life scientists and describe how IMEx data can support biomedical research.

    • Pablo Porras
    • Elisabet Barrera
    • Sandra Orchard
    Perspective Open Access
  • Marine aquaculture is widely proposed as compatible with ocean sustainability, biodiversity conservation, and human nutrition goals. In this Perspective, Belton and colleagues dispute the empirical validity of such claims and contend that the potential of marine aquaculture has been much exaggerated.

    • Ben Belton
    • David C. Little
    • Shakuntala H. Thilsted
    Perspective Open Access
  • Marine microbial activities fuel biogeochemical cycles that impact the climate, but global models do not account for the myriad physiological processes that microbes perform. Here the authors argue for a model framework that reinterprets the ocean as physics coupled to biologically-driven redox chemistry.

    • Emily J. Zakem
    • Martin F. Polz
    • Michael J. Follows
    Perspective Open Access
  • Discovering a sustainable route to ammonia as a fertiliser and as an energy carrier is critically important, but many recent reports on the electrochemical nitrogen reduction are false positives. Here the authors uncover the emerging experimental traps and detail protocols to reliably avoid them.

    • Jaecheol Choi
    • Bryan H. R. Suryanto
    • Alexandr N. Simonov
    Perspective Open Access
  • The accurate representation of data is essential in science communication, however, colour maps that visually distort data through uneven colour gradients or are unreadable to those with colour vision deficiency remain prevalent. Here, the authors present a simple guide for the scientific use of colour and highlight ways for the scientific community to identify and prevent the misuse of colour in science.

    • Fabio Crameri
    • Grace E. Shephard
    • Philip J. Heron
    Perspective Open Access
  • Oncogenic signalling has been historically associated with sustained cancer cell-intrinsic proliferation, however its role in promoting tumour immunoresistance has also become evident. Here, Hamarsheh and colleagues review and discuss the preclinical work on the immune modulatory effects of oncogenic KRAS and the potential clinical application.

    • Shaima’a Hamarsheh
    • Olaf Groß
    • Robert Zeiser
    Perspective Open Access