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  • Progress in treatment for glioblastoma is hindered by the blood-brain barrier (BBB). In genetic mouse models recapitulating brain invasion and abnormal angiogenesis of human glioblastoma, Cai and colleagues demonstrate that optical modulation of the BBB with nanoparticles boosts intratumoural chemotherapy concentration, prolonging survival. We discuss prospects for clinical translation of exemplary innovative techniques.

    • Imran Noorani
    • Jorge de la Rosa
    CommentOpen Access
  • WHO guidelines for classification of malaria elimination in a country require that the risk of human infection from zoonotic, as well as nonzoonotic, malaria parasites is negligible. In this Comment, the authors discuss the implications of this policy for countries, such as Malaysia, with no recent reported nonzoonotic cases but ongoing zoonotic transmission.

    • Kimberly M. Fornace
    • Chris J. Drakeley
    • Kamruddin Ahmed
    CommentOpen Access
  • Rapid Arctic warming may increase erosion and stream channel formation, which alters the flux of sediments, carbon, and nutrients in these sensitive ecosystems. Yet, understanding landscape change is hampered by a lack of predictive tools applicable to permafrost settings.

    • Joel C. Rowland
    CommentOpen Access
  • Adopting standardized and reliable methodologies to accurately measure particle removal efficiency when developing fibrous materials for controlling airborne contamination is crucial. Here, the authors recommend best practices for experimental assessments and reporting to ensure a reliable evaluation of new airborne particle filtration media and technologies.

    • Paolo Tronville
    • Vincenzo Gentile
    • Jesus Marval
    CommentOpen Access
  • Molecular chaperones establish essential protein-protein interaction networks. Modified versions of these assemblies are generally enriched in certain maladies. A study published in Nature Communications used epichaperomics to identify unique changes occurring in chaperone-formed protein networks during mitosis in cancer cells.

    • Mark R. Woodford
    • Dimitra Bourboulia
    • Mehdi Mollapour
    CommentOpen Access
  • The current gap between computing algorithms and neuromorphic hardware to emulate brains is an outstanding bottleneck in developing neural computing technologies. Aimone and Parekh discuss the possibility of bridging this gap using theoretical computing frameworks from a neuroscience perspective.

    • James B. Aimone
    • Ojas Parekh
    CommentOpen Access
  • The response of aquatic and terrestrial organisms to climate change can depend on biological sex. A key challenge is to unravel the interactive effects of sex and climate change at the individual and population levels and the cascading effects on communities. This new understanding is essential to improve climate adaptation and mitigation strategies.

    • Elena Gissi
    • Londa Schiebinger
    • Fiorenza Micheli
    CommentOpen Access
  • Urea, a crucial nitrogen fertilizer, plays a vital role in meeting global food demand. However, its current production method is energy-intensive and environmentally unfriendly. In this commentary article, the authors propose strategies to address and overcome these challenges.

    • Jie Ding
    • Runping Ye
    • Maohong Fan
    CommentOpen Access
  • Resveratrol (REV) is a natural polyphenol with anti-obesity effects. However, the mechanisms remain unclear due to its low bioavailability and the lack of defined membrane-bound or nuclear receptors. Pang and colleagues reported that REV intervention (REV-I) alters gut microbiota and bile acid profile, leading to the inhibition of farnesoid X receptor (FXR) and attenuation of scavenger receptor class B type 1 (SR-B1)-mediated chylomicron secretion. This highlights a therapeutic potential of targeting gut microbiome and intestinal SR-B1 for obesity and diabetes treatment.

    • Eryun Zhang
    • Alon Agua
    • Wendong Huang
    CommentOpen Access
  • Protein lysine methylation plays important biological roles but its experimental characterization is limited by the lack of suitable mimetics of methylated and unmethylated lysine among the natural amino acids. Here, we summarize the consequent challenges and discuss alternative approaches for biochemical and cellular lysine methylation studies.

    • Sara Weirich
    • Albert Jeltsch
    CommentOpen Access
  • A new study sheds light on the impact of bimetallic interfaces in nanomaterials for heat generation using single-particle thermometry. Moving from nanoparticle ensembles to single particles is key to developing consistent knowledge of material performance and nanoscale processes, but also involves assumptions and definitions that require careful consideration.

    • Marta Quintanilla
    CommentOpen Access
  • Topological electronics is an emerging field aiming at exploiting the topological properties of matter in devices with extended functionalities. Recent experiments demonstrate a topological current divider, a key circuit element for this emerging technology.

    • Francesco Romeo
    • Antonio Di Bartolomeo
    CommentOpen Access
  • Here, we provide a brief overview of the approaches and strategies underlying bacteria-based cancer immunotherapy (BCiT). We also describe and summarize research in the field of synthetic biology, which aims to regulate bacterial growth and gene expression for immunotherapeutic use. Finally, we discuss the current clinical status and limitations of BCiT.

    • Dinh-Huy Nguyen
    • Ari Chong
    • Jung-Joon Min
    CommentOpen Access
  • Whole genome sequencing has enabled new insights into the genetic architecture of complex traits, especially through access to low-frequency and rare variation. This Comment highlights the key contributions from this technology and discusses considerations for its use and future perspectives.

    • Ozvan Bocher
    • Cristen J. Willer
    • Eleftheria Zeggini
    CommentOpen Access
  • While over 99% of coastal arctic rivers drain small catchments, future projections of land-ocean fluxes are based on data from large rivers. We encourage inclusion of and increased focus on smaller catchments to support representative assessments of arctic ecosystem change.

    • J. E. Vonk
    • N. J. Speetjens
    • A. E. Poste
    CommentOpen Access
  • In this Comment, the authors discuss the current status, the challenges, and potential technological impact of exciton transport in transition metal dichalcogenide (TMD) monolayers, lateral and vertical heterostructures as well as moiré excitons in twisted TMD heterostacks.

    • Ermin Malic
    • Raül Perea-Causin
    • Samuel Brem
    CommentOpen Access
  • The Tara Pacific program and expedition focused on coral reefs across the Pacific Ocean and used a coordinated sampling effort to address questions at multiple scales using a common suite of samples. Here, we highlight some of the Tara Pacific achievements, discussing the benefits of long-duration sea expeditions for investigating a wide array of research questions within a selected ecosystem.

    • Serge Planes
    • Denis Allemand
    CommentOpen Access
  • The samples returned from near-Earth asteroid (162173) Ryugu provide a pristine record of the 4.6 billion years since the birth of the Solar System. The Hayabusa2 initial analysis team has integrated a range of analytical techniques to investigate Ryugu’s organic chemistry. Here, we highlight their latest findings, the potential questions which may be answered, and provide an overview of new prospects in the decade to come.

    • Yasuhiro Oba
    • Yoshinori Takano
    • Hiroshi Naraoka
    CommentOpen Access