Articles

  • Article | | open

    ATAC-seq is widely used to identify regulatory regions in the genome. Here the authors develop a simple and robust plate-based single-cell ATAC-seq method that works in fresh and cryopreserved cells.

    • Xi Chen
    • , Ricardo J. Miragaia
    • , Kedar Nath Natarajan
    •  & Sarah A. Teichmann
  • Article | | open

    It is unclear if multiple sclerosis (MS) genetic susceptibility can be mediated through perturbations of CNS-intrinsic pathways. Authors show that the rs7665090 risk variant is associated with astrocyte responses that enhance lymphocyte recruitment, and with increased lymphocyte infiltration and lesion sizes in MS lesions.

    • Gerald Ponath
    • , Matthew R. Lincoln
    • , Maya Levine-Ritterman
    • , Calvin Park
    • , Somiah Dahlawi
    • , Mayyan Mubarak
    • , Tomokazu Sumida
    • , Laura Airas
    • , Shun Zhang
    • , Cigdem Isitan
    • , Thanh D. Nguyen
    • , Cedric S. Raine
    • , David A. Hafler
    •  & David Pitt
  • Article | | open

    Human embryonic stem cells can be differentiated in vitro into primordial germ cell-like cells (PGCLCs) that resemble early primordial germ cells (PGCs). Here the authors transplant PGCLCs generated from rhesus macaque iPSCs into mouse and rhesus macaque seminiferous tubules, which matures these into late PGCs and spermatogonia-like cells.

    • Enrique Sosa
    • , Di Chen
    • , Ernesto J. Rojas
    • , Jon D. Hennebold
    • , Karen A. Peters
    • , Zhuang Wu
    • , Truong N. Lam
    • , Jennifer M. Mitchell
    • , Meena Sukhwani
    • , Ramesh C. Tailor
    • , Marvin L. Meistrich
    • , Kyle E. Orwig
    • , Gunapala Shetty
    •  & Amander T. Clark
  • Article | | open

    Developing new technologies for the neuromodulation of the vagus nerve can enable therapeutic strategies for body weight control in obese patients. Here, the authors present a battery-free self-powered implantable vagus nerve stimulation system that electrically responds to stomach movement.

    • Guang Yao
    • , Lei Kang
    • , Jun Li
    • , Yin Long
    • , Hao Wei
    • , Carolina A. Ferreira
    • , Justin J. Jeffery
    • , Yuan Lin
    • , Weibo Cai
    •  & Xudong Wang
  • Article | | open

    The cell polarity regulator aPKC is associated with cell proliferation but the precise mechanism are unknown. Here, the authors find that aPKC lambda phosphorylates the FoxO1 transcription factor, a gatekeeper of endothelial growth, during both angiogenesis and angiosarcomas.

    • Meghan Riddell
    • , Akiko Nakayama
    • , Takao Hikita
    • , Fatemeh Mirzapourshafiyi
    • , Takuji Kawamura
    • , Ayesha Pasha
    • , Mengnan Li
    • , Mikio Masuzawa
    • , Mario Looso
    • , Tim Steinbacher
    • , Klaus Ebnet
    • , Michael Potente
    • , Tomonori Hirose
    • , Shigeo Ohno
    • , Ingrid Fleming
    • , Stefan Gattenlöhner
    • , Phyu P. Aung
    • , Thuy Phung
    • , Osamu Yamasaki
    • , Teruki Yanagi
    • , Hiroshi Umemura
    •  & Masanori Nakayama
  • Article | | open

    Mutations in nucleotide-binding oligomerization domain protein 12 (NLRP12) are known to effect inflammatory processes. Here the authors show that NLRP12-mediated proteasomal degradation of NOD2 in monocytes promotes bacterial tolerance and colonisation in a model of enteric infection.

    • Sylvain Normand
    • , Nadine Waldschmitt
    • , Andreas Neerincx
    • , Ruben Julio Martinez-Torres
    • , Camille Chauvin
    • , Aurélie Couturier-Maillard
    • , Olivier Boulard
    • , Laetitia Cobret
    • , Fawaz Awad
    • , Ludovic Huot
    • , Andre Ribeiro-Ribeiro
    • , Katja Lautz
    • , Richard Ruez
    • , Myriam Delacre
    • , Clovis Bondu
    • , Martin Guilliams
    • , Charlotte Scott
    • , Anthony Segal
    • , Serge Amselem
    • , David Hot
    • , Sonia Karabina
    • , Erwin Bohn
    • , Bernhard Ryffel
    • , Lionel F. Poulin
    • , Thomas A. Kufer
    •  & Mathias Chamaillard
  • Article | | open

    Water-based semiconducting polymer nanoparticles are eco-friendly and non-toxic but their performance suffers from the surfactants. Here Xie et al. design an approach to minimize the amount of residual surfactant in these nanoparticles and make high-efficiency and stability solar cells.

    • Chen Xie
    • , Thomas Heumüller
    • , Wolfgang Gruber
    • , Xiaofeng Tang
    • , Andrej Classen
    • , Isabel Schuldes
    • , Matthew Bidwell
    • , Andreas Späth
    • , Rainer H. Fink
    • , Tobias Unruh
    • , Iain McCulloch
    • , Ning Li
    •  & Christoph J. Brabec
  • Article | | open

    The authors present a molecular approach and a software suite for high-throughput sequencing and characterization of microbial tRNA transcripts, which provide unique physiological insights into complex environmental microbes.

    • Michael H. Schwartz
    • , Haipeng Wang
    • , Jessica N. Pan
    • , Wesley C. Clark
    • , Steven Cui
    • , Matthew J. Eckwahl
    • , David W. Pan
    • , Marc Parisien
    • , Sarah M. Owens
    • , Brian L. Cheng
    • , Kristina Martinez
    • , Jinbo Xu
    • , Eugene B. Chang
    • , Tao Pan
    •  & A. Murat Eren
  • Article | | open

    Candida auris is an emergent fungal pathogen that is resistant to multiple antifungals. Here, Muñoz et al. analyse genomic sequences for isolates from each of the four major C. auris clades and for three related species, and identify genetic features associated with virulence, antifungal resistance and mating.

    • José F. Muñoz
    • , Lalitha Gade
    • , Nancy A. Chow
    • , Vladimir N. Loparev
    • , Phalasy Juieng
    • , Elizabeth L. Berkow
    • , Rhys A. Farrer
    • , Anastasia P. Litvintseva
    •  & Christina A. Cuomo
  • Article | | open

    ATR kinase is a key regulator of chromosome integrity. Here the authors by analysing the phenotype of a mouse model expressing a kinase-dead ATR, reveal the effect of ATR inhibition compared to ATR loss and its consequences for meiosis, DNA replication, checkpoint activation and genome instability .

    • Demis Menolfi
    • , Wenxia Jiang
    • , Brian J. Lee
    • , Tatiana Moiseeva
    • , Zhengping Shao
    • , Verna Estes
    • , Mark G. Frattini
    • , Christopher J. Bakkenist
    •  & Shan Zha
  • Article | | open

    Invariant natural killer T (iNKT) cells rapidly enhance cytokine secretion and effector function following activation, but the underlying mechanism is still unclear. Here the authors show that an endoplasmic reticulum stress sensor, inositol-requiring enzyme 1α, activates the p38 kinase to stabilize cytokine mRNA for enhanced iNKT functions.

    • Srinath Govindarajan
    • , Djoere Gaublomme
    • , Renée Van der Cruyssen
    • , Eveline Verheugen
    • , Sofie Van Gassen
    • , Yvan Saeys
    • , Simon Tavernier
    • , Takao Iwawaki
    • , Yehudi Bloch
    • , Savvas. N. Savvides
    • , Bart N. Lambrecht
    • , Sophie Janssens
    • , Dirk Elewaut
    •  & Michael B. Drennan
  • Article | | open

    How cells regulate their lysosomal proteolytic capacity is only partly understood. Here, the authors show that lysosomal protease deficiency or substrate overload induces lysosomal stress leading to activation of a STAT3-dependent, TFEB-independent pathway of lysosomal hydrolase expression.

    • Jonathan Martínez-Fábregas
    • , Alan Prescott
    • , Sander van Kasteren
    • , Deena Leslie Pedrioli
    • , Irwin McLean
    • , Anna Moles
    • , Thomas Reinheckel
    • , Valeria Poli
    •  & Colin Watts
  • Article | | open

    BAG3 is a Hsp70 co-chaperone that is highly expressed in muscles. Here the authors show that several myofibrillar myopathy causing BAG3 mutations are not impaired in Hsp70 binding, but rather impair the ADP-ATP exchange step of the Hsp70 cycle, causing the aggregation of BAG3, Hsp70 and Hsp70 clients and leading to a collapse of protein homeostasis.

    • Melanie Meister-Broekema
    • , Rebecca Freilich
    • , Chandhuru Jagadeesan
    • , Jennifer N. Rauch
    • , Rocio Bengoechea
    • , William W. Motley
    • , E. F. Elsiena Kuiper
    • , Melania Minoia
    • , Gabriel V. Furtado
    • , Maria A. W. H. van Waarde
    • , Shawn J. Bird
    • , Adriana Rebelo
    • , Stephan Zuchner
    • , Peter Pytel
    • , Steven S. Scherer
    • , Federica F. Morelli
    • , Serena Carra
    • , Conrad C. Weihl
    • , Steven Bergink
    • , Jason E. Gestwicki
    •  & Harm H. Kampinga
  • Article | | open

    To realize the potential of soft hybrid (inorganic-organic) materials for thermoelectrics, the underlying transport-related physics must be understood. Here, the authors extend the Kang-Synder framework with experimental analysis to gain insight on the thermoelectric transport in hybrid materials.

    • Pawan Kumar
    • , Edmond W. Zaia
    • , Erol Yildirim
    • , D. V. Maheswar Repaka
    • , Shuo-Wang Yang
    • , Jeffrey J. Urban
    •  & Kedar Hippalgaonkar
  • Article | | open

    Sampling strategies may bias tree-ring datasets to not accurately represent the regional response to climate change. Here, Klesse et al. use a new representative dataset to show that the International Tree-Ring Data Bank in the U.S. Southwest overestimates climate sensitivity of forests by 41–59%

    • Stefan Klesse
    • , R. Justin DeRose
    • , Christopher H. Guiterman
    • , Ann M. Lynch
    • , Christopher D. O’Connor
    • , John D. Shaw
    •  & Margaret E. K. Evans
  • Article | | open

    The methylammonium lead halide perovskites have shown excellent optoelectronic properties but the field-effect transistors are much less studied. Here Yu et al. synthesize micrometer-thin crystals of perovskites with low surface contamination and make ambipolar transistor devices with high mobilities.

    • Weili Yu
    • , Feng Li
    • , Liyang Yu
    • , Muhammad R. Niazi
    • , Yuting Zou
    • , Daniel Corzo
    • , Aniruddha Basu
    • , Chun Ma
    • , Sukumar Dey
    • , Max L. Tietze
    • , Ulrich Buttner
    • , Xianbin Wang
    • , Zhihong Wang
    • , Mohamed N. Hedhili
    • , Chunlei Guo
    • , Tom Wu
    •  & Aram Amassian
  • Article | | open

    Similarly to entropy, majorization allows to quantify deviation from uniformity in a wide range of fields. In this paper, the authors use its generalization to the quantum realm to derive a complete set of necessary and sufficient conditions for thermal transformations of quantum states.

    • Gilad Gour
    • , David Jennings
    • , Francesco Buscemi
    • , Runyao Duan
    •  & Iman Marvian
  • Article | | open

    53BP1 is a key player in non-homologous end joining (NHEJ). Here the authors reveal an important role for the multifunctional homodimeric protein hub dynein light chain 1 (DYNLL1) in increasing the efficacy of 53BP1-mediated repair of DNA double-strand breaks (DSBs) by NHEJ.

    • Jordan R. Becker
    • , Raquel Cuella-Martin
    • , Marco Barazas
    • , Rui Liu
    • , Catarina Oliveira
    • , Antony W. Oliver
    • , Kirstin Bilham
    • , Abbey B. Holt
    • , Andrew N. Blackford
    • , Jörg Heierhorst
    • , Jos Jonkers
    • , Sven Rottenberg
    •  & J. Ross Chapman
  • Article | | open

    Regulatory T (Treg) cells need to be differentiated into effector Treg (eTreg), with the transcription factor IRF4 implicated during this process. Here the authors show that an AP-1 family transcription factor, JunB, is expressed in eTreg to promote the IRF4 transcription program, and regulate eTreg homeostasis and function.

    • Shin-ichi Koizumi
    • , Daiki Sasaki
    • , Tsung-Han Hsieh
    • , Naoyuki Taira
    • , Nana Arakaki
    • , Shinichi Yamasaki
    • , Ke Wang
    • , Shukla Sarkar
    • , Hiroki Shirahata
    • , Mio Miyagi
    •  & Hiroki Ishikawa
  • Article | | open

    High expression of Mcl-1 promotes tumorigenesis and resistance to anticancer therapies. Here they report a macrocyclic molecule with high selectivity and affinity for Mcl-1 that exhibits potent anti-tumor effects as single agent and in combination with bortezomib or venetoclax in preclinical models of multiple myeloma and acute myeloid leukemia.

    • Adriana E. Tron
    • , Matthew A. Belmonte
    • , Ammar Adam
    • , Brian M. Aquila
    • , Lawrence H. Boise
    • , Elisabetta Chiarparin
    • , Justin Cidado
    • , Kevin J. Embrey
    • , Eric Gangl
    • , Francis D. Gibbons
    • , Gareth P. Gregory
    • , David Hargreaves
    • , J. Adam Hendricks
    • , Jeffrey W. Johannes
    • , Ricky W. Johnstone
    • , Steven L. Kazmirski
    • , Jason G. Kettle
    • , Michelle L. Lamb
    • , Shannon M. Matulis
    • , Ajay K. Nooka
    • , Martin J. Packer
    • , Bo Peng
    • , Philip B. Rawlins
    • , Daniel W. Robbins
    • , Alwin G. Schuller
    • , Nancy Su
    • , Wenzhan Yang
    • , Qing Ye
    • , Xiaolan Zheng
    • , J. Paul Secrist
    • , Edwin A. Clark
    • , David M. Wilson
    • , Stephen E. Fawell
    •  & Alexander W. Hird
  • Article | | open

    The mechanisms of ZIKV persistence in the male reproductive tract (MRT) are poorly understood. Here, Tsetsarkin et al. applied microRNA-targeting approach to trace routes of ZIKV dissemination in the testis and epididymis and to generate immunogenic live-attenuated ZIKV vaccine candidate, restricted for MRT infection.

    • Konstantin A. Tsetsarkin
    • , Olga A. Maximova
    • , Guangping Liu
    • , Heather Kenney
    • , Natalia Teterina
    • , Marshall E. Bloom
    • , Jeffrey M. Grabowski
    • , Luwanika Mlera
    • , Bianca M. Nagata
    • , Ian Moore
    • , Craig Martens
    • , Emerito Amaro-Carambot
    • , Elaine W. Lamirande
    • , Stephen S. Whitehead
    •  & Alexander G. Pletnev
  • Article | | open

    Power dissipation is usually unavoidable in transistor channels due to the inelastic scattering of electrons. Here, Firdaus et al. propose a nanoscaled silicon electron-aspirator to remove this constraint, which shows enhanced current output by 3 times at 8 K without additional power supply.

    • Himma Firdaus
    • , Tokinobu Watanabe
    • , Masahiro Hori
    • , Daniel Moraru
    • , Yasuo Takahashi
    • , Akira Fujiwara
    •  & Yukinori Ono
  • Article | | open

    Glasses show peculiar relaxation dynamics below glass transition temperature, yet a deeper understanding of this phenomenon is still lacking. Wu et al. show the coexistence of stretched and compressed relaxation in a metallic glass system and attribute their origins to different local cluster structures.

    • Zhen Wei Wu
    • , Walter Kob
    • , Wei-Hua Wang
    •  & Limei Xu
  • Article | | open

    The meiotic telomere complex (MAJIN, TERB1, TERB2) tethers telomere ends to the nuclear envelope. Here the authors present the crystal structure of human MAJIN-TERB2 and combine biophysical approaches and structured illumination microscopy analysis of mouse meiotic chromosomes to characterize the molecular architecture of the wider MAJIN-TERB2-TERB1 complex and its interactions with TRF1.

    • James M. Dunce
    • , Amy E. Milburn
    • , Manickam Gurusaran
    • , Irene da Cruz
    • , Lee T. Sen
    • , Ricardo Benavente
    •  & Owen R. Davies
  • Article | | open

    Copy number variants in the human genome (CNVs) are associated with neurodevelopmental and psychiatric disorders such as schizophrenia and autism. Here the authors investigate how  the large deletion CNV on chromosome 22q11.2 alters chromatin organization.

    • Xianglong Zhang
    • , Ying Zhang
    • , Xiaowei Zhu
    • , Carolin Purmann
    • , Michael S. Haney
    • , Thomas Ward
    • , Arineh Khechaduri
    • , Jie Yao
    • , Sherman M. Weissman
    •  & Alexander E. Urban
  • Article | | open

    Noisy gene expression leading to phenotypic variability can help organisms to survive in changing environments. Here, Patange et al. show that noisy expression of a stress response regulator, RpoS, allows E. coli cells to modulate their growth rates to survive future adverse environments.

    • Om Patange
    • , Christian Schwall
    • , Matt Jones
    • , Casandra Villava
    • , Douglas A. Griffith
    • , Andrew Phillips
    •  & James C. W. Locke
  • Article | | open

    The complement membrane attack complex (MAC) is a lytic immune pore that kills pathogens. Here the authors use cryoEM to provide a structural and biophysical mechanism for how β-pore forming proteins breach the lipid bilayer, providing pathways to explore pore-formation in molecular detail.

    • Anaïs Menny
    • , Marina Serna
    • , Courtney M. Boyd
    • , Scott Gardner
    • , Agnel Praveen Joseph
    • , B. Paul Morgan
    • , Maya Topf
    • , Nicholas J. Brooks
    •  & Doryen Bubeck
  • Article | | open

    Hardware implementation of spiking neural networks holds promise for high energy efficient brain-inspired computing. Here, Prezioso et al. realize the detection of synchrony in a demo circuit composed of 20 metal-oxide memristor synapses connected to a leaky-integrate-and-fire silicon neuron.

    • M. Prezioso
    • , M. R. Mahmoodi
    • , F. Merrikh Bayat
    • , H. Nili
    • , H. Kim
    • , A. Vincent
    •  & D. B. Strukov
  • Article | | open

    In gene regulation, diversification at the transcriptome 3′end is linked to differentiation and dedifferentiation. Here, the authors discover extensive transcriptome 3′end-alterations in neuroblastoma, regulated by PCF11, and provide an interactive data repository of transcriptome-wide alternative polyadenylation.

    • Anton Ogorodnikov
    • , Michal Levin
    • , Surendra Tattikota
    • , Sergey Tokalov
    • , Mainul Hoque
    • , Denise Scherzinger
    • , Federico Marini
    • , Ansgar Poetsch
    • , Harald Binder
    • , Stephan Macher-Göppinger
    • , Hans Christian Probst
    • , Bin Tian
    • , Michael Schaefer
    • , Karl J. Lackner
    • , Frank Westermann
    •  & Sven Danckwardt
  • Article | | open

    The need for cheap water-splitting materials in order to scale-up and commercialize solar-to-fuel technologies is urgent, but there are still few candidate materials. Here, authors integrate layered double hydroxides with graphdiyne as high-performance overall water-splitting electrocatalysts.

    • Lan Hui
    • , Yurui Xue
    • , Bolong Huang
    • , Huidi Yu
    • , Chao Zhang
    • , Danyan Zhang
    • , Dianzeng Jia
    • , Yingjie Zhao
    • , Yongjun Li
    • , Huibiao Liu
    •  & Yuliang Li
  • Article | | open

    To realize the potential of resistive RAM crossbar arrays as platforms for neuromorphic computing, reduced network-level energy consumption must be achieved. Here, the authors use a hardware/software co-design approach to realize reduced energy consumption during network training for the network.

    • Yuhan Shi
    • , Leon Nguyen
    • , Sangheon Oh
    • , Xin Liu
    • , Foroozan Koushan
    • , John R. Jameson
    •  & Duygu Kuzum
  • Article | | open

    Inherent or acquired resistance to treatment of glioblastoma (GBM) is nearly universal. Here, the authors introduce a platform to identify synergistic drug combinations for patient-specific treatment of GBM based on gene expression signatures and small molecule perturbation-response profiles.

    • Vasileios Stathias
    • , Anna M. Jermakowicz
    • , Marie E. Maloof
    • , Michele Forlin
    • , Winston Walters
    • , Robert K. Suter
    • , Michael A. Durante
    • , Sion L. Williams
    • , J. William Harbour
    • , Claude-Henry Volmar
    • , Nicholas J. Lyons
    • , Claes Wahlestedt
    • , Regina M. Graham
    • , Michael E. Ivan
    • , Ricardo J. Komotar
    • , Jann N. Sarkaria
    • , Aravind Subramanian
    • , Todd R. Golub
    • , Stephan C. Schürer
    •  & Nagi G. Ayad
  • Article | | open

    The flammability and toxicity of the currently used electrolytes are the concerns that must be addressed. Here the authors show a non-fluorinated and non-toxic ionomeric aqueous gel electrolyte called water-in-ionomer that allows an enlargement of electrochemical stability window and design of environmentally friendly battery cell chemistries.

    • Xin He
    • , Bo Yan
    • , Xin Zhang
    • , Zigeng Liu
    • , Dominic Bresser
    • , Jun Wang
    • , Rui Wang
    • , Xia Cao
    • , Yixi Su
    • , Hao Jia
    • , Clare P. Grey
    • , Henrich Frielinghaus
    • , Donald G. Truhlar
    • , Martin Winter
    • , Jie Li
    •  & Elie Paillard
  • Article | | open

    Metabolism is frequently dysregulated in cancer. Here, the authors conduct a pan-cancer analysis of The Cancer Genome Atlas to determine significant metabolic pathway alterations, highlight master metabolic transcriptional regulators, and predict patient response to metabolism targeted-therapeutics

    • S. R. Rosario
    • , M. D. Long
    • , H. C. Affronti
    • , A. M. Rowsam
    • , K. H. Eng
    •  & D. J. Smiraglia
  • Article | | open

    Cubic crystalline single networks of large open-space lattices are ubiquitous in nature. Here the authors show that the topology of the circumferential bilayer of polymer cubosomes differentiates between two non-intersecting pore networks embedded in the cubic mesophase by sealing one channel network at the interface.

    • Yunju La
    • , Jeongeun Song
    • , Moon Gon Jeong
    • , Arah Cho
    • , Seon-Mi Jin
    • , Eunji Lee
    •  & Kyoung Taek Kim
  • Article | | open

    Biogenesis and function of miRNAs in somatic cells is well characterized, but their role in the germline has not been established. Here the authors identify and characterize Drosha independent and dependent miRNAs during C. elegans oogenesis, revealing their roles in meiotic progression and oocyte development.

    • Amanda L. Minogue
    • , Michael R. Tackett
    • , Elnaz Atabakhsh
    • , Genesis Tejada
    •  & Swathi Arur
  • Article | | open

    Significant improvements in numerical methods for quantum systems often come from finding new ways of representing quantum states that can be optimized and simulated more efficiently. Here the authors demonstrate a method to calculate exact neural network representations of many-body ground states.

    • Giuseppe Carleo
    • , Yusuke Nomura
    •  & Masatoshi Imada
  • Article | | open

    The mechanisms of sensing of blood flow and responses to it in vascular remodelling are poorly understood. Here, the authors show that in zebrafish blood flow controls both the fate determination of individual blood vessels and the arterial versus venous identity of endothelial cells lining them.

    • Bart Weijts
    • , Edgar Gutierrez
    • , Semion K. Saikin
    • , Ararat J. Ablooglu
    • , David Traver
    • , Alex Groisman
    •  & Eugene Tkachenko
  • Article | | open

    Alphaviruses are enveloped RNA viruses that contain several human pathogens. Here, the authors use block-based reconstruction method and provide a 3.5 Å cryo-EM structure of sindbis virus that identifies a conserved hydrophobic pocket near the viral membrane that is stabilized by an unknown pocket factor.

    • Lihong Chen
    • , Ming Wang
    • , Dongjie Zhu
    • , Zhenzhao Sun
    • , Jun Ma
    • , Jinglin Wang
    • , Lingfei Kong
    • , Shida Wang
    • , Zaisi Liu
    • , Lili Wei
    • , Yuwen He
    • , Jingfei Wang
    •  & Xinzheng Zhang
  • Article | | open

    SRY and its target SOX9 are known key determinants in testis development. Here the authors by studying duplications and deletions upstream of SOX9 from patient samples with disorders of sex development (DSD) reveal enhancers for SOX9 critical for human sex development and DSD.

    • Brittany Croft
    • , Thomas Ohnesorg
    • , Jacky Hewitt
    • , Josephine Bowles
    • , Alexander Quinn
    • , Jacqueline Tan
    • , Vincent Corbin
    • , Emanuele Pelosi
    • , Jocelyn van den Bergen
    • , Rajini Sreenivasan
    • , Ingrid Knarston
    • , Gorjana Robevska
    • , Dung Chi Vu
    • , John Hutson
    • , Vincent Harley
    • , Katie Ayers
    • , Peter Koopman
    •  & Andrew Sinclair
  • Article | | open

    Cyclic polymers can be usually accessed by ring-expansion and ring-closure approaches. Here, the authors report an alternative blocking-cyclization technique which enables the tunable synthesis of multicyclic polymers via commercial Ru-based Grubbs catalysts and conventional ring-opening metathesis polymerisation.

    • Jie Chen
    • , Hongfei Li
    • , Hengchen Zhang
    • , Xiaojuan Liao
    • , Huijing Han
    • , Lidong Zhang
    • , Ruyi Sun
    •  & Meiran Xie
  • Article | | open

    The plant trans-Golgi network comprises functionally distinct subcompartments. Here Renna et al. show that the TGNap1 protein acts in microtubule-dependent biogenesis, tracking and function of a TGN subset, highlighting diversification within the plant TGN.

    • Luciana Renna
    • , Giovanni Stefano
    • , Erin Slabaugh
    • , Clarissa Wormsbaecher
    • , Alan Sulpizio
    • , Krzysztof Zienkiewicz
    •  & Federica Brandizzi
  • Article | | open

    Chiroptical sensing in complex mixtures remains a challenging task. Here, the authors report an efficient coumarin probe for chiroptical click chirality sensing of absolute configuration, concentration and enantiomeric excess of several compound classes. The method can be directly applied to crude asymmetric reaction mixtures.

    • F. Yushra Thanzeel
    • , Kaluvu Balaraman
    •  & Christian Wolf
  • Article | | open

    Interventions in metabolic networks can improve microbes for chemical production. Here, the authors develop a tool to identify metabolic valves that can decouple growth and production to systematically improve the rate and yield of biochemical production processes.

    • Naveen Venayak
    • , Axel von Kamp
    • , Steffen Klamt
    •  & Radhakrishnan Mahadevan
  • Article | | open

    Methods to silence broadband noise and shield large volumes are lacking. Here, the authors show theoretically and experimentally that acoustic bianisotropic materials, with non-zero strain to momentum coupling, lead to effective sound barriers with excellent efficiency in terms of attenuation, bandwidth, and shielded volume.

    • Bogdan-Ioan Popa
    • , Yuxin Zhai
    •  & Hyung-Suk Kwon
  • Article | | open

    While nanocarrier-based drug delivery is a promising therapeutic approach, in situ characterization of drug nanocarriers in blood remains difficult. Here, the authors demonstrate how the fluorescence correlation spectroscopy can be used to directly characterize drug nanocarriers in flowing blood.

    • Inka Negwer
    • , Andreas Best
    • , Meike Schinnerer
    • , Olga Schäfer
    • , Leon Capeloa
    • , Manfred Wagner
    • , Manfred Schmidt
    • , Volker Mailänder
    • , Mark Helm
    • , Matthias Barz
    • , Hans-Jürgen Butt
    •  & Kaloian Koynov
  • Article | | open

    Regulatory T (Treg) cells are important for maintaining immune homeostasis by suppressing immune cell activation, but how the Treg cell pool is maintained is still unclear. Here the authors show that a kinase, Lkb1, operates in dendritic cells (DC) to inhibit Treg cell expansion and immunosuppression via mechanisms involving NF-kB/OX40L signalling.

    • Song Chen
    • , Lijun Fang
    • , Wei Guo
    • , Yushan Zhou
    • , Gang Yu
    • , Wenwen Li
    • , Kui Dong
    • , Jingru Liu
    • , Yuechen Luo
    • , Bing Wang
    • , Zhonglong Li
    • , Chunxiao Zhao
    • , Zhina Sun
    • , Yue Shen
    • , Qibing Leng
    • , Dongming Zhou
    • , Zhongchao Han
    • , Huifang Huang
    • , He Ren
    • , Guogang Xu
    •  & Xiaoming Feng
  • Article | | open

    Schizophrenia (SCZ) risk is influenced by genetic and environmental factors. Here, the authors develop a statistical method for analyzing gene-by-environment effects in SCZ risk across Denmark with fine spatial resolution.

    • Chun Chieh Fan
    • , John J. McGrath
    • , Vivek Appadurai
    • , Alfonso Buil
    • , Michael J. Gandal
    • , Andrew J. Schork
    • , Preben Bo Mortensen
    • , Esben Agerbo
    • , Sandy A. Geschwind
    • , Daniel Geschwind
    • , Thomas Werge
    • , Wesley K. Thompson
    •  & Carsten Bøcker Pedersen
  • Article | | open

    During HIV infection, antiviral therapy can suppress viraemia to undetectable levels and hinder the progression towards AIDS; however the HIV-1 provirus can remain in long-lived CD4+ memory T cells. Here the authors show that intronic RNA from the HIV-1 provirus can induce type I interferon and inflammatory cytokine production.

    • Sean Matthew McCauley
    • , Kyusik Kim
    • , Anetta Nowosielska
    • , Ann Dauphin
    • , Leonid Yurkovetskiy
    • , William Edward Diehl
    •  & Jeremy Luban