Articles

  • Article | | open

    Owing to their lack of a conventional cavity, random lasers typically do not emit a defined beam in a specific direction. Here, the authors combine spatial solitons and collinear pumping to achieve light-confined random lasing with a smooth output profile and a controllable direction of emission.

    • Sreekanth Perumbilavil
    • , Armando Piccardi
    • , Raouf Barboza
    • , Oleksandr Buchnev
    • , Martti Kauranen
    • , Giuseppe Strangi
    •  & Gaetano Assanto
  • Article | | open

    The bacterial type III secretion system of Gram-negative bacteria uses its core, the needle complex, to penetrate through the infected host cell membrane. Here authors show a near-atomic resolution structure of a needle complex which sheds light on the assembly and function of this nanomachine.

    • J. Hu
    • , L. J. Worrall
    • , C. Hong
    • , M. Vuckovic
    • , C. E. Atkinson
    • , N. Caveney
    • , Z. Yu
    •  & N. C. J. Strynadka
  • Article | | open

    Sunlight-harvesting materials require the clean integration of light-absorbing and catalytic components to be efficient. Here, authors link silicon photoelectrodes and molybdenum sulfide catalysts with defect-free gallium nitride nanowire to improve photoelectrochemical hydrogen evolution.

    • Baowen Zhou
    • , Xianghua Kong
    • , Srinivas Vanka
    • , Sheng Chu
    • , Pegah Ghamari
    • , Yichen Wang
    • , Nick Pant
    • , Ishiang Shih
    • , Hong Guo
    •  & Zetian Mi
  • Article | | open

    Insulin-like polypeptide binding proteins (IBPs) from insects can bind diverse insulin-like proteins (ILPs) including human insulin and IGFs. Here, the authors present structures of a Drosophila IBP in its free and ILP-bound forms, providing insights into the regulation of ILP bioavailability by insect IBPs.

    • Nikolaj Kulahin Roed
    • , Cristina M. Viola
    • , Ole Kristensen
    • , Gerd Schluckebier
    • , Mathias Norrman
    • , Waseem Sajid
    • , John D. Wade
    • , Asser Sloth Andersen
    • , Claus Kristensen
    • , Timothy R. Ganderton
    • , Johan P. Turkenburg
    • , Pierre De Meyts
    •  & Andrzej M. Brzozowski
  • Article | | open

    The function of genes linked to type 2 diabetes is poorly characterized. Here the authors combine Drosophila genetics and physiology with human islet biology to identify new regulators of insulin secretion including BCL11A.

    • Heshan Peiris
    • , Sangbin Park
    • , Shreya Louis
    • , Xueying Gu
    • , Jonathan Y. Lam
    • , Olof Asplund
    • , Gregory C. Ippolito
    • , Rita Bottino
    • , Leif Groop
    • , Haley Tucker
    •  & Seung K. Kim
  • Article | | open

    Metabolic reprogramming of smooth muscle cells (SMCs) plays an important role in the pathogenesis of pulmonary arterial hypertension (PAH). Here, Dai et al. show that the glycolytic enzyme alpha-enolase contributes to this reprogramming, and that its inhibition limits SMC proliferation and disease progression in animal models of PAH.

    • Jingbo Dai
    • , Qiyuan Zhou
    • , Jiwang Chen
    • , Megan L. Rexius-Hall
    • , Jalees Rehman
    •  & Guofei Zhou
  • Article | | open

    Single-site catalysts supported by ultrathin two-dimensional (2D) porous matrix are desirable for catalytic reactions, yet their synthesis remains a great challenge. Herein the authors report a cocoon silk chemistry strategy to synthesize isolated metal single-site catalysts embedded in ultrathin 2D porous N-doped carbon nanosheets.

    • Youqi Zhu
    • , Wenming Sun
    • , Jun Luo
    • , Wenxing Chen
    • , Tai Cao
    • , Lirong Zheng
    • , Juncai Dong
    • , Jian Zhang
    • , Maolin Zhang
    • , Yunhu Han
    • , Chen Chen
    • , Qing Peng
    • , Dingsheng Wang
    •  & Yadong Li
  • Article | | open

    Configuring surfaces on-demand for desired functionalities is an ongoing challenge. Here, diverse and tailorable modifications of quartz and porous silica surfaces that are rapidly and reversibly switchable by the use of visible light are achieved via ruthenium-thioether coordination.

    • Chaoming Xie
    • , Wen Sun
    • , Hao Lu
    • , Annika Kretzschmann
    • , Jiahui Liu
    • , Manfred Wagner
    • , Hans-Jürgen Butt
    • , Xu Deng
    •  & Si Wu
  • Article | | open

    Human memory and marginal zone B cells share some features including CD27 expression and somatic hypermutation, but their lineage relationship is still unclear. Here the authors use mass cytometry and sequential clustering methods to show that, despite their shared features, memory and marginal zone B cells represent distinct lineage choices.

    • Yuan Zhao
    • , Mohamed Uduman
    • , Jacqueline H. Y. Siu
    • , Thomas J. Tull
    • , Jeremy D. Sanderson
    • , Yu-Chang Bryan Wu
    • , Julian Q. Zhou
    • , Nedyalko Petrov
    • , Richard Ellis
    • , Katrina Todd
    • , Konstantia-Maria Chavele
    • , William Guesdon
    • , Anna Vossenkamper
    • , Wayel Jassem
    • , David P. D’Cruz
    • , David J. Fear
    • , Susan John
    • , Dagmar Scheel-Toellner
    • , Claire Hopkins
    • , Estefania Moreno
    • , Natalie L. Woodman
    • , Francesca Ciccarelli
    • , Susanne Heck
    • , Steven H. Kleinstein
    • , Mats Bemark
    •  & Jo Spencer
  • Article | | open

    The lack of understanding of mixed transport in ion-permeable conjugated polymer films hinders the advance of organic electrochemical transistors for bioelectronics. Here, the authors elucidate the structure-property-performance relationships for conventional and crystallized PEDOT:PSS films.

    • Seong-Min Kim
    • , Chang-Hyun Kim
    • , Youngseok Kim
    • , Nara Kim
    • , Won-June Lee
    • , Eun-Hak Lee
    • , Dokyun Kim
    • , Sungjun Park
    • , Kwanghee Lee
    • , Jonathan Rivnay
    •  & Myung-Han Yoon
  • Article | | open

    Brain function alterations in schizophrenia and other psychotic disorders remain poorly understood. Here, the authors discover that increased neural connectivity in the cerebello-thalamo-cortical circuitry predicts psychosis in those at high risk, and is present in people with schizophrenia.

    • Hengyi Cao
    • , Oliver Y. Chén
    • , Yoonho Chung
    • , Jennifer K. Forsyth
    • , Sarah C. McEwen
    • , Dylan G. Gee
    • , Carrie E. Bearden
    • , Jean Addington
    • , Bradley Goodyear
    • , Kristin S. Cadenhead
    • , Heline Mirzakhanian
    • , Barbara A. Cornblatt
    • , Ricardo E. Carrión
    • , Daniel H. Mathalon
    • , Thomas H. McGlashan
    • , Diana O. Perkins
    • , Aysenil Belger
    • , Larry J. Seidman
    • , Heidi Thermenos
    • , Ming T. Tsuang
    • , Theo G. M. van Erp
    • , Elaine F. Walker
    • , Stephan Hamann
    • , Alan Anticevic
    • , Scott W. Woods
    •  & Tyrone D. Cannon
  • Article | | open

    To fully exploit the potential of multiferroic materials the control of their intrinsic degrees of freedom is a prerequisite. Here, the control of spin orientation in strained BiFeO3 films is demonstrated elucidating the microscopic mechanism of the complex interplay of polar and magnetic order.

    • Zuhuang Chen
    • , Zhanghui Chen
    • , Chang-Yang Kuo
    • , Yunlong Tang
    • , Liv R. Dedon
    • , Qian Li
    • , Lei Zhang
    • , Christoph Klewe
    • , Yen-Lin Huang
    • , Bhagwati Prasad
    • , Alan Farhan
    • , Mengmeng Yang
    • , James D. Clarkson
    • , Sujit Das
    • , Sasikanth Manipatruni
    • , A. Tanaka
    • , Padraic Shafer
    • , Elke Arenholz
    • , Andreas Scholl
    • , Ying-Hao Chu
    • , Z. Q. Qiu
    • , Zhiwei Hu
    • , Liu-Hao Tjeng
    • , Ramamoorthy Ramesh
    • , Lin-Wang Wang
    •  & Lane W. Martin
  • Article | | open

    Current influenza vaccine approaches largely focus on highly variable epitopes with high immunogenicity or epitopes of low variability that often have low immunogenicity. Here, Thompson et al. identify a highly immunogenic epitope of limited variability in the head domain of the H1 haemagglutinin and show protection from diverse H1N1 strains in mice.

    • Craig P. Thompson
    • , José Lourenço
    • , Adam A. Walters
    • , Uri Obolski
    • , Matthew Edmans
    • , Duncan S. Palmer
    • , Kreepa Kooblall
    • , George W. Carnell
    • , Daniel O’Connor
    • , Thomas A. Bowden
    • , Oliver G. Pybus
    • , Andrew J. Pollard
    • , Nigel J. Temperton
    • , Teresa Lambe
    • , Sarah C. Gilbert
    •  & Sunetra Gupta
  • Article | | open

    Synthetic active particles with inter-particle propulsion have been served as a model system to study the collective animal behaviors. Here, Khadka et al. add complexity to the model by spatially controlling particle motions through a laser feedback loop in response to the collective dynamics of particles.

    • Utsab Khadka
    • , Viktor Holubec
    • , Haw Yang
    •  & Frank Cichos
  • Article | | open

    Lipid-based membranes coupled to biochemical reaction networks can be difficult to implement in vitro. Here the authors use elastin-like peptides to create self-assembled vesicle structures containing transcription-translation systems for autonomous growth.

    • Kilian Vogele
    • , Thomas Frank
    • , Lukas Gasser
    • , Marisa A. Goetzfried
    • , Mathias W. Hackl
    • , Stephan A. Sieber
    • , Friedrich C. Simmel
    •  & Tobias Pirzer
  • Article | | open

    Upon ligand binding epidermal growth factor receptor (EGFR) dimerizes and activates its intrinsic kinase to auto-phosphorylate EGFR. Here, the authors engineer and image a FRET-based conformational EGFR indicator which reveals that activation loop phosphorylation induces a catalytically active conformation in EGFR monomers.

    • Martin Baumdick
    • , Márton Gelléri
    • , Chayasith Uttamapinant
    • , Václav Beránek
    • , Jason W. Chin
    •  & Philippe I. H. Bastiaens
  • Article | | open

    The neural mechanisms underlying the suppression of fMRI responses to repeated stimuli are under debate. Here, the authors compare computational models to show that only a local scaling model can fit univariate and multivariate fMRI repetition effects across two paradigms and multiple brain regions.

    • Arjen Alink
    • , Hunar Abdulrahman
    •  & Richard N. Henson
  • Article | | open

    Omecamtiv mecarbil (OM) is a positive cardiac inotrope in clinical trials for the treatment of heart failure whose mechanism of action is incompletely understood. Here the authors show that OM inhibits myosin's working stroke and prolongs actomyosin attachment and propose a model that reconciles the OM-induced increase in cardiac performance in vivo with the inhibitory actions observed in vitro.

    • Michael S. Woody
    • , Michael J. Greenberg
    • , Bipasha Barua
    • , Donald A. Winkelmann
    • , Yale E. Goldman
    •  & E. Michael Ostap
  • Article | | open

    The chromatin remodeler RSF1 is enriched at mitotic centromeres but its function there is poorly understood. Here, the authors show that RSF1 regulates H2A phosphorylation and acetylation at mitotic centromeres and contributes to chromosome stability.

    • Ho-Soo Lee
    • , Zhonghui Lin
    • , Sunyoung Chae
    • , Young-Suk Yoo
    • , Byung-Gyu Kim
    • , Youngsoo Lee
    • , Jared L. Johnson
    • , You-Sun Kim
    • , Lewis C. Cantley
    • , Chang-Woo Lee
    • , Hongtao Yu
    •  & Hyeseong Cho
  • Article | | open

    Nematic liquid crystals have a rich energy landscape which can define elastic fields to guide colloidal assembly. Here the authors show controllable trapping of colloidal particles by placing them in a system with wavy walls which are exploited to obtain stable, metastable and unstable equilibria.

    • Yimin Luo
    • , Daniel A. Beller
    • , Giuseppe Boniello
    • , Francesca Serra
    •  & Kathleen J. Stebe
  • Article | | open

    Bend faulting prior to subduction is considered to promote hydration, yet the relationship remains ambiguous. Here, via analysis of seismic surveys from the Japan and Kuril trenches junction, the authors show that pre-subduction bend faulting and post-subduction plate hydration are strongly correlated.

    • Gou Fujie
    • , Shuichi Kodaira
    • , Yuka Kaiho
    • , Yojiro Yamamoto
    • , Tsutomu Takahashi
    • , Seiichi Miura
    •  & Tomoaki Yamada
  • Article | | open

    Connexins are components of gap junctions that link cells and allow intercellular communication. Here, the authors show that the Connexin 43 carboxy tail interacts with basic transcription factor-3, leading to nuclear translocation and direct regulation of N-cadherin expression and neural crest migration.

    • Maria Kotini
    • , Elias H. Barriga
    • , Jonathan Leslie
    • , Marc Gentzel
    • , Verena Rauschenberger
    • , Alexandra Schambon
    •  & Roberto Mayor
  • Article | | open

    The harlequin ladybird beetle, Harmonia axyridis, has remarkable phenotypic diversity, with over 200 colour patterns. Here, Ando et al. show that this patterning is regulated by the transcription factor gene pannier and has diversified by repeated inversions and cis-regulatory modifications of pannier.

    • Toshiya Ando
    • , Takeshi Matsuda
    • , Kumiko Goto
    • , Kimiko Hara
    • , Akinori Ito
    • , Junya Hirata
    • , Joichiro Yatomi
    • , Rei Kajitani
    • , Miki Okuno
    • , Katsushi Yamaguchi
    • , Masaaki Kobayashi
    • , Tomoyuki Takano
    • , Yohei Minakuchi
    • , Masahide Seki
    • , Yutaka Suzuki
    • , Kentaro Yano
    • , Takehiko Itoh
    • , Shuji Shigenobu
    • , Atsushi Toyoda
    •  & Teruyuki Niimi
  • Article | | open

    The processes regulating cardiomyocyte (CM) maturation are unclear. Here, the authors show that serum response factor regulates CM maturation only in neonatal CMs through stage-specific chromatin occupancy that affects cell size, sarcomere and transverse-tubule organization, and mitochondria

    • Yuxuan Guo
    • , Blake D. Jardin
    • , Pingzhu Zhou
    • , Isha Sethi
    • , Brynn N. Akerberg
    • , Christopher N Toepfer
    • , Yulan Ai
    • , Yifei Li
    • , Qing Ma
    • , Silvia Guatimosim
    • , Yongwu Hu
    • , Grigor Varuzhanyan
    • , Nathan J. VanDusen
    • , Donghui Zhang
    • , David C. Chan
    • , Guo-Cheng Yuan
    • , Christine E. Seidman
    • , Jonathan G. Seidman
    •  & William T. Pu
  • Article | | open

    Self-interacting chromatin domains encompass genes and their cis-regulatory elements. Here the authors use high-resolution chromosome conformation capture and super-resolution imaging to study a 70 kb domain that includes the mouse α-globin regulatory locus and find that a tissue-specific self-interacting chromatin domain forms independently of enhancer-promoter interactions.

    • Jill M. Brown
    • , Nigel A. Roberts
    • , Bryony Graham
    • , Dominic Waithe
    • , Christoffer Lagerholm
    • , Jelena M. Telenius
    • , Sara De Ornellas
    • , A. Marieke Oudelaar
    • , Caroline Scott
    • , Izabela Szczerbal
    • , Christian Babbs
    • , Mira T. Kassouf
    • , Jim R. Hughes
    • , Douglas R. Higgs
    •  & Veronica J. Buckle
  • Article | | open

    The Wnt pathway is one of the core de-regulated pathways in chronic lymphocytic leukaemia (CLL) and is activated in only a subset of patients; however, no universal drivers of the disease have been identified. Here the authors show that Notch2 and β-catenin pathways are the main drivers of the pro-survival bidirectional crosstalk between stromal cells and leukemic cells.

    • Maurizio Mangolini
    • , Frederik Götte
    • , Andrew Moore
    • , Tim Ammon
    • , Madlen Oelsner
    • , Gloria Lutzny-Geier
    • , Ludger Klein-Hitpass
    • , James C. Williamson
    • , Paul J. Lehner
    • , Jan Dürig
    • , Michael Möllmann
    • , Lívia Rásó-Barnett
    • , Katherine Hughes
    • , Antonella Santoro
    • , Simón Méndez-Ferrer
    • , Robert A. J. Oostendorp
    • , Ursula Zimber-Strobl
    • , Christian Peschel
    • , Daniel J. Hodson
    • , Marc Schmidt-Supprian
    •  & Ingo Ringshausen
  • Article | | open

    Extraterrestrial sources may have provided prebiotic phosphorus to the early Earth. Here, the authors investigate the potential of phosphine-doped astrochemical analog ices to form phosphorus oxoacids as precursors to more complex prebiotic compounds.

    • Andrew M. Turner
    • , Alexandre Bergantini
    • , Matthew J. Abplanalp
    • , Cheng Zhu
    • , Sándor Góbi
    • , Bing-Jian Sun
    • , Kang-Heng Chao
    • , Agnes H. H. Chang
    • , Cornelia Meinert
    •  & Ralf I. Kaiser
  • Article | | open

    The Cretaceous Oceanic Anoxic Event 2 represents one of the warmest episodes in the last 250 million years. Here, the authors present spore-pollen data and temperature estimates (TEX86) across an expanded stratigraphic section illustrating the dynamic response of vegetation during this exceptionally warm interval.

    • Ulrich Heimhofer
    • , Nina Wucherpfennig
    • , Thierry Adatte
    • , Stefan Schouten
    • , Elke Schneebeli-Hermann
    • , Silvia Gardin
    • , Gerta Keller
    • , Sarah Kentsch
    •  & Ariane Kujau
  • Article | | open

    Pfs48/45 is a promising component for a transmission-blocking malaria vaccine. Here, the authors develop a system to produce full-length Pfs48/45 for immunisation, characterise a panel of monoclonal antibodies and determine the structure of a potent transmission-blocking epitope.

    • Frank Lennartz
    • , Florian Brod
    • , Rebecca Dabbs
    • , Kazutoyo Miura
    • , David Mekhaiel
    • , Arianna Marini
    • , Matthijs M. Jore
    • , Max M. Søgaard
    • , Thomas Jørgensen
    • , Willem A. de Jongh
    • , Robert W. Sauerwein
    • , Carole A. Long
    • , Sumi Biswas
    •  & Matthew K. Higgins
  • Article | | open

    Fast radio bursts (FRBs) are likely to be gravitationally lensed by intervening galaxies. Here, the authors propose to make accurate measurements of time delays between images of lensed FRBs as a powerful probe for precision cosmology.

    • Zheng-Xiang Li
    • , He Gao
    • , Xu-Heng Ding
    • , Guo-Jian Wang
    •  & Bing Zhang
  • Article | | open

    Mechanism of lymph node (LN) metastasis induced by tumor associated macrophages (TAMs) remains unclear. Here they demonstrate that a long noncoding RNA LNMAT1 promotes LN metastasis of bladder cancer via recruitment of TAMs through epigenetic regulation of CCL2 expression.

    • Changhao Chen
    • , Wang He
    • , Jian Huang
    • , Bo Wang
    • , Hui Li
    • , Qingqing Cai
    • , Feng Su
    • , Junming Bi
    • , Hongwei Liu
    • , Bin Zhang
    • , Ning Jiang
    • , Guangzheng Zhong
    • , Yue Zhao
    • , Wen Dong
    •  & Tianxin Lin
  • Article | | open

    Single-cell DNA methylome profiling allows the study of epigenomic heterogeneity in tissues but has been impeded by library quality. Here the authors demonstrate snmC-seq2 which improves mapping, throughput and library complexity.

    • Chongyuan Luo
    • , Angeline Rivkin
    • , Jingtian Zhou
    • , Justin P. Sandoval
    • , Laurie Kurihara
    • , Jacinta Lucero
    • , Rosa Castanon
    • , Joseph R. Nery
    • , António Pinto-Duarte
    • , Brian Bui
    • , Conor Fitzpatrick
    • , Carolyn O’Connor
    • , Seth Ruga
    • , Marc E. Van Eden
    • , David A. Davis
    • , Deborah C. Mash
    • , M. Margarita Behrens
    •  & Joseph R. Ecker
  • Article | | open

    The development of potassium-ion batteries requires cathode materials that can maintain the structural stability during cycling. Here the authors have developed honeycomb-layered tellurates K2M2TeO6 that afford high ionic conductivity and reversible intercalation of large K ions at high voltages.

    • Titus Masese
    • , Kazuki Yoshii
    • , Yoichi Yamaguchi
    • , Toyoki Okumura
    • , Zhen-Dong Huang
    • , Minami Kato
    • , Keigo Kubota
    • , Junya Furutani
    • , Yuki Orikasa
    • , Hiroshi Senoh
    • , Hikari Sakaebe
    •  & Masahiro Shikano
  • Article | | open

    Understanding the location and nature of the catalytic active site is critical for controlling a catalyst’s activity and selectivity. Here, the authors separate the metal from the support by a controlled distance while maintaining the ability to promote defects via the use of carbon nanotube hydrogen highways.

    • Nicholas M. Briggs
    • , Lawrence Barrett
    • , Evan C. Wegener
    • , Leidy V. Herrera
    • , Laura A. Gomez
    • , Jeffrey T. Miller
    •  & Steven P. Crossley
  • Article | | open

    Cells sense mechanical properties of their environment using various cellular structures including focal adhesions. Here, the authors identify flat clathrin-coated structures (CCSs) as mechanosensitive signaling platforms that form independently of contractility and in response to substrate rigidity.

    • Francesco Baschieri
    • , Stéphane Dayot
    • , Nadia Elkhatib
    • , Nathalie Ly
    • , Anahi Capmany
    • , Kristine Schauer
    • , Timo Betz
    • , Danijela Matic Vignjevic
    • , Renaud Poincloux
    •  & Guillaume Montagnac
  • Article | | open

    Although Ftx lncRNA has been linked to X-chromosome inactivation, its physiological roles in vivo remain unclear. Here the authors show that deletion of mouse Ftx causes eye abnormalities similar to human microphthalmia in a subset of female mice but rarely in males and provide evidence that Ftx plays a role in gene silencing on the inactive X chromosome.

    • Yusuke Hosoi
    • , Miki Soma
    • , Hirosuke Shiura
    • , Takashi Sado
    • , Hidetoshi Hasuwa
    • , Kuniya Abe
    • , Takashi Kohda
    • , Fumitoshi Ishino
    •  & Shin Kobayashi
  • Article | | open

    Aspergillus fumigatus regularly colonises the lungs but in the context of respiratory disease can be associated with increased pathology. Here the authors show mutations in ZNF77 result in altered bronchial epithelial characteristics and enhanced fungal burden.

    • Sara Gago
    • , Nicola L. D. Overton
    • , Nagwa Ben-Ghazzi
    • , Lilyann Novak-Frazer
    • , Nick D. Read
    • , David W. Denning
    •  & Paul Bowyer
  • Article | | open

    Vitamin E metabolites are proposed to have signalling capacity, but how they may regulate immune responses is still unclear. Here the authors show that a vitamin E metabolite, α-T-13′-COOH, can inhibit 5-lipoxygenase and thereby suppress the synthesis of lipid mediators of immune activation and inflammatory responses.

    • Helmut Pein
    • , Alexia Ville
    • , Simona Pace
    • , Veronika Temml
    • , Ulrike Garscha
    • , Martin Raasch
    • , Khaled Alsabil
    • , Guillaume Viault
    • , Chau-Phi Dinh
    • , David Guilet
    • , Fabiana Troisi
    • , Konstantin Neukirch
    • , Stefanie König
    • , Rosella Bilancia
    • , Birgit Waltenberger
    • , Hermann Stuppner
    • , Maria Wallert
    • , Stefan Lorkowski
    • , Christina Weinigel
    • , Silke Rummler
    • , Marc Birringer
    • , Fiorentina Roviezzo
    • , Lidia Sautebin
    • , Jean-Jacques Helesbeux
    • , Denis Séraphin
    • , Alexander S. Mosig
    • , Daniela Schuster
    • , Antonietta Rossi
    • , Pascal Richomme
    • , Oliver Werz
    •  & Andreas Koeberle
  • Article | | open

    While multi-carbon (C2+) products present high-value species attainable from emitted carbon dioxide, it is challenging to prepare stable, C2+ selective catalysts. Here, authors support copper on copper nitride to improve copper’s electrocatalytic stability and selectivity toward C2+ synthesis.

    • Zhi-Qin Liang
    • , Tao-Tao Zhuang
    • , Ali Seifitokaldani
    • , Jun Li
    • , Chun-Wei Huang
    • , Chih-Shan Tan
    • , Yi Li
    • , Phil De Luna
    • , Cao Thang Dinh
    • , Yongfeng Hu
    • , Qunfeng Xiao
    • , Pei-Lun Hsieh
    • , Yuhang Wang
    • , Fengwang Li
    • , Rafael Quintero-Bermudez
    • , Yansong Zhou
    • , Peining Chen
    • , Yuanjie Pang
    • , Shen-Chuan Lo
    • , Lih-Juann Chen
    • , Hairen Tan
    • , Zheng Xu
    • , Suling Zhao
    • , David Sinton
    •  & Edward H. Sargent
  • Article | | open

    Alumina is thought to be the main condensate to form in the gas outflow from oxygen-rich evolved stars. Here, the authors perform a condensation experiment with alumina in a low-gravity environment, and find spectroscopic evidence for a sharp feature at a wavelength of 13.55 μm.

    • Shinnosuke Ishizuka
    • , Yuki Kimura
    • , Itsuki Sakon
    • , Hiroshi Kimura
    • , Tomoya Yamazaki
    • , Shinsuke Takeuchi
    •  & Yuko Inatomi
  • Article | | open

    Cost and stability of catalysts hinder widespread use of proton exchange membrane fuel cells. Here the authors synthesize zigzag-edged graphene nanoribbons for electrocatalysis of oxygen reduction. Employment of such a metal-free catalyst in a fuel cell yields remarkable power density and durability.

    • Longfei Xue
    • , Yongcheng Li
    • , Xiaofang Liu
    • , Qingtao Liu
    • , Jiaxiang Shang
    • , Huiping Duan
    • , Liming Dai
    •  & Jianglan Shui
  • Article | | open

    High performance flexible strain sensors with accurate signal detection and noise screening are key to the development of smart sensing systems. Here, the authors demonstrate metal–organic framework based strain sensors that are ultrasensitive, robust, and non-responsive to environmental noise.

    • Liang Pan
    • , Gang Liu
    • , Wenxiong Shi
    • , Jie Shang
    • , Wan Ru Leow
    • , Yaqing Liu
    • , Ying Jiang
    • , Shuzhou Li
    • , Xiaodong Chen
    •  & Run-Wei Li
  • Article | | open

    Alpha-functionalized organic acids are building blocks of many bioactive compounds. Here, the authors developed a toolbox-like, modular set of enzymes that reset chiral groups, turning achiral glycine and simple aldehydes into stereodefined α-keto acids, α-hydroxy acids, and α-amino acids.

    • Wei Song
    • , Jin-Hui Wang
    • , Jing Wu
    • , Jia Liu
    • , Xiu-Lai Chen
    •  & Li-Ming Liu
  • Article | | open

    Processive chitinase is a linear molecular motor which moves on the surface of crystalline chitin. Here authors use single-molecule imaging, X-ray crystallography and simulations on chitinase A (SmChiA) and show that Brownian motion along the single chitin chain is rectified forward by substrate-assisted catalysis.

    • Akihiko Nakamura
    • , Kei-ichi Okazaki
    • , Tadaomi Furuta
    • , Minoru Sakurai
    •  & Ryota Iino
  • Article | | open

    Outbreaks of porcine epidemic diarrhea virus (PEDV) have seriously affected pig farms around the world. Here, Li et al. show that PEDV can cause disease in piglets when inoculated by nasal spray, and provide insights into the cellular mechanisms underlying PEDV dissemination within the host.

    • Yuchen Li
    • , Qingxin Wu
    • , Lulu Huang
    • , Chen Yuan
    • , Jialu Wang
    •  & Qian Yang
  • Article | | open

    The potential of flexible organic/inorganic hybrids for thermoelectrics is limited by the inability to control their microstructure. Here, the authors demonstrate polymer-nanoparticle hybrids with a monodispersed, periodic nanophase that shows high thermoelectric performance at room temperature.

    • Liming Wang
    • , Zimeng Zhang
    • , Yuchen Liu
    • , Biran Wang
    • , Lei Fang
    • , Jingjing Qiu
    • , Kun Zhang
    •  & Shiren Wang
  • Article | | open

    ApoE4 is a risk factor for small vessel disease, which can lead to cognitive impairment. Here the authors assess the microvasculature of the corpus callosum using 3-photon microscopy and find that mice expressing the ApoE4 allele are more susceptible than wild-type to white matter injury and cognitive impairment in a model of hypoperfusion-induced hypoxia.

    • Kenzo Koizumi
    • , Yorito Hattori
    • , Sung Ji Ahn
    • , Izaskun Buendia
    • , Antonio Ciacciarelli
    • , Ken Uekawa
    • , Gang Wang
    • , Abigail Hiller
    • , Lingzhi Zhao
    • , Henning U. Voss
    • , Steven M. Paul
    • , Chris Schaffer
    • , Laibaik Park
    •  & Costantino Iadecola
  • Article | | open

    Adaptation is thought to improve discrimination by pulling neural representations of similar stimuli farther apart. Here, the authors separately show that adaptation to a 3D shape class leads to better discrimination performance on similar shapes, and activity patterns diverge in object selective cortical areas.

    • Marcelo G. Mattar
    • , Maria Olkkonen
    • , Russell A. Epstein
    •  & Geoffrey K. Aguirre
  • Article | | open

    Roquin targets are known to contain two types of sequence-structure motifs, the constitutive and the alternative decay elements (CDE and ADE). Here, the authors describe a linear Roquin binding element (LBE) also involved in target recognition, and show that Roquin binding affects the translation of a subset of targeted mRNAs.

    • Katharina Essig
    • , Nina Kronbeck
    • , Joao C. Guimaraes
    • , Claudia Lohs
    • , Andreas Schlundt
    • , Anne Hoffmann
    • , Gesine Behrens
    • , Sven Brenner
    • , Joanna Kowalska
    • , Cristina Lopez-Rodriguez
    • , Jacek Jemielity
    • , Helmut Holtmann
    • , Kristin Reiche
    • , Jörg Hackermüller
    • , Michael Sattler
    • , Mihaela Zavolan
    •  & Vigo Heissmeyer