Articles

  • Article | | open

    Identifying gene subsets affecting disease phenotypes from transcriptome data is challenge. Here, the authors develop a method that combines transcriptional data with disease ordinal clinical measurements to discover a sphingolipid metabolism regulator involving in Huntington’s disease progression.

    • Leila Pirhaji
    • , Pamela Milani
    • , Simona Dalin
    • , Brook T. Wassie
    • , Denise E. Dunn
    • , Robert J. Fenster
    • , Julian Avila-Pacheco
    • , Paul Greengard
    • , Clary B. Clish
    • , Myriam Heiman
    • , Donald C. Lo
    •  & Ernest Fraenkel
  • Article | | open

    Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease. Here, Wray and colleagues identify association of the GPX3-TNIP1 locus with ALS using cross-ethnic meta-analyses.

    • Beben Benyamin
    • , Ji He
    • , Qiongyi Zhao
    • , Jacob Gratten
    • , Fleur Garton
    • , Paul J. Leo
    • , Zhijun Liu
    • , Marie Mangelsdorf
    • , Ammar Al-Chalabi
    • , Lisa Anderson
    • , Timothy J. Butler
    • , Lu Chen
    • , Xiang-Ding Chen
    • , Katie Cremin
    • , Hong-Weng Deng
    • , Matthew Devine
    • , Janette Edson
    • , Jennifer A. Fifita
    • , Sarah Furlong
    • , Ying-Ying Han
    • , Jessica Harris
    • , Anjali K. Henders
    • , Rosalind L. Jeffree
    • , Zi-Bing Jin
    • , Zhongshan Li
    • , Ting Li
    • , Mengmeng Li
    • , Yong Lin
    • , Xiaolu Liu
    • , Mhairi Marshall
    • , Emily P. McCann
    • , Bryan J. Mowry
    • , Shyuan T. Ngo
    • , Roger Pamphlett
    • , Shu Ran
    • , David C. Reutens
    • , Dominic B. Rowe
    • , Perminder Sachdev
    • , Sonia Shah
    • , Sharon Song
    • , Li-Jun Tan
    • , Lu Tang
    • , Leonard H. Berg
    • , Wouter Rheenen
    • , Jan H. Veldink
    • , Robyn H. Wallace
    • , Lawrie Wheeler
    • , Kelly L. Williams
    • , Jinyu Wu
    • , Xin Wu
    • , Jian Yang
    • , Weihua Yue
    • , Zong-Hong Zhang
    • , Dai Zhang
    • , Peter G. Noakes
    • , Ian P. Blair
    • , Robert D. Henderson
    • , Pamela A. McCombe
    • , Peter M. Visscher
    • , Huji Xu
    • , Perry F. Bartlett
    • , Matthew A. Brown
    • , Naomi R. Wray
    •  & Dongsheng Fan
  • Article | | open

    Anthracenols with multiple chiral centres are common motifs in natural products. Here, the authors show a highly stereoselective photoenolization/Diels–Alder methodology involving a key Lewis acid reagent enabling the efficient construction of a family of anthracenol derivatives with quaternary centers.

    • Baochao Yang
    • , Kuaikuai Lin
    • , Yingbo Shi
    •  & Shuanhu Gao
  • Article | | open

    Strain engineering is an essential tool for modifying local electronic properties in silicon-based electronics. Here, Ahn et al. demonstrate control of biaxial strain in two-dimensional materials based on the growth substrate, enabling more complex low-dimensional electronics.

    • Geun Ho Ahn
    • , Matin Amani
    • , Haider Rasool
    • , Der-Hsien Lien
    • , James P. Mastandrea
    • , Joel W. Ager III
    • , Madan Dubey
    • , Daryl C. Chrzan
    • , Andrew M. Minor
    •  & Ali Javey
  • Article | | open

    Post-translational modifications can affect antibody function in health and disease, but identification of all variants is difficult using existing technologies. Here the authors develop a microfluidic method to identify and quantify low-abundance IgG N-glycans and show some of these IgGs can be used as biomarkers for rheumatoid arthritis.

    • Jing-Rong Wang
    • , Wei-Na Gao
    • , Rudolf Grimm
    • , Shibo Jiang
    • , Yong Liang
    • , Hua Ye
    • , Zhan-Guo Li
    • , Lee-Fong Yau
    • , Hao Huang
    • , Ju Liu
    • , Min Jiang
    • , Qiong Meng
    • , Tian-Tian Tong
    • , Hai-Hui Huang
    • , Stephanie Lee
    • , Xing Zeng
    • , Liang Liu
    •  & Zhi-Hong Jiang
  • Article | | open

    The performance of silicon single-photon avalanche detectors is currently limited by the trade-off between photon detection efficiency and timing jitter. Here, the authors demonstrate how a CMOS-compatible, nanostructured, thin junction structure can make use of tailored light trapping to break this trade-off.

    • Kai Zang
    • , Xiao Jiang
    • , Yijie Huo
    • , Xun Ding
    • , Matthew Morea
    • , Xiaochi Chen
    • , Ching-Ying Lu
    • , Jian Ma
    • , Ming Zhou
    • , Zhenyang Xia
    • , Zongfu Yu
    • , Theodore I. Kamins
    • , Qiang Zhang
    •  & James S. Harris
  • Article | | open

    Developmental cues for the different dendritic cell (DC) subsets in the intestine are yet to be defined. Here the authors show that TGFβR1 signalling is needed for development of CD103+CD11b+ intestinal DCs from CD103CD11b+ cells and that they contribute to the generation of Th17 and regulatory T cells

    • C. C. Bain
    • , J. Montgomery
    • , C. L. Scott
    • , J. M. Kel
    • , M. J. H. Girard-Madoux
    • , L. Martens
    • , T. F. P. Zangerle-Murray
    • , J. Ober-Blöbaum
    • , D. Lindenbergh-Kortleve
    • , J. N. Samsom
    • , S. Henri
    • , T. Lawrence
    • , Y. Saeys
    • , B. Malissen
    • , M. Dalod
    • , B. E. Clausen
    •  & A. McI. Mowat
  • Article | | open

    FAM46C is one of the most frequently mutated genes in multiple myeloma (MM), but its molecular function remains unknown. Here the authors show that FAM46C is a poly(A) polymerase and that loss of function of FAM46C drives multiple myeloma through the destabilisation of ER response transcripts.

    • Seweryn Mroczek
    • , Justyna Chlebowska
    • , Tomasz M. Kuliński
    • , Olga Gewartowska
    • , Jakub Gruchota
    • , Dominik Cysewski
    • , Vladyslava Liudkovska
    • , Ewa Borsuk
    • , Dominika Nowis
    •  & Andrzej Dziembowski
  • Article | | open

    Optical clearing of tissue has enabled optical imaging deeper into tissue due to significantly reduced light scattering. Here, Ryan et al. tackle first-order defocus, an artefact of a non-uniform refractive index, extending light-sheet microscopy to partially cleared samples.

    • Duncan P. Ryan
    • , Elizabeth A. Gould
    • , Gregory J. Seedorf
    • , Omid Masihzadeh
    • , Steven H. Abman
    • , Sukumar Vijayaraghavan
    • , Wendy B. Macklin
    • , Diego Restrepo
    •  & Douglas P. Shepherd
  • Article | | open

    Punishment by peers can enforce social norms, such as contributing to a public good. Here, Abbink and colleagues show that individuals will enforce norms even when contributions reduce the net benefit of the group, resulting in the maintenance of wasteful contributions.

    • Klaus Abbink
    • , Lata Gangadharan
    • , Toby Handfield
    •  & John Thrasher
  • Article | | open

    Dorsal premotor cortex (PMd) is thought to be involved in making somatomotor decisions. Chandrasekaran et al. investigated the temporal response dynamics of PMd neurons across cortical layers and show stronger and earlier decision-related responses in the superficial layers and more action execution-related signals in the deeper layers.

    • Chandramouli Chandrasekaran
    • , Diogo Peixoto
    • , William T. Newsome
    •  & Krishna V. Shenoy
  • Article | | open

    Bacterial outer membrane vesicles (OMVs) contain immunogens but no study has yet examined their potential in treating cancer. Here, the authors demonstrate that OMVs can suppress established tumours and prevent tumour metastasis by an interferon-γ mediated antitumor response.

    • Oh Youn Kim
    • , Hyun Taek Park
    • , Nhung Thi Hong Dinh
    • , Seng Jin Choi
    • , Jaewook Lee
    • , Ji Hyun Kim
    • , Seung-Woo Lee
    •  & Yong Song Gho
  • Article | | open

    Simplified device concepts may become important for the development of low cost photovoltaics. Lin et al. report solar cells based on interdigitated gold back-contacts and metal halide perovskites where charge extraction is assisted via a dipole field generated by self-assembled molecular monolayers.

    • Xiongfeng Lin
    • , Askhat N. Jumabekov
    • , Niraj N. Lal
    • , Alexander R. Pascoe
    • , Daniel E. Gómez
    • , Noel W. Duffy
    • , Anthony S. R. Chesman
    • , Kallista Sears
    • , Maxime Fournier
    • , Yupeng Zhang
    • , Qiaoliang Bao
    • , Yi-Bing Cheng
    • , Leone Spiccia
    •  & Udo Bach
  • Article | | open

    Diffusion plays an important role in sintering, damage tolerance and transport. Here authors perform classical and accelerated molecular dynamics simulations of vacancy-mediated cation diffusion in Gd2Ti2O7 pyrochlore and report non-monotonic evolution of cation diffusivity.

    • Romain Perriot
    • , Blas P. Uberuaga
    • , Richard J. Zamora
    • , Danny Perez
    •  & Arthur F. Voter
  • Article | | open

    The properties of complex oxides such as strontium titanate are strongly affected by the presence and distribution of oxygen vacancies. Here, the authors demonstrate that a scanning probe microscope tip can be used to manipulate vacancies by the flexoelectric effect.

    • Saikat Das
    • , Bo Wang
    • , Ye Cao
    • , Myung Rae Cho
    • , Yeong Jae Shin
    • , Sang Mo Yang
    • , Lingfei Wang
    • , Minu Kim
    • , Sergei V. Kalinin
    • , Long-Qing Chen
    •  & Tae Won Noh
  • Article | | open

    The neural circuits of the vestibular system, which detects gravity and motion, remain incompletely characterised. Here the authors use an optical trap to manipulate otoliths (ear stones) in zebrafish larvae, and elicit corrective tail movements and eye rolling, thus establishing a method for mapping vestibular processing.

    • Itia A. Favre-Bulle
    • , Alexander B. Stilgoe
    • , Halina Rubinsztein-Dunlop
    •  & Ethan K. Scott
  • Article | | open

    Current estimates of dissolved CO2 in subduction-zone fluids based on thermodynamic models rely on a very sparse experimental data base. Here, the authors show that experimental graphite-saturated COH fluids interacting with silicates at 1–3 GPa and 800 °C display unpredictably high CO2 contents.

    • S. Tumiati
    • , C. Tiraboschi
    • , D. A. Sverjensky
    • , T. Pettke
    • , S. Recchia
    • , P. Ulmer
    • , F. Miozzi
    •  & S. Poli
  • Article | | open

    The Ediacaran–Cambrian oxygenation of seawater is thought to have been caused by lifeforms engaging in ecosystem engineering. Here, the authors show that siliceous sponges increased seawater dissolved oxygen concentrations by redistributing organic carbon oxidation through filtering suspended organic matter.

    • Michael Tatzel
    • , Friedhelm Blanckenburg
    • , Marcus Oelze
    • , Julien Bouchez
    •  & Dorothee Hippler
  • Article | | open

    Water is usually not favorable in high-voltage window aprotic electrolytes. Here the authors discover some lithium titanate hydrates that allow superior power rate and ultralong cycle life in aprotic electrolytes.

    • Shitong Wang
    • , Wei Quan
    • , Zhi Zhu
    • , Yong Yang
    • , Qi Liu
    • , Yang Ren
    • , Xiaoyi Zhang
    • , Rui Xu
    • , Ye Hong
    • , Zhongtai Zhang
    • , Khalil Amine
    • , Zilong Tang
    • , Jun Lu
    •  & Ju Li
  • Article | | open

    Spinal cord injury can induce synaptic reorganization and remodeling in the brain. Here the authors study how severed distal axons signal back to the cell body to induce hyperexcitability, loss of inhibition and enhanced presynaptic release through netrin-1.

    • Tharkika Nagendran
    • , Rylan S. Larsen
    • , Rebecca L. Bigler
    • , Shawn B. Frost
    • , Benjamin D. Philpot
    • , Randolph J. Nudo
    •  & Anne Marion Taylor
  • Article | | open

    Spectroscopic ellipsometry is an established technique to characterize the optical properties of a material. Here, Minamikawa et al. combine the method with dual-comb spectroscopy, which allows them to obtain ellipsometric parameters including the phase difference between s-polarized and p-polarized light.

    • Takeo Minamikawa
    • , Yi-Da Hsieh
    • , Kyuki Shibuya
    • , Eiji Hase
    • , Yoshiki Kaneoka
    • , Sho Okubo
    • , Hajime Inaba
    • , Yasuhiro Mizutani
    • , Hirotsugu Yamamoto
    • , Tetsuo Iwata
    •  & Takeshi Yasui
  • Article | | open

    Bio-oil is a potential major source of renewable fuels and chemicals. Here, the authors report a palladium-molybdenum mixed catalyst for the selective hydrodeoxygenation of water-insoluble bio-oil to mixtures of alkanes with high carbon yield.

    • Haohong Duan
    • , Juncai Dong
    • , Xianrui Gu
    • , Yung-Kang Peng
    • , Wenxing Chen
    • , Titipong Issariyakul
    • , William K. Myers
    • , Meng-Jung Li
    • , Ni Yi
    • , Alexander F. R. Kilpatrick
    • , Yu Wang
    • , Xusheng Zheng
    • , Shufang Ji
    • , Qian Wang
    • , Junting Feng
    • , Dongliang Chen
    • , Yadong Li
    • , Jean-Charles Buffet
    • , Haichao Liu
    • , Shik Chi Edman Tsang
    •  & Dermot O’Hare
  • Article | | open

    Efficient detection of single molecules is vital to many biosensing technologies, which require analytical platforms with high selectivity and sensitivity. Ren et al. combine a nanopore sensor and a field-effect transistor, whereby gate voltage mediates DNA and protein transport through the nanopore.

    • Ren Ren
    • , Yanjun Zhang
    • , Binoy Paulose Nadappuram
    • , Bernice Akpinar
    • , David Klenerman
    • , Aleksandar P. Ivanov
    • , Joshua B. Edel
    •  & Yuri Korchev
  • Article | | open

    Pathological angiogenesis in the retina is a major cause of blindness. Here the authors show that adenosine receptor A2A drives pathological angiogenesis in the oxygen-induced retinopathy mouse model by promoting glycolysis in endothelial cells via the ERK/Akt/HIF-1α pathway, thereby suggesting new therapeutic targets for disease treatment.

    • Zhiping Liu
    • , Siyuan Yan
    • , Jiaojiao Wang
    • , Yiming Xu
    • , Yong Wang
    • , Shuya Zhang
    • , Xizhen Xu
    • , Qiuhua Yang
    • , Xianqiu Zeng
    • , Yaqi Zhou
    • , Xuejiao Gu
    • , Sarah Lu
    • , Zhongjie Fu
    • , David J. Fulton
    • , Neal L. Weintraub
    • , Ruth B. Caldwell
    • , Wenbo Zhang
    • , Chaodong Wu
    • , Xiao-Ling Liu
    • , Jiang-Fan Chen
    • , Aftab Ahmad
    • , Ismail Kaddour-Djebbar
    • , Mohamed Al-Shabrawey
    • , Qinkai Li
    • , Xuejun Jiang
    • , Ye Sun
    • , Akrit Sodhi
    • , Lois Smith
    • , Mei Hong
    •  & Yuqing Huo