Articles

  • Article | | open

    Pancreatic progenitors (PPs) can be derived from human pluripotent stem cells in vitro but efficiency of differentiation varies, making it hard to sort for insulin-producing cells. Here, the authors use a proteomic approach to identify the secretory granule membrane glycoprotein 2 as a marker for PDX1+/NKX6-1+ PPs.

    • Kathryn F. Cogger
    • , Ankit Sinha
    • , Farida Sarangi
    • , Emily C. McGaugh
    • , Diane Saunders
    • , Craig Dorrell
    • , Salvador Mejia-Guerrero
    • , Yasaman Aghazadeh
    • , Jillian L. Rourke
    • , Robert A. Screaton
    • , Markus Grompe
    • , Philip R. Streeter
    • , Alvin C. Powers
    • , Marcela Brissova
    • , Thomas Kislinger
    •  & M. Cristina Nostro
  • Article | | open

    Magnesium rechargeable batteries potentially offer high-energy density, safety, and low cost. Here the authors show a battery that reversibly intercalates magnesium monochloride cations with excellent rate and cycle performances in addition to the large capacity.

    • Hyun Deog Yoo
    • , Yanliang Liang
    • , Hui Dong
    • , Junhao Lin
    • , Hua Wang
    • , Yisheng Liu
    • , Lu Ma
    • , Tianpin Wu
    • , Yifei Li
    • , Qiang Ru
    • , Yan Jing
    • , Qinyou An
    • , Wu Zhou
    • , Jinghua Guo
    • , Jun Lu
    • , Sokrates T. Pantelides
    • , Xiaofeng Qian
    •  & Yan Yao
  • Article | | open

    Plants are able to prime anti-herbivore defenses in response to olfactory cues of insect pests. Here, Helms et al. identify the insect pheromone E,S-conophthorin produced by the goldenrod gall fly as the specific chemical component that elicits this priming response in goldenrod plants.

    • Anjel M. Helms
    • , Consuelo M. De Moraes
    • , Armin Tröger
    • , Hans T. Alborn
    • , Wittko Francke
    • , John F. Tooker
    •  & Mark C. Mescher
  • Article | | open

    Control over charge transfer in carbon-supported metal nanoparticles is essential for designing new catalysts. Here, the authors show that thermal treatments effectively tune the interfacial charge distribution in carbon-supported palladium catalysts with consequential changes in hydrogenation performance.

    • Radhika G. Rao
    • , Raoul Blume
    • , Thomas W. Hansen
    • , Erika Fuentes
    • , Kathleen Dreyer
    • , Simona Moldovan
    • , Ovidiu Ersen
    • , David D. Hibbitts
    • , Yves J. Chabal
    • , Robert Schlögl
    •  & Jean-Philippe Tessonnier
  • Article | | open

    Chromatid segregation must be coordinated with cytokinesis to preserve genomic stability. Here the authors show that cells clear trailing chromatids from the cleavage site in a two-step cell elongation and demonstrate the role of myosin efflux in the second phase.

    • Emilie Montembault
    • , Marie-Charlotte Claverie
    • , Lou Bouit
    • , Cedric Landmann
    • , James Jenkins
    • , Anna Tsankova
    • , Clemens Cabernard
    •  & Anne Royou
  • Article | | open

    Cold atom quantum simulation has had challenges in realising the tailored, dynamic types of disorder relevant to real materials. Here, the authors use synthetic momentum-space lattices to engineer spatially and dynamically controlled disorder to observe ballistic, diffusive, and arrested atomic transport.

    • Fangzhao Alex An
    • , Eric J. Meier
    •  & Bryce Gadway
  • Article | | open

    Most bacteria live in biofilms, surface-attached communities encased in an extracellular matrix. Here, Yan et al. show that matrix production in Vibrio cholerae increases the osmotic pressure within the biofilm, promoting biofilm expansion and physical exclusion of non-matrix producing cheaters.

    • Jing Yan
    • , Carey D. Nadell
    • , Howard A. Stone
    • , Ned S. Wingreen
    •  & Bonnie L. Bassler
  • Article | | open

    Screening libraries of genetically engineered microbes for secreted products is limited by the available assay throughput. Here the authors combine aptamer-based fluorescent detection with droplet microfluidics to achieve high throughput screening of yeast strains engineered for enhanced tyrosine or streptavidin production.

    • Joseph Abatemarco
    • , Maen F. Sarhan
    • , James M. Wagner
    • , Jyun-Liang Lin
    • , Leqian Liu
    • , Wafa Hassouneh
    • , Shuo-Fu Yuan
    • , Hal S. Alper
    •  & Adam R. Abate
  • Article | | open

    Von Willebrand factor (VWF) is a blood protein involved in clotting and is proposed to be activated by flow, but the mechanism is unknown. Here the authors show that VWF is first converted from a compact to linear form by flow, and is subsequently activated to bind GPIbα in a tension-dependent manner.

    • Hongxia Fu
    • , Yan Jiang
    • , Darren Yang
    • , Friedrich Scheiflinger
    • , Wesley P. Wong
    •  & Timothy A. Springer
  • Article | | open

    Both transcription binding kinetics and post-translational modifications of transcription factors are thought to play a role in the modulation of transcription. Here the authors use single-molecule tracking to directly demonstrate that p53 acetylation modulates promoter residence time and transcriptional activity.

    • Alessia Loffreda
    • , Emanuela Jacchetti
    • , Sofia Antunes
    • , Paolo Rainone
    • , Tiziana Daniele
    • , Tatsuya Morisaki
    • , Marco E. Bianchi
    • , Carlo Tacchetti
    •  & Davide Mazza
  • Article | | open

    Natural hyperbolic materials retain the peculiar optical properties of traditional metamaterials whilst not requiring artificial structuring. Here, the authors perform a theoretical screening of a large class of natural materials with hyperbolic dispersion among the family of layered transition metal dichalcogenides.

    • M. N. Gjerding
    • , R. Petersen
    • , T. G. Pedersen
    • , N. A. Mortensen
    •  & K. S. Thygesen
  • Article | | open

    How glial cells, such as astrocytes, acquire their characteristic morphology during development is poorly understood. Here the authors describe the morphogenesis of astrocyte-like glia in the Drosophila optic lobe, and through a RNAi screen, they identify a transmembrane LRR protein–Lapsyn–that plays a critical role in this process.

    • Benjamin Richier
    • , Cristina de Miguel Vijandi
    • , Stefanie Mackensen
    •  & Iris Salecker
  • Article | | open

    Bacteria can exchange nutrients and macromolecules through tubular membranous structures called nanotubes. Here, the authors show that Bacillus subtilis can kill and prey on Bacillus megaterium by delivering a toxin and extracting nutrients in a nanotube-dependent manner.

    • Ofer Stempler
    • , Amit K. Baidya
    • , Saurabh Bhattacharya
    • , Ganesh Babu Malli Mohan
    • , Elhanan Tzipilevich
    • , Lior Sinai
    • , Gideon Mamou
    •  & Sigal Ben-Yehuda
  • Article | | open

    Metastatic disease is the major reason for breast cancer-related deaths; therefore, a better understanding of this process and its players is needed. Here the authors report the role of SIRT7 in inhibiting SMAD4-mediated breast cancer metastasis providing a possible therapeutic avenue.

    • Xiaolong Tang
    • , Lei Shi
    • , Ni Xie
    • , Zuojun Liu
    • , Minxian Qian
    • , Fanbiao Meng
    • , Qingyang Xu
    • , Mingyan Zhou
    • , Xinyue Cao
    • , Wei-Guo Zhu
    •  & Baohua Liu
  • Article | | open

    There are very few inorganic materials with auxetic homogenous Poisson’s ratio in polycrystalline form. Here authors develop an approach to screening materials databases for target properties such as negative Poisson’s ratio by using stability and structural motifs to predict new instances of homogenous auxetic behavior as well as a number of materials with near-zero Poisson’s ratio.

    • John Dagdelen
    • , Joseph Montoya
    • , Maarten de Jong
    •  & Kristin Persson
  • Article | | open

    The biosynthetic pathway of preakuammicine, a monoterpene precursor of the anti-cancer agent vinblastine, has remained largely unexplored. Here, the authors provide transcriptomic and biochemical data to identify two enzymes that, in tandem, convert strictosidine to akuammicine, the stable shunt product of preakuammicine.

    • Evangelos C. Tatsis
    • , Inês Carqueijeiro
    • , Thomas Dugé de Bernonville
    • , Jakob Franke
    • , Thu-Thuy T. Dang
    • , Audrey Oudin
    • , Arnaud Lanoue
    • , Florent Lafontaine
    • , Anna K. Stavrinides
    • , Marc Clastre
    • , Vincent Courdavault
    •  & Sarah E. O’Connor
  • Article | | open

    Two-dimensional van der Waals heterostructures are of interest due to their unique interlayer coupling and optoelectronic properties. Here authors develop a Langmuir-Blodgett method to organize charge transfer molecular heterostructures with externally tunable conductance and capacitance and broadband photoresponse.

    • Beibei Xu
    • , Himanshu Chakraborty
    • , Vivek K. Yadav
    • , Zhuolei Zhang
    • , Michael L. Klein
    •  & Shenqiang Ren
  • Article | | open

    The quiescence-exit process is noisy even in genetically identical cells under the same environmental conditions. Here the authors show that the heterogeneity of quiescence exit reflects a memory of preceding cell growth at quiescence induction and immediate division history prior to quiescence entry.

    • Xia Wang
    • , Kotaro Fujimaki
    • , Geoffrey C. Mitchell
    • , Jungeun Sarah Kwon
    • , Kimiko Della Croce
    • , Chris Langsdorf
    • , Hao Helen Zhang
    •  & Guang Yao
  • Article | | open

    Diamond’s properties are dictated by its crystalline, fully tetrahedrally bonded structure. Here authors synthesize a bulk sp 3-bonded amorphous form of carbon under high pressure and temperature, show that it has bulk modulus comparable to crystalline diamond and that it can be recovered under ambient conditions.

    • Zhidan Zeng
    • , Liuxiang Yang
    • , Qiaoshi Zeng
    • , Hongbo Lou
    • , Hongwei Sheng
    • , Jianguo Wen
    • , Dean J. Miller
    • , Yue Meng
    • , Wenge Yang
    • , Wendy L. Mao
    •  & Ho-kwang Mao
  • Article | | open

    Most tumours associated with germline BRCA1/BRCA2 loss of function mutations respond to DNA damaging agents, however, some do not. Herein, the authors identify that a subset of breast/ovarian tumors retain a normal allele, which is associated with decreased overall survival after DNA damage-inducing platinum chemotherapy.

    • Kara N. Maxwell
    • , Bradley Wubbenhorst
    • , Brandon M. Wenz
    • , Daniel De Sloover
    • , John Pluta
    • , Lyndsey Emery
    • , Amanda Barrett
    • , Adam A. Kraya
    • , Ioannis N. Anastopoulos
    • , Shun Yu
    • , Yuchao Jiang
    • , Hao Chen
    • , Nancy R. Zhang
    • , Nicole Hackman
    • , Kurt D’Andrea
    • , Robert Daber
    • , Jennifer J. D. Morrissette
    • , Nandita Mitra
    • , Michael Feldman
    • , Susan M. Domchek
    •  & Katherine L. Nathanson
  • Article | | open

    The miniaturization of antennas beyond a wavelength is limited by designs which rely on electromagnetic resonances. Here, Nan et al. have developed acoustically actuated antennas that couple the acoustic resonance of the antenna with the electromagnetic wave, reducing the antenna footprint by up to 100.

    • Tianxiang Nan
    • , Hwaider Lin
    • , Yuan Gao
    • , Alexei Matyushov
    • , Guoliang Yu
    • , Huaihao Chen
    • , Neville Sun
    • , Shengjun Wei
    • , Zhiguang Wang
    • , Menghui Li
    • , Xinjun Wang
    • , Amine Belkessam
    • , Rongdi Guo
    • , Brian Chen
    • , James Zhou
    • , Zhenyun Qian
    • , Yu Hui
    • , Matteo Rinaldi
    • , Michael E. McConney
    • , Brandon M. Howe
    • , Zhongqiang Hu
    • , John G. Jones
    • , Gail J. Brown
    •  & Nian Xiang Sun
  • Article | | open

    Quantum phase transitions are governed by Landau-Ginzburg theory and the exceptions are rare. Here, Li et al. propose a type of Landau-forbidden quantum critical points induced by gapless fermions in two-dimensional Dirac semimetals.

    • Zi-Xiang Li
    • , Yi-Fan Jiang
    • , Shao-Kai Jian
    •  & Hong Yao
  • Article | | open

    The lectin receptor CLEC5A is a pattern recognition receptor that has been shown to detect dengue and Japanese encephalitis virus. Here the authors show that CLEC5A is needed for optimal ROS production, NET formation and other immune responses to Listeria monocytogenes in mice.

    • Szu-Ting Chen
    • , Fei-Ju Li
    • , Tzy-yun Hsu
    • , Shu-Mei Liang
    • , Yi-Chen Yeh
    • , Wen-Yu Liao
    • , Teh-Ying Chou
    • , Nien-Jun Chen
    • , Michael Hsiao
    • , Wen-Bin Yang
    •  & Shie-Liang Hsieh
  • Article | | open

    Alternative splicing coupled to nonsense-mediated decay (AS-NMD) is a conserved mechanism for post-transcriptional gene regulation. Here, the authors provide evidence that AS-NMD is enhanced during dietary restriction (DR) and is required for DR-mediated longevity assurance in C. elegans.

    • Syed Shamsh Tabrez
    • , Ravi Datta Sharma
    • , Vaibhav Jain
    • , Atif Ahmed Siddiqui
    •  & Arnab Mukhopadhyay