Articles

  • Article | | open

    High-entropy alloys represent a new strategy for the design of materials with properties superior to those of conventional alloys, but are largely limited to simple phases of cubic symmetry. By applying high pressures on CrMnFeCoNi, here authors demonstrate synthesis of a hexagonal close-packed phase.

    • Cameron L. Tracy
    • , Sulgiye Park
    • , Dylan R. Rittman
    • , Steven J. Zinkle
    • , Hongbin Bei
    • , Maik Lang
    • , Rodney C. Ewing
    •  & Wendy L. Mao
  • Article | | open

    Selective functionalization of aromatic compounds is important in synthetic chemistry. Here the authors report an N-heterocyclic carbene-catalysed approach for enantioselectively converting ortho-hydroxyaldehydes to cyclic products, via activation of both phenol and aldehyde groups.

    • Xingkuan Chen
    • , Hongling Wang
    • , Kazuki Doitomi
    • , Chong Yih Ooi
    • , Pengcheng Zheng
    • , Wangsheng Liu
    • , Hao Guo
    • , Song Yang
    • , Bao-An Song
    • , Hajime Hirao
    •  & Yonggui Robin Chi
  • Article | | open

    The role of long noncoding RNAs in regulating T-cell differentiation within the tumour microenvironment is unclear. Here the authors identify a lncRNA that, through direct interactions with EGFR, promotes T-regulatory cell differentiation within the microenvironment of hepatocellular carcinoma, thus promoting tumour growth via immune suppression.

    • Runqiu Jiang
    • , Junwei Tang
    • , Yun Chen
    • , Lei Deng
    • , Jie Ji
    • , Yu Xie
    • , Ke Wang
    • , Wei Jia
    • , Wen-Ming Chu
    •  & Beicheng Sun
  • Article | | open

    The leakiness of commonly used genetic components can make the construction of complex synthetic circuits difficult. Here the authors construct NOR gate architecture, using dCas9 fused to the chromatin remodeller Mxi1, that can be wired together into complex circuits.

    • Miles W. Gander
    • , Justin D. Vrana
    • , William E. Voje
    • , James M. Carothers
    •  & Eric Klavins
  • Article | | open

    During non-REM sleep, the thalamus produces spindles and the cortex produces downstates, but the interaction between these two areas in these sleep phenomena is not understood. Here, authors describe the dynamic loop between the thalamus and cortex that organizes the production of spindles and downstates in the human brain.

    • Rachel A. Mak-McCully
    • , Matthieu Rolland
    • , Anna Sargsyan
    • , Chris Gonzalez
    • , Michel Magnin
    • , Patrick Chauvel
    • , Marc Rey
    • , Hélène Bastuji
    •  & Eric Halgren
  • Article | | open

    Mutations in the granulin gene are associated with frontotemporal lobe dementia (FTLD) and a lysosomal storage disease. The authors show that reduced progranulin levels leads to impaired neuronal uptake and lysosomal delivery of prosaposin, and that decreased prosaposin expression in mice leads to FTLD-like behaviour.

    • Xiaolai Zhou
    • , Lirong Sun
    • , Oliver Bracko
    • , Ji Whae Choi
    • , Yan Jia
    • , Alissa L. Nana
    • , Owen Adam Brady
    • , Jean C. Cruz Hernandez
    • , Nozomi Nishimura
    • , William W. Seeley
    •  & Fenghua Hu
  • Article | | open

    Disassembly of three-dimensionally ordered materials generates nanoparticles with new structural and physicochemical properties. Here the authors show a fragmentation strategy applied to a perovskite material leading to nanostructures with improved catalytic activity in the methane combustion.

    • Yuan Wang
    • , Hamidreza Arandiyan
    • , Hassan A. Tahini
    • , Jason Scott
    • , Xin Tan
    • , Hongxing Dai
    • , Julian D. Gale
    • , Andrew L. Rohl
    • , Sean C. Smith
    •  & Rose Amal
  • Article | | open

    Large negative magnetoresistance is usually related to magnetism and the exceptions are rare. Here, Breunig et al. report a large negative magnetoresistance in a topological insulator, TlBi0.15Sb0.85Te2, which is likely due to the Zeeman effect on a barely percolating current path formed in the disordered bulk.

    • Oliver Breunig
    • , Zhiwei Wang
    • , A A Taskin
    • , Jonathan Lux
    • , Achim Rosch
    •  & Yoichi Ando
  • Article | | open

    The WHO targets measles elimination by 2020, a goal that relies on high vaccination coverage. Here, Takahashi et al. identify ‘coldspots’ in the African Great Lakes region where measles vaccine coverage is below 80%, suggesting that these regions should be targeted in future vaccination campaigns.

    • Saki Takahashi
    • , C. Jessica E. Metcalf
    • , Matthew J. Ferrari
    • , Andrew J. Tatem
    •  & Justin Lessler
  • Article | | open

    A number of natural occurring small-molecule splicing modulators are known. Here, the authors combine chemogenomic, structural and biochemical methods and show that these compounds also target the spliceosome-associated protein PHF5A and propose a potential modulator binding site in the PHF5A–SF3B1 complex.

    • Teng Teng
    • , Jennifer HC Tsai
    • , Xiaoling Puyang
    • , Michael Seiler
    • , Shouyong Peng
    • , Sudeep Prajapati
    • , Daniel Aird
    • , Silvia Buonamici
    • , Benjamin Caleb
    • , Betty Chan
    • , Laura Corson
    • , Jacob Feala
    • , Peter Fekkes
    • , Baudouin Gerard
    • , Craig Karr
    • , Manav Korpal
    • , Xiang Liu
    • , Jason T. Lowe
    • , Yoshiharu Mizui
    • , James Palacino
    • , Eunice Park
    • , Peter G. Smith
    • , Vanitha Subramanian
    • , Zhenhua Jeremy Wu
    • , Jian Zou
    • , Lihua Yu
    • , Agustin Chicas
    • , Markus Warmuth
    • , Nicholas Larsen
    •  & Ping Zhu
  • Article | | open

    Mechanical properties of living organisms are determined by intra- and extra-cellular biopolymer networks. Here, the authors show how the mechanics of polyisocyanopeptide hydrogels, mimicking biopolymers, can be readily manipulated by introducing a second polymer network.

    • Maarten Jaspers
    • , Sarah L. Vaessen
    • , Pim van Schayik
    • , Dion Voerman
    • , Alan E. Rowan
    •  & Paul H. J. Kouwer
  • Article | | open

    The derivation of blood progenitor cells from human pluripotent stem cells is of interest for cell therapy but remains an inefficient process. Here the authors micropattern hPSC-derived haemogenic endothelial (HE) cells into spatially-organized, size-controlled colonies and identify a geometry that achieves increased efficiency in deriving blood cells.

    • Nafees Rahman
    • , Patrick M. Brauer
    • , Lilian Ho
    • , Tatiana Usenko
    • , Mukul Tewary
    • , Juan Carlos Zúñiga-Pflücker
    •  & Peter W. Zandstra
  • Article | | open

    Skeletal muscle atrophy can occur in response to stimuli such as inactivity, fasting, and ageing. Here the authors show that expression of microRNA-29b promotes muscle atrophy by targeting IGF-1 and PI3K, and that its inhibition attenuates atrophy induced by denervation and immobilization in mice.

    • Jin Li
    • , Mun Chun Chan
    • , Yan Yu
    • , Yihua Bei
    • , Ping Chen
    • , Qiulian Zhou
    • , Liming Cheng
    • , Lei Chen
    • , Olivia Ziegler
    • , Glenn C. Rowe
    • , Saumya Das
    •  & Junjie Xiao
  • Article | | open

    Protein-protein interactions (PPIs) play a major role in defining biological functions. Here, the authors present PPiSeq, a method to quantitatively score dynamic PPIs in yeast combining fragment complementation assays, genomic double-barcoding, and an analytical framework to precisely call fitness from barcode lineage trajectories.

    • Ulrich Schlecht
    • , Zhimin Liu
    • , Jamie R. Blundell
    • , Robert P. St.Onge
    •  & Sasha F. Levy
  • Article | | open

    Though humans often learn about negative outcomes from observing the response of others, the neurochemistry underlying this learning is unknown. Here, authors show that blocking opioid receptors enhances social threat learning and describe the brain regions underlying this effect.

    • Jan Haaker
    • , Jonathan Yi
    • , Predrag Petrovic
    •  & Andreas Olsson
  • Article | | open

    The proteasome regulates several important cellular processes and has been identified as a target for therapeutic interventions. Here the authors map the conformational and energy landscape of the 26S proteasome upon Oprozomib binding and uncover long-range allosteric effects that control the dynamic behaviour of the proteasome.

    • David Haselbach
    • , Jil Schrader
    • , Felix Lambrecht
    • , Fabian Henneberg
    • , Ashwin Chari
    •  & Holger Stark
  • Article | | open

    Expanding pore sizes and volumes in metal-organic frameworks is challenging, but crucial for the encapsulation of larger guest molecules. Here, Zhou and colleagues report a linker labilization strategy to construct MOFs containing hierarchical pore architectures with dimensions ranging from 1.5 to 18 nm.

    • Shuai Yuan
    • , Lanfang Zou
    • , Jun-Sheng Qin
    • , Jialuo Li
    • , Lan Huang
    • , Liang Feng
    • , Xuan Wang
    • , Mathieu Bosch
    • , Ali Alsalme
    • , Tahir Cagin
    •  & Hong-Cai Zhou
  • Article | | open

    Summer rainfall in the agriculturally-reliant Sahel is extremely variable, with the region particularly vulnerable to major droughts. Here, the authors investigate the mechanisms that drive Sahel summer rainfall change on inter-annual and multi-year timescales and show that Sahel rainfall can be skilfully predicted.

    • K. L. Sheen
    • , D. M. Smith
    • , N. J. Dunstone
    • , R. Eade
    • , D. P. Rowell
    •  & M. Vellinga
  • Article | | open

    Bicuspid aortic valve (BAV) is the most common human congenital cardiovascular malformation. Here, the authors perform a genome-wide association study for BAV and identify risk variants in the gene region of cardiac-specific transcription factor GATA4 and implicate GATA4 in heart valve development.

    • Bo Yang
    • , Wei Zhou
    • , Jiao Jiao
    • , Jonas B. Nielsen
    • , Michael R. Mathis
    • , Mahyar Heydarpour
    • , Guillaume Lettre
    • , Lasse Folkersen
    • , Siddharth Prakash
    • , Claudia Schurmann
    • , Lars Fritsche
    • , Gregory A. Farnum
    • , Maoxuan Lin
    • , Mohammad Othman
    • , Whitney Hornsby
    • , Anisa Driscoll
    • , Alexandra Levasseur
    • , Marc Thomas
    • , Linda Farhat
    • , Marie-Pierre Dubé
    • , Eric M. Isselbacher
    • , Anders Franco-Cereceda
    • , Dong-chuan Guo
    • , Erwin P. Bottinger
    • , G. Michael Deeb
    • , Anna Booher
    • , Sachin Kheterpal
    • , Y. Eugene Chen
    • , Hyun Min Kang
    • , Jacob Kitzman
    • , Heather J. Cordell
    • , Bernard D. Keavney
    • , Judith A. Goodship
    • , Santhi K. Ganesh
    • , Gonçalo Abecasis
    • , Kim A. Eagle
    • , Alan P. Boyle
    • , Ruth J. F. Loos
    • , Per Eriksson
    • , Jean-Claude Tardif
    • , Chad M. Brummett
    • , Dianna M. Milewicz
    • , Simon C. Body
    •  & Cristen J. Willer
  • Article | | open

    The rates of acid-catalysed reactions vary in constrained environments. Here the authors show that molecularly sized pores greatly promote aqueous phase alcohol dehydration by enhancing the association between substrate and hydronium ions, and even by lowering the free energy barrier.

    • Hui Shi
    • , Sebastian Eckstein
    • , Aleksei Vjunov
    • , Donald M. Camaioni
    •  & Johannes A. Lercher
  • Article | | open

    The cytoskeleton plays a key role in cell/cell junction formation, but how the coordinated behaviour of the cytoskeleton contributes is not known. Here the authors show that actin-microtubule crosslinker ACF7 plays a key role in tight junction stabilization and wound healing in intestinal epithelium.

    • Yanlei Ma
    • , Jiping Yue
    • , Yao Zhang
    • , Chenzhang Shi
    • , Matt Odenwald
    • , Wenguang G. Liang
    • , Qing Wei
    • , Ajay Goel
    • , Xuewen Gou
    • , Jamie Zhang
    • , Shao-Yu Chen
    • , Wei-Jen Tang
    • , Jerrold R. Turner
    • , Feng Yang
    • , Hong Liang
    • , Huanlong Qin
    •  & Xiaoyang Wu
  • Article | | open

    Nanoscopic water droplets in a hydrophobic liquid are abundant in the earth, our bodies and the sky. Here, it is shown that the surface of such a droplet has stronger hydrogen bonds than a planar interface of water and a hydrophobic liquid, equivalent to a 50 K reduction of the surface temperature.

    • Nikolay Smolentsev
    • , Wilbert J. Smit
    • , Huib J. Bakker
    •  & Sylvie Roke