Browse Articles

  • Article | | open

    Two-dimensional materials are promising for electrochemical storage and conversion, but are somewhat limited in composition. Here the authors use a computational strategy to predict the existence of a layered boride material, which they synthesize and demonstrate prospective for use as an anode material.

    • Junjie Wang
    • , Tian-Nan Ye
    • , Yutong Gong
    • , Jiazhen Wu
    • , Nanxi Miao
    • , Tomofumi Tada
    •  & Hideo Hosono
  • Article | | open

    Dynamic topological phenomena remain challenging to be probed experimentally. Here, Wang et al. theoretically characterize and experimentally detect dynamical skyrmions in parity‐time‐symmetric non‐unitary quench dynamics in single‐photon discrete‐time quantum walks.

    • Kunkun Wang
    • , Xingze Qiu
    • , Lei Xiao
    • , Xiang Zhan
    • , Zhihao Bian
    • , Barry C. Sanders
    • , Wei Yi
    •  & Peng Xue
  • Article | | open

    Social life requires us to store information about each person’s unique disposition. Here, the authors show that the brain represents people as the sums of the mental states that those people are believed to experience.

    • Mark A. Thornton
    • , Miriam E. Weaverdyck
    •  & Diana I. Tamir
  • Article | | open

    Active nematics consist of elongated self-driven units and can emerge in bacterial systems. Here the authors investigate such emergence in a growing bacterial biofilm and demonstrate that localized stress and mechanical instabilities drive the formation of large-scale order.

    • Yusuf Ilker Yaman
    • , Esin Demir
    • , Roman Vetter
    •  & Askin Kocabas
  • Article | | open

    We make decisions with varying degrees of confidence and, if our confidence in a decision falls, we may change our mind. Here, the authors present a neuronal circuit model to account for how change of mind occurs under particular low-confidence conditions.

    • Nadim A. A. Atiya
    • , Iñaki Rañó
    • , Girijesh Prasad
    •  & KongFatt Wong-Lin
  • Article | | open

    The wheat Pm3 immune receptors confer resistance against powdery mildew by recognizing isolate-specific avirulence (AVR) effectors of the pathogen. Here, the authors identify and characterize two new AVR genes and demonstrate that Pm3 receptors are determinants of host-specificity for grass mildews.

    • Salim Bourras
    • , Lukas Kunz
    • , Minfeng Xue
    • , Coraline Rosalie Praz
    • , Marion Claudia Müller
    • , Carol Kälin
    • , Michael Schläfli
    • , Patrick Ackermann
    • , Simon Flückiger
    • , Francis Parlange
    • , Fabrizio Menardo
    • , Luisa Katharina Schaefer
    • , Roi Ben-David
    • , Stefan Roffler
    • , Simone Oberhaensli
    • , Victoria Widrig
    • , Stefan Lindner
    • , Jonatan Isaksson
    • , Thomas Wicker
    • , Dazhao Yu
    •  & Beat Keller
  • Article | | open

    Molecular switches that can access more than just a few states are difficult to realize. Here, the authors use scanning tunnelling microscopy and spectroscopy to show that a surface-bound Li@C60 endofullerene can be switched between 14 molecular states—distinguished by the location of the Li atom inside the fullerene cage—by resonant tunnelling through the superatom molecular orbitals.

    • Henry J. Chandler
    • , Minas Stefanou
    • , Eleanor E. B. Campbell
    •  & Renald Schaub
  • Article | | open

    The growth of oriented crystalline metal–organic frameworks is desirable to exploit their surface area and porosity, but has proven difficult. Here the authors fabricate highly-oriented and simultaneously activated free-standing MOFs by an acoustically driven microcentrifugation platform.

    • Heba Ahmed
    • , Amgad R. Rezk
    • , Joseph J. Richardson
    • , Lauren K. Macreadie
    • , Ravichandar Babarao
    • , Edwin L. H. Mayes
    • , Lillian Lee
    •  & Leslie Y. Yeo
  • Article | | open

    Sustained sperm production is dependent on activity of undifferentiated spermatogonia. Here, the authors demonstrate an essential role for RNA helicase DDX5 in maintenance of spermatogonia in adults through control of gene transcription plus RNA processing and export.

    • Julien M. D. Legrand
    • , Ai-Leen Chan
    • , Hue M. La
    • , Fernando J. Rossello
    • , Minna-Liisa Änkö
    • , Frances V. Fuller-Pace
    •  & Robin M. Hobbs
  • Article | | open

    Magnetohydrodynamic (MHD) waves and plasma instabilities can be studied during solar flares. Here the authors show evidence for an MHD sausage mode oscillation periodically triggering electron acceleration at a magnetic null point in the solar corona, indicating MHD oscillations in plasma can indirectly lead to loss-cone instability modulation.

    • Eoin P. Carley
    • , Laura A. Hayes
    • , Sophie A. Murray
    • , Diana E. Morosan
    • , Warren Shelley
    • , Nicole Vilmer
    •  & Peter T. Gallagher
  • Article | | open

    The role of fungi in the biogeochemical cycling of gold remains unclear. Here the authors show that fungi can initiate gold oxidation under supergene conditions, thereby impacting gold mobilisation and secondary deposit formation in terrestrial environments.

    • Tsing Bohu
    • , Ravi Anand
    • , Ryan Noble
    • , Mel Lintern
    • , Anna H. Kaksonen
    • , Yuan Mei
    • , Ka Yu Cheng
    • , Xiao Deng
    • , Jean-Pierre Veder
    • , Michael Bunce
    • , Matthew Power
    •  & Mike Verrall
  • Article | | open

    Animal diversity, measured in numbers of species, is rapidly being lost to extinction. Here, Cooke et al. show that the diversity of ecological strategies employed by land mammals and birds is also expected to narrow towards small, fecund, insect-eating generalists with fast-paced life histories.

    • Robert S. C. Cooke
    • , Felix Eigenbrod
    •  & Amanda E. Bates
  • Article | | open

    Here, the authors determine the respiratory virome and serum cytokine profile in children diagnosed with acute respiratory tract infections (ARTI) and show that relative abundance of Propionibacterium phages as well as serum levels of TIMP-1 and PDGF-BB are increased in multiple ARTIs compared with single ARTI.

    • Yanpeng Li
    • , Xuemin Fu
    • , Jinmin Ma
    • , Jianhui Zhang
    • , Yihong Hu
    • , Wei Dong
    • , Zhenzhou Wan
    • , Qiongfang Li
    • , Yi-Qun Kuang
    • , Ke Lan
    • , Xia Jin
    • , Jian-Hua Wang
    •  & Chiyu Zhang
  • Article | | open

    The determination of the antiferromagnetic (AFM) orders by the anisotropic magnetoresistance (AMR) is one of the key components to the AFM-spintronics. Here the authors report enhanced AMR ~160% in Sr2IrO4 due to the combination of atomic scale giant-MR-like effect and magnetocrystalline anisotropy energy.

    • Haowen Wang
    • , Chengliang Lu
    • , Jun Chen
    • , Yong Liu
    • , S. L. Yuan
    • , Sang-Wook Cheong
    • , Shuai Dong
    •  & Jun-Ming Liu
  • Article | | open

    While hydrogen as a renewable fuel can be produced from water, there is a scarcity of metal-free materials that serve as effective electrocatalysts. Here, authors functionalize carbon fiber cloth with amides to improve hydrogen evolution activities in both acid and alkaline water.

    • Yurui Xue
    • , Lan Hui
    • , Huidi Yu
    • , Yuxin Liu
    • , Yan Fang
    • , Bolong Huang
    • , Yingjie Zhao
    • , Zhibo Li
    •  & Yuliang Li
  • Article | | open

    Mutation of LMNA, encoding Lamin A/C nuclear proteins, cause dilated cardiomyopathy and conduction disorders. Here, the authors show that patient-specific iPSC-derived CMs carrying the K219T LMNA mutation have downregulated Nav1.5 channels due to dynamic cooperation of Lamin A/C and Polycomb repressor complex 2 at the SCN5A promoter.

    • Nicolò Salvarani
    • , Silvia Crasto
    • , Michele Miragoli
    • , Alessandro Bertero
    • , Marianna Paulis
    • , Paolo Kunderfranco
    • , Simone Serio
    • , Alberto Forni
    • , Carla Lucarelli
    • , Matteo Dal Ferro
    • , Veronica Larcher
    • , Gianfranco Sinagra
    • , Paolo Vezzoni
    • , Charles E. Murry
    • , Giuseppe Faggian
    • , Gianluigi Condorelli
    •  & Elisa Di Pasquale
  • Article | | open

    While photoredox catalysis presents exciting avenues for molecular transformations, balancing optimal photochemical and materials properties can be challenging. Here, the authors prepare carbon-coated In2O3 nanoparticles as recoverable photocatalysts for arylboronic acid oxidative hydroxylation.

    • Liming Sun
    • , Rong Li
    • , Wenwen Zhan
    • , Yusheng Yuan
    • , Xiaojun Wang
    • , Xiguang Han
    •  & Yanli Zhao
  • Article | | open

    Turning tumour promoting macrophages into an anti-tumour phenotype is an attractive therapeutic strategy. Here, the authors develop a polysaccharide-based structure that mimicks pathogen-associated molecular patterns and, by activating the toll-like receptors on macrophage surface, promotes a safe anti-tumour immune response in mouse models.

    • Yanxian Feng
    • , Ruoyu Mu
    • , Zhenzhen Wang
    • , Panfei Xing
    • , Junfeng Zhang
    • , Lei Dong
    •  & Chunming Wang
  • Article | | open

    Multidomain RNA-binding proteins recognize specific target sequences through mechanisms that are not well understood. Here the authors present an integrated approach to define the RNA-binding specificity and RNP topology and apply it to the analysis of the prototypical multidomain RNA-binding protein IMP3.

    • Tim Schneider
    • , Lee-Hsueh Hung
    • , Masood Aziz
    • , Anna Wilmen
    • , Stephanie Thaum
    • , Jacqueline Wagner
    • , Robert Janowski
    • , Simon Müller
    • , Silke Schreiner
    • , Peter Friedhoff
    • , Stefan Hüttelmaier
    • , Dierk Niessing
    • , Michael Sattler
    • , Andreas Schlundt
    •  & Albrecht Bindereif
  • Article | | open

    Helicobacter pylori, a bacterial pathogen that infects human stomachs, has high genetic diversity across hosts. Here, Ailloud et al. reveal genetic structuring of H. pylori populations among different stomach regions of individual hosts and find signals of genetic associations with stomach region.

    • Florent Ailloud
    • , Xavier Didelot
    • , Sabrina Woltemate
    • , Gudrun Pfaffinger
    • , Jörg Overmann
    • , Ruth Christiane Bader
    • , Christian Schulz
    • , Peter Malfertheiner
    •  & Sebastian Suerbaum
  • Article | | open

    The Cre-Lox system allows high spatiotemporal control of genetic modifications. Here the authors present iSuRe-Cre that significantly increases Cre activity in reporter expressing cells, which ultimately increases the efficiency and reliability of Cre-dependent reporter and gene function analysis.

    • Macarena Fernández-Chacón
    • , Verónica Casquero-García
    • , Wen Luo
    • , Federica Francesca Lunella
    • , Susana Ferreira Rocha
    • , Sergio Del Olmo-Cabrera
    •  & Rui Benedito
  • Article | | open

    Despite the current human CD4 memory T cell stratification by CD45RA/CCR7, functional heterogeneities still exist within the respective subsets. Here the authors show that several surface markers, including KLRB1, KLRG1, GPR56 and KLRF1, help to further refine the subsetting of human CD4 memory T cells and provide insights for their differentiation.

    • Kim-Long Truong
    • , Stephan Schlickeiser
    • , Katrin Vogt
    • , David Boës
    • , Katarina Stanko
    • , Christine Appelt
    • , Mathias Streitz
    • , Gerald Grütz
    • , Nadja Stobutzki
    • , Christian Meisel
    • , Christina Iwert
    • , Stefan Tomiuk
    • , Julia K. Polansky
    • , Andreas Pascher
    • , Nina Babel
    • , Ulrik Stervbo
    • , Igor Sauer
    • , Undine Gerlach
    •  & Birgit Sawitzki
  • Article | | open

    Triboelectric nanogenerators harvest energy by contacting two solids or a liquid and a solid. Here the authors use a conductive liquid membrane as a permeable electrode to demonstrate triboelectrification via liquid–liquid contact by passing liquid droplets through a liquid membrane to generate power.

    • Jinhui Nie
    • , Ziming Wang
    • , Zewei Ren
    • , Shuyao Li
    • , Xiangyu Chen
    •  & Zhong Lin Wang
  • Article | | open

    Hepatitis delta virus (HDV) depends on the envelope proteins of hepatitis B virus (HBV) for virion production. Here, Lempp et al. produce a cell line expressing HBV envelope proteins and their receptor, which allows continuous secretion of infectious progeny HDV and testing of antiviral drugs.

    • Florian A. Lempp
    • , Franziska Schlund
    • , Lisa Rieble
    • , Lea Nussbaum
    • , Corinna Link
    • , Zhenfeng Zhang
    • , Yi Ni
    •  & Stephan Urban
  • Article | | open

    During evoked swims, zebrafish larvae transition from fast to slow speeds. Here, the authors elucidate the circuit mechanisms in the central pattern generators in the spinal cord and show that genetically labeled V1 spinal interneurons provide in phase inhibition onto fast and slow motor neurons that are involved in the switching behaviour.

    • Yukiko Kimura
    •  & Shin-ichi Higashijima
  • Article | | open

    Mammalian eggs require a single sperm for viable fertilization, and cortical granule exocytosis prevents additional sperm binding. Vogt et al. image at single granule resolution to document that cortical granule anchoring in the cortex ensures proper trafficking, exocytosis and polyspermy block.

    • Edgar-John Vogt
    • , Keizo Tokuhiro
    • , Min Guo
    • , Ryan Dale
    • , Guanghui Yang
    • , Maria Jimenez Movilla
    • , Hari Shroff
    •  & Jurrien Dean
  • Article | | open

    The perception of spatial patterns (form vision) is thought to rely on rod and cone cells in the retina. Here, the authors show that a third kind of retinal cell, melanopsin-expressing ganglion cells, can also detect form in humans, under particular conditions.

    • Annette E. Allen
    • , Franck P. Martial
    •  & Robert J. Lucas
  • Article | | open

    Cyclic GMP-AMP synthase (cGAS) is involved in the modulation of inflammatory responses. Here, the authors present small-molecule inhibitors of human cGAS, characterize their interaction with the protein, and show that the compounds are active in interferon-producing cells including primary human macrophages.

    • Lodoe Lama
    • , Carolina Adura
    • , Wei Xie
    • , Daisuke Tomita
    • , Taku Kamei
    • , Vitaly Kuryavyi
    • , Tasos Gogakos
    • , Joshua I. Steinberg
    • , Michael Miller
    • , Lavoisier Ramos-Espiritu
    • , Yasutomi Asano
    • , Shogo Hashizume
    • , Jumpei Aida
    • , Toshihiro Imaeda
    • , Rei Okamoto
    • , Andy J. Jennings
    • , Mayako Michino
    • , Takanobu Kuroita
    • , Andrew Stamford
    • , Pu Gao
    • , Peter Meinke
    • , J. Fraser Glickman
    • , Dinshaw J. Patel
    •  & Thomas Tuschl
  • Article | | open

    Episodic memory retrieval is hypothesized to rely on hippocampal reinstatement of item-context associations which drives reinstatement of item information in cortex. Here, the authors confirm this sequence of events, using iEEG recordings from the human hippocampus and lateral temporal cortex.

    • D. Pacheco Estefan
    • , M. Sánchez-Fibla
    • , A. Duff
    • , A. Principe
    • , R. Rocamora
    • , H. Zhang
    • , N. Axmacher
    •  & P. F. M. J. Verschure
  • Article | | open

    Two challenging theories, accretion versus collision, approach the orogenesis of the North American Cordillera. Here, the authors present new, high-resolution geophysical datasets consistent with a model of collision in response to westward subduction of the North American craton.

    • Yunfeng Chen
    • , Yu Jeffrey Gu
    • , Claire A. Currie
    • , Stephen T. Johnston
    • , Shu-Huei Hung
    • , Andrew J. Schaeffer
    •  & Pascal Audet
  • Article | | open

    Garden bird feeding is a prolific human activity that provides a reliable foraging opportunity to wild birds. Here the authors use a 40-year data set to show that large-scale restructuring of garden bird communities and growth in urban bird populations can be linked to changing feeding practices.

    • Kate E. Plummer
    • , Kate Risely
    • , Mike P. Toms
    •  & Gavin M. Siriwardena
  • Article | | open

    The development of tissue-engineered vascular grafts heavily relies on the availability of large animal models that allow long-term assessment of graft patency. Here Itoh et al. propose a novel model of immunodeficient pigs that allows long-term accommodation of human cell-derived three-dimensional bioprinted vascular tubes.

    • Manabu Itoh
    • , Yosuke Mukae
    • , Takahiro Kitsuka
    • , Kenichi Arai
    • , Anna Nakamura
    • , Kazuyoshi Uchihashi
    • , Shuji Toda
    • , Kumika Matsubayashi
    • , Jun-ichi Oyama
    • , Koichi Node
    • , Daisuke Kami
    • , Satoshi Gojo
    • , Shigeki Morita
    • , Takahiro Nishida
    • , Koichi Nakayama
    •  & Eiji Kobayashi
  • Article | | open

    The tectonic evolution of the Laxmi basin, in the northwest Indian Ocean, remains controversial. Here, the authors present new geochemical and seismic data which indicate the Laxmi basin formed by a subduction initiation event during the break-up of Gondwana.

    • Dhananjai K. Pandey
    • , Anju Pandey
    •  & Scott A. Whattam
  • Article | | open

    It is known that Purkinje cell PKC-dependent depression is involved in the stabilization of self-motion based hippocampal representation. Here the authors describe decreased stability of hippocampal place cells based on allocentric cues in mice lacking Purkinje cell PP2B-dependent potentiation.

    • Julie Marie Lefort
    • , Jean Vincent
    • , Lucille Tallot
    • , Frédéric Jarlier
    • , Chris Innocentius De Zeeuw
    • , Laure Rondi-Reig
    •  & Christelle Rochefort
  • Article | | open

    Universal non-equilibrium behaviour can emerge in physical systems when they are driven through a parameter regime where their energy gap closes. Dóra et al. show that the Kibble-Zurek scaling associated with exceptional points in non-Hermitian systems is distinct from the conventional Hermitian result.

    • Balázs Dóra
    • , Markus Heyl
    •  & Roderich Moessner
  • Article | | open

    Complement activation contributes to vascular inflammation in the contexts of allograft rejection and connective tissue disease. Here Fang et al. identify ZFYVE21 as a novel effector of Rab5 and find it regulates pro-inflammatory NF-κB signaling in endothelial cells in response to complement activation.

    • Caodi Fang
    • , Thomas D. Manes
    • , Lufang Liu
    • , Kevin Liu
    • , Lingfeng Qin
    • , Guangxin Li
    • , Zuzana Tobiasova
    • , Nancy C. Kirkiles-Smith
    • , Manal Patel
    • , Jonathan Merola
    • , Whitney Fu
    • , Rebecca Liu
    • , Catherine Xie
    • , Gregory T. Tietjen
    • , Peter A. Nigrovic
    • , George Tellides
    • , Jordan S. Pober
    •  & Dan Jane-wit
  • Article | | open

    Sediments have the potential to preserve the signature of geologic events such as earthquakes. Here, the authors provide a paleoseismological analysis of the sediments of Lake Rara, Nepal, to reconstruct the number of earthquakes that caused lake shaking and subsequent turbidite deposition during the last centuries.

    • Z. Ghazoui
    • , S. Bertrand
    • , K. Vanneste
    • , Y. Yokoyama
    • , J. Nomade
    • , A. P. Gajurel
    •  & P. A. van der Beek
  • Article | | open

    Symmetry breaking is an important process in fundamental understanding of matter and dark matter. Here the authors discuss an experimental bound on an exotic parity odd spin- and velocity-dependent interaction between electron and nucleon by using a sensitive spin-exchange relaxation-free atomic magnetometer.

    • Young Jin Kim
    • , Ping-Han Chu
    • , Igor Savukov
    •  & Shaun Newman
  • Article | | open

    ABC exporters hydrolyze ATP to pump substrates across membranes, but critical steps of the transport mechanism remain poorly understood. Here, the authors solve the crystal structure of outward-facing TM287/288 with the help of a state-specific sybody and gain insights into the role of the extracellular gate.

    • Cedric A. J. Hutter
    • , M. Hadi Timachi
    • , Lea M. Hürlimann
    • , Iwan Zimmermann
    • , Pascal Egloff
    • , Hendrik Göddeke
    • , Svetlana Kucher
    • , Saša Štefanić
    • , Mikko Karttunen
    • , Lars V. Schäfer
    • , Enrica Bordignon
    •  & Markus A. Seeger
  • Article | | open

    Viral rebound following discontinuation of antiretroviral therapy (ART) is a major obstacle for HIV cure. Here, the authors show that adoptive cellular therapy using autologous Env-specific T cells augmented by therapeutic vaccination can control viral rebound after ART interruption in a SHIV macaque model.

    • Jin Fan
    • , Hua Liang
    • , Xiaolin Ji
    • , Shuo Wang
    • , Jing Xue
    • , Dan Li
    • , Hong Peng
    • , Chuan Qin
    • , Cassian Yee
    •  & Yiming Shao
  • Article | | open

    Artisanal fish fences are used for fishing along many tropical coastlines. Here, Exton et al. examine the impact footprint of artisanal fish fences, showing that they are highly non-selective, cause direct harm across the tropical seascape, disrupt ecological connectivity and create social conflict.

    • Dan A. Exton
    • , Gabby N. Ahmadia
    • , Leanne C. Cullen-Unsworth
    • , Jamaluddin Jompa
    • , Duncan May
    • , Joel Rice
    • , Paul W. Simonin
    • , Richard K. F. Unsworth
    •  & David J. Smith
  • Article | | open

    Post-translational protein modifications can affect lifespan and aging but age-dependent ubiquitylation changes have not yet been systematically characterized. Here, the authors analyze age-related proteome and ubiquitylome dynamics in Drosophila and identify increasing H2A ubiquitylation as a conserved aging marker.

    • Lu Yang
    • , Zaijun Ma
    • , Han Wang
    • , Kongyan Niu
    • , Ye Cao
    • , Le Sun
    • , Yang Geng
    • , Bo Yang
    • , Feng Gao
    • , Zuolong Chen
    • , Zhen Wu
    • , Qingqing Li
    • , Yong Shen
    • , Xumin Zhang
    • , Hong Jiang
    • , Yelin Chen
    • , Rui Liu
    • , Nan Liu
    •  & Yaoyang Zhang
  • Article | | open

    The red nucleus (RN) is a midbrain nucleus known to be involved in the fine control of limb movements, but its role in motor learning is unclear. Here, the authors identified a neuronal population within the red nucleus, co-expressing Vglut2, PV and C1Ql2, which undergoes training-dependent plasticity.

    • Giorgio Rizzi
    • , Mustafa Coban
    •  & Kelly R. Tan
  • Article | | open

    Chemical imaging and spectroscopy have previously been used to identify eumelanin residue in fossils and infer dark coloration. Here, Manning and colleagues develop an approach to identify pheomelanin (red pigment) residues and ascertain their distribution in fossils.

    • Phillip L. Manning
    • , Nicholas P. Edwards
    • , Uwe Bergmann
    • , Jennifer Anné
    • , William I. Sellers
    • , Arjen van Veelen
    • , Dimosthenis Sokaras
    • , Victoria M. Egerton
    • , Roberto Alonso-Mori
    • , Konstantin Ignatyev
    • , Bart E. van Dongen
    • , Kazumasa Wakamatsu
    • , Shosuke Ito
    • , Fabien Knoll
    •  & Roy A. Wogelius