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The stereoselective synthesis of 1,3-dienes represents a challenge in organic synthesis. Here, the authors report a ligand-controlled stereodivergent access to both Z- and E-sulfonyl-1,3-dienes via photoredox and nickel catalysis.
Characterisation of quantum hardware requires clear indications on what can and cannot be learned about quantum noise. Here, the authors show how to characterise learnable degrees of freedom of a Clifford gate using tools from algebraic graph theory.
Aromatic amino acids in proteins support ligand binding and protein stability. To parse the physiocochemical roles of aromatic interactions, here Galles, Infield and co-authors identify pyrrolysine-based aminoacyl-tRNA synthetases that enable the encoding of fluorinated phenylalanine amino acids.
The avalanche of publications challenges the norm that researchers extract knowledge from literature to design materials. Here the authors present a text-mining method that is implemented based on the abstracts of 6.4 million papers to enable the design of new high entropy alloys.
All-inorganic nanocrystals are of great importance for a variety of electronic applications. Here, the authors use metal salts to remove organic ligands to obtain passivated nanocrystals with improved fluorescence yield for direct optical patterning.
Nagao et al. show that the insulin receptor can mediate receptor-dependent, but ligand- and tyrosine kinase-independent, events. These are associated with regulation of extracellular matrix, cell cycle, ATM signaling, senescence and apoptosis.
Extremophilic red algae have thrived in hot springs for more than a billion years. Here, the authors analyze chromosome-level assemblies from three red algal species, finding that horizontal gene transfer, subtelomeric gene duplication, and loss of genes or reduction in gene family size have supported key extremophilic adaptations.
This study assesses the probability that deaths following a COVID-19 vaccination are attributable to the vaccine. The authors review all deaths that occurred within 30 days of vaccine receipt in Qatar until June 2022 and find that deaths attributable to vaccination are extremely rare.
With advances in robotic technology, the complexity of control of robot has been increasing owing to fundamental von Neumann bottlenecks. Here, we demonstrate coordinated movement by a fully parallel-processable synaptic array with reduced control complexity.
Nanoscale circularly polarized light sources are an important building block for future integrated photonics. Here the authors demonstrate circularly polarized light emission from a thin organic single crystal light-emitting diode.
Impacts of Tibetan Plateau darkening remain unclear. Here authors show that darkening under the RCP8.5 scenario will increase South Asian monsoon precipitation and the “South Flood-North Drought” pattern over East Asia, while lead to local glacier loss.
Authors carry out a systematic review and meta-analysis to evaluate the performance of fibrosis biomarkers for the diagnosis of fibrosis and cirrhosis in patients with chronic hepatitis B virus infection living in sub-Saharan Africa.
Self-assembled nanocomposites present opportunities for a range of phase morphologies and desirable properties. Here authors present tuneable self-assembled nanostructures in the SnO2:NiO system; the double-percolated system expands the design of self-assembled oxides for practical applications, e.g. in optoelectronics.
Heteroepitaxy on colloidal nanocrystals often yields defective heterostructures due to intricate reaction pathways. Here, the authors decode the surface chemistry at the molecular level to realise defect-free interfaces with atomic uniformity.
Deep level transient spectroscopy (DLTS) is an established characterization technique used to study electrically active defects in 3D semiconductors. Here, the authors show that DLTS can also be applied to monolayer semiconductors, enabling in-situ characterization of the energy states of different defects and their interactions.
Enhanced IL-1β signaling pathway causes hematopoietic stem cell (HSC) to differentiate into myeloid cells and contributes to malignant hematopoiesis. Here the authors reveal that HSC differentiation is controlled by balanced levels of IL-1 receptor antagonist (IL-1rn) and IL-1β under steady-state, and that IL-1rn protects against pre-leukemic myelopoiesis by repressing IL-1β signaling.
The mammalian mitochondrial genome contains two noncanonical stop codons, AGA and AGG. Here, the authors show that mtRF1, a mitochondrial protein of unknown function, triggers translation termination at AGA or AGG, placing mtRF1 among mitochondrial translation factors.
GABAB receptors mediate the effects of the main inhibitory neurotransmitter in the brain. Here, authors identify the cytoskeletal protein filamin A as a key player that controls the exact location and function of GABAB receptors at the cell surface.
Despite their vast potential, the practical deployment of MXenes has been hampered by their tendency to be oxidized. Here, the authors show that simply vibrating MXene films in just a minute can remove the oxide layer formed and restore their electrochemical performance close to its original state.
The covid pandemic has highlighted the need for rapid antibody development. Here, authors develop an approach called SLISY, which uses NGS with phage display to simultaneously assess millions of clones to rapidly isolate specific antibodies against SARS-CoV-2 and its evolving variants.