Articles

Cardiac dysfunction is a hallmark of aging in humans and mice. Here, the authors show that by restoring youthful Bridging Integrator 1 (BIN1) protein levels in the hearts of 24-month-old mice in vivo cardiac systolic function is rejuvenated, and the aging phenotype partially reversed within two weeks.

The precise regulatory mechanisms controlling ciliary Hedgehog signaling remain incomplete. Here, the authors use ciliary proteomics to reveal that Numb facilitates the endocytosis of the receptor Ptch1 from the ciliary pocket, thereby enabling activation of Hedgehog signaling.

Many of the most industrially important magnets require the addition of rare-earths to improve their coercivity and magnetic performance. Here, the authors place a single paramagnetic rare-earth ion, Er³⁺, in a diamagnetic nanoparticle, and study the slow relaxation of the resulting nanoparticles, providing vital information for the further development of rare-earth magnetic materials.

Quantum annealing is usually discussed as a means of finding an optimal solution for a problem where there are many local minima, such as the travelling salesman. Here, Zhao et al present an intriguing example of quantum annealing in the case of the frustrated magnet α-CoV₂O₆, where a transverse magnetic field triggers the quantum annealing process.

DDX3X is a member of the RNA helicase family, which remodels RNA structures. Using solution NMR, here the authors show that DDX3X preferentially binds to single-stranded RNA, which underlies its unwinding activity toward various structured RNA substrates.

Dengue is a major public health concern in the Americas, and the Caribbean can be a source for reintroduction and spread. Here, the authors use travel surveillance data and genomic epidemiology to reconstruct Dengue epidemic dynamics in the Caribbean from 2009-2022.

Existing neuroimaging tools are still hampered by restricted field-of-view, slow imaging speed or suboptimal spatial resolution. Here, the authors present a fluorescence localization imaging approach aided by sparsely-labeled red blood cells for cortex-wide morphological and functional cerebral angiography with high spatiotemporal resolution.

The development of fluorescent polymer hydrogels without the use of extended pi-conjugation is challenging. Here, the authors report the use of clustering-trigger emission to give red fluorescence on boiling polymer hydrogels, with tuneable emission properties.

The temperature-sensitivity of soil dissolved organic carbon (DOC) export is widely debated but limited by the duration of observations. New data from environmental archives supports a pronounced sensitivity between soil DOC leaching and warming.

Hard carbon is regarded as a promising negative electrode for Na-ion batteries but suffers from low initial Coulombic efficiency (ICE). Here, the authors identify the time-dependent ion pre-desolvation on the nanopore of hard carbons, which remarkably improves the ICE by simply extending the aging time.

Recently, excitons with unconventional properties were reported in a van der Waals antiferromagnet NiPS₃. Here, using resonant inelastic x-ray scattering, the authors show that the formation of these excitons is primarily driven by Hund’s coupling and that they propagate similarly to two-magnon excitations.

This study explores the variation in gene regulation across plant species and genotypes using interpretable deep learning on DNA sequence and RNA-seq data, demonstrating the models’ utility in functional genomics and phenotypic trait prediction.

Carbon dioxide concentration has previously been used as a proxy for overall ventilation efficiency to indirectly estimate the risk of indoor SARS-CoV-2 transmission. Here, authors investigate whether the concentration of carbon dioxide also has a direct mechanistic role in improving transmission efficiency.

Spider silk has desirable properties, but these are hard to replicate with artificial materials. Here, the authors report a polyelectrolyte artificial spider silk, with control over dissociation of the polymer chains by introduction of ions, and thermally driven supercontraction.

Choosing best chemical cross-linking (XL) reagents and conditions for studying protein-protein interactions in structural biology is laborious and lacks in accuracy. The authors develop here an accurate, fast, robust and quantiative denaturing mass photometry approach for screening of XL conditions.

The conversion of atmospheric N₂ into NH₃ under ambient pressure is highly interesting but very challenging. In this study, the authors present a tandem air-NO_x and NO_x-NH₃ system that combines non-thermal plasma-enabled N₂ oxidation with Ni(OH)_x/Cu-catalyzed electrochemical NO_x⁻reduction, resulting in a high NH₃ yield from N₂ under ambient pressure conditions.

Porous carbons with high specific surface area and electronic conductivity are of interest for their electron and ion transport ability. Here authors use ultra-high temperature reactions of Li metal and polytetrafluoroethylene to make graphitized porous carbon for electrochemical energy storage.

Omics data’s diversity and high-dimensionality challenge integration across technologies and with imaging. Here, authors introduce mapping method xIV-LDDMM that estimates geometric and feature transformations to integrate tissue-scale atlases with molecular and cellular-scale data.

Knowledge of pathogenesis mechanisms and effective treatments for viral myocarditis is lacking. Here, Wang et al show that loss of TRIM29 and PERK inhibitor mitigate viral myocarditis by attenuating PERK-driven ER stress and ROS responses in male mice.

Ice sheets and precession are shown to control westerly strength and position, impacting nutrient-rich water upwelling and productivity in the subarctic Pacific. This finding underscores the subarctic Pacific’s significant contribution to Pleistocene CO2, particularly on a precession timescale.