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New olfactory sensory neurons (OSNs) wire into highly organized olfactory bulb circuits throughout life. Here, the authors show that immature OSNs provide behaviourally relevant sensory input to olfactory bulb neurons that is functionally distinct from that provided by mature OSNs.
Endoplasmic reticulum stress activates the unfolded protein response (UPR). The authors show that glucose extends the lifespan of aged animals by activating the otherwise quiescent UPR while causing a UPR-dependent reduced longevity in young animals
Long-duration human space travel creates challenges for maintaining healthy diets. Here the authors discuss using synthetic biology approaches to modify yeast into an optimal, and enjoyable, food production platform.
Ferroelectricity normally exists in either solid crystals or liquid crystals. Here, the authors report a homochiral organic compound which shows ferroelectricity in both solid crystal and liquid crystal phases.
Decatungstate-enabled Hydrogen Atom Transfer (HAT) photocatalysis of hydrocarbon scaffolds enabled rapid access to new C(sp3)-enriched chemical space. Here, the authors present in-line TBADT recovery with organic solvent nanofiltration (OSN) as an answer to the concerns surrounding the scale-up of decatungstate HAT reactions, i.e., catalyst loading and cost.
Many survivors of COVID-19 experience persistent symptoms, continuing beyond three months from the onset of infection. In this study, authors investigate the effect of remdesivir on recovery and long-COVID-19 symptoms, as well as quality of life and other symptom outcomes, in the 1-year follow-up of a randomised trial.
Neural activity from perception is thought to be reactivated during memory recall. Here, the authors show that memory reactivation in visual cortex exhibits different tuning properties from those observed during perception.
Protein abundance is controlled at the transcriptional, translational and posttranslational levels. Here, Öztürk et al. determine proteome changes resulting from individual knockout of 3308 nonessential genes in the yeast S. pombe, infer gene functionality, and show that protein upregulation under stable transcript expression utilizes optimal codons.
Visualization of the Rashbasplit bands in oxide two-dimensional electron gases is lacking, which hampers understanding of their rich spin-orbit physics. Here, the authors investigate KTaO3 two dimensional electron gases and their Rashba-split bands.
The intercalated disc (ICD) is a membrane structure of the cardiac muscle involved in normal heart function. Here the authors report that knockdown of the ICD-bound transmembrane protein 65 results in impaired ICD structure, abnormal cardiac electrophysiology and cardiomyopathy in mice.
Development of high-performance polymer electrolyte fuel cells has historically focused on designing new catalysts and ionomers. Here, the authors present a bottom-up approach for designing catalyst support that achieves superior oxygen reduction activity and low local oxygen transport resistance in a membrane electrode assembly.
Here the structure of transposase from Tn3 family is reported in apo form and bound to the transposon ends. The activation of the transposase induces metamorphic refolding of the catalytic domain suggesting the family-specific regulation mechanism.
The nuclear pore complex (NPC) barrier is a selective phase assembled from disordered but cohesive FG domains. The authors provide a thermodynamic description of an FG phase that is ultimately simplified and yet closely recapitulates NPC transport selectivity.
Precise and scalable regulation of gene expression in mammalian cells is challenging. Here, the authors created a highly tunable CRISPR-based synthetic transcription system for programmable control of mammalian gene expression and cellular activity.
Myeloid cells contribute to the tumor microenvironment of thyroid cancers, but their functional relevance is lesser known. Here authors show that myeloid cells infiltrating non-medullary thyroid carcinomas upregulate their antigen presentation-related genes, release less cytokines and over-produce reactive oxygen species, with transcriptional changes already present in extra-tumoral myeloid cells.
Finding a selective modulator of Lys63-linked ubiquitin chains has proven very challenging. Here, the authors develop potent macrocyclic peptide binders of Lys63-linked di-ubiquitin chains that interrupt DNA damage repair and lead to apoptotic cell death.
Sound and Vision: In-situ synchrotron x-ray imaging with simultaneous acoustic monitoring captures grain scale damage mechanisms and unlocks the relationship between seismic and aseismic processes during catastrophic failure of porous rock.
The analysis of protein NMR spectra is time-consuming and can occupy a human expert for weeks or months. The researchers in this work present a deep learning-based method that delivers signal positions, chemical shift assignments, and structures of proteins within hours after completion of the NMR measurements.
Neuronal assemblies remain understudied in human data. Here, the authors show that gamma phase-locked neuronal firing sequences comprise assemblies in human single unit recordings, and their ability to incorporate new neurons over time facilitates memory.