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  • Investigating biomembrane curvature formation is important for studying intracellular processes, but the instability of liposome models mimicking these membranes restricts exploration of membrane processes. Here, the authors demonstrate control over the curvature formation in polymersome membranes by insertion of PNIPAm as stimuli responsive polymer.

    • Jiawei Sun
    • Sjoerd J. Rijpkema
    • Daniela A. Wilson
    Article Open Access
  • Acquisition of dying tumor cell-associated antigens is an essential step for the initiation of anti-tumor immune response by conventional type 1 dendritic cells (cDC1). Here the authors show that the loss of TIM4 expression in lung tumor associated cDC1 is associated with less efficient uptake of cell associated antigens and reduction of CD8 + T cell activation in advanced lung tumors.

    • Nicoletta Caronni
    • Giulia Maria Piperno
    • Federica Benvenuti
    Article Open Access
  • Clostridioides difficile infection (CDI) is the most common cause of antibiotic-associated diarrhoea (AAD); however, markers predictive of CDI or AAD development are as yet lacking. Here, to identify markers predictive of CDI, the authors profile the intestinal microbiota of 945 hospitalised patients from 34 hospitals in 6 different European countries and show distinct microbiota enriched in Enterococcus and depleted of Ruminococcus, Blautia, Prevotella and Bifidobacterium compared to non-CDI patients.

    • Matilda Berkell
    • Mohamed Mysara
    • Odile Launay
    Article Open Access
  • Though there is a long archaeological record of the use of honey, beeswax and other bee products, there are few known records from Africa. Here Dunne et al. analyse lipid residues from pottery from the Nok culture, Nigeria, dating to ~3500 years ago and find evidence of the collection and processing of bee products, likely honey.

    • Julie Dunne
    • Alexa Höhn
    • Richard P. Evershed
    Article Open Access
  • Peritoneal adhesions are a major cause of complications after abdominal surgery. Here the authors use a post-operative abdominal adhesion model in mice to show that resident F4/80HighCD206 macrophages form a protective barrier that can be enhanced by IL-4 administration or adoptive transfer of these cells.

    • Tomoya Ito
    • Yusuke Shintani
    • Ken Suzuki
    Article Open Access
  • The molecular architecture of α-Synuclein (α-Syn) inclusions, pathognomonic of various neurodegenerative disorders, remains unclear. Here, authors use cryo-electron tomography to image neuronal α-Syn inclusions in situ and find that inclusions consist of α-Syn fibrils intermixed with cellular organelles without interacting directly.

    • Victoria A. Trinkaus
    • Irene Riera-Tur
    • Rubén Fernández-Busnadiego
    Article Open Access
  • Precise knowledge of chemical composition and atomic structure of functional nanosized systems, such as metal clusters stabilized by an organic molecular layer, allows for detailed computational work to investigate structure-property relations. Here, we discuss selected recent examples of computational work that has advanced understanding of how these clusters work in catalysis, how they interact with biological systems, and how they can make self-assembled, macroscopic materials. A growing challenge is to develop effective new simulation methods that take into account the cluster-environment interactions. These new hybrid methods are likely to contain components from electronic structure theory combined with machine learning algorithms for accelerated evaluations of atom-atom interactions.

    • Sami Malola
    • Hannu Häkkinen
    Comment Open Access
  • The organization and force-generating property of actomyosin dictate the plasticity and behaviour of cells but the spatio-temporal regulation of this network is unclear. Here, the authors show that coupling between EpCAM/RhoA co-trafficking and actomyosin rearrangement is pivotal during cell spreading and polarization.

    • Cécile Gaston
    • Simon De Beco
    • Delphine Delacour
    Article Open Access
  • Prioritising genes as potential drug targets is challenging and often unsuccessful once testing efficacy in humans. Here, the authors propose an approach to identifying drug targets that uses evidence from gain- or loss-of-function mutations associated with bidirectional effects on phenotypes.

    • Karol Estrada
    • Steven Froelich
    • Lon R. Cardon
    Article Open Access
  • Engineering efforts have focused on acyltransferase (AT) domains of modular polyketide synthases (PKSs) to site-selectively modify the resulting polyketides, but critical AT residues involved in substrate selection have not been fully elucidated. Here, the authors use molecular dynamics to pinpoint mutations that impact AT domain selectivity and exchange structural motifs to obtain chimeric PKS modules with expanded substrate specificity.

    • Edward Kalkreuter
    • Kyle S. Bingham
    • Gavin J. Williams
    Article Open Access
  • Climate models struggle to track the response of Arctic sea ice to warming, leading to efforts to improve sea-ice models. Here the author shows standard model metrics are poor judges of the impact of model improvements, but a new one, marginal ice zone fraction, is optimally suited to this task.

    • Christopher Horvat
    Article Open Access
  • The micro-structures of zeolite catalysts affect their macroarchitectures and catalytic performances. Here, the different SAPO-34/18 intergrowth catalysts are atomically resolved, and the correlation between synthesis conditions and zeolite structures is revealed to further enhance their performances in methanol conversion.

    • Boyuan Shen
    • Xiao Chen
    • Fei Wei
    Article Open Access
  • It is difficult to compute the transport properties of a broad array of complex materials both accurately and inexpensively. Here, the authors develop a computationally efficient method for calculating carrier scattering rates of semiconductors, with good accuracy but low cost.

    • Alex M. Ganose
    • Junsoo Park
    • Anubhav Jain
    Article Open Access