Browse Articles

  • Article | | open

    Gels filtering particles by interactions are a goal of nanotechnology; this is difficult when particles are larger than the mesh of the gel. Here, the authors present an equilibrium mechanism where binding dynamics of crosslinks are affected by interacting particles so that particles experience enhanced diffusion.

    • Carl P. Goodrich
    • , Michael P. Brenner
    •  & Katharina Ribbeck
  • Article | | open

    Dynamics in cold atomic ensembles involve complex many-body interactions that are hard to treat analytically. Here, the authors use machine learning to optimise the cooling and trapping of neutral atoms, showing an improvement in the resulting resonant optical depth compared to more traditional solutions.

    • A. D. Tranter
    • , H. J. Slatyer
    • , M. R. Hush
    • , A. C. Leung
    • , J. L. Everett
    • , K. V. Paul
    • , P. Vernaz-Gris
    • , P. K. Lam
    • , B. C. Buchler
    •  & G. T. Campbell
  • Article | | open

    Manipulating the assembly of π-conjugated organic molecules into alloys to control composition and shape remains a largely unsolved problem. Here the authors show the co-assembly of two structurally similar organic semiconductors into two-component helices by control of their growth kinetics as well as the molar ratio of the building blocks.

    • Yilong Lei
    • , Yanqiu Sun
    • , Yi Zhang
    • , Hongyang Zhang
    • , Haihua Zhang
    • , Zhengong Meng
    • , Wai-Yeung Wong
    • , Jiannian Yao
    •  & Hongbing Fu
  • Article | | open

    The mitotic checkpoint complex (MCC) is assembled during both mitosis and interphase. Here, the authors use auxin-inducible degron tags to rapidly degrade TRIP13 and find that mitotic exit requires MCC disassembly by TRIP13-catalyzed removal of Mad2 or APC1-driven ubiquitination of Cdc20.

    • Dong Hyun Kim
    • , Joo Seok Han
    • , Peter Ly
    • , Qiaozhen Ye
    • , Moira A. McMahon
    • , Kyungjae Myung
    • , Kevin D. Corbett
    •  & Don W. Cleveland
  • Article | | open

    Climate change may impact forest disturbances, though local variability is high. Here, Sommerfeld et al. show that disturbance patterns across the temperate biome vary with agents and tree traits, yet large disturbances are consistently linked to warmer and drier than average conditions.

    • Andreas Sommerfeld
    • , Cornelius Senf
    • , Brian Buma
    • , Anthony W. D’Amato
    • , Tiphaine Després
    • , Ignacio Díaz-Hormazábal
    • , Shawn Fraver
    • , Lee E. Frelich
    • , Álvaro G. Gutiérrez
    • , Sarah J. Hart
    • , Brian J. Harvey
    • , Hong S. He
    • , Tomáš Hlásny
    • , Andrés Holz
    • , Thomas Kitzberger
    • , Dominik Kulakowski
    • , David Lindenmayer
    • , Akira S. Mori
    • , Jörg Müller
    • , Juan Paritsis
    • , George L. W. Perry
    • , Scott L. Stephens
    • , Miroslav Svoboda
    • , Monica G. Turner
    • , Thomas T. Veblen
    •  & Rupert Seidl
  • Article | | open

    Termination of RNA polymerase II (RNAPII) transcription is an essential step of gene expression. Here the authors provide evidence that in fission yeast termination of ncRNA genes occurs by a cleavage-dependent mechanism involving recruitment of mRNA 3′ end processing factors and requires the conserved Ysh1/CPSF-73 and Dhp1/XRN2 nucleases.

    • Marc Larochelle
    • , Marc-Antoine Robert
    • , Jean-Nicolas Hébert
    • , Xiaochuan Liu
    • , Dominick Matteau
    • , Sébastien Rodrigue
    • , Bin Tian
    • , Pierre-Étienne Jacques
    •  & François Bachand
  • Article | | open

    Arsenic trioxide (ATO) based therapy in solid cancers is limited. Here they repurpose nanodiamonds (NDs) as a safe and potent autophagic inhibitor to improve the efficacy of ATO-based treatment in solid tumors and show the combination therapy to work better in orthotopic liver cancer model.

    • Zhifen Cui
    • , Yu Zhang
    • , Kai Xia
    • , Qinglong Yan
    • , Huating Kong
    • , Jichao Zhang
    • , Xiaolei Zuo
    • , Jiye Shi
    • , Lihua Wang
    • , Ying Zhu
    •  & Chunhai Fan
  • Article | | open

    The reaction of hydroxyl and methylperoxy radicals has recently been suggested as the source of missing methanol in the remote troposphere. Here, the authors present direct experimental measurements demonstrating the reaction leads to further underprediction of modelled methanol.

    • Rebecca L. Caravan
    • , M. Anwar H. Khan
    • , Judit Zádor
    • , Leonid Sheps
    • , Ivan O. Antonov
    • , Brandon Rotavera
    • , Krupa Ramasesha
    • , Kendrew Au
    • , Ming-Wei Chen
    • , Daniel Rösch
    • , David L. Osborn
    • , Christa Fittschen
    • , Coralie Schoemaecker
    • , Marius Duncianu
    • , Asma Grira
    • , Sebastien Dusanter
    • , Alexandre Tomas
    • , Carl J. Percival
    • , Dudley E. Shallcross
    •  & Craig A. Taatjes
  • Article | | open

    Tumour heterogeneity hinders translation of large-scale genomic data into the clinic. Here the authors develop a method for the stratification of cancer patients based on the molecular gene status, including genetic interactions, rather than clinico-histological data, and apply it to TCGA data for over 8000 cases across 22 cancer types.

    • Jack Kuipers
    • , Thomas Thurnherr
    • , Giusi Moffa
    • , Polina Suter
    • , Jonas Behr
    • , Ryan Goosen
    • , Gerhard Christofori
    •  & Niko Beerenwinkel
  • Article | | open

    Dimethyl fumarate (DMF) is a major drug in the treatment of psoriasis and multiple sclerosis. Here the authors reveal a mechanism of RSK/MSK inhibition through covalent inhibition that can explain the observed clinical effects and the dose–response characteristics of DMF treatment.

    • Jacob Lauwring Andersen
    • , Borbala Gesser
    • , Erik Daa Funder
    • , Christine Juul Fælled Nielsen
    • , Helle Gotfred-Rasmussen
    • , Mads Kirchheiner Rasmussen
    • , Rachel Toth
    • , Kurt Vesterager Gothelf
    • , J. Simon C. Arthur
    • , Lars Iversen
    •  & Poul Nissen
  • Article | | open

    Hepatocyte nuclear factor 4 alpha (HNF4α) is regulated by different promoters to generate two isoforms, one of which functions as a tumor suppressor. Here, the authors reveal that induction of the alternative isoform in hepatocellular carcinoma inhibits the circadian clock by repressing BMAL1, and the reintroduction of BMAL1 prevents HCC tumor growth.

    • Baharan Fekry
    • , Aleix Ribas-Latre
    • , Corrine Baumgartner
    • , Jonathan R. Deans
    • , Christopher Kwok
    • , Pooja Patel
    • , Loning Fu
    • , Rebecca Berdeaux
    • , Kai Sun
    • , Mikhail G. Kolonin
    • , Sidney H. Wang
    • , Seung-Hee Yoo
    • , Frances M. Sladek
    •  & Kristin Eckel-Mahan
  • Article | | open

    While water electrolysis provides an attractive means to produce high-energy hydrogen (H2), the process imposes significant material overpotential barriers. Here, authors employ the more-facile hydrazine splitting reaction, coupled to a hydrazine fuel cell, to perform self-powered H2 evolution.

    • Xijun Liu
    • , Jia He
    • , Shunzheng Zhao
    • , Yunpeng Liu
    • , Zhe Zhao
    • , Jun Luo
    • , Guangzhi Hu
    • , Xiaoming Sun
    •  & Yi Ding
  • Article | | open

    AI is used increasingly in medical diagnostics. Here, the authors present a deep learning model that masters medical knowledge, demonstrated by it having passed the written test of the 2017 National Medical Licensing Examination in China, and can provide help with clinical diagnosis based on electronic health care records.

    • Ji Wu
    • , Xien Liu
    • , Xiao Zhang
    • , Zhiyang He
    •  & Ping Lv
  • Article | | open

    In two-dimensional electron systems, strong Coulomb interactions lead to the formation of new phases. Here the authors observe a transition between two of these correlated phases, a composite fermion liquid and Wigner solid, in a zinc oxide heterostructure.

    • D. Maryenko
    • , A. McCollam
    • , J. Falson
    • , Y. Kozuka
    • , J. Bruin
    • , U. Zeitler
    •  & M. Kawasaki
  • Article | | open

    The cardiac autonomic nervous system produces various neuropeptides, such as neurokinin substance-P (Sub-P), whose function remains largely unclear. Here, authors show that Sub-P causes a receptor-mediated prolongation of the atrial action potential through a reduced background potassium current, and prevents atrial fibrillation.

    • Marieke W. Veldkamp
    • , Guillaume S. C. Geuzebroek
    • , Antonius Baartscheer
    • , Arie O. Verkerk
    • , Cees A. Schumacher
    • , Gedeon G. Suarez
    • , Wouter R. Berger
    • , Simona Casini
    • , Shirley C. M. van Amersfoorth
    • , Koen T. Scholman
    • , Antoine H. G. Driessen
    • , Charly N. W. Belterman
    • , Antoni C. G. van Ginneken
    • , Joris R. de Groot
    • , Jacques M. T. de Bakker
    • , Carol Ann Remme
    • , Bas J. Boukens
    •  & Ruben Coronel
  • Article | | open

    Inteins can act as post-translational environmental sensors in vivo. Here the authors characterize two inteins present in the Mycobacterium smegmatis replicative helicase DnaB that display distinct splicing behaviors and are differentially sensitive to inhibition by biological stressors and propose that splicing inhibition could modulate DnaB levels to protect the cell against replication stress.

    • Danielle S. Kelley
    • , Christopher W. Lennon
    • , Zhong Li
    • , Michael R. Miller
    • , Nilesh K. Banavali
    • , Hongmin Li
    •  & Marlene Belfort
  • Article | | open

    Rhabdopeptides are synthesized by non-ribosomal peptide synthetases (NRPSs) and the multiple NRPS subunits interact through docking domains (DD). Here the authors provide insights into DD interaction patterns and present the structures of three N-terminal docking domains (NDD) and a NDD-CDD complex and derive a set of recognition rules for DD interactions.

    • Carolin Hacker
    • , Xiaofeng Cai
    • , Carsten Kegler
    • , Lei Zhao
    • , A. Katharina Weickhmann
    • , Jan Philip Wurm
    • , Helge B. Bode
    •  & Jens Wöhnert
  • Article | | open

    The growth-promoting activity of mTORC1 is regulated by amino acid availability via the Rag GTPases. Here, the authors demonstrate Src-dependent control of cell size and autophagy through disruption of the Rag GTPase–GATOR1 complex and mTORC1 activation at the lysosomal surface.

    • Rituraj Pal
    • , Michela Palmieri
    • , Arindam Chaudhury
    • , Tiemo Jürgen Klisch
    • , Alberto di Ronza
    • , Joel R. Neilson
    • , George G. Rodney
    •  & Marco Sardiello
  • Article | | open

    Men are often more willing to compete compared to women, which may contribute to gender differences in wages and career advancement. Here, the authors show that ‘power priming’ - encouraging people to imagine themselves in a situation of power - can close the gender gap in competitiveness.

    • Loukas Balafoutas
    • , Helena Fornwagner
    •  & Matthias Sutter
  • Article | | open

    The early molecular events that ultimately lead to neuronal cell death in pathologies such as Parkinson’s disease are poorly understood. Here the authors use pluripotent stem-cell-derived human midbrain neurons and chemical biology tools to gain molecular level insight into the events induced by toxic and genetic stresses that mimic those occurring during neurodegeneration.

    • Sarah Kishinevsky
    • , Tai Wang
    • , Anna Rodina
    • , Sun Young Chung
    • , Chao Xu
    • , John Philip
    • , Tony Taldone
    • , Suhasini Joshi
    • , Mary L. Alpaugh
    • , Alexander Bolaender
    • , Simon Gutbier
    • , Davinder Sandhu
    • , Faranak Fattahi
    • , Bastian Zimmer
    • , Smit K. Shah
    • , Elizabeth Chang
    • , Carmen Inda
    • , John Koren 3rd
    • , Nathalie G. Saurat
    • , Marcel Leist
    • , Steven S. Gross
    • , Venkatraman E. Seshan
    • , Christine Klein
    • , Mark J. Tomishima
    • , Hediye Erdjument-Bromage
    • , Thomas A. Neubert
    • , Ronald C. Henrickson
    • , Gabriela Chiosis
    •  & Lorenz Studer
  • Article | | open

    In the ventral basal ganglia circuit, the ventral pallidum (VP) receives major inputs from the nucleus accumbens (NAc) and is involved in reward processing. Here, the authors report that, contrary to the accepted model, signals related to the relative value of reward in VP emerge before NAc and are more robust.

    • David Ottenheimer
    • , Jocelyn M. Richard
    •  & Patricia H. Janak
  • Article | | open

    Oncolytic virotherapy is a promising strategy for cancer treatment. In this study, the authors demonstrate that DNA-dependent protein kinase (DNA-PK) inhibition sensitizes cancer cells to M1 virus and improves therapeutic effects in refractory cancer models in vivo and in patient tumour samples.

    • Xiao Xiao
    • , Jiankai Liang
    • , Chunlong Huang
    • , Kai Li
    • , Fan Xing
    • , Wenbo Zhu
    • , Ziqing Lin
    • , Wencang Xu
    • , Guangen Wu
    • , Jifu Zhang
    • , Xi Lin
    • , Yaqian Tan
    • , Jing Cai
    • , Jun Hu
    • , Xueqin Chen
    • , Youwei Huang
    • , Zixi Qin
    • , Pengxin Qiu
    • , Xingwen Su
    • , Lijun Chen
    • , Yuan Lin
    • , Haipeng Zhang
    •  & Guangmei Yan
  • Article | | open

    Interactions between metal nanoparticles (NPs) and metal–organic frameworks (MOFs) in their composite forms have proven to exhibit beneficial properties. Here the authors present a unique approach to immobilise Pd NPs and, more importantly, to generate tunable basic sites within an anionic defective MOF.

    • Ying Chuan Tan
    •  & Hua Chun Zeng
  • Article | | open

    Current digital coding metasurfaces are only space-encoded. Here, the authors propose space-time modulated digital coding metasurfaces to obtain simultaneous manipulations of electromagnetic waves and present harmonic beam steering, beam shaping, and scattering-signature control as application examples.

    • Lei Zhang
    • , Xiao Qing Chen
    • , Shuo Liu
    • , Qian Zhang
    • , Jie Zhao
    • , Jun Yan Dai
    • , Guo Dong Bai
    • , Xiang Wan
    • , Qiang Cheng
    • , Giuseppe Castaldi
    • , Vincenzo Galdi
    •  & Tie Jun Cui
  • Publisher Correction | | open

    • Louis Longley
    • , Sean M. Collins
    • , Chao Zhou
    • , Glen J. Smales
    • , Sarah E. Norman
    • , Nick J. Brownbill
    • , Christopher W. Ashling
    • , Philip A. Chater
    • , Robert Tovey
    • , Carola-Bibiane Schönlieb
    • , Thomas F. Headen
    • , Nicholas J. Terrill
    • , Yuanzheng Yue
    • , Andrew J. Smith
    • , Frédéric Blanc
    • , David A. Keen
    • , Paul A. Midgley
    •  & Thomas D. Bennett
  • Article | | open

    The FtsZ protein assembles into a structure known as ‘Z-ring’ at midcell for bacterial cell division. Here, Söderström et al. show that Z-ring assembly and dynamics in E. coli cells with unnatural shapes, such as squares and hearts, are generally similar to those observed in cells with normal shape.

    • Bill Söderström
    • , Alexander Badrutdinov
    • , Helena Chan
    •  & Ulf Skoglund
  • Article | | open

    Ischemic reperfusion or nutrient deprivation that produces reactive oxygen species can lead to a loss of muscle contractile function. Here the authors show that glutathionylation of the lysine methyltransferase SMYD2 contributes to degradation or disassembly of sarcomeres.

    • Dhanushka N. P. Munkanatta Godage
    • , Garrett C. VanHecke
    • , Kusal T. G. Samarasinghe
    • , Han-Zhong Feng
    • , Mark Hiske
    • , Joshua Holcomb
    • , Zhe Yang
    • , Jian-Ping Jin
    • , Charles S. Chung
    •  & Young-Hoon Ahn
  • Article | | open

    Interfering RNA have a range of therapeutic and research based applications, issues with delivery have made systems that make siRNA in situ of interest. Here, the author report on the creation of a DNA hydrogel with improved stability and transcription efficiency over plasmid DNA.

    • Jaejung Song
    • , Minhyuk Lee
    • , Taeyoung Kim
    • , Jeongkyeong Na
    • , Yebin Jung
    • , Gyoo Yeol Jung
    • , Sungjee Kim
    •  & Nokyoung Park
  • Article | | open

    It is challenging to design photosensitizers (PS) with high quantum yields generating singlet oxygen due to severe aggregation between the hydrophobic PSs. Here they develop organoplatinum(II) metallatocage-based PS to overcome these challenges and show excellent antitumor effect.

    • Guocan Yu
    • , Shan Yu
    • , Manik Lal Saha
    • , Jiong Zhou
    • , Timothy R. Cook
    • , Bryant C. Yung
    • , Jin Chen
    • , Zhengwei Mao
    • , Fuwu Zhang
    • , Zijian Zhou
    • , Yijing Liu
    • , Li Shao
    • , Sheng Wang
    • , Changyou Gao
    • , Feihe Huang
    • , Peter J. Stang
    •  & Xiaoyuan Chen
  • Review | | open

    Polyelectrolytes are a class of macromolecules containing charged groups. Here the authors review properties and functions of metallo-polyelectrolytes to shed light on how to harness fundamental physiochemical properties for applications in biomedical sciences and advanced materials.

    • Tianyu Zhu
    • , Ye Sha
    • , Jing Yan
    • , Parasmani Pageni
    • , Md Anisur Rahman
    • , Yi Yan
    •  & Chuanbing Tang
  • Article | | open

    Exciton diffusion length and directionality are important parameters in artificial photosynthetic devices. Here, the authors present a way to make crystalline chromophore assemblies with bespoke architecture, fabricating one exhibiting anisotropic exciton transport properties.

    • Ritesh Haldar
    • , Marius Jakoby
    • , Antoine Mazel
    • , Qiang Zhang
    • , Alexander Welle
    • , Tawheed Mohamed
    • , Peter Krolla
    • , Wolfgang Wenzel
    • , Stéphane Diring
    • , Fabrice Odobel
    • , Bryce S. Richards
    • , Ian A. Howard
    •  & Christof Wöll
  • Article | | open

    Bounding the capacity of thermal attenuators would give a powerful instrument to describe decoherence occurring in optical fibres and free space links. Here, the authors improve on the existing upper bounds in the region of small thermal noise, which is of interest for quantum communication.

    • Matteo Rosati
    • , Andrea Mari
    •  & Vittorio Giovannetti
  • Article | | open

    Enzymes of the six-transmembrane epithelial antigen of the prostate (STEAP) family reduce Fe3+ and Cu2+ ions to facilitate metal-ion uptake by mammalian cells. Here, authors employ single-particle cryo-EM to gain insights into the molecular principles of iron reduction by human STEAP4 .

    • Wout Oosterheert
    • , Laura S. van Bezouwen
    • , Remco N. P. Rodenburg
    • , Joke Granneman
    • , Friedrich Förster
    • , Andrea Mattevi
    •  & Piet Gros
  • Article | | open

    The decision when to stop an intervention is a critical component of parasite elimination programmes, but reliance on surveillance data alone can be inaccurate. Here, Michael et al. combine parasite transmission model predictions with disease survey data to more reliably determine when interventions can be stopped.

    • Edwin Michael
    • , Morgan E. Smith
    • , Moses N. Katabarwa
    • , Edson Byamukama
    • , Emily Grisworld
    • , Peace Habomugisha
    • , Thomson Lakwo
    • , Edridah Tukahebwa
    • , Emmanuel S. Miri
    • , Abel Eigege
    • , Evelyn Ngige
    • , Thomas R. Unnasch
    •  & Frank O. Richards
  • Article | | open

    The halictid bee Lasioglossum albipes has both solitary and eusocial individuals, making it a model for social evolution. Here, Kocher et al. identify a genetic variation associated with this social polymorphism, including a variant that can regulate the expression of an autism-associated gene, syntaxin 1a.

    • Sarah D. Kocher
    • , Ricardo Mallarino
    • , Benjamin E. R. Rubin
    • , Douglas W. Yu
    • , Hopi E. Hoekstra
    •  & Naomi E. Pierce
  • Article | | open

    The emergence of superconductivity from the normal state in the cuprates above the transition temperature (Tc) has been controversial. Here, Pelc et al. report nonlinear conductivity, resulting from superconducting precursors only, vanishing exponentially above Tc both with temperature and with magnetic field.

    • Damjan Pelc
    • , Marija Vučković
    • , Mihael S. Grbić
    • , Miroslav Požek
    • , Guichuan Yu
    • , Takao Sasagawa
    • , Martin Greven
    •  & Neven Barišić
  • Article | | open

    To prevent ligand-independent dimerisation the epidermal growth factor receptor (EGFR) is autoinhibited by an extracellular dimer interaction. Here, the authors use several imaging technologies and simulations to provide structural insights on the inactive species and on how intracellular mutations circumvent the autoinhibition of the basal state.

    • Laura C. Zanetti-Domingues
    • , Dimitrios Korovesis
    • , Sarah R. Needham
    • , Christopher J. Tynan
    • , Shiori Sagawa
    • , Selene K. Roberts
    • , Antonija Kuzmanic
    • , Elena Ortiz-Zapater
    • , Purvi Jain
    • , Rob C. Roovers
    • , Alireza Lajevardipour
    • , Paul M. P. van Bergen en Henegouwen
    • , George Santis
    • , Andrew H. A. Clayton
    • , David T. Clarke
    • , Francesco L. Gervasio
    • , Yibing Shan
    • , David E. Shaw
    • , Daniel J. Rolfe
    • , Peter J. Parker
    •  & Marisa L. Martin-Fernandez
  • Article | | open

    It was previously suggested that formation of RNA secondary structure tends to bring the 5′ and 3′ ends of RNA into close proximity. Here the authors use experimental and computational approaches to show that mRNAs and lncRNAs have an intrinsic propensity to fold into structures in which the 5′ end and 3′ end are ≤7 nm apart irrespective of length.

    • Wan-Jung C. Lai
    • , Mohammad Kayedkhordeh
    • , Erica V. Cornell
    • , Elie Farah
    • , Stanislav Bellaousov
    • , Robert Rietmeijer
    • , Enea Salsi
    • , David H. Mathews
    •  & Dmitri N. Ermolenko
  • Article | | open

    The MILL (MHC-I-like located near the leukocyte receptor complex) family is a group of related nonclassical MHC-I molecules. Here the authors present the crystal structure of MILL2, which reveals an unusual interdomain flexibility, and show that MILL2 binds heparan sulfate on the surface of fibroblasts through a basic patch.

    • Mizuho Kajikawa
    • , Toyoyuki Ose
    • , Yuko Fukunaga
    • , Yuki Okabe
    • , Naoki Matsumoto
    • , Kento Yonezawa
    • , Nobutaka Shimizu
    • , Simon Kollnberger
    • , Masanori Kasahara
    •  & Katsumi Maenaka
  • Article | | open

    Brain tumors are difficult to treat using existing immunotherapeutic strategies. Here, the authors show that in brain tumors resistant to PD-1 blockade, HSCs expressing CCR2+ can reverse treatment resistance and sensitizes mice to immunotherapy.

    • Catherine T. Flores
    • , Tyler J. Wildes
    • , Jeffrey A. Drake
    • , Ginger L. Moore
    • , Bayli DiVita Dean
    • , Rebecca S. Abraham
    •  & Duane A. Mitchell
  • Article | | open

    Despite the need to develop resistive random access memory (RRAM) devices for machine learning, RRAM array-based hardware methods for algorithm require external electronics. Here, the authors realize a Markov chain algorithm in a single 2D multilayer SnSe device without external electronics.

    • He Tian
    • , Xue-Feng Wang
    • , Mohammad Ali Mohammad
    • , Guang-Yang Gou
    • , Fan Wu
    • , Yi Yang
    •  & Tian-Ling Ren
  • Article | | open

    The Mitotic Exit Network (MEN) promotes mitotic exit and cytokinesis but if and how MEN independently controls these two processes is unclear. Here, the authors report that MEN displaces septins from the cell division site to promote actomyosin ring constriction, independently of MEN control of mitotic exit.

    • Davide Tamborrini
    • , Maria Angeles Juanes
    • , Sandy Ibanes
    • , Giulia Rancati
    •  & Simonetta Piatti
  • Article | | open

    RNA-seq is a powerful tool to investigate how drugs affect the transcriptome but library construction can be costly. Here the authors introduce DRUG-seq, an automated platform for high-throughput transcriptome profiling.

    • Chaoyang Ye
    • , Daniel J. Ho
    • , Marilisa Neri
    • , Chian Yang
    • , Tripti Kulkarni
    • , Ranjit Randhawa
    • , Martin Henault
    • , Nadezda Mostacci
    • , Pierre Farmer
    • , Steffen Renner
    • , Robert Ihry
    • , Leandra Mansur
    • , Caroline Gubser Keller
    • , Gregory McAllister
    • , Marc Hild
    • , Jeremy Jenkins
    •  & Ajamete Kaykas
  • Article | | open

    Non-Hermitian properties were proposed to be beneficial to sensing but it is not clear if this concept can be extended to the quantum regime. Here, Lau and Clerk self-consistently consider the impact of noise and measurement, and identify that nonreciprocity can improve sensing capabilities.

    • Hoi-Kwan Lau
    •  & Aashish A. Clerk