Browse Articles

  • Article | | open

    The pilus type 1 of uropathogenic E. coli must resist mechanical forces to remain attached to the epithelium. Here the authors use single-molecule force spectroscopy to demonstrate a hierarchy of mechanical stability among the pilus domains and show that the oxidoreductase DsbA also acts as a folding chaperone on the domains.

    • Alvaro Alonso-Caballero
    • , Jörg Schönfelder
    • , Simon Poly
    • , Fabiano Corsetti
    • , David De Sancho
    • , Emilio Artacho
    •  & Raul Perez-Jimenez
  • Article | | open

    Particle-attached bacteria play a key ecosystem role by degrading complex organic materials in the ocean. Here, the authors use model marine microbial communities to show that community composition and interspecies interactions can significantly slowdown the rates of particle turnover in the environment.

    • Tim N. Enke
    • , Gabriel E. Leventhal
    • , Matthew Metzger
    • , José T. Saavedra
    •  & Otto X. Cordero
  • Article | | open

    CD32 has been previously shown to be expressed preferentially by CD4 T cells latently harbouring HIV-1. Here the authors show that CD32 expression in CD4 T cells is associated with T cell activation, is up-regulated by HIV-1 infection and importantly does not appear to represent an enriched cellular niche for latent HIV-1.

    • Roger Badia
    • , Ester Ballana
    • , Marc Castellví
    • , Edurne García-Vidal
    • , Maria Pujantell
    • , Bonaventura Clotet
    • , Julia G. Prado
    • , Jordi Puig
    • , Miguel A. Martínez
    • , Eva Riveira-Muñoz
    •  & José A. Esté
  • Article | | open

    One of the major causes of cancer-related mortality is represented by metastatic lung cancer. Here the authors characterize the role of TMEM106B in driving metastatic lung adenocarcinoma and suggest that TMEM106B-mediated secretion of cathespin impacts cell migration and invasion of lung cancer cells, increasing metastatic spreading.

    • Samrat T. Kundu
    • , Caitlin L. Grzeskowiak
    • , Jared J. Fradette
    • , Laura A. Gibson
    • , Leticia B. Rodriguez
    • , Chad J. Creighton
    • , Kenneth L. Scott
    •  & Don L. Gibbons
  • Article | | open

    KRAS-driven lung cancers represent an aggressive form of NSCLC. In this study the authors perform an in vivo functional screening and identify GATAD2B as a driver of tumor growth and metastasis in KRAS-driven lung cancer.

    • Caitlin L. Grzeskowiak
    • , Samrat T. Kundu
    • , Xiulei Mo
    • , Andrei A. Ivanov
    • , Oksana Zagorodna
    • , Hengyu Lu
    • , Richard H. Chapple
    • , Yiu Huen Tsang
    • , Daniela Moreno
    • , Maribel Mosqueda
    • , Karina Eterovic
    • , Jared J. Fradette
    • , Sumreen Ahmad
    • , Fengju Chen
    • , Zechen Chong
    • , Ken Chen
    • , Chad J. Creighton
    • , Haian Fu
    • , Gordon B. Mills
    • , Don L. Gibbons
    •  & Kenneth L. Scott
  • Article | | open

    Owing to the energetic nature of N–N bonds, poly-nitrogen compounds are considered promising high energy density materials. Here, the authors synthesize three iron–nitrogen compounds at high pressure, including FeN4, which features polymeric nitrogen chains of [N42−]n units.

    • M. Bykov
    • , E. Bykova
    • , G. Aprilis
    • , K. Glazyrin
    • , E. Koemets
    • , I. Chuvashova
    • , I. Kupenko
    • , C. McCammon
    • , M. Mezouar
    • , V. Prakapenka
    • , H.-P. Liermann
    • , F. Tasnádi
    • , A. V. Ponomareva
    • , I. A. Abrikosov
    • , N. Dubrovinskaia
    •  & L. Dubrovinsky
  • Article | | open

    Little information is available on molecular changes in response to treatment of rheumatoid arthritis (RA). Here the authors report a multi-omics study collecting patients' transcriptome, proteome, and immunophenotype data to help understand the impact of drug treatments on RA molecular phenotypes.

    • Shinya Tasaki
    • , Katsuya Suzuki
    • , Yoshiaki Kassai
    • , Masaru Takeshita
    • , Atsuko Murota
    • , Yasushi Kondo
    • , Tatsuya Ando
    • , Yusuke Nakayama
    • , Yuumi Okuzono
    • , Maiko Takiguchi
    • , Rina Kurisu
    • , Takahiro Miyazaki
    • , Keiko Yoshimoto
    • , Hidekata Yasuoka
    • , Kunihiro Yamaoka
    • , Rimpei Morita
    • , Akihiko Yoshimura
    • , Hiroyoshi Toyoshiba
    •  & Tsutomu Takeuchi
  • Article | | open

    Time series single cell expression data has large variance between time points and is challenging for analysis. Here, the authors develop a new dimension reduction and data visualization tool for large scale temporal scRNA-seq data which identifies trajectories and subpopulations.

    • Wuming Gong
    • , Il-Youp Kwak
    • , Naoko Koyano-Nakagawa
    • , Wei Pan
    •  & Daniel J. Garry
  • Article | | open

    Hippocampus is necessary for integrating the context with sensory cues to retrieve memory for unique episodes. Here, the authors show that inhibiting topographically organized projections from hippocampus to the anterior olfactory nucleus independently impairs spatial and temporal odour memory recall.

    • Afif J. Aqrabawi
    •  & Jun Chul Kim
  • Article | | open

    Next-generation organic electronics require flexible organic field effect transistors that show low-voltage operation and are biodegradable. Here, Huang and co-workers demonstrate high-performance transistors that utilize solid-state ionic conductive cellulose nanopaper as the dielectric.

    • Shilei Dai
    • , Yingli Chu
    • , Dapeng Liu
    • , Fei Cao
    • , Xiaohan Wu
    • , Jiachen Zhou
    • , Bilei Zhou
    • , Yantao Chen
    •  & Jia Huang
  • Article | | open

    Plants can modify soil microbiota through root exudation, but how this process influences plant health in turn is often unclear. Here, Hu et al. show that maize benzoxazinoids released into the soil modify root-associated microbiota and thereby increase leaf defenses of the next plant generation.

    • Lingfei Hu
    • , Christelle A. M. Robert
    • , Selma Cadot
    • , Xi Zhang
    • , Meng Ye
    • , Beibei Li
    • , Daniele Manzo
    • , Noemie Chervet
    • , Thomas Steinger
    • , Marcel G. A. van der Heijden
    • , Klaus Schlaeppi
    •  & Matthias Erb
  • Article | | open

    Photocatalytic water splitting on TiO2 is a promising route to H2 fuel production, but the mechanistic pathway at the water–TiO2 interface remains poorly understood. Here, using liquid environmental TEM and first-principles calculations, the authors unveil the formation of a self-hydrogenated shell on the TiO2 surface that further promotes H2 production.

    • Yue Lu
    • , Wen-Jin Yin
    • , Kai-Lin Peng
    • , Kuan Wang
    • , Qi Hu
    • , Annabella Selloni
    • , Fu-Rong Chen
    • , Li-Min Liu
    •  & Man-Ling Sui
  • Article | | open

    Insulin promotes lipogenesis but, on the other hand, insulin resistance is associated with increased lipogenesis in the liver. Here the authors show that Snail1 is upregulated by insulin and inhibits lipogenesis by repressing Fasn expression but insulin-mediated Snail1 upregulation is impaired during obesity and insulin resistance.

    • Yan Liu
    • , Lin Jiang
    • , Chengxin Sun
    • , Nicole Ireland
    • , Yatrik M. Shah
    • , Yong Liu
    •  & Liangyou Rui
  • Article | | open

    In the germinal center (GC), B and T cells interact to induce the production of protective antibodies against threats. Here the authors show that microRNA miR-146a modulates CD40 signaling in GC B cells, while both miR-146a and miR-146b synergize to control GC T cell responses, thereby implicating intricate controls of GC response by miR-146.

    • Sunglim Cho
    • , Hyang-Mi Lee
    • , I-Shing Yu
    • , Youn Soo Choi
    • , Hsi-Yuan Huang
    • , Somaye Sadat Hashemifar
    • , Ling-Li Lin
    • , Mei-Chi Chen
    • , Nikita D. Afanasiev
    • , Aly Azeem Khan
    • , Shu-Wha Lin
    • , Alexander Y. Rudensky
    • , Shane Crotty
    •  & Li-Fan Lu
  • Article | | open

    Different stimuli can induce dynamic changes in blood flow velocity, vessel diameter and permeability. Here the authors develop a multi-photon microscopy-based image analysis tool allowing the identification of vessels and the assessment of rapid changes in large vascular networks.

    • Naoki Honkura
    • , Mark Richards
    • , Bàrbara Laviña
    • , Miguel Sáinz-Jaspeado
    • , Christer Betsholtz
    •  & Lena Claesson-Welsh
  • Article | | open

    Bacterial phytochrome-based probes improved sensitivity in photoacoustic computed tomography. Here the authors engineer a small near-infrared switchable photochromic probe that allows multi-contrast imaging at depths and can be adapted to study protein–protein interactions in deep-seated tumors.

    • Lei Li
    • , Anton A. Shemetov
    • , Mikhail Baloban
    • , Peng Hu
    • , Liren Zhu
    • , Daria M. Shcherbakova
    • , Ruiying Zhang
    • , Junhui Shi
    • , Junjie Yao
    • , Lihong V. Wang
    •  & Vladislav V. Verkhusha
  • Article | | open

    ASXL1 gene is often mutated in myeloid malignancies. Here, the authors show that mutant ASXL1 and BAP1 are in a positive feedback loop such that BAP1 induces monoubiquitination of mutant ASXL1, which in turn enhances BAP1 activity to potentiate myeloid transformation via HOXA clusters and IRF8.

    • Shuhei Asada
    • , Susumu Goyama
    • , Daichi Inoue
    • , Shiori Shikata
    • , Reina Takeda
    • , Tsuyoshi Fukushima
    • , Taishi Yonezawa
    • , Takeshi Fujino
    • , Yasutaka Hayashi
    • , Kimihito Cojin Kawabata
    • , Tomofusa Fukuyama
    • , Yosuke Tanaka
    • , Akihiko Yokoyama
    • , Satoshi Yamazaki
    • , Hiroko Kozuka-Hata
    • , Masaaki Oyama
    • , Shinya Kojima
    • , Masahito Kawazu
    • , Hiroyuki Mano
    •  & Toshio Kitamura
  • Article | | open

    The performance of energy materials is affected by structural defects, as well as physicochemical heterogeneity over different length scales. Here the authors map nanoscale correlations between morphological and functional heterogeneity, quantifying the trap states limiting electronic transport in bismuth vanadate thin films.

    • Johanna Eichhorn
    • , Christoph Kastl
    • , Jason K. Cooper
    • , Dominik Ziegler
    • , Adam M. Schwartzberg
    • , Ian D. Sharp
    •  & Francesca M. Toma
  • Article | | open

    Adaptor for IL-17 receptors (Act1) is known to be crucial for IL-17-mediated immune responses. Here the authors show that Act1 also functions as a negative regulator of T and B cells by direct inhibition of STAT3.

    • Cun-Jin Zhang
    • , Chenhui Wang
    • , Meiling Jiang
    • , Chunfang Gu
    • , Jianxin Xiao
    • , Xing Chen
    • , Bradley N. Martin
    • , Fangqiang Tang
    • , Erin Yamamoto
    • , Yibo Xian
    • , Han Wang
    • , Fengling Li
    • , R. Balfour Sartor
    • , Howard Smith
    • , M. Elaine Husni
    • , Fu-Dong Shi
    • , Ji Gao
    • , Julie Carman
    • , Ashok Dongre
    • , Susan C. McKarns
    • , Ken Coppieters
    • , Trine N. Jørgensen
    • , Warren J. Leonard
    •  & Xiaoxia Li
  • Article | | open

    Aspergillus fumigatus is a pathogenic fungus. Here the authors perform solid-state NMR measurements with intact Aspergillus cells, which provides insights into cell wall composition and dynamics and propose a structural model for fungal cell walls.

    • Xue Kang
    • , Alex Kirui
    • , Artur Muszyński
    • , Malitha C. Dickwella Widanage
    • , Adrian Chen
    • , Parastoo Azadi
    • , Ping Wang
    • , Frederic Mentink-Vigier
    •  & Tuo Wang