Browse Articles

  • Article
    | Open Access

    Designing efficient light-emitting diodes with full-color-tunability and white-light-emission remains a challenge. Here, the authors demonstrate a multifunctional hybrid tandem LED by stacking a yellow quantum-dot LED with a blue organic LED using an indium–zinc oxide intermediate connecting electrode.

    • Heng Zhang
    • , Qiang Su
    •  & Shuming Chen
  • Article
    | Open Access

    Large-scale production of fibers from two dimensional materials opens a pathway to promising applications. Here the authors report meter-long MXene fibers with high electrical conductivity that are fabricated via continuous wet spinning and demonstrated in electrical wires.

    • Wonsik Eom
    • , Hwansoo Shin
    • , Rohan B. Ambade
    • , Sang Hoon Lee
    • , Ki Hyun Lee
    • , Dong Jun Kang
    •  & Tae Hee Han
  • Article
    | Open Access

    In Parkinson’s disease (PD) the monomeric protein alpha-synuclein (aSyn) misfolds and aggregates into insoluble fibrils. Here the authors use NMR measurements and hydrogen–deuterium exchange mass spectrometry and find that the more solvent exposed the N-terminus of aSyn is, the more aggregation prone its conformation becomes, and further show how PD mutations and post translational modifications influence the extent of the N-terminus solvent exposure.

    • Amberley D. Stephens
    • , Maria Zacharopoulou
    • , Rani Moons
    • , Giuliana Fusco
    • , Neeleema Seetaloo
    • , Anass Chiki
    • , Philippa J. Woodhams
    • , Ioanna Mela
    • , Hilal A. Lashuel
    • , Jonathan J. Phillips
    • , Alfonso De Simone
    • , Frank Sobott
    •  & Gabriele S. Kaminski Schierle
  • Article
    | Open Access

    Phosphor-glass/ceramic composites are attractive for high-power white light-emitting diodes, but interfacial reaction leads to loss of quantum efficiency. Here the authors report a reduction sintering method for embedment of phosphors into silica glass with limited interfacial reaction.

    • Dao Zhang
    • , Wenge Xiao
    • , Chang Liu
    • , Xiaofeng Liu
    • , Jinjun Ren
    • , Beibei Xu
    •  & Jianrong Qiu
  • Article
    | Open Access

    REV7 has emerged as a critical regulator of DNA double-strand breaks repair. Here, the authors show that REV7 is crucial for both antibody class switch recombination and somatic hypermutation in activated B cells, in addition to their survival upon AID-deamination.

    • Dingpeng Yang
    • , Ying Sun
    • , Jingjing Chen
    • , Ying Zhang
    • , Shuangshuang Fan
    • , Min Huang
    • , Xia Xie
    • , Yanni Cai
    • , Yafang Shang
    • , Tuantuan Gui
    • , Liming Sun
    • , Jiazhi Hu
    • , Junchao Dong
    • , Leng-Siew Yeap
    • , Xiaoming Wang
    • , Wei Xiao
    •  & Fei-Long Meng
  • Article
    | Open Access

    The Thoeris defense system is a recently discovered bacterial defense system that protects bacteria against phage infection and consists of the two genes thsA and thsB. Here, the authors present the crystal structures of Bacillus cereus ThsA and ThsB and show that ThsA is a NAD+ cleaving enzyme.

    • Donghyun Ka
    • , Hyejin Oh
    • , Eunyoung Park
    • , Jeong-Han Kim
    •  & Euiyoung Bae
  • Article
    | Open Access

    Label-free trapping of nanoparticles via dielectophoretic forces is traditionally done with electrodes in a horizontal gap layout. Here, the authors present a vertical nanogap architecture, which allows for precise capture and spatiotemporal manipulation of nanoparticles and molecular assemblies.

    • Eui-Sang Yu
    • , Hyojin Lee
    • , Sun-Mi Lee
    • , Jiwon Kim
    • , Taehyun Kim
    • , Jongsu Lee
    • , Chulki Kim
    • , Minah Seo
    • , Jae Hun Kim
    • , Young Tae Byun
    • , Seung-Chul Park
    • , Seung-Yeol Lee
    • , Sin-Doo Lee
    •  & Yong-Sang Ryu
  • Article
    | Open Access

    In S. pombe, small non-coding RNA mediates heterochromatin formation by recruiting the nucleosome remodeling and histone deacetylase complex. Here, the authors show that fly nucleosome remodeler Mi-2 and histone deacetylase Rpd3 are involved in piRNA-dependent transcriptional silencing of transposable elements.

    • Bruno Mugat
    • , Simon Nicot
    • , Carolina Varela-Chavez
    • , Christophe Jourdan
    • , Kaoru Sato
    • , Eugenia Basyuk
    • , François Juge
    • , Mikiko C. Siomi
    • , Alain Pélisson
    •  & Séverine Chambeyron
  • Article
    | Open Access

    Porous coordination frameworks that undergo reversible structural transformations are promising for sensing, switching and separations. Here, the authors report an electroactive framework that exhibits a reversible single crystal-to-single crystal double [2+2] photocyclisation, leading to property changes.

    • Dylan A. Sherman
    • , Ryuichi Murase
    • , Samuel G. Duyker
    • , Qinyi Gu
    • , William Lewis
    • , Teng Lu
    • , Yun Liu
    •  & Deanna M. D’Alessandro
  • Article
    | Open Access

    There is growing interest in non-traditional materials for logic applications. Here, the authors demonstrate a domain device architecture based on ferroelectric LiNbO3 crystals with gate voltage controlled transistor without subthreshold swing and source voltage controlled nonvolatile transistor.

    • Xiaojie Chai
    • , Jun Jiang
    • , Qinghua Zhang
    • , Xu Hou
    • , Fanqi Meng
    • , Jie Wang
    • , Lin Gu
    • , David Wei Zhang
    •  & An Quan Jiang
  • Article
    | Open Access

    Mutation of the C-terminal extension of 5′-aminolevulinate synthase 2 (ALAS2) is the molecular cause for X-linked protoporphyria, but the underlying mechanism is unclear. Based on crystal structures and MD simulations of ALAS2, the authors here show how the C-terminal extension regulates ALAS2 activity.

    • Henry J. Bailey
    • , Gustavo A. Bezerra
    • , Jason R. Marcero
    • , Siladitya Padhi
    • , William R. Foster
    • , Elzbieta Rembeza
    • , Arijit Roy
    • , David F. Bishop
    • , Robert J. Desnick
    • , Gopalakrishnan Bulusu
    • , Harry A. Dailey Jr
    •  & Wyatt W. Yue
  • Article
    | Open Access

    Anorexia nervosa is an eating disorder characterized by fear of gaining weight that can lead to serious complications. Here the authors show that inhibition of SIRT1 is protective against the onset and progression of anorectic behavior in an activity-based anorexia model, suggesting SIRT1 could be a potential therapeutic target.

    • Timothy M. Robinette
    • , Justin W. Nicholatos
    • , Adam B. Francisco
    • , Kayla E. Brooks
    • , Rachel Y. Diao
    • , Sandro Sorbi
    • , Valdo Ricca
    • , Benedetta Nacmias
    • , Miguel A. Brieño-Enríquez
    •  & Sergiy Libert
  • Article
    | Open Access

    Genetic resources for livestock are valuable for understanding their demography and past selection, and may inform future breeding programs and agricultural improvement. Here, the authors present deep resequencing of 248 wild and domestic sheep, with associated data and analysis.

    • Xin Li
    • , Ji Yang
    • , Min Shen
    • , Xing-Long Xie
    • , Guang-Jian Liu
    • , Ya-Xi Xu
    • , Feng-Hua Lv
    • , Hua Yang
    • , Yong-Lin Yang
    • , Chang-Bin Liu
    • , Ping Zhou
    • , Peng-Cheng Wan
    • , Yun-Sheng Zhang
    • , Lei Gao
    • , Jing-Quan Yang
    • , Wen-Hui Pi
    • , Yan-Ling Ren
    • , Zhi-Qiang Shen
    • , Feng Wang
    • , Juan Deng
    • , Song-Song Xu
    • , Hosein Salehian-Dehkordi
    • , Eer Hehua
    • , Ali Esmailizadeh
    • , Mostafa Dehghani-Qanatqestani
    • , Ondřej Štěpánek
    • , Christina Weimann
    • , Georg Erhardt
    • , Agraw Amane
    • , Joram M. Mwacharo
    • , Jian-Lin Han
    • , Olivier Hanotte
    • , Johannes A. Lenstra
    • , Juha Kantanen
    • , David W. Coltman
    • , James W. Kijas
    • , Michael W. Bruford
    • , Kathiravan Periasamy
    • , Xin-Hua Wang
    •  & Meng-Hua Li
  • Article
    | Open Access

    Argonaute 2 (AGO2) binds RAS and is required for cellular transformation. Here, the authors establish a KRAS-driven mouse model of pancreatic cancer with conditional loss of AGO2 and show that the early phase of neoplastic lesion initiation is dependent on EGFR/RAS but not AGO2, while AGO2 is required for pancreatic ductal adenocarcinoma progression and metastasis.

    • Sunita Shankar
    • , Jean Ching-Yi Tien
    • , Ronald F. Siebenaler
    • , Seema Chugh
    • , Vijaya L. Dommeti
    • , Sylvia Zelenka-Wang
    • , Xiao-Ming Wang
    • , Ingrid J. Apel
    • , Jessica Waninger
    • , Sanjana Eyunni
    • , Alice Xu
    • , Malay Mody
    • , Andrew Goodrum
    • , Yuping Zhang
    • , John J. Tesmer
    • , Rahul Mannan
    • , Xuhong Cao
    • , Pankaj Vats
    • , Sethuramasundaram Pitchiaya
    • , Stephanie J. Ellison
    • , Jiaqi Shi
    • , Chandan Kumar-Sinha
    • , Howard C. Crawford
    •  & Arul M. Chinnaiyan
  • Article
    | Open Access

    Model biases and internal variability are a cause for uncertainties in climate projections. Here, the authors show that 45% of projected uncertainty in the western Pacific Subtropical High can be reduced by correcting sea surface temperature biases in the equatorial Pacific and beneath marine stratocumulus clouds.

    • Xiaolong Chen
    • , Tianjun Zhou
    • , Peili Wu
    • , Zhun Guo
    •  & Minghuai Wang
  • Article
    | Open Access

    Resolving concerted nuclear and electronic motion in real-time is a primary goal in chemistry. The authors monitor nuclear and valence electronic dynamics in the excited state single-bond isomerisation of a chromophore of photoactive yellow protein, using time-resolved photoelectron imaging and electronic structure calculations.

    • Cate S. Anstöter
    • , Basile F. E. Curchod
    •  & Jan R. R. Verlet
  • Article
    | Open Access

    FinO-domain proteins are bacterial RNA-binding proteins with a wide range of target specificities. Here, the authors employ UV CLIP-seq and show that minimal ProQ protein of Neisseria meningitidis binds to various small non-coding RNAs and mRNAs involved in virulence.

    • Saskia Bauriedl
    • , Milan Gerovac
    • , Nadja Heidrich
    • , Thorsten Bischler
    • , Lars Barquist
    • , Jörg Vogel
    •  & Christoph Schoen
  • Article
    | Open Access

    Understanding lithium ion dynamics holds the key to unlocking better battery materials and devices. Here, by combining electron energy-loss spectroscopy and machine learning, the authors reveal how lithium is extracted from LiCoO2 cathode used in a solid-state battery.

    • Yuki Nomura
    • , Kazuo Yamamoto
    • , Mikiya Fujii
    • , Tsukasa Hirayama
    • , Emiko Igaki
    •  & Koh Saitoh
  • Article
    | Open Access

    Uropathogenic E. coli can adhere to vaginal epithelial cells preceding urinary tract infection (UTI). Here, Brannon et al. show that urinary E. coli isolates can not only adhere to, but also invade vaginal cells in mouse UTI models and in clinical samples obtained from women with recurrent UTI.

    • John R. Brannon
    • , Taryn L. Dunigan
    • , Connor J. Beebout
    • , Tamia Ross
    • , Michelle A. Wiebe
    • , William S. Reynolds
    •  & Maria Hadjifrangiskou
  • Article
    | Open Access

    Breeding crops with delayed senescence could plausibly increase grain yield. Here the authors show that variation at the rice SGR locus contributes to differences in senescence between indica and japonica subspecies and show that introgression can increase yield in an elite indica rice variety.

    • Dongjin Shin
    • , Sichul Lee
    • , Tae-Heon Kim
    • , Jong-Hee Lee
    • , Joonheum Park
    • , Jinwon Lee
    • , Ji Yoon Lee
    • , Lae-Hyeon Cho
    • , Jae Young Choi
    • , Wonhee Lee
    • , Ji-Hwan Park
    • , Dae-Woo Lee
    • , Hisashi Ito
    • , Dae Heon Kim
    • , Ayumi Tanaka
    • , Jun-Hyeon Cho
    • , You-Chun Song
    • , Daehee Hwang
    • , Michael D. Purugganan
    • , Jong-Seong Jeon
    • , Gynheung An
    •  & Hong Gil Nam
  • Article
    | Open Access

    Tau plays an important role in tauopathies and undergoes liquid-liquid phase separation (LLPS). The authors show that disease-related P301L mutant and phosphomimic (S199E/S202E/T205E) tau enhance LLPS in vitro at physiological levels, and using specific antibodies, that tau LLPS leads to pathological conformations such as N-terminal exposure and oligomeric species.

    • Nicholas M. Kanaan
    • , Chelsey Hamel
    • , Tessa Grabinski
    •  & Benjamin Combs
  • Article
    | Open Access

    Focal adhesion kinase (FAK) is required for tumour angiogenesis and growth. Here, the authors show that deletion of pericyte FAK upregulates Gas6-Axl mediated Cyr61 production, which increases endothelial cell proliferation and angiogenesis, while elevating tissue factor production to enhance tumour cell proliferation.

    • Tanguy Lechertier
    • , Louise E. Reynolds
    • , Hyojin Kim
    • , Ana Rita Pedrosa
    • , Jesús Gómez-Escudero
    • , José M. Muñoz-Félix
    • , Silvia Batista
    • , Matthew Dukinfield
    • , Fevzi Demircioglu
    • , Ping Pui Wong
    • , Kylie P. Matchett
    • , Neil C. Henderson
    • , Gabriela D’Amico
    • , Maddy Parsons
    • , Catherine Harwood
    • , Pascal Meier
    •  & Kairbaan M. Hodivala-Dilke
  • Author Correction
    | Open Access

    • Rajesha Rupaimoole
    • , Sherry Y. Wu
    • , Sunila Pradeep
    • , Cristina Ivan
    • , Chad V. Pecot
    • , Kshipra M. Gharpure
    • , Archana S. Nagaraja
    • , Guillermo N. Armaiz-Pena
    • , Michael McGuire
    • , Behrouz Zand
    • , Heather J. Dalton
    • , Justyna Filant
    • , Justin Bottsford Miller
    • , Chunhua Lu
    • , Nouara C. Sadaoui
    • , Lingegowda S. Mangala
    • , Morgan Taylor
    • , Twan van den Beucken
    • , Elizabeth Koch
    • , Cristian Rodriguez-Aguayo
    • , Li Huang
    • , Menashe Bar-Eli
    • , Bradly G. Wouters
    • , Milan Radovich
    • , Mircea Ivan
    • , George A. Calin
    • , Wei Zhang
    • , Gabriel Lopez-Berestein
    •  & Anil K. Sood
  • Article
    | Open Access

    Genetic variants at the RSPO3 locus are associated with waist-to-hip ratio (adjusted for BMI). Here, Loh et al. describe two independent RSPO3 signals that associate with body fat distribution, perform fine-mapping and explore the function of RSPO3 in human adipocyte biology and body fat distribution in zebrafish

    • Nellie Y. Loh
    • , James E. N. Minchin
    • , Katherine E. Pinnick
    • , Manu Verma
    • , Marijana Todorčević
    • , Nathan Denton
    • , Julia El-Sayed Moustafa
    • , John P. Kemp
    • , Celia L. Gregson
    • , David M. Evans
    • , Matt J. Neville
    • , Kerrin S. Small
    • , Mark I. McCarthy
    • , Anubha Mahajan
    • , John F. Rawls
    • , Fredrik Karpe
    •  & Constantinos Christodoulides
  • Article
    | Open Access

    Mediator is a multiprotein complex required to activate gene transcription by RNAPII. Here, the authors report that MED12 and MED13 are conditional positive regulators that facilitate the expression of genes depleted in active chromatin marks and the induction of gene expression in response to environmental stimuli in Arabidopsis.

    • Qikun Liu
    • , Sylvain Bischof
    • , C. Jake Harris
    • , Zhenhui Zhong
    • , Lingyu Zhan
    • , Calvin Nguyen
    • , Andrew Rashoff
    • , William D. Barshop
    • , Fei Sun
    • , Suhua Feng
    • , Magdalena Potok
    • , Javier Gallego-Bartolome
    • , Jixian Zhai
    • , James A. Wohlschlegel
    • , Michael F. Carey
    • , Jeffrey A. Long
    •  & Steven E. Jacobsen
  • Article
    | Open Access

    The orbitofrontal cortex (OFC) encodes expected outcomes and plays a key role in outcome-guided behavior. The authors show here that the top-down projection from the OFC to the visual cortex drives visual associative learning by modulating the response gain of V1 neurons to non-relevant stimuli.

    • Dechen Liu
    • , Juan Deng
    • , Zhewei Zhang
    • , Zhi-Yu Zhang
    • , Yan-Gang Sun
    • , Tianming Yang
    •  & Haishan Yao
  • Article
    | Open Access

    Black carbon is a recalcitrant and unique form of organic carbon formed from incomplete combustion. Here the authors use global sampling to reduce uncertainty in the flux of terrestrial black carbon to the oceans, predicting that 34% of black carbon produced by fires has an oceanic fate.

    • Matthew W. Jones
    • , Alysha I. Coppola
    • , Cristina Santín
    • , Thorsten Dittmar
    • , Rudolf Jaffé
    • , Stefan H. Doerr
    •  & Timothy A. Quine
  • Article
    | Open Access

    Sequestration of reactants in lipid vesicles is a strategy prevalent in biological systems to raise the rate and specificity of chemical reactions. Here, the authors show that micelle-assisted reactions facilitate native chemical ligation between a peptide-thioester and a Cys-peptide modified by a lipid-like moiety.

    • Shuaijiang Jin
    • , Roberto J. Brea
    • , Andrew K. Rudd
    • , Stuart P. Moon
    • , Matthew R. Pratt
    •  & Neal K. Devaraj
  • Article
    | Open Access

    Previous study identified in vivo structured mRNA regions in Saccharomyces cerevisiae by dimethyl sulfate-sequencing. Here the authors use quantitative proteomics to identify protein interactors of 186 RNA folds in S. cerevisiae, providing functional links between RNA binding proteins and distinct mRNA fold.

    • Nuria Casas-Vila
    • , Sergi Sayols
    • , Lara Pérez-Martínez
    • , Marion Scheibe
    •  & Falk Butter
  • Article
    | Open Access

    Mutations that affect Treg cell function can cause lethal autoimmunity, but whether correcting these mutations can reverse established disease is unclear. Here, the authors correct Treg cell-specific Brg1 mutation in a minor fraction of Treg cells, which supercharges these cells to rescue mice from otherwise fatal IPEX-like autoimmunity.

    • Yongqin Li
    • , Yuxin Chen
    • , Shaoshuai Mao
    • , Ravinder Kaundal
    • , Zhengyu Jing
    • , Qin Chen
    • , Xinxin Wang
    • , Jing Xia
    • , Dahai Liu
    • , Jianlong Sun
    • , Haopeng Wang
    •  & Tian Chi
  • Article
    | Open Access

    There lacks a method to measure the rapid changes of vehicle emissions. Here the authors proposed a big data approach ‘TrackATruck’, and their estimates using the new approach show that the heavy-duty trucks (HDT) emissions of primary cargo routes/terminals were underestimated by 2–10 times in proxy-based emission inventories.

    • Fanyuan Deng
    • , Zhaofeng Lv
    • , Lijuan Qi
    • , Xiaotong Wang
    • , Mengshuang Shi
    •  & Huan Liu
  • Article
    | Open Access

    The signals restricting specification of vascular progenitors are unclear. Here, the authors use scRNAseq to identify transitional steps during blood and vascular development in zebrafish and identify Etv2 as repressing skeletal muscle differentiation in vascular progenitors.

    • Brendan Chestnut
    • , Satish Casie Chetty
    • , Andrew L. Koenig
    •  & Saulius Sumanas
  • Article
    | Open Access

    The location and extent of intranasal oxytocin brain penetrance has not been shown. Here the authors show that oxytocin, administered intranasally, enters brain regions along the trajectories of the olfactory and trigeminal nerves and there, reaches biologically relevant concentrations.

    • M. R. Lee
    • , T. A. Shnitko
    • , S. W. Blue
    • , A. V. Kaucher
    • , A. J. Winchell
    • , D. W. Erikson
    • , K. A. Grant
    •  & L. Leggio
  • Article
    | Open Access

    Plasma can act as strong nonlinear refractive index medium that can be exploited to downshift the frequency of a laser pulse. Here, the authors show the generation of single-cycle tunable infrared pulses using strong density gradients associated with laser-produced wakes in plasmas.

    • Zan Nie
    • , Chih-Hao Pai
    • , Jie Zhang
    • , Xiaonan Ning
    • , Jianfei Hua
    • , Yunxiao He
    • , Yipeng Wu
    • , Qianqian Su
    • , Shuang Liu
    • , Yue Ma
    • , Zhi Cheng
    • , Wei Lu
    • , Hsu-Hsin Chu
    • , Jyhpyng Wang
    • , Chaojie Zhang
    • , Warren B. Mori
    •  & Chan Joshi
  • Article
    | Open Access

    Fibroblast contributions to lung fibrosis and in particular their crosstalk with immune cells in the lung are incompletely understood. Here, the authors show an overall immune suppressive environment transcriptionally controlled and maintained by fibroblasts in lung fibrosis with possible therapeutic implications.

    • Lu Cui
    • , Shih-Yu Chen
    • , Tristan Lerbs
    • , Jin-Wook Lee
    • , Pablo Domizi
    • , Sydney Gordon
    • , Yong-hun Kim
    • , Garry Nolan
    • , Paola Betancur
    •  & Gerlinde Wernig
  • Article
    | Open Access

    First-principles calculations can help design and understand the behaviour of quantum technologies, but this requires the development of accurate methods to predict material properties. Here the authors present a method for calculating the spin-phonon relaxation time of general systems, a key quantity for spintronic devices.

    • Junqing Xu
    • , Adela Habib
    • , Sushant Kumar
    • , Feng Wu
    • , Ravishankar Sundararaman
    •  & Yuan Ping
  • Article
    | Open Access

    Small molecule polyamines participate in diverse aspects of cell growth and differentiation and are known to regulate ion channel gating. Here authors reveal that cellular polyamines control nicotinic acetylcholine receptor (nAChR) biogenesis, and either catabolic degradation or inhibition of polyamine production augments nAChR assembly.

    • Madhurima Dhara
    • , Jose A. Matta
    • , Min Lei
    • , Daniel Knowland
    • , Hong Yu
    • , Shenyan Gu
    •  & David S. Bredt
  • Article
    | Open Access

    Landslides are damaging natural hazards and can often lead to unexpected casualties and property damage. Here, the authors conduct geodetic and hydrological data analyses of the Slumgullion landslide, Colorado, and quantify the mass movement to find it fits a power-law flow theory and responds to hydroclimatic variability.

    • Xie Hu
    • , Roland Bürgmann
    • , William H. Schulz
    •  & Eric J. Fielding