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Chemical probes and their correct use are essential for accurate and robust data. Here, authors show that only 4% of analyzed publications used chemical probes in line with recommendations. This indicates that the best practice with chemical probes is yet to be implemented in research.
In this study, the authors use eddy-resolving climate model simulations and project an almost linear increase of extreme atmospheric rivers with global warming and a doubling of their occurrence under a high emission scenario.
Generally, net O2 consumption becomes dominant when photosynthesis is suppressed at night in green organisms. Here, Bag et al. show that Scots pine and Norway spruce needles display strong O2 consumption when extremely low temperatures coincide with high solar irradiation during early spring.
Electrochemical CO2 conversion to methane offers a promising solution for the large-scale storage of renewable electricity, yet the catalytic selectivity at high current density still needs to be refined. Here the authors report to use both dissolved CO2 and in-situ generated CO2 from bicarbonate to sustain high local CO2 concentration around Cu electrode and thus achieve selective CO2 conversion to methane.
Chromium tellurides are a particularly promising family of quasi-2D magnetic materials; towards the single van der Waals layer limit, they preserve magnetic ordering, some even above room temperature, and exhibit a variety of intrinsic topological properties. Here, Hang Chi, Yunbo Ou and co-authors demonstrate a strain tunable Berry curvature induced reversal of the anomalous Hall effect in Cr2Te3.
Map post-processing is crucial for cryo-EM modeling building. Here, the authors present a deep learning approach to improve both the quality and interpretability of cryo-EM maps by simultaneously considering local and non-local effects.
Progesterone (P4) signalling is involved in physiological control of the endometrium and contributes to the pathogenesis of endometrial diseases such as endometriosis. Here the authors report that CFP1, a regulator of histone methylation, controls endometrial responses to P4 and lack of endometrial CFP1 leads to failure of embryo implantation and exacerbated experimental endometriosis in mice.
A significant barrier to the mass adoption of electric vehicles is the long charge time (>30 min) of high-energy Li-ion batteries. Here, the authors propose a practical solution to enable fast charging of commercial Li-ion batteries by combining thermal switching and self-heating.
The usage of specific distal regulatory regions within the genome is critical for fate specification and cell maturation. Here, the authors show that the accumulation of the oncoprotein SET, as occurring in the rare Schinzel-Giedion syndrome, and associated histone hypo-acetylation interfere with normal enhancer repertoire employed during brain development.
Chronic kidney disease (CKD) is a disease that irreversibly leads to loss of renal function. Here, the authors demonstrate the beneficial effect of intrinsic TGF-b signaling on mitochondrial function and inflammation in the proximal tubule epithelium in response to kidney injury.
In this work the authors use coherent anti-Stokes Raman scattering to study collisional vibrational excitation in highly rotationally excited CO2 molecules prepared in an optical centrifuge.
The thermoelectric properties of SnSe are attributed to a high-temperature phase transition, whose nature has not been resolved. Here the authors probe the transition at different length scales using neutron pair distribution function analysis and diffraction data, revealing a dynamic order-disorder nature, and shedding light on previous discrepancies.
The cell-like structures and the ability of assembling catalytic species are interesting features of bioinspired multicompartment architectures but it remains a challenge to build them. Here, the authors describe a Pickering double emulsion-directed interfacial synthesis to fabricate multi-compartmented metal-organic framework microreactors. The cell-like structures and the ability of assembling catalytic species are interesting features of bioinspired multicompartment architectures but it remains a challenge to build them. Here, the authors describe a Pickering double emulsion-directed interfacial synthesis to fabricate multi-compartmented metal-organic framework microreactors.
Understanding dosage-sensitive processes requires quantitative modulation of protein abundance. Here the authors report a CRISPR-based methodology for analog tuning of endogenous gene expression, CasTuner, and show homogeneous gene expression tuning across mouse and human cells.
Despite the therapeutic interest in targeting CDK2, developing a selective CDK2 inhibitor has been challenging. Here, the authors describe a potent and selective CDK2 inhibitor that binds an allosteric pocket, preventing activating protein partners from binding and showing potential as a contraceptive.
Switchable porous materials offer adaptive voids mutating in size and shape in response to molecular stimuli. Here authors use PFG NMR to reveal the decisive role of metastable states leading to counterintuitive negative gas adsorption transitions in responsive MOFs.
Voltage-gated sodium (Nav) channels are targeted by various clinically applied and investigational drugs. Here cryo-EM structures of Nav1.7 bound to 7 compounds with diverse chemical skeletons reveal the structural basis of action of these drugs and provide a 3D structural map for drug binding sites on Nav channels.
Smart windows offer more efficient sunlight modulation and heat management. Here, the authors propose a co-assembly strategy to produce smart windows that combine electrochromic and thermochromic functions with tunable components and ordered structures for dynamic solar radiation regulation.
In a magneto-electric material, the magnetic and electric properties are coupled. This coupling allows the magnetic order to be controlled by electric stimuli, making magnetoelectric materials promising candidates for new data storage technologies. Here Gu et al demonstrate a magnetoelectric effect in a van der Waals antiferromagnetic CrOCl which persists down to monolayer, and using this realize a multi-state data storage device.
