Browse Articles

  • Article
    | Open Access

    SERS can be unreliable for biomedical use. The authors demonstrate a metal-free nanostructure composed of porous carbon nanowires in an array as a SERS substrate. It offers 106 signal enhancement due to strong broadband charge-transfer resonance and substrate-to-substrate, spot-to-spot and time-to-time consistency in the SERS spectrum.

    • Nan Chen
    • , Ting-Hui Xiao
    • , Zhenyi Luo
    • , Yasutaka Kitahama
    • , Kotaro Hiramatsu
    • , Naoki Kishimoto
    • , Tamitake Itoh
    • , Zhenzhou Cheng
    •  & Keisuke Goda
  • Article
    | Open Access

    Multivalent ligand-receptor interactions enhance binding selectivity in biological systems, and may be exploited to design synthetic systems. Here the authors demonstrate a multivalent behavior where the ability to bind the target occurs when the receptor density is within a specific range.

    • Meng Liu
    • , Azzurra Apriceno
    • , Miguel Sipin
    • , Edoardo Scarpa
    • , Laura Rodriguez-Arco
    • , Alessandro Poma
    • , Gabriele Marchello
    • , Giuseppe Battaglia
    •  & Stefano Angioletti-Uberti
  • Article
    | Open Access

    Herpesviruses code for conserved protein kinases (CHPKs) that exert several regulatory functions by interacting with cellular factors. Here, the authors use affinity purification mass spectrometry (AP–MS) to identify differential interaction partners of CHPKs from seven different human herpesviruses, finding Cyclin A and associated factors as a specific signature of β-herpesvirus kinases.

    • Boris Bogdanow
    • , Max Schmidt
    • , Henry Weisbach
    • , Iris Gruska
    • , Barbara Vetter
    • , Koshi Imami
    • , Eleonore Ostermann
    • , Wolfram Brune
    • , Matthias Selbach
    • , Christian Hagemeier
    •  & Lüder Wiebusch
  • Article
    | Open Access

    The role of PD-L1 expression on tumor-infiltrating immune cells in promoting tumor immune escape is not fully understood. Here, the authors show that PD-L1 expression by dendritic cells plays a crucial role in hindering anti-tumor T cell responses and is essential for the therapeutic efficacy of PD-L1 blockade.

    • Qi Peng
    • , Xiangyan Qiu
    • , Zihan Zhang
    • , Silin Zhang
    • , Yuanyuan Zhang
    • , Yong Liang
    • , Jingya Guo
    • , Hua Peng
    • , Mingyi Chen
    • , Yang-Xin Fu
    •  & Haidong Tang
  • Article
    | Open Access

    Iodide based energy storage is a potential candidate to improve performance of hybrid supercapacitors and batteries. Here, the authors revisit the previous understanding and show that electrochemical oxidation of iodide results in solid iodine deposits stabilized by the confinement of nanoporous carbons.

    • Christian Prehal
    • , Harald Fitzek
    • , Gerald Kothleitner
    • , Volker Presser
    • , Bernhard Gollas
    • , Stefan A. Freunberger
    •  & Qamar Abbas
  • Article
    | Open Access

    Superfluid 3He under confinement can be used as a model system for topological quantum matter, but few related measurements are reported. Here, the authors report on the thermal conduction of helium-3 in a micro-fabricated channel with unanticipated effects in both the normal and superfluid states.

    • D. Lotnyk
    • , A. Eyal
    • , N. Zhelev
    • , T. S. Abhilash
    • , E. N. Smith
    • , M. Terilli
    • , J. Wilson
    • , E. Mueller
    • , D. Einzel
    • , J. Saunders
    •  & J. M. Parpia
  • Article
    | Open Access

    Dynamic pricing schemes are increasingly employed in on-demand mobility. Here the authors show that ride-hailing services across the globe exhibit anomalous price surges induced by collective action of drivers, uncovered from price time-series at 137 locations, and explain under which conditions they emerge.

    • Malte Schröder
    • , David-Maximilian Storch
    • , Philip Marszal
    •  & Marc Timme
  • Article
    | Open Access

    Manual postprocessing of computed tomography angiography (CTA) images is extremely labor intensive and error prone. Here, the authors propose an artificial intelligence reconstruction system that can automatically achieve CTA reconstruction in healthcare services.

    • Fan Fu
    • , Jianyong Wei
    • , Miao Zhang
    • , Fan Yu
    • , Yueting Xiao
    • , Dongdong Rong
    • , Yi Shan
    • , Yan Li
    • , Cheng Zhao
    • , Fangzhou Liao
    • , Zhenghan Yang
    • , Yuehua Li
    • , Yingmin Chen
    • , Ximing Wang
    •  & Jie Lu
  • Article
    | Open Access

    Dielectric capacitors are widely used in electronic systems but they possess inferior energy density in comparison with other electrochemical energy storage. Here, the authors construct a diffused phase boundary to simultaneously achieve high energy storage density and efficiency in AgNbO3antiferroelectrics.

    • Nengneng Luo
    • , Kai Han
    • , Matthew J. Cabral
    • , Xiaozhou Liao
    • , Shujun Zhang
    • , Changzhong Liao
    • , Guangzu Zhang
    • , Xiyong Chen
    • , Qin Feng
    • , Jing-Feng Li
    •  & Yuezhou Wei
  • Article
    | Open Access

    The performance of a trained neural network may be biased even by generic features of its architecture. Yu et al. ask for the disordered lattice of atoms producing a certain wave localization and the network prefers to answer with power-law distributed displacements.

    • Sunkyu Yu
    • , Xianji Piao
    •  & Namkyoo Park
  • Article
    | Open Access

    Though literature reports improvements in organic electronic device performance, understanding the correlation between static and dynamic device responses remains a challenge. Here, the authors correlate static and dynamic parameters in organic transistors by using the radiofrequency circuit model.

    • Taiki Sawada
    • , Akifumi Yamamura
    • , Mari Sasaki
    • , Kayo Takahira
    • , Toshihiro Okamoto
    • , Shun Watanabe
    •  & Jun Takeya
  • Article
    | Open Access

    Very-Low-Frequency (VLF) communication transmitters, operate worldwide, radiate emissions at particular frequencies 10-30 kHz. Here, the authors show VLF transmitter emissions that leak from the Earth’s ground are primarily responsible for bifurcating the energetic electron belt over 20–100 keV.

    • Man Hua
    • , Wen Li
    • , Binbin Ni
    • , Qianli Ma
    • , Alex Green
    • , Xiaochen Shen
    • , Seth G. Claudepierre
    • , Jacob Bortnik
    • , Xudong Gu
    • , Song Fu
    • , Zheng Xiang
    •  & Geoffrey D. Reeves
  • Article
    | Open Access

    Abiraterone acetate (AA) is indicated for the treatment of patients with metastatic castrate-resistant prostate cancer. Here, the authors show that, in prostate cancer patients, orally administered AA remodels the gut microbiome and promotes the enrichment of the commensal bacterium Akkermansia muciniphila at the expense of androgen-utilizing Corynebacterium species.

    • Brendan A. Daisley
    • , Ryan M. Chanyi
    • , Kamilah Abdur-Rashid
    • , Kait F. Al
    • , Shaeley Gibbons
    • , John A. Chmiel
    • , Hannah Wilcox
    • , Gregor Reid
    • , Amanda Anderson
    • , Malcolm Dewar
    • , Shiva M. Nair
    • , Joseph Chin
    •  & Jeremy P. Burton
  • Article
    | Open Access

    OgpA is an O-glycopeptidase from Akkermansia muciniphila, a mucin-degrading bacterium commonly found in the human gut. A thorough characterization of OgpA, including crystal structures in complex with substrate or product, reveals molecular basis of O-glycan recognition and enzyme specificity.

    • Beatriz Trastoy
    • , Andreas Naegeli
    • , Itxaso Anso
    • , Jonathan Sjögren
    •  & Marcelo E. Guerin
  • Article
    | Open Access

    The nucleus is a mechanically stiff organelle of the cell and the DNA damage response protein ATR can localize to the nuclear envelope upon mechanical stress. Here, the authors show that ATR may contribute to the integrity of the nuclear envelope and may play a role in cell migration.

    • Gururaj Rao Kidiyoor
    • , Qingsen Li
    • , Giulia Bastianello
    • , Christopher Bruhn
    • , Irene Giovannetti
    • , Adhil Mohamood
    • , Galina V. Beznoussenko
    • , Alexandre Mironov
    • , Matthew Raab
    • , Matthieu Piel
    • , Umberto Restuccia
    • , Vittoria Matafora
    • , Angela Bachi
    • , Sara Barozzi
    • , Dario Parazzoli
    • , Emanuela Frittoli
    • , Andrea Palamidessi
    • , Tito Panciera
    • , Stefano Piccolo
    • , Giorgio Scita
    • , Paolo Maiuri
    • , Kristina M. Havas
    • , Zhong-Wei Zhou
    • , Amit Kumar
    • , Jiri Bartek
    • , Zhao-Qi Wang
    •  & Marco Foiani
  • Article
    | Open Access

    Characterizing individual catalyst nanoparticles at operando conditions is a cornerstone of catalysis research. Here the authors utilize plasmonic optical nanoimaging in a nanofluidic reactor to map the impact of reactor geometry on single Cu particle oxidation state dynamics and active phase during CO oxidation.

    • David Albinsson
    • , Astrid Boje
    • , Sara Nilsson
    • , Christopher Tiburski
    • , Anders Hellman
    • , Henrik Ström
    •  & Christoph Langhammer
  • Article
    | Open Access

    “Electric field control of ferromagnetism is typically limited by screening, and is restricted to the first few layers of metals. Here the authors overcome this limitation via the absorption of hydrogen into metal structure, demonstrating voltage control of magnetic properties of micron-scale SmCo5.”

    • Xinglong Ye
    • , Harish K. Singh
    • , Hongbin Zhang
    • , Holger Geßwein
    • , Mohammed Reda Chellali
    • , Ralf Witte
    • , Alan Molinari
    • , Konstantin Skokov
    • , Oliver Gutfleisch
    • , Horst Hahn
    •  & Robert Kruk
  • Article
    | Open Access

    Mitochondria maintain a balance between thermogenesis and ATP synthesis, but how this is coordinated is largely unknown. Here, the authors show that MFSD7C coordinates ATP synthesis and thermogenesis in response to heme by directly binding to electron transport chain complexes and SERCA2b.

    • Yingzhong Li
    • , Nikola A. Ivica
    • , Ting Dong
    • , Dimitrios P. Papageorgiou
    • , Yanpu He
    • , Douglas R. Brown
    • , Marianna Kleyman
    • , Guangan Hu
    • , Walter W. Chen
    • , Lucas B. Sullivan
    • , Amanda Del Rosario
    • , Paula T. Hammond
    • , Matthew G. Vander Heiden
    •  & Jianzhu Chen
  • Article
    | Open Access

    Single-cell metabolomics can offer deep insights into the metabolic reprogramming that accompanies disease states. Here, the authors use Raman spectro-microscopy for non-invasive metabolite analysis and identification of druggable metabolic susceptibilities in single live melanoma cells.

    • Jiajun Du
    • , Yapeng Su
    • , Chenxi Qian
    • , Dan Yuan
    • , Kun Miao
    • , Dongkwan Lee
    • , Alphonsus H. C. Ng
    • , Reto S. Wijker
    • , Antoni Ribas
    • , Raphael D. Levine
    • , James R. Heath
    •  & Lu Wei
  • Article
    | Open Access

    The ability to alter surface chemistry on a variety of materials makes polydopamine (PDA) and excellent surface coating material, but weak wear resistance and high surface roughness limits its application. Here, the authors demonstrate a laser annealing process to improve the mechanical properties of PDA coatings.

    • Kyueui Lee
    • , Minok Park
    • , Katerina G. Malollari
    • , Jisoo Shin
    • , Sally M. Winkler
    • , Yuting Zheng
    • , Jung Hwan Park
    • , Costas P. Grigoropoulos
    •  & Phillip B. Messersmith
  • Article
    | Open Access

    Short hairpin RNAs can be used to modulate and regulate gene expression. Here the authors generate chimeric RNAs that interact with the photoreceptor PAL, allowing for optoribogenetic control of cell physiology.

    • Sebastian Pilsl
    • , Charles Morgan
    • , Moujab Choukeife
    • , Andreas Möglich
    •  & Günter Mayer
  • Article
    | Open Access

    As low-carbon energy technologies advance, markets are driving demand for energy transition metals, increasing the stress placed on people and the environment in extractive locations. Here, the authors quantify this stress by developing a set of global composite environmental, social and governance risk indicators, and find that 84% of platinum resources and 70% of cobalt resources are located in high-risk contexts.

    • Éléonore Lèbre
    • , Martin Stringer
    • , Kamila Svobodova
    • , John R. Owen
    • , Deanna Kemp
    • , Claire Côte
    • , Andrea Arratia-Solar
    •  & Rick K. Valenta
  • Article
    | Open Access

    Coupling between fault zone fluid flow, permeability evolution, and elastic stress transfer produces fault valving and fluid-driven aseismic slip and pore pressure pulses. This model might explain late interseismic fault unlocking, slow slip, and rapid pressure transmission in induced seismicity.

    • Weiqiang Zhu
    • , Kali L. Allison
    • , Eric M. Dunham
    •  & Yuyun Yang
  • Article
    | Open Access

    The mechanisms for regulating translation re-initiation in bacteria remain poorly understood. Here, the authors screened a library of synthetic operons and identified a ribosome termination structure that modulates re-initiation efficiency and which is conserved across bacteria.

    • Yonatan Chemla
    • , Michael Peeri
    • , Mathias Luidor Heltberg
    • , Jerry Eichler
    • , Mogens Høgh Jensen
    • , Tamir Tuller
    •  & Lital Alfonta
  • Article
    | Open Access

    Magnetic topological heterostructures are promising devices to manipulate emergent quantum effects. Here, Hirahara et al. fabricate a novel magnetic topological heterostructure with a massive Dirac cone which becomes a massless one tuned by temperature.

    • T. Hirahara
    • , M. M. Otrokov
    • , T. T. Sasaki
    • , K. Sumida
    • , Y. Tomohiro
    • , S. Kusaka
    • , Y. Okuyama
    • , S. Ichinokura
    • , M. Kobayashi
    • , Y. Takeda
    • , K. Amemiya
    • , T. Shirasawa
    • , S. Ideta
    • , K. Miyamoto
    • , K. Tanaka
    • , S. Kuroda
    • , T. Okuda
    • , K. Hono
    • , S. V. Eremeev
    •  & E. V. Chulkov
  • Article
    | Open Access

    The mechanisms underlying resistance to immunotherapy are still poorly understood. Here, the authors show that BMP7, a molecule part of the TGF-beta superfamily, suppresses proinflammatory antitumor responses and may represent a target for overcoming resistance to PD1 inhibitors.

    • Maria Angelica Cortez
    • , Fatemeh Masrorpour
    • , Cristina Ivan
    • , Jie Zhang
    • , Ahmed Younes
    • , Yue Lu
    • , Marcos R Estecio
    • , Hampartsoum B. Barsoumian
    • , Hari Menon
    • , Mauricio da Silva Caetano
    • , Rishab Ramapriyan
    • , Jonathan E. Schoenhals
    • , Xiaohong Wang
    • , Ferdinandos Skoulidis
    • , Mark D. Wasley
    • , George Calin
    • , Patrick Hwu
    •  & James W. Welsh
  • Article
    | Open Access

    All-trans retinoic acid - ATRA- is known to remodulate the stroma of pancreatic cancer in mice. Here, the authors carried out a Phase Ib trial in pancreatic patients and show that ATRA in combination with chemotherapy is a safe potential treatment for patients with advanced pancreatic cancer, and demonstrate a stromal modulatory effect.

    • Hemant M. Kocher
    • , Bristi Basu
    • , Fieke E. M. Froeling
    • , Debashis Sarker
    • , Sarah Slater
    • , Dominic Carlin
    • , Nandita M. deSouza
    • , Katja N. De Paepe
    • , Michelle R. Goulart
    • , Christine Hughes
    • , Ahmet Imrali
    • , Rhiannon Roberts
    • , Maria Pawula
    • , Richard Houghton
    • , Cheryl Lawrence
    • , Yathushan Yogeswaran
    • , Kelly Mousa
    • , Carike Coetzee
    • , Peter Sasieni
    • , Aaron Prendergast
    •  & David J. Propper
  • Article
    | Open Access

    Protein tyrosine O-sulfation is crucial for biomolecular interactions. Here the authors report in vitro engineering and in vivo validation of a tyrosyl-tRNA synthetase mutant for the genetic encoding of sulfotyrosine in mammalian cells.

    • Xinyuan He
    • , Yan Chen
    • , Daisy Guiza Beltran
    • , Maia Kelly
    • , Bin Ma
    • , Justin Lawrie
    • , Feng Wang
    • , Eric Dodds
    • , Limei Zhang
    • , Jiantao Guo
    •  & Wei Niu
  • Author Correction
    | Open Access

    • Xiao Gao
    • , Qingwei Wang
    • , Ying Wang
    • , Jiang Liu
    • , Shuang Liu
    • , Jian Liu
    • , Xingli Zhou
    • , Li Zhou
    • , Hui Chen
    • , Linian Pan
    • , Jiwei Chen
    • , Da Wang
    • , Qing Zhang
    • , Shihui Shen
    • , Yu Xiao
    • , Zhipeng Wu
    • , Yiyun Cheng
    • , Geng Chen
    • , Syeda Kubra
    • , Jun Qin
    • , Lan Huang
    • , Pei Zhang
    • , Chuangui Wang
    • , Robb E. Moses
    • , David M. Lonard
    • , Bert W. O’ Malley
    • , Fuad Fares
    • , Bianhong Zhang
    • , Xiaotao Li
    • , Lei Li
    •  & Jianru Xiao
  • Article
    | Open Access

    Though realizing organic materials with deep blue emission is attractive for next-generation display technologies, achieving this emission in afterglow molecules remains a challenge. Here, the authors report blue organic afterglow via a strategy involving guest sensitization and matrix rigidification.

    • Shen Xu
    • , Wu Wang
    • , Hui Li
    • , Jingyu Zhang
    • , Runfeng Chen
    • , Shuang Wang
    • , Chao Zheng
    • , Guichuan Xing
    • , Chunyuan Song
    •  & Wei Huang
  • Article
    | Open Access

    The realisation of film made up of different compositions using colloidal QD inks remains a challenge because of redispersing of underlying films by polar solvents. Here, the authors introduce aromatic ligands to achieve QD inks in weakly-polar solvents that enable fabrication of multi-compositional films.

    • Seungjin Lee
    • , Min-Jae Choi
    • , Geetu Sharma
    • , Margherita Biondi
    • , Bin Chen
    • , Se-Woong Baek
    • , Amin Morteza Najarian
    • , Maral Vafaie
    • , Joshua Wicks
    • , Laxmi Kishore Sagar
    • , Sjoerd Hoogland
    • , F. Pelayo García de Arquer
    • , Oleksandr Voznyy
    •  & Edward H. Sargent
  • Article
    | Open Access

    Inflammasome activation may contribute to type 2 diabetes, but whether targeting inflammasome is beneficial is unclear. Here the authors show that repurposing nucleoside reverse transcriptase inhibitors for inhibiting inflammasome activation is associated with reduced diabetes development in people and improves insulin sensitivity in experimental settings.

    • Jayakrishna Ambati
    • , Joseph Magagnoli
    • , Hannah Leung
    • , Shao-bin Wang
    • , Chris A. Andrews
    • , Dongxu Fu
    • , Akshat Pandey
    • , Srabani Sahu
    • , Siddharth Narendran
    • , Shuichiro Hirahara
    • , Shinichi Fukuda
    • , Jian Sun
    • , Lekha Pandya
    • , Meenakshi Ambati
    • , Felipe Pereira
    • , Akhil Varshney
    • , Tammy Cummings
    • , James W. Hardin
    • , Babatunde Edun
    • , Charles L. Bennett
    • , Kameshwari Ambati
    • , Benjamin J. Fowler
    • , Nagaraj Kerur
    • , Christian Röver
    • , Norbert Leitinger
    • , Brian C. Werner
    • , Joshua D. Stein
    • , S. Scott Sutton
    •  & Bradley D. Gelfand
  • Article
    | Open Access

    Cardiotoxic adverse events associated with kinase inhibitors are a growing concern in clinical oncology. Here the authors use cellular transcriptomic responses of human cardiomyocytes treated with protein kinase inhibitors and the associated drug structural signatures to determine an integrated predictive signature of cardiotoxicity.

    • J. G. Coen van Hasselt
    • , Rayees Rahman
    • , Jens Hansen
    • , Alan Stern
    • , Jaehee V. Shim
    • , Yuguang Xiong
    • , Amanda Pickard
    • , Gomathi Jayaraman
    • , Bin Hu
    • , Milind Mahajan
    • , James M. Gallo
    • , Joseph Goldfarb
    • , Eric A. Sobie
    • , Marc R. Birtwistle
    • , Avner Schlessinger
    • , Evren U. Azeloglu
    •  & Ravi Iyengar
  • Article
    | Open Access

    Meningiomas are heterogeneous tumours. Here, the authors analysed genetic, epigenetic, and transcriptomic features across spatially-distinct meningioma samples to identify molecular programs underlying tumorigenesis that can be detected preoperatively using magnetic resonance imaging.

    • Stephen T. Magill
    • , Harish N. Vasudevan
    • , Kyounghee Seo
    • , Javier E. Villanueva-Meyer
    • , Abrar Choudhury
    • , S. John Liu
    • , Melike Pekmezci
    • , Sarah Findakly
    • , Stephanie Hilz
    • , Sydney Lastella
    • , Benjamin Demaree
    • , Steve E. Braunstein
    • , Nancy Ann Oberheim Bush
    • , Manish K. Aghi
    • , Philip V. Theodosopoulos
    • , Penny K. Sneed
    • , Adam R. Abate
    • , Mitchel S. Berger
    • , Michael W. McDermott
    • , Daniel A. Lim
    • , Erik M. Ullian
    • , Joseph F. Costello
    •  & David R. Raleigh
  • Article
    | Open Access

    Transport properties of melts in the deep Earth have dictated the evolution of the early Earth’s magma oceans and also govern many modern dynamic processes, such as plate tectonics. Here, the authors find there is a reversal in the trends of transport properties of basaltic melts at pressures near 50 GPa, with implications for the timescales of early Earth’s magma oceans.

    • Arnab Majumdar
    • , Min Wu
    • , Yuanming Pan
    • , Toshiaki Iitaka
    •  & John S. Tse
  • Article
    | Open Access

    Myeloid cells are involved in hypertension, but their exact role in renin-induced hypertension remains unclear. Here the authors show that impaired vitamin D signaling in myeloid cells causes hypertension via macrophage-specific miR-106b-5p secretion, which activates renin production in the kidney.

    • J. Oh
    • , S. J. Matkovich
    • , A. E. Riek
    • , S. M. Bindom
    • , J. S. Shao
    • , R. D. Head
    • , R. A. Barve
    • , M. S. Sands
    • , G. Carmeliet
    • , P. Osei-Owusu
    • , R. H. Knutsen
    • , H. Zhang
    • , K. J. Blumer
    • , C. G. Nichols
    • , R. P. Mecham
    • , Á Baldán
    • , B. A. Benitez
    • , M. L. Sequeira-Lopez
    • , R. A. Gomez
    •  & C. Bernal-Mizrachi
  • Article
    | Open Access

    Beneficiary defects could be utilized to introduce magnetism into materials that are not intrinsically magnetic. Here, the authors demonstrate long range magnetic order in the air-stable, defective Platinum Diselenide in the ultimate limit of thickness by using proximitized graphene as a probe.

    • Ahmet Avsar
    • , Cheol-Yeon Cheon
    • , Michele Pizzochero
    • , Mukesh Tripathi
    • , Alberto Ciarrocchi
    • , Oleg V. Yazyev
    •  & Andras Kis
  • Article
    | Open Access

    Chimeric antigen receptor (CAR)-based therapy for the treatment of liver cancer represents a promising therapeutic strategy. Here the authors show that CD147-targeting CAR-NK or CAR-T can induce anti-tumor activity against hepatocellular carcinoma in vitro and in vivo.

    • Hsiang-chi Tseng
    • , Wei Xiong
    • , Saiaditya Badeti
    • , Yan Yang
    • , Minh Ma
    • , Ting Liu
    • , Carlos A. Ramos
    • , Gianpietro Dotti
    • , Luke Fritzky
    • , Jie-gen Jiang
    • , Qing Yi
    • , James Guarrera
    • , Wei-Xing Zong
    • , Chen Liu
    •  & Dongfang Liu
  • Article
    | Open Access

    SARS-CoV-2 infection is widely diagnosed by RT-PCR, but RNA extraction is a bottleneck for fast and cheap diagnosis. Here, the authors develop protocols to perform RT-PCR directly on heat-inactivated subject samples or samples lysed with readily available detergents and benchmark performance against 597 clinically diagnosed patient samples.

    • Ioanna Smyrlaki
    • , Martin Ekman
    • , Antonio Lentini
    • , Nuno Rufino de Sousa
    • , Natali Papanicolaou
    • , Martin Vondracek
    • , Johan Aarum
    • , Hamzah Safari
    • , Shaman Muradrasoli
    • , Antonio Gigliotti Rothfuchs
    • , Jan Albert
    • , Björn Högberg
    •  & Björn Reinius
  • Article
    | Open Access

    Unlike human teeth, mouse incisors grow throughout life, based on stem and progenitor cell activity. Here the authors generate single cell RNA-seq comparative maps of continuously-growing mouse incisor, non-growing mouse molar and human teeth, combined with lineage tracing to reveal dental cell complexity.

    • Jan Krivanek
    • , Ruslan A. Soldatov
    • , Maria Eleni Kastriti
    • , Tatiana Chontorotzea
    • , Anna Nele Herdina
    • , Julian Petersen
    • , Bara Szarowska
    • , Marie Landova
    • , Veronika Kovar Matejova
    • , Lydie Izakovicova Holla
    • , Ulrike Kuchler
    • , Ivana Vidovic Zdrilic
    • , Anushree Vijaykumar
    • , Anamaria Balic
    • , Pauline Marangoni
    • , Ophir D. Klein
    • , Vitor C. M. Neves
    • , Val Yianni
    • , Paul T. Sharpe
    • , Tibor Harkany
    • , Brian D. Metscher
    • , Marc Bajénoff
    • , Mina Mina
    • , Kaj Fried
    • , Peter V. Kharchenko
    •  & Igor Adameyko
  • Article
    | Open Access

    Carbyne, a linear sp-hybridized carbon allotrope, is synthetically inaccessible and its properties are extrapolated from those of defined oligomers. Here the authors analyze weak optical bands in two series of oligoynes and reassess the optical and fundamental gap of carbyne to lower values than previously suggested.

    • Johannes Zirzlmeier
    • , Stephen Schrettl
    • , Jan C. Brauer
    • , Emmanuel Contal
    • , Laurent Vannay
    • , Éric Brémond
    • , Eike Jahnke
    • , Dirk M. Guldi
    • , Clémence Corminboeuf
    • , Rik R. Tykwinski
    •  & Holger Frauenrath
  • Article
    | Open Access

    Buckling instabilities in amphiphile-based lamellar systems can lead to the formation of tubular fingers. Van der Weijden et al. show how to shepherd their growth and destination by using drain droplets that help establishing stable interconnected mesoscale droplet networks.

    • Arno van der Weijden
    • , Mitch Winkens
    • , Sandra M. C. Schoenmakers
    • , Wilhelm T. S. Huck
    •  & Peter A. Korevaar
  • Article
    | Open Access

    Despite the identification of genetic risk loci for late-onset Alzheimer’s disease (LOAD), the genetic architecture and prediction remains unclear. Here, the authors use genetic risk scores for prediction of LOAD across three datasets and show evidence suggesting oligogenic variant architecture for this disease.

    • Qian Zhang
    • , Julia Sidorenko
    • , Baptiste Couvy-Duchesne
    • , Riccardo E. Marioni
    • , Margaret J. Wright
    • , Alison M. Goate
    • , Edoardo Marcora
    • , Kuan-lin Huang
    • , Tenielle Porter
    • , Simon M. Laws
    • , Colin L. Masters
    • , Ashley I. Bush
    • , Christopher Fowler
    • , David Darby
    • , Kelly Pertile
    • , Carolina Restrepo
    • , Blaine Roberts
    • , Jo Robertson
    • , Rebecca Rumble
    • , Tim Ryan
    • , Steven Collins
    • , Christine Thai
    • , Brett Trounson
    • , Kate Lennon
    • , Qiao-Xin Li
    • , Fernanda Yevenes Ugarte
    • , Irene Volitakis
    • , Michael Vovos
    • , Rob Williams
    • , Jenalle Baker
    • , Alyce Russell
    • , Madeline Peretti
    • , Lidija Milicic
    • , Lucy Lim
    • , Mark Rodrigues
    • , Kevin Taddei
    • , Tania Taddei
    • , Eugene Hone
    • , Florence Lim
    • , Shane Fernandez
    • , Stephanie Rainey-Smith
    • , Steve Pedrini
    • , Ralph Martins
    • , James Doecke
    • , Pierrick Bourgeat
    • , Jurgen Fripp
    • , Simon Gibson
    • , Hugo Leroux
    • , David Hanson
    • , Vincent Dore
    • , Ping Zhang
    • , Samantha Burnham
    • , Christopher C. Rowe
    • , Victor L. Villemagne
    • , Paul Yates
    • , Sveltana Bozin Pejoska
    • , Gareth Jones
    • , David Ames
    • , Elizabeth Cyarto
    • , Nicola Lautenschlager
    • , Kevin Barnham
    • , Lesley Cheng
    • , Andy Hill
    • , Neil Killeen
    • , Paul Maruff
    • , Brendan Silbert
    • , Belinda Brown
    • , Harmid Sohrabi
    • , Greg Savage
    • , Michael Vacher
    • , Perminder S. Sachdev
    • , Karen A. Mather
    • , Nicola J. Armstrong
    • , Anbupalam Thalamuthu
    • , Henry Brodaty
    • , Loic Yengo
    • , Jian Yang
    • , Naomi R. Wray
    • , Allan F. McRae
    •  & Peter M. Visscher
  • Article
    | Open Access

    Kemp eliminases are artificial enzymes that catalyze the concerted deprotonation and ring-opening of benzisoxazoles. Here, the authors use room-temperature X-ray crystallography to investigate changes to the conformational ensemble of the Kemp eliminase HG3 along a directed evolutionary trajectory, and develop an experimentally guided, ensemble-based computational enzyme design procedure.

    • Aron Broom
    • , Rojo V. Rakotoharisoa
    • , Michael C. Thompson
    • , Niayesh Zarifi
    • , Erin Nguyen
    • , Nurzhan Mukhametzhanov
    • , Lin Liu
    • , James S. Fraser
    •  & Roberto A. Chica
  • Article
    | Open Access

    In vivo, cells migrate across a diverse landscape of extracellular matrix containing gaps which present a challenge for cells to protrude across. Here, the authors show that T-Plastin strengthens protrusive actin networks to promote protrusion, extracellular matrix gap-bridging, and cell migration.

    • Damien Garbett
    • , Anjali Bisaria
    • , Changsong Yang
    • , Dannielle G. McCarthy
    • , Arnold Hayer
    • , W. E. Moerner
    • , Tatyana M. Svitkina
    •  & Tobias Meyer
  • Article
    | Open Access

    Monodisperse colloidal particles with tunable properties show promise for biomedical, energy, and environmental applications and simple routes for fabricating these particles are of interest. Here, the authors report a facile strategy for fabrication of diverse particles based on the supramolecular assembly of phenols and self-polymerizable thiols

    • Jiajing Zhou
    • , Zhixing Lin
    • , Matthew Penna
    • , Shuaijun Pan
    • , Yi Ju
    • , Shiyao Li
    • , Yiyuan Han
    • , Jingqu Chen
    • , Gan Lin
    • , Joseph J. Richardson
    • , Irene Yarovsky
    •  & Frank Caruso
  • Article
    | Open Access

    Artemisinin (ART) resistance poses a problem for malaria elimination. Here, the authors perform genome-wide CRISPR screens in Toxoplasma gondii and identify that the putative transporter Tmem14c and mitochondrial heme metabolism, through mitochondrial protease DegP2, affect ART susceptibility.

    • Clare R. Harding
    • , Saima M. Sidik
    • , Boryana Petrova
    • , Nina F. Gnädig
    • , John Okombo
    • , Alice L. Herneisen
    • , Kurt E. Ward
    • , Benedikt M. Markus
    • , Elizabeth A. Boydston
    • , David A. Fidock
    •  & Sebastian Lourido