formation of a tumour in the nervous system

Mechanisms specifying cancer cell states and response to therapy in schwannomas

Three articles analyse the molecular features of schwannomas, tumours of the peripheral nervous system that arise from Schwann cells, which normally wrap around and protect nerves.

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Latest Research articles

  • Extracting rare earth elements (REEs) from wastewater is essential for the growth of an eco-friendly sustainable economy but separating individual rare earth elements remains challenging. Here, the authors report a REE nanotrap that features dense uncoordinated carboxyl groups and triazole N atoms in a two-fold interpenetrated metalorganic framework which is highly responsive to the size variation of rareearth ions.

    • Qing-Hua Hu
    • An-Min Song
    • Jian-Ding Qiu
    ArticleOpen Access
  • Optical computing via free-space-based structured optical materials allows to access optical information without the need for preprocessing or optoelectronic conversion. In this Perspective, the authors describe opportunities and challenges in their use for optical computing, information processing, computational imaging and sensing.

    • Jingtian Hu
    • Deniz Mengu
    • Aydogan Ozcan
    PerspectiveOpen Access
  • Relating the degree of network crosslinking as a descriptor to the desalination performance of crosslinked polymer membranes remains challenging. Here, the authors introduce a parameter based on distinct amide bonds per unit mass of polyamide, to unravel the relationship between the crosslinked networks of polyamide membranes and their desalination performance.

    • Yu-Ren Xue
    • Chang Liu
    • Zhi-Kang Xu
    ArticleOpen Access
  • Loss of communication between the brain and the body severely impacts the sensorimotor abilities of disabled individuals. Here, the authors design and test a neuroscience-driven framework for advancing bionic devices that leverages biomimetic stimulation to induce physiologically plausible information flow in animals and enhances patient performance with neuroprostheses.

    • Giacomo Valle
    • Natalija Katic Secerovic
    • Stanisa Raspopovic
    ArticleOpen Access
  • Researchers showcase an integrated photonic device with monocrystalline CsPbBr3 perovskite. Employing top-down etching approach, it introduces for micro lasers, beam splitters, X-couplers, Mach-Zehnder interferometers on perovskite films. This opens avenues for integrating perovskite semiconductors into optical chips, promising advancements in information and computing science.

    • Qi Han
    • Jun Wang
    • Li Ji
    ArticleOpen Access

Subjects within Physical sciences

Subjects within Earth and environmental sciences

  • Phage-plasmids are mobile genetic elements that transfer horizontally between bacterial cells as viruses, and vertically within bacterial lineages as plasmids. Here, Pfeifer & Rocha show that phage-plasmids can mediate gene transfer across mobile elements within their hosts, and can act as intermediates in the conversion of one type of element into another.

    • Eugen Pfeifer
    • Eduardo P. C. Rocha
    ArticleOpen Access
  • Advancements in plasma lipidomic profiling increase specificity of measurements but pose challenges in aligning datasets created at different times or platforms. Here the authors present a predictive framework for harmonising such datasets with different levels of granularity in their lipid measurements.

    • Aleksandar Dakic
    • Jingqin Wu
    • Peter J. Meikle
    ArticleOpen Access
  • Gene variants can affect folding and stability of the encoded protein. Here, the authors apply deep mutational scanning to provide genotype-phenotype information for 99% of the possible PRKN variants and reveal mechanistic details on how some variants cause loss-of-function and Parkinsons disease.

    • Lene Clausen
    • Vasileios Voutsinos
    • Rasmus Hartmann-Petersen
    ArticleOpen Access

Subjects within Biological sciences

Subjects within Health sciences

Subjects within Scientific community and society

  • Contact between organelles such as the mitochondria (Mito) and endoplasmic reticulum (ER) is crucial to coordinate vital cellular homeostatic processes. Here we discuss recent work showing that Mito-ER proximity is regulated by heterotypic complexes between the F-actin polymerizing protein Diaphanous-1) and the mitochondrial dynamics protein Mitofusin 2, which confers increased susceptibility to ischemia/reperfusion injury.

    • Lorrie A. Kirshenbaum
    • Rimpy Dhingra
    • Sergio Lavandero
    CommentOpen Access
  • Selecting omic biomarkers using both their effect size and their differential status significance (i.e., selecting the “volcano-plot outer spray”) has long been equally biologically relevant and statistically troublesome. However, recent proposals are paving the way to resolving this dilemma.

    • Thomas Burger
    CommentOpen Access
  • Professor Sabine Oertelt-Prigione has been working in the field of sex and gender-sensitive research for the last 15 years. Her current work is focused on trying to understand how sex and gender-sensitive medicine can be successfully implemented in research and practice as well as methods to investigate gender in medical research. Dr. Brandon Turner is a resident physician in the Department of Radiation Oncology at Massachusetts General Hospital and Brigham and Women’s Hospital. He has conducted and is involved in numerous studies looking to evaluate race and ethnicity reporting and representation in clinical trials. In this interview for Nature Communications, Sabine Oertelt-Prigione, and Brandon Turner share their knowledge about the biases that can occur in clinical trials and how they can be minimized.

    Q&AOpen Access
  • Tuberculosis is the leading cause of death from a single infectious agent, with over 25% of these occurring in the African region. Multi-drug resistant strains which do not respond to first-line antibiotics continue to emerge, putting at risk numerous public health strategies which aim to reduce incidence and mortality. Here, we speak with Professor Valerie Mizrahi, world-leading researcher and former director of the Institute of Infectious Disease and Molecular Medicine at the University of Cape Town, regarding the tuberculosis burden in South Africa. We discuss the challenges faced by researchers, the lessons that need to be learnt and current innovations to better understand the overall response required to accelerate progress.

    Q&AOpen Access
  • Africa is undergoing a demographic transition1 that has led to significant reductions in the number of individuals living in extreme poverty, and to positive shifts in related health outcomes, across its diverse populations2. Building on these successes requires a consideration of intersecting factors that impact health metrics, which is the focus of the United Nations Sustainable Development Goals3. To support researchers in their efforts towards reaching these goals, Nature Communications, Communications Medicine and Scientific Reports invite submissions of papers that advance our understanding of all aspects of health in Africa.

    EditorialOpen Access
  • The emergence of high-entropy materials has inspired the exploration of novel materials in diverse technologies. In electrochemical energy storage, high-entropy design has shown advantageous impacts on battery materials such as suppressing undesired short-range order, frustrating energy landscape, decreasing volumetric change and reducing the reliance on critical metals. This comment addresses the definition and potential improper use of the term “high entropy” in the context of battery materials design, highlights the unique properties of high-entropy materials in battery applications, and outlines the remaining challenges in the synthesis, characterization, and computational modeling of high-entropy battery materials.

    • Bin Ouyang
    • Yan Zeng
    CommentOpen Access
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Structural biology, biochemistry and biophysics

On this page, we highlight some of our most exciting recently published articles in the areas of biochemistry, biophysics, mass spectrometry and structural biology as well as related methodology papers.
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