The efficiency of lead-halide perovskite photovoltaics is related to the tolerance of their band-edge charge-carriers to point defects. Here, the authors show that this tolerance can be extended to hot carriers depending on the defect energy level.

Microscopic reaction pathways are crucial for electrochemical performance, but manipulating them remains challenging. Here, the authors report an approach that involves integrating Mn into RuO₂ catalysts to switch the reaction mechanism of the oxygen evolution reaction from a traditional single metal-site adsorbate evolution mechanism to a different dual-metal-site oxide path mechanism.

Physical reservoir computing allows real-time low power information processing. Here, the authors report reservoir computing with magnetic skyrmions able to detect millisecond time-scale hand gestures, matching software neural networks’ performance.

PEDOT:PSS is a conductive polymer with potential as electrodes in flexible electronics, but conductivity is not always satisfactory. Here, the authors report the use of dodecyl sulfate in place of polystyrene sulfonate to prepare a durable and conductive film with large crystal domains.

Silica encapsulation can quench nonradiative relaxation and yield afterglow emission in materials. Here, the authors transfer this strategy to molecular emitters by doping them into silica microparticles enhancing both emission intensity and lifetimes.

Forest structural complexity plays a crucial role in ecosystem functioning, influencing factors like light, nutrient cycling, and biodiversity. Here, a global map of 3D canopy complexity modeled from spaceborne lidar reveals that highly complex forests are concentrated in the tropics, with significant variations observed across biomes.

This study finds that U.S. vehicle assembly plants that have fully transitioned from gas engine to electric vehicle assembly have required higher labor intensity. It suggests that more, not fewer, workers are needed for electric vehicle assembly.

In wildlife tagging, stress from capture and handling can alter post- release behavior and potentially study interpretations. This study of 42 mammal species shows that these effects diminish within 4–7 days, and quicker for animals in high human activity areas indicating adaptation to disturbance.

The expansion and intensification of agriculture has led to a loss of soil carbon. Here the authors show that increasing plant diversity within an agricultural soil increases positive associations within the soil microbial community, which increases carbon use efficiency.

Lake total organic carbon storage is usually assumed to be a constant. Here, the authors demonstrate that dissolved and particulate organic carbon storage increase by 45% and 34%, respectively, in Chinses lakes during 1984–2023.

VMAT2 regulates neurotransmitter uptake into synaptic vesicles. Here, the authors determined the cryo-EM structures of VMAT2, providing a structural basis for understanding VMAT2- mediated vesicular transport of neurotransmitters.

The mystery of mammalian lifespan is examined through DNA methylation dynamics, revealing an inverse relationship between lifespan and average methylation rate changes in bivalent promoter regions. Results vary depending on chromatin context.

Development of targeted MYC inhibitors for cancer therapy remains challenging. Here, the authors design an mRNA medicine which downregulates MYC gene transcription via epigenetic modification of MYC regulatory elements, showing significant antitumor activity in preclinical models of hepatocellular carcinoma.

Here, Nair et al show that constitutive activation of the cytoprotective transcription factor SKN-1 within the digestive and nervous system of Caenorhabditis elegans impedes serotonin signalling and leads to pathogen-apathy behaviour.

Brown planthopper is a rice-specific piercing-sucking pest. This study reveals that ACL1-ROC4/5 complexes regulate both brown planthopper resistance and drought tolerance in rice through modulating bulliform cell development and cuticular wax content.

Erythropoietin (EPO) regulates energy metabolism via its receptor (EpoR) in adipose tissue. The authors demonstrate that EPO influences glucose tolerance, insulin sensitivity, and fat mass and that EPO treatment reduces lipogenic gene expression through the EPO-EpoR-RUNX1 axis.

Efficient delivery of copper and iodine ions into tumor cells is promising for boosting the antitumor effect but elusive. Here the authors report a mitochondrial-targeted copper-iodide nanoparticles for the cancer treatment in which copper and iodide ions induce cell death by modulating mitochondrial functions under low-dose Xray irradiation.

How hematopoietic stem cells respond, if at all, to acute anemia has remained unclear. Here, the authors show that acute anemia triggers hematopoietic stem cell proliferation and guides differentiation towards erythroid cells in a process mediated by apolipoprotein E.

Mucopolysaccharidoses (MPS) are inherited metabolic disorders caused by enzyme deficiencies leading to glycosaminoglycan accumulation and systemic degenerative disease. Here, the authors show that iPSC-derived microglia progenitors can reduce glycosaminoglycan accumulation and prevent behavioral deficits in MPS mouse models.

The authors previously reported that normothermic ex vivo kidney perfusion is superior to static cold storage in terms of organ protection, but the detailed mechanism was unclear. Here the authors show that the organ-protective effects of normothermic perfusion are mediated by maintenance of mitochondrial function and enhanced by administration of AP39, a mitochondria-targeted hydrogen sulfide donor.

This study finds that U.S. vehicle assembly plants that have fully transitioned from gas engine to electric vehicle assembly have required higher labor intensity. It suggests that more, not fewer, workers are needed for electric vehicle assembly.

One quarter of households globally owns air-conditioning, but this could reach 41% by 2050. Yet, access and use will remain highly unequal. Electricity demand for air-conditioning will double, potentially increasing global CO2 emissions.

Reproducibility of computational research remains challenging. Here, authors present ENCORE, an approach to enhance reproducibility. The most significant challenge to the routine adoption of approaches like ENCORE is the lack of incentives for researchers to dedicate sufficient time and effort to ensure reproducibility.

The chemical sector is both hard-to-abate and hard-to-defossilize. This study shows how limiting the availability of alternative carbon feedstocks impacts climate goals and efforts to phase out fossil fuels.

Despite high levels of trade, the basic characteristics of the aquatic food trade are largely unknown. Here, the authors present a global seafood trade database showing the increasing globalization of farmed and wild aquatic foods.