Peter Boone, Lauren Rochelle et al.

A rainbow mouse model for visualizing clonal expansion of oncogenes in the intestine

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Physical sciences

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  • Article
    | Open Access

    Quasi-2D halide perovskites are good candidates for efficient and stable solar cells but they suffer from high open-circuit voltage (Voc) deficit. Here He et al. show that homogeneous energy landscape of the charge transport levels is important to suppressing the recombination and increasing Voc.

    • Tingwei He
    • , Saisai Li
    • , Yuanzhi Jiang
    • , Chaochao Qin
    • , Minghuan Cui
    • , Lu Qiao
    • , Hongyu Xu
    • , Jien Yang
    • , Run Long
    • , Huanhua Wang
    •  & Mingjian Yuan
  • Article
    | Open Access

    Identifying kinases responsible for specific phosphorylation events remains challenging. Here, the authors leverage kinase inhibitor profiles for the identification of kinase-substrate site pairs in cell extracts, developing a method that can identify the enzymes responsible for unassigned phosphorylation events.

    • Nikolaus A. Watson
    • , Tyrell N. Cartwright
    • , Conor Lawless
    • , Marcos Cámara-Donoso
    • , Onur Sen
    • , Kosuke Sako
    • , Toru Hirota
    • , Hiroshi Kimura
    •  & Jonathan M. G. Higgins
  • Article
    | Open Access

    XPD is part of the TFIIH complex which plays major roles in transcription initiation and nucleotide excision repair (NER). Here the authors present a high-resolution crystal structure of the XPD-MAT1 interface and dissect the role of this interface in transcription and NER.

    • Stefan Peissert
    • , Florian Sauer
    • , Daniel B. Grabarczyk
    • , Cathy Braun
    • , Gudrun Sander
    • , Arnaud Poterszman
    • , Jean-Marc Egly
    • , Jochen Kuper
    •  & Caroline Kisker

Earth and environmental sciences

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  • Article
    | Open Access

    Earth’s drylands are expected to expand due to climate change, but how this will affect vegetation remains unclear. Here the authors use models to show that despite expansion, primary productivity in drylands is likely to increase through the 21st Century.

    • Jingyu Yao
    • , Heping Liu
    • , Jianping Huang
    • , Zhongming Gao
    • , Guoyin Wang
    • , Dan Li
    • , Haipeng Yu
    •  & Xingyuan Chen
  • Article
    | Open Access

    Theoretical studies suggested that plasmapause surface waves related to the sharp inhomogeneity exist and act as a source of geomagnetic pulsations. Here, the authors show direct observations of a plasmapause surface wave and its impacts during a geomagnetic storm using multi-satellite and ground-based observations.

    • Fei He
    • , Rui-Long Guo
    • , William R. Dunn
    • , Zhong-Hua Yao
    • , Hua-Sen Zhang
    • , Yi-Xin Hao
    • , Quan-Qi Shi
    • , Zhao-Jin Rong
    • , Jiang Liu
    • , An-Min Tian
    • , Xiao-Xin Zhang
    • , Yong Wei
    • , Yong-Liang Zhang
    • , Qiu-Gang Zong
    • , Zu-Yin Pu
    •  & Wei-Xing Wan
  • Article
    | Open Access

    Measurement of species abundance is fundamental in ecology, yet challenging at large spatial scales. Here, the authors show estimates of abundance of 1248 woody plant species over the East Asian islands that highlight macroevolutionary processes of biodiversity and the status of the national red listing.

    • Keiichi Fukaya
    • , Buntarou Kusumoto
    • , Takayuki Shiono
    • , Junichi Fujinuma
    •  & Yasuhiro Kubota

Biological sciences

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  • Article
    | Open Access

    Macrophages can differentiate to perform homeostatic tissue-specific functions. Here the authors show that RXR signalling is critical for large peritoneal macrophage (LPM) expansion during neonatal life and LPM lipid metabolism and survival during adult homeostasis, and that ovarian cancer growth relies on RXR-dependent LPMs. 

    • María Casanova-Acebes
    • , María Piedad Menéndez-Gutiérrez
    • , Jesús Porcuna
    • , Damiana Álvarez-Errico
    • , Yonit Lavin
    • , Ana García
    • , Soma Kobayashi
    • , Jessica Le Berichel
    • , Vanessa Núñez
    • , Felipe Were
    • , Daniel Jiménez-Carretero
    • , Fátima Sánchez-Cabo
    • , Miriam Merad
    •  & Mercedes Ricote
  • Article
    | Open Access

    Identifying kinases responsible for specific phosphorylation events remains challenging. Here, the authors leverage kinase inhibitor profiles for the identification of kinase-substrate site pairs in cell extracts, developing a method that can identify the enzymes responsible for unassigned phosphorylation events.

    • Nikolaus A. Watson
    • , Tyrell N. Cartwright
    • , Conor Lawless
    • , Marcos Cámara-Donoso
    • , Onur Sen
    • , Kosuke Sako
    • , Toru Hirota
    • , Hiroshi Kimura
    •  & Jonathan M. G. Higgins
  • Article
    | Open Access

    XPD is part of the TFIIH complex which plays major roles in transcription initiation and nucleotide excision repair (NER). Here the authors present a high-resolution crystal structure of the XPD-MAT1 interface and dissect the role of this interface in transcription and NER.

    • Stefan Peissert
    • , Florian Sauer
    • , Daniel B. Grabarczyk
    • , Cathy Braun
    • , Gudrun Sander
    • , Arnaud Poterszman
    • , Jean-Marc Egly
    • , Jochen Kuper
    •  & Caroline Kisker

Health sciences

See All
  • Article
    | Open Access

    Macrophages can differentiate to perform homeostatic tissue-specific functions. Here the authors show that RXR signalling is critical for large peritoneal macrophage (LPM) expansion during neonatal life and LPM lipid metabolism and survival during adult homeostasis, and that ovarian cancer growth relies on RXR-dependent LPMs. 

    • María Casanova-Acebes
    • , María Piedad Menéndez-Gutiérrez
    • , Jesús Porcuna
    • , Damiana Álvarez-Errico
    • , Yonit Lavin
    • , Ana García
    • , Soma Kobayashi
    • , Jessica Le Berichel
    • , Vanessa Núñez
    • , Felipe Were
    • , Daniel Jiménez-Carretero
    • , Fátima Sánchez-Cabo
    • , Miriam Merad
    •  & Mercedes Ricote
  • Article
    | Open Access

    Non-human primate models are important for the development of high quality vision restoration therapies for blindness. Here, the authors demonstrate restoration of light responses in foveal retinal ganglion cells of the living macaque following optogenetic gene therapy.

    • Juliette E. McGregor
    • , Tyler Godat
    • , Kamal R. Dhakal
    • , Keith Parkins
    • , Jennifer M. Strazzeri
    • , Brittany A. Bateman
    • , William S. Fischer
    • , David R. Williams
    •  & William H. Merigan
  • Article
    | Open Access

    Pulmonary arterial hypertension (PAH) is a heterogeneous disease, causing severe breathing problems and cardiac morbidity. Here, the authors study chromatin marks in pulmonary arterial endothelial cells from PAH patients and controls and find changes in transcription factor and enhancer activity that suggest an aberrant response to signalling in PAH.

    • Armando Reyes-Palomares
    • , Mingxia Gu
    • , Fabian Grubert
    • , Ivan Berest
    • , Silin Sa
    • , Maya Kasowski
    • , Christian Arnold
    • , Mao Shuai
    • , Rohith Srivas
    • , Simon Miao
    • , Dan Li
    • , Michael P. Snyder
    • , Marlene Rabinovitch
    •  & Judith B. Zaugg

News & Comment

  • Comment
    | Open Access

    Asteroids, comets and moons are leftovers of planet formation. Studying them and their samples, including meteorites, can help us to learn how the Earth was made and acquired the ingredients for life, to obtain practical information for deflecting near-Earth objects (NEOs), and to access resources that would enable space habitats and voyages. Answers are hidden beneath their complex and evolving exteriors.

    • Erik Asphaug
  • Comment
    | Open Access

    Observations from the Juno and Cassini missions provide essential constraints on the internal structures and compositions of Jupiter and Saturn, resulting in profound revisions of our understanding of the interior and atmospheres of Gas Giant planets. The next step to understand planetary origins in our Solar System requires a mission to their Ice Giant siblings, Uranus and Neptune.

    • Tristan Guillot
    •  & Leigh N. Fletcher
  • Comment
    | Open Access

    Jupiter’s satellite Europa almost certainly hides a global saltwater ocean beneath its icy surface. Chemistry at the ice surface and ocean-rock interface might provide the building blocks for life, and NASA’s Europa Clipper mission will assess Europa’s habitability.

    • Samuel M. Howell
    •  & Robert T. Pappalardo
  • Comment
    | Open Access

    How does chemistry scale in complexity to unerringly direct biological functions? Nass Kovacs et al. have shown that bacteriorhodopsin undergoes structural changes tantalizingly similar to the expected pathway even under excessive excitation. Is the protein structure so highly evolved that it directs all deposited energy into the designed function?

    • R. J. Dwayne Miller
    • , Olivier Paré-Labrosse
    • , Antoine Sarracini
    •  & Jessica E. Besaw
  • Comment
    | Open Access

    Utilising identical genetic aberrations but targeting different cells, Zhang and colleagues seek to uncover how the cell of origin influences high-grade serous ovarian cancer biology, metastasis and response to treatment.

    • Emily K. Colvin
    •  & Viive M. Howell

Focus

Stem Cells and Disease

Wenjuan Pu et al./doi:10.1038/ncomms13369

Stem Cells and Disease

Editors' Highlights: Each month our editors select a small number of Articles recently published in Nature Communications that they believe are particularly interesting or important.

Ann Le Good, Ylenia Lombardo, Alfredo Sansone and Robert Stephenson

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