Hyunwoo Yuk, Baoyang Lu et al.

3D printing of conducting polymers

Latest Research

Physical sciences

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  • Article
    | Open Access

    Thioglycoligases have proved useful for bonding carbohydrates to non-sugar acceptors, however, the scope of these biocatalysts is usually limited. Here, the authors engineer a xylosidase into a thioglycoligase with the ability to form O-, N-, S- and Se- glycosides together with sugar esters and phosphoesters.

    • Manuel Nieto-Domínguez
    • , Beatriz Fernández de Toro
    • , Laura I. de Eugenio
    • , Andrés G. Santana
    • , Lara Bejarano-Muñoz
    • , Zach Armstrong
    • , Juan Antonio Méndez-Líter
    • , Juan Luis Asensio
    • , Alicia Prieto
    • , Stephen G. Withers
    • , Francisco Javier Cañada
    •  & María Jesús Martínez
  • Article
    | Open Access

    In metabolic engineering, mechanistic models require prior metabolism knowledge of the chassis strain, whereas machine learning models need ample training data. Here, the authors combine the mechanistic and machine learning models to improve prediction performance of tryptophan metabolism in baker’s yeast.

    • Jie Zhang
    • , Søren D. Petersen
    • , Tijana Radivojevic
    • , Andrés Ramirez
    • , Andrés Pérez-Manríquez
    • , Eduardo Abeliuk
    • , Benjamín J. Sánchez
    • , Zak Costello
    • , Yu Chen
    • , Michael J. Fero
    • , Hector Garcia Martin
    • , Jens Nielsen
    • , Jay D. Keasling
    •  & Michael K. Jensen
  • Article
    | Open Access

    Formation of tertiary C(sp3)-C bonds is a formidable challenge due to steric interactions and low barriers for isomerization of intermediates. Here, the authors show a Ni-catalyzed migratory 3,3-difluoroallylation of unactivated alkyl bromides at remote tertiary carbon centers.

    • Chuan Zhu
    • , Ze-Yao Liu
    • , Luning Tang
    • , Heng Zhang
    • , Yu-Feng Zhang
    • , Patrick J. Walsh
    •  & Chao Feng

Earth and environmental sciences

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  • Article
    | Open Access

    Very-Low-Frequency (VLF) communication transmitters, operate worldwide, radiate emissions at particular frequencies 10-30 kHz. Here, the authors show VLF transmitter emissions that leak from the Earth’s ground are primarily responsible for bifurcating the energetic electron belt over 20–100 keV.

    • Man Hua
    • , Wen Li
    • , Binbin Ni
    • , Qianli Ma
    • , Alex Green
    • , Xiaochen Shen
    • , Seth G. Claudepierre
    • , Jacob Bortnik
    • , Xudong Gu
    • , Song Fu
    • , Zheng Xiang
    •  & Geoffrey D. Reeves
  • Article
    | Open Access

    As low-carbon energy technologies advance, markets are driving demand for energy transition metals, increasing the stress placed on people and the environment in extractive locations. Here, the authors quantify this stress by developing a set of global composite environmental, social and governance risk indicators, and find that 84% of platinum resources and 70% of cobalt resources are located in high-risk contexts.

    • Éléonore Lèbre
    • , Martin Stringer
    • , Kamila Svobodova
    • , John R. Owen
    • , Deanna Kemp
    • , Claire Côte
    • , Andrea Arratia-Solar
    •  & Rick K. Valenta
  • Article
    | Open Access

    Coupling between fault zone fluid flow, permeability evolution, and elastic stress transfer produces fault valving and fluid-driven aseismic slip and pore pressure pulses. This model might explain late interseismic fault unlocking, slow slip, and rapid pressure transmission in induced seismicity.

    • Weiqiang Zhu
    • , Kali L. Allison
    • , Eric M. Dunham
    •  & Yuyun Yang

Biological sciences

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  • Article
    | Open Access

    Thioglycoligases have proved useful for bonding carbohydrates to non-sugar acceptors, however, the scope of these biocatalysts is usually limited. Here, the authors engineer a xylosidase into a thioglycoligase with the ability to form O-, N-, S- and Se- glycosides together with sugar esters and phosphoesters.

    • Manuel Nieto-Domínguez
    • , Beatriz Fernández de Toro
    • , Laura I. de Eugenio
    • , Andrés G. Santana
    • , Lara Bejarano-Muñoz
    • , Zach Armstrong
    • , Juan Antonio Méndez-Líter
    • , Juan Luis Asensio
    • , Alicia Prieto
    • , Stephen G. Withers
    • , Francisco Javier Cañada
    •  & María Jesús Martínez
  • Article
    | Open Access

    Poly(ADP-ribose) glycohydrolase (PARG) is involved in different cellular processes including DNA repair. Here the authors reveal a role for PARG in regulating meiotic DNA double strand break induction and repair in Caenorhabditis elegans.

    • Eva Janisiw
    • , Marilina Raices
    • , Fabiola Balmir
    • , Luis F. Paulin
    • , Antoine Baudrimont
    • , Arndt von Haeseler
    • , Judith L. Yanowitz
    • , Verena Jantsch
    •  & Nicola Silva
  • Article
    | Open Access

    The atypical chemokine receptor 3 (ACKR3) is known to regulate cell migration, but the underlying mechanisms are unclear. Here, the authors show, from an interactome analysis, ACKR3 association with the gap junction protein Connexin 43 in vivo and ACKR3-mediated inhibition of astrocyte gap junctional communication.

    • Amos Fumagalli
    • , Joyce Heuninck
    • , Anne Pizzoccaro
    • , Enora Moutin
    • , Joyce Koenen
    • , Martial Séveno
    • , Thierry Durroux
    • , Marie-Pierre Junier
    • , Géraldine Schlecht-Louf
    • , Francoise Bachelerie
    • , Dagmar Schütz
    • , Ralf Stumm
    • , Martine J. Smit
    • , Nathalie C. Guérineau
    • , Séverine Chaumont-Dubel
    •  & Philippe Marin

Health sciences

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  • Article
    | Open Access

    Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired social interactions with repetitive and restrictive behaviours. Here the authors integrate mRNA expression, miRNA expression, DNA methylation, and histone acetylation datasets from a collection of post mortem brain tissues and identify a convergent molecular subtype of ASD.

    • Gokul Ramaswami
    • , Hyejung Won
    • , Michael J. Gandal
    • , Jillian Haney
    • , Jerry C. Wang
    • , Chloe C. Y. Wong
    • , Wenjie Sun
    • , Shyam Prabhakar
    • , Jonathan Mill
    •  & Daniel H. Geschwind
  • Article
    | Open Access

    Tumours are made up of heterogeneous subclones. Here, the authors show using breast cancer imaging and gene expression datasets that these subclones can be inferred by the deconvolution of gene expression data, mapped to MRI derived radiogenomic signatures and used to estimate prognosis.

    • Ming Fan
    • , Pingping Xia
    • , Robert Clarke
    • , Yue Wang
    •  & Lihua Li
  • Article
    | Open Access

    Single-cell whole-exome sequencing is a powerful method for deciphering intratumor heterogeneity and identifying cancer drivers. Here, the authors analyze SNVs and CNVs simultaneously in bulk and single cells of BRCA1-associated breast tissues and cancers and show that Plekha5 deficiency promotes metastasis.

    • Jianlin Liu
    • , Ragini Adhav
    • , Kai Miao
    • , Sek Man Su
    • , Lihua Mo
    • , Un In Chan
    • , Xin Zhang
    • , Jun Xu
    • , Jianjie Li
    • , Xiaodong Shu
    • , Jianming Zeng
    • , Xu Zhang
    • , Xueying Lyu
    • , Lakhansing Pardeshi
    • , Kaeling Tan
    • , Heng Sun
    • , Koon Ho Wong
    • , Chuxia Deng
    •  & Xiaoling Xu

News & Comment

  • Editorial
    | Open Access

    Coastal regions are disproportionately affected by the impacts of climate change. Preserving the ecological, economic and societal benefits of these environments will rely on synergy across disciplines.

  • Editorial
    | Open Access

    The robustness of science is best revealed when independent investigations of the same problem arrive at similar conclusions. At Nature Communications, we commit to disregard from our editorial evaluation any competing works that are published while a submission to our journal is under review or under revision by the authors.

  • Comment
    | Open Access

    Bayesian brain theories suggest that perception, action and cognition arise as animals minimise the mismatch between their expectations and reality. This principle could unify cognitive science with the broader natural sciences, but leave key elements of cognition and behaviour unexplained.

    • Daniel Yon
    • , Cecilia Heyes
    •  & Clare Press
  • Comment
    | Open Access

    Single cell transcriptomics technologies have vast potential in advancing our understanding of biology and disease. Here, Sarah Aldridge and Sarah Teichmann review the last decade of technological advancements in single-cell transcriptomics and highlight some of the recent discoveries enabled by this technology.

    • Sarah Aldridge
    •  & Sarah A. Teichmann
  • Comment
    | Open Access

    Controlling the hybridization of single atoms in suitable host materials opens unique opportunities for catalyst design, but equally faces many challenges. Here, we highlight emerging directions from the last, highly productive, decade in single-atom catalysis and identify frontiers for future research.

    • Sharon Mitchell
    •  & Javier Pérez-Ramírez

Focus

Organic Chemistry and Chemical Biology

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Organic Chemistry and Chemical Biology

Editors' Highlights: Each month our editors select a small number of Articles recently published in Nature Communications that they believe are particularly interesting or important.

Giovanni Bottari, Majda Bratovič, Johannes Kreutzer and Prabhjot Saini

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