DNA synthesis for true random number generation

Secure data encryption increasingly needs large volumes of true random numbers. Linda Meiser et al. use the stochastic nature of DNA synthesis to obtain millions of gigabytes of unbiased randomness.

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Subjects within Physical sciences

  • The extent to which chemical products of water radiolysis could sustain subseafloor microbial life is unknown. Here the authors show that sediment catalyzes radiolytic production of H2 and oxidants, providing the primary energy source for life in ancient marine sediment.

    • Justine F. Sauvage
    • Ashton Flinders
    • Steven D’Hondt
    Article Open Access
  • Here, the authors identify that magnetotelluric conductive anomalies commonly observed on the trenchward-side of volcanic arcs in subduction zones can be explained by subducted sediments. High-pressure experiments show that these sediment melts will react with the overlying mantle wedge to produce electrically conductive phlogopite pyroxenites.

    • M. W. Förster
    • K. Selway
    Article Open Access
  • Generally it is thought that ash aggregation leads to reduced atmospheric travel distances. Here, the authors show that the rafting effect can increase dispersal range by up to 3.7 times for particles between 300–500 μm, compared to sedimentation of individual clasts.

    • Eduardo Rossi
    • Gholamhossein Bagheri
    • Costanza Bonadonna
    Article Open Access
  • COVID-19 might occur together with other natural disasters but frameworks to quantify collective effects is lacking. Here, the authors investigated the readiness of a healthcare system in the face of wildfire during an epidemic by assuming the COVID-19 pandemic occurred around the same time with the Camp Fire case in Butte Country California 2018/2019.

    • Emad M. Hassan
    • Hussam N. Mahmoud
    Article Open Access

Subjects within Earth and environmental sciences

Subjects within Biological sciences

  • Pain management is an extremely important topic both medically and socio-economically. Here the authors offer an overview of the use of degrading polymeric materials for delivery of pharmaceutical agents for pain management and offer a perspective of the future directions of the field.

    • Natasha C. Brigham
    • Ru-Rong Ji
    • Matthew L. Becker
    Perspective Open Access
  • Nanoparticles have been used to reduce the toxicity associated with chemotherapeutic agents. Here, the authors report a Z-scheme SnS1.68-WO2.41 nanocatalyst for photocatalytic generation of oxidative holes and hydrogen molecules for drug-free therapeutic strategy.

    • Bin Zhao
    • Yingshuai Wang
    • Qianjun He
    Article Open Access
  • COVID-19 might occur together with other natural disasters but frameworks to quantify collective effects is lacking. Here, the authors investigated the readiness of a healthcare system in the face of wildfire during an epidemic by assuming the COVID-19 pandemic occurred around the same time with the Camp Fire case in Butte Country California 2018/2019.

    • Emad M. Hassan
    • Hussam N. Mahmoud
    Article Open Access
  • Muscle atrophy is associated with ageing, but the underlying molecular mechanisms are not well understood. Here, they authors show that ablation of the E3 ubiquitin ligase Mib1 is important for myofibre maintenance via a mechanism that involves targeting and degradation of Actn3, and that Mib1 ablation in mice induces muscle atrophy which can be rescued by knockown of Actn3 expression.

    • Ji-Yun Seo
    • Jong-Seol Kang
    • Young-Yun Kong
    Article Open Access

Subjects within Health sciences

  • The unprecedented cost of the 2018 eruption in Hawai’i reflects an intersection of disparate physical and social phenomena: widely spaced, highly destructive eruptions, and atypically high population growth. These were linked and the former indirectly drove the latter with unavoidable consequences.

    • Bruce F. Houghton
    • Wendy A. Cockshell
    • Eric Yamashita
    Comment Open Access
  • Neural recording technologies increasingly enable simultaneous measurement of neural activity from multiple brain areas. To gain insight into distributed neural computations, a commensurate advance in experimental and analytical methods is necessary. We discuss two opportunities towards this end: the manipulation and modeling of neural population dynamics.

    • Krishna V. Shenoy
    • Jonathan C. Kao
    Comment Open Access
  • Writing in Nature communications, Zhu and collaborators reported the development of a genetically encoded sensor for the detection of formaldehyde in cells and tissues. This tool has great potential to transform formaldehyde research; illuminating a cellular metabolite that has remained elusive in live structures.

    • Carla Umansky
    • Agustín E. Morellato
    • Lucas B. Pontel
    Comment Open Access
  • Many newly-discovered microbial phyla have been studied solely by cultivation-independent techniques such as metagenomics. Much of their biology thus remains elusive, because the organisms have not yet been isolated and grown in the lab. Katayama et al. lift the curtain on some intriguing biology by cultivating and studying bacteria from the elusive OP9 phylum (Atribacterota).

    • Muriel C. F. van Teeseling
    • Christian Jogler
    Comment Open Access
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