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The rapid evolution of durophagy in lungfish

Xindong Cui et al. describe exceptionally preserved fossils of lungfish (air-breathing fish) from the Early Devonian that show early adaptations to durophagy, or the consumption of hard-shelled prey.

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Latest Research articles

  • Deuterium-labelled compounds are useful for mechanistic studies and pharmaceutical science, but syntheses are not trivial. Here, the authors report deuteration of unactivated alkyl (pseudo)halides driven by electrochemical force, using deuterium oxide as the source of the isotope.

    • Pengfei Li
    • Chengcheng Guo
    • Youai Qiu
    Article Open Access
  • Device-level complexity represents a big shortcoming for the hardware realization of analogue memory-based deep neural networks. Mackin et al. report a generalized computational framework, translating software-trained weights into analogue hardware weights, to minimise inference accuracy degradation.

    • Charles Mackin
    • Malte J. Rasch
    • Geoffrey W. Burr
    Article Open Access
  • Spin-hall nano-oscillators are a variation on spin-torque nano-oscillators, where the spin-Hall effect is used to drive oscillations, however past examples have had limited frequency tunability. Here, Choi et al demonstrate spin-hall oscillators with wide voltage controlled frequency tunability.

    • Jong-Guk Choi
    • Jaehyeon Park
    • Byong-Guk Park
    Article Open Access

Subjects within Physical sciences

Subjects within Earth and environmental sciences

  • Genome-scale metabolic models have been widely used for quantitative exploration of the relation between genotype and phenotype. Here the authors present GECKO 2, an automated framework for continuous and version controlled update of enzyme-constrained models of metabolism, producing an interesting catalogue of high-quality models for diverse yeasts, bacteria and human metabolism, aiming to facilitate their use in basic science, metabolic engineering and synthetic biology purposes.

    • Iván Domenzain
    • Benjamín Sánchez
    • Jens Nielsen
    Article Open Access
  • In this work, the authors report a sophisticated combination of genetic, biophysical, and biochemical analyses to identifies the cycling conformational states of PPM1D. The findings reveal how an allosteric inhibitor locks the protein into a conformationally inactive state, and explain the distribution of PPM1D activating mutations in cancer.

    • Peter G. Miller
    • Murugappan Sathappa
    • Benjamin L. Ebert
    Article Open Access
  • Trace metals have been an important ingredient for life throughout Earth’s history. Here, the authors show that a member of an elusive archaeal lineage (Caldarchaeales or Aigarchaeota) requires tungsten for growth, and provide evidence that tungsten-dependent metabolism played a role in the origin and evolution of this lineage.

    • Steffen Buessecker
    • Marike Palmer
    • Jeremy A. Dodsworth
    Article Open Access
  • Host versus graft reaction is a major impediment to CAR-T cell immune therapy in allogeneic settings. Authors show here that CAR-T cells, engineered to be deficient in MHC I expression but to express the NK inhibitor HLA-E, are resistant to destruction by both T and NK cells of the host.

    • Sumin Jo
    • Shipra Das
    • Julien Valton
    Article Open Access

Subjects within Biological sciences

  • COVID-19 vaccines may reduce the susceptibility of an individual to infection and/or the infectiousness of breakthrough infections. Here, the authors use data from Denmark and estimate that vaccine effectiveness was 61% for susceptibility and 31% for infectiousness during a period of Delta variant dominance.

    • Frederik Plesner Lyngse
    • Kåre Mølbak
    • Carsten Thure Kirkeby
    Article Open Access
  • Host versus graft reaction is a major impediment to CAR-T cell immune therapy in allogeneic settings. Authors show here that CAR-T cells, engineered to be deficient in MHC I expression but to express the NK inhibitor HLA-E, are resistant to destruction by both T and NK cells of the host.

    • Sumin Jo
    • Shipra Das
    • Julien Valton
    Article Open Access
  • The inherited basis of body fat distribution is not fully understood. Here, the authors use genetic data and MRI-derived measures of local adiposity to highlight fat depot-specific genetic architecture with implications for cardiometabolic health.

    • Saaket Agrawal
    • Minxian Wang
    • Amit V. Khera
    Article Open Access
  • A patient with a multidrug-resistant bacterial infection was successfully treated in 2016 using phage therapy. Here, the authors sequence the genomes of the therapeutic phages and three bacterial strains isolated before and during treatment, and show that the same mutations conferring phage resistance are found in in vitro-generated mutants and in phage-insensitive strains isolated from the patient.

    • Mei Liu
    • Adriana Hernandez-Morales
    • Jason J. Gill
    Article Open Access

Subjects within Health sciences

  • Floods are most devastating for those who can least afford to be hit. Globally, 1.8 billion people face high flood risks; 89% of them live in developing countries; 170 million of them live in extreme poverty making them most vulnerable.

    • Jun Rentschler
    • Melda Salhab
    • Bramka Arga Jafino
    Article Open Access
  • An ethically-based method for allocating climate change mitigation effort among subsidiaries, applicable worldwide, is proposed. Applied to the EU Green Deal, this results in a wider range of targets than the Commission’s proposal of 2021.

    • Karl W. Steininger
    • Keith Williges
    • Keywan Riahi
    Article Open Access
  • Bioinks used in current in-situ bioprinting have limitations when applied to complex operational environments. Here, the authors report on the creation of a microgel reinforced GelMA bioink which can be simply prepared and used in different biomedical settings. The application is demonstrated in a cranial defect model.

    • Mingjun Xie
    • Yang Shi
    • Yong He
    Article Open Access

Subjects within Scientific community and society

  • Flooding is a pervasive natural hazard, with new research demonstrating that more than one in five people around the world live in areas directly exposed to 1-in-100 year flood risk. Exposure to such flood risk is particularly concentrated amongst lower income households worldwide.

    • Thomas K. J. McDermott
    Comment Open Access
  • Our peer review programme was launched in 2020 to support Early Career Researchers in building confidence to participate in peer review. The initiative has proved very successful and popular with both ECRs and editors and we are pleased to invite applicants to apply to our 2022 programme.

    Editorial Open Access
  • Habitability of exoplanet’s deepest oceans could be limited by the presence of high-pressure ices at their base. New work demonstrates that efficient chemical transport within deep planetary ice mantles is possible through significant salt incorporation within the high-pressure ice.

    • Baptiste Journaux
    Comment Open Access
  • Diagonal integration of multimodal single-cell data emerges as a trending topic. However, empowering diagonal methods for novel biological discoveries requires bridging huge gaps. Here, we comment on potential risks and future directions of diagonal integration for multimodal single-cell data.

    • Yang Xu
    • Rachel Patton McCord
    Comment Open Access
  • A Global Forum on Synthetic Biology is needed to engage policymakers with practitioners across borders at the highest level. The international community needs a global confidence-building measure focused on discussing policy futures for the age of engineering biology.

    • Thomas A. Dixon
    • Paul S. Freemont
    • Isak S. Pretorius
    Comment Open Access
  • Writing in Nature communications, Seo and collaborators presented PICASSO as a method to achieve 15-color imaging of spatially overlapping proteins using no reference emission spectra in a single staining and imaging round. This accessible tool has the potential to be applied to diverse applications within the spatial biology field without neglecting accuracy.

    • Archibald Enninful
    • Alev Baysoy
    • Rong Fan
    Comment Open Access
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