10 years 2010-2020

Nature Communications at ten

Latest Research

Physical sciences

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  • Article
    | Open Access

    Benzylic oxygenation of methylarenes is a direct but challenging method for aldehyde synthesis from simple starting materials. Here, the authors show an electrochemical, site-selective method for the oxidation of methyl benzoheterocycles to aromatic acetals without using chemical oxidants or transition metal catalysts.

    • Peng Xiong
    • , Huai-Bo Zhao
    • , Xue-Ting Fan
    • , Liang-Hua Jie
    • , Hao Long
    • , Pin Xu
    • , Zhan-Jiang Liu
    • , Zheng-Jian Wu
    • , Jun Cheng
    •  & Hai-Chao Xu
  • Article
    | Open Access

    The anti-CRISPR protein IF9 (AcrIF9) specifically inhibits the type I-F CRISPR adaptive immune system. Here, the authors present the cryo-EM structure of AcrIF9 in complex with the type I-F CRISPR RNA-guided surveillance complex (Csy) and a dsDNA bound Csy-AcrIF9 structure, and find that AcrIF9 binding to the Csy complex triggers non-sequence specific dsDNA binding to Csy-AcrIF9, which might sequester the complex from its target DNA.

    • Marscha Hirschi
    • , Wang-Ting Lu
    • , Andrew Santiago-Frangos
    • , Royce Wilkinson
    • , Sarah M. Golden
    • , Alan R. Davidson
    • , Gabriel C. Lander
    •  & Blake Wiedenheft
  • Matters Arising
    | Open Access

    Recently, Pandey et al proposed relict subduction initiation occurred along a passive margin in the northwest Indian Ocean. Here, Clift et al question the evidence for subduction initiation, suggesting that simpler rifting-related processes can more simply explain the available data for the Laxmi Basin.

    • Peter D. Clift
    • , Gérôme Calvès
    •  & Tara N. Jonell

Earth and environmental sciences

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  • Matters Arising
    | Open Access

    Recently, Pandey et al proposed relict subduction initiation occurred along a passive margin in the northwest Indian Ocean. Here, Clift et al question the evidence for subduction initiation, suggesting that simpler rifting-related processes can more simply explain the available data for the Laxmi Basin.

    • Peter D. Clift
    • , Gérôme Calvès
    •  & Tara N. Jonell
  • Article
    | Open Access

    Biology can profoundly influence the planet’s climate, but over Earth’s long history these effects are poorly constrained. Here the authors show that on early Earth, the evolution of microbes producing and consuming methane likely controlled warming and glacial events, and thus Earth’s habitability

    • Boris Sauterey
    • , Benjamin Charnay
    • , Antonin Affholder
    • , Stéphane Mazevet
    •  & Régis Ferrière
  • Article
    | Open Access

    Environmental change and species diversity could jointly affect the stability of animal communities. Here the authors use citizen science data on bats, birds, and butterflies along urbanization and agricultural intensification gradients in France to show that both environmental change and diversity loss destabilise communities, but in different ways.

    • Théophile Olivier
    • , Elisa Thébault
    • , Marianne Elias
    • , Benoit Fontaine
    •  & Colin Fontaine

Biological sciences

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  • Article
    | Open Access

    Northern China contains some of the world’s earliest farming societies. Here, authors use 55 ancient genomes to trace the genetic history of human migrations across northern China for the last 7500 years, and document genetic changes mirroring shifts in subsistence strategy.

    • Chao Ning
    • , Tianjiao Li
    • , Ke Wang
    • , Fan Zhang
    • , Tao Li
    • , Xiyan Wu
    • , Shizhu Gao
    • , Quanchao Zhang
    • , Hai Zhang
    • , Mark J. Hudson
    • , Guanghui Dong
    • , Sihao Wu
    • , Yanming Fang
    • , Chen Liu
    • , Chunyan Feng
    • , Wei Li
    • , Tao Han
    • , Ruo Li
    • , Jian Wei
    • , Yonggang Zhu
    • , Yawei Zhou
    • , Chuan-Chao Wang
    • , Shengying Fan
    • , Zenglong Xiong
    • , Zhouyong Sun
    • , Maolin Ye
    • , Lei Sun
    • , Xiaohong Wu
    • , Fawei Liang
    • , Yanpeng Cao
    • , Xingtao Wei
    • , Hong Zhu
    • , Hui Zhou
    • , Johannes Krause
    • , Martine Robbeets
    • , Choongwon Jeong
    •  & Yinqiu Cui
  • Article
    | Open Access

    The anti-CRISPR protein IF9 (AcrIF9) specifically inhibits the type I-F CRISPR adaptive immune system. Here, the authors present the cryo-EM structure of AcrIF9 in complex with the type I-F CRISPR RNA-guided surveillance complex (Csy) and a dsDNA bound Csy-AcrIF9 structure, and find that AcrIF9 binding to the Csy complex triggers non-sequence specific dsDNA binding to Csy-AcrIF9, which might sequester the complex from its target DNA.

    • Marscha Hirschi
    • , Wang-Ting Lu
    • , Andrew Santiago-Frangos
    • , Royce Wilkinson
    • , Sarah M. Golden
    • , Alan R. Davidson
    • , Gabriel C. Lander
    •  & Blake Wiedenheft
  • Article
    | Open Access

    Nebulin-based nemaline myopathy is a heterogenous disease with unclear pathological mechanisms. Here, the authors generate a mouse model that mimics the most common genetic cause of the disease and demonstrate that muscle weakness in this model is associated with twisted actin filaments and altered tropomyosin and troponin behaviour.

    • Johan Lindqvist
    • , Weikang Ma
    • , Frank Li
    • , Yaeren Hernandez
    • , Justin Kolb
    • , Balazs Kiss
    • , Paola Tonino
    • , Robbert van der Pijl
    • , Esmat Karimi
    • , Henry Gong
    • , Josh Strom
    • , Zaynab Hourani
    • , John E. Smith III
    • , Coen Ottenheijm
    • , Thomas Irving
    •  & Henk Granzier

Health sciences

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  • Article
    | Open Access

    Nebulin-based nemaline myopathy is a heterogenous disease with unclear pathological mechanisms. Here, the authors generate a mouse model that mimics the most common genetic cause of the disease and demonstrate that muscle weakness in this model is associated with twisted actin filaments and altered tropomyosin and troponin behaviour.

    • Johan Lindqvist
    • , Weikang Ma
    • , Frank Li
    • , Yaeren Hernandez
    • , Justin Kolb
    • , Balazs Kiss
    • , Paola Tonino
    • , Robbert van der Pijl
    • , Esmat Karimi
    • , Henry Gong
    • , Josh Strom
    • , Zaynab Hourani
    • , John E. Smith III
    • , Coen Ottenheijm
    • , Thomas Irving
    •  & Henk Granzier
  • Article
    | Open Access

    Here the authors perform a gain-of-function screen and identify CDKN2C as a host factor for HBV replication, inducing cell cycle arrest and expression of HBV transcription enhancers. CDKN2C expression correlates with disease progression suggesting a potential role in HBV-induced liver disease.

    • Carla Eller
    • , Laura Heydmann
    • , Che C. Colpitts
    • , Houssein El Saghire
    • , Federica Piccioni
    • , Frank Jühling
    • , Karim Majzoub
    • , Caroline Pons
    • , Charlotte Bach
    • , Julie Lucifora
    • , Joachim Lupberger
    • , Michael Nassal
    • , Glenn S. Cowley
    • , Naoto Fujiwara
    • , Sen-Yung Hsieh
    • , Yujin Hoshida
    • , Emanuele Felli
    • , Patrick Pessaux
    • , Camille Sureau
    • , Catherine Schuster
    • , David E. Root
    • , Eloi R. Verrier
    •  & Thomas F. Baumert
  • Article
    | Open Access

    How and where VEGF-C is processed in lymphangiogenesis is unclear. Here, the authors show that development of the zebrafish lymphatic system is locally restricted by Vegfc maturation causing lymphatic sprouting in certain regions, which is regulated by the metalloproteases ADAMTS3 and ADAMTS14.

    • Guangxia Wang
    • , Lars Muhl
    • , Yvonne Padberg
    • , Laura Dupont
    • , Josi Peterson-Maduro
    • , Martin Stehling
    • , Ferdinand le Noble
    • , Alain Colige
    • , Christer Betsholtz
    • , Stefan Schulte-Merker
    •  & Andreas van Impel

News & Comment

  • Comment
    | Open Access

    Time horizons for nuclear materials development and qualification must be shortened to realize future nuclear energy concepts. Inspired by the Materials Genome Initiative, we present an integrated approach to materials discovery and qualification to insert new materials into service.

    • Jeffery A. Aguiar
    • , Andrea M. Jokisaari
    • , Matthew Kerr
    •  & R. Allen Roach
  • Comment
    | Open Access

    The 2019 Nobel Prize in Chemistry has been awarded to John B. Goodenough, M. Stanley Whittingham and Akira Yoshino for their contributions in the development of lithium-ion batteries, a technology that has revolutionized our way of life. Here we look back at the milestone discoveries that have shaped the modern lithium-ion batteries for inspirational insights to guide future breakthroughs.

    • Jing Xie
    •  & Yi-Chun Lu
  • Comment
    | Open Access

    Exotic degeneracies in open quantum systems, so-called exceptional points, show rich physics and promise new applications, such as sensors with greatly enhanced response. Recent research on laser gyroscopes has uncovered limits of such sensors due to excess quantum noise.

    • Jan Wiersig
  • Comment
    | Open Access

    3D printing can allow for the efficient manufacturing of elaborate structures difficult to realise conventionally without waste, such as the hollow geometries of nickel-based superalloy aeronautic components. To fully exploit this method, we must move towards new alloys and processes.

    • Chinnapat Panwisawas
    • , Yuanbo T. Tang
    •  & Roger C. Reed
  • Comment
    | Open Access

    Optical elements play a crucial role in many modern systems, from cellphones to missiles. The miniaturization trend poses a challenge to optics, since classical lenses and mirrors tend to be bulky. One way of dealing with this challenge is using flat optics. For many years flat optics has been implemented using diffractive optics technology, but in the last two decades a new technology called metasurfaces has emerged. This technology does not replace diffractive optics, but rather expands on it, leveraging the new ability to manufacture subwavelength features on optical substrates. For imaging and focusing applications, diffractive lenses and metalenses are used, as a subset of diffractive optics and metasurfaces, respectively. Recently there has been debate over whether metalenses offer any real advantages over diffractive lenses. In this commentary we will try to gain some insight into this debate and present our opinion on the subject.

    • Jacob Engelberg
    •  & Uriel Levy
  • Comment
    | Open Access

    Big data reveals new, stark pictures of the state of our environments. It also reveals ‘bright spots’ amongst the broad pattern of decline and—crucially—the key conditions for these cases. Big data analyses could benefit the planet if tightly coupled with ongoing sustainability efforts.

    • Rebecca K. Runting
    • , Stuart Phinn
    • , Zunyi Xie
    • , Oscar Venter
    •  & James E. M. Watson

Focus

Organic Chemistry and Chemical Biology

SEBASTIAN KAULITZKI/SCIENCE PHOTO LIBRARY/Getty

Organic Chemistry and Chemical Biology

Editors' Highlights: Each month our editors select a small number of Articles recently published in Nature Communications that they believe are particularly interesting or important.

Giovanni Bottari, Majda Bratovič, Johannes Kreutzer and Prabhjot Saini

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