DNA synthesis for true random number generation

Secure data encryption increasingly needs large volumes of true random numbers. Linda Meiser et al. use the stochastic nature of DNA synthesis to obtain millions of gigabytes of unbiased randomness.

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Subjects within Physical sciences

  • The authors here present geodetic and seismic data for a complete eruptive cycle (2005-2018) for Sierra Negra volcano, Galapagos Island. The data shows the largest pre-eruptive inflation (6.5 m) and rates of seismicity ever observed before a basaltic eruption and provides a rare illustration of caldera resurgence mechanisms.

    • Andrew F. Bell
    • Peter C. La Femina
    • Michael J. Stock
    Article Open Access
  • The extent to which chemical products of water radiolysis could sustain subseafloor microbial life is unknown. Here the authors show that sediment catalyzes radiolytic production of H2 and oxidants, providing the primary energy source for life in ancient marine sediment.

    • Justine F. Sauvage
    • Ashton Flinders
    • Steven D’Hondt
    Article Open Access
  • Here, the authors identify that magnetotelluric conductive anomalies commonly observed on the trenchward-side of volcanic arcs in subduction zones can be explained by subducted sediments. High-pressure experiments show that these sediment melts will react with the overlying mantle wedge to produce electrically conductive phlogopite pyroxenites.

    • M. W. Förster
    • K. Selway
    Article Open Access

Subjects within Earth and environmental sciences

  • The lipid regulation of mammalian ion channel function has emerged as a fundamental mechanism in the control of electrical signalling and transport specificity. Here, the authors combine molecular dynamics simulations, mutagenesis, and electrophysiology to provide mechanistic insights into how lipophilic molecules alter gating kinetics and K+ currents of hERG1.

    • Williams E. Miranda
    • Jiqing Guo
    • Sergei Yu. Noskov
    Article Open Access
  • The NCI-60 cancer cell line panel covers multiple cancer types but has not been extensively investigated at the epigenetic level. Here, the authors present H3K4me3, H3K27ac, H3K9me3, and H4K20me3 ChIP-Seq analysis of the cell lines, and describe features of chromatin states and integrative analyses of expression, epigenetic and genetic mutation data.

    • Lijin K. Gopi
    • Benjamin L. Kidder
    Article Open Access
  • Neural networks trained using predictive models generate representations that recover the underlying low-dimensional latent structure in the data. Here, the authors demonstrate that a network trained on a spatial navigation task generates place-related neural activations similar to those observed in the hippocampus and show that these are related to the latent structure.

    • Stefano Recanatesi
    • Matthew Farrell
    • Eric Shea-Brown
    Article Open Access
  • Current vaccine strategies for SARS-CoV-2 focus on eliciting neutralising antibodies to the spike protein (S), but differences in immunogenicity of full-length S versus receptor binding domain (RBD) only aren’t fully understood. Here, the authors show immunogenicity of different prime-boost strategies with S and/or RBD in mice and macaques.

    • Hyon-Xhi Tan
    • Jennifer A. Juno
    • Adam K. Wheatley
    Article Open Access
  • Piwi deficiency results in sterility and is associated with transposon expression and genomic instability. Here the authors show that sterility of C. elegans Piwi prg-1 mutant is not associated with transposon-induced DNA damage but is associated with and is phenocopied by dysfunction of germ granules.

    • Maya Spichal
    • Bree Heestand
    • Shawn Ahmed
    Article Open Access

Subjects within Biological sciences

Subjects within Health sciences

  • The unprecedented cost of the 2018 eruption in Hawai’i reflects an intersection of disparate physical and social phenomena: widely spaced, highly destructive eruptions, and atypically high population growth. These were linked and the former indirectly drove the latter with unavoidable consequences.

    • Bruce F. Houghton
    • Wendy A. Cockshell
    • Eric Yamashita
    Comment Open Access
  • Neural recording technologies increasingly enable simultaneous measurement of neural activity from multiple brain areas. To gain insight into distributed neural computations, a commensurate advance in experimental and analytical methods is necessary. We discuss two opportunities towards this end: the manipulation and modeling of neural population dynamics.

    • Krishna V. Shenoy
    • Jonathan C. Kao
    Comment Open Access
  • Writing in Nature communications, Zhu and collaborators reported the development of a genetically encoded sensor for the detection of formaldehyde in cells and tissues. This tool has great potential to transform formaldehyde research; illuminating a cellular metabolite that has remained elusive in live structures.

    • Carla Umansky
    • Agustín E. Morellato
    • Lucas B. Pontel
    Comment Open Access
  • Many newly-discovered microbial phyla have been studied solely by cultivation-independent techniques such as metagenomics. Much of their biology thus remains elusive, because the organisms have not yet been isolated and grown in the lab. Katayama et al. lift the curtain on some intriguing biology by cultivating and studying bacteria from the elusive OP9 phylum (Atribacterota).

    • Muriel C. F. van Teeseling
    • Christian Jogler
    Comment Open Access
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