Secure data encryption increasingly needs large volumes of true random numbers. Linda Meiser et al. use the stochastic nature of DNA synthesis to obtain millions of gigabytes of unbiased randomness.
Subduction is the primary driver of plate tectonics, yet we still do not fully understand how subduction zones initiate or the budgets of life-supporting elements recycled via subduction. At Nature Communications, we advocate for more transdisciplinary initiatives and collaborative projects, which are essential if we are to continue to bring new dynamics to subduction research.
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Latest Research articles
Current-induced switching of proximity-induced ferromagnetic surface states in a topological insulator
Electrical manipulation of magnetization in devices made of topological materials may be an essential route towards future spintronics technology. Here, Mogi et al. show efficient current-induced switching of surface ferromagnetism in hetero-bilayers of topological insulator (Bi1-xSbx)2Te3 and ferromagnetic insulator Cr2Ge2Te6.
Photonic solutions for generating free space millimeter radiation is a fast developing field that combines optoelectronics and RF domains but has many challenges. Here the authors present a quantum cascade laser (QCL) based solution for THz laser emission and millimeter wave generation in a single device.
Monitoring metallic sub-micrometric lithium structures in Li-ion batteries by in situ electron paramagnetic resonance correlated spectroscopy and imaging
Monitoring the nucleation of dendrites in Li-ion batteries during cell cycling is important for the development of new electrochemical materials. Here, the authors use the spectral-spatial mode in electron paramagnetic resonance imaging to visualize the spatial distribution of metallic sub-micrometric lithium structures.
Though thermal drawing methods are attractive for fabricating fiber-based sensor devices, existing methods allow limited access to low viscosity and low modulus materials. Here, the authors demonstrate a two-step soluble-core fiber fabrication method with wide applicability to soft polymer materials.
Designing efficient light-emitting diodes with white-light-emission from broadband-emission metal halides remains a challenge. Here, the authors demonstrate bright and efficient lead-free LEDs based on cesium copper halides enabled by introducing Tween organic additive in the precursor.
- Astronomy and planetary science
- Energy science and technology
- Materials science
- Mathematics and computing
- Nanoscience and technology
- Optics and photonics
The authors here present geodetic and seismic data for a complete eruptive cycle (2005-2018) for Sierra Negra volcano, Galapagos Island. The data shows the largest pre-eruptive inflation (6.5 m) and rates of seismicity ever observed before a basaltic eruption and provides a rare illustration of caldera resurgence mechanisms.
Trace amounts of Cerium can act as a catalyst by enhancing fluid-mediated magnetite alteration, which preconditions ore systems and could contribute to the large size and metal content of world-class ore deposits.
Potentially bioavailable iron produced through benthic cycling in glaciated Arctic fjords of Svalbard
The impacts of a melting Arctic on the biogeochemistry of marine ecosystems are unknown. Here, the authors investigate glacial input of iron to Svalbard fjords finding that reworking of glacial iron in fjord sediment is important to make iron bioavailable, but could be susceptible to glacial retreat.
The extent to which chemical products of water radiolysis could sustain subseafloor microbial life is unknown. Here the authors show that sediment catalyzes radiolytic production of H2 and oxidants, providing the primary energy source for life in ancient marine sediment.
Here, the authors identify that magnetotelluric conductive anomalies commonly observed on the trenchward-side of volcanic arcs in subduction zones can be explained by subducted sediments. High-pressure experiments show that these sediment melts will react with the overlying mantle wedge to produce electrically conductive phlogopite pyroxenites.
- Climate sciences
- Environmental sciences
- Environmental social sciences
- Natural hazards
- Ocean sciences
- Planetary science
- Solid Earth sciences
- Space physics
The lipid regulation of mammalian ion channel function has emerged as a fundamental mechanism in the control of electrical signalling and transport specificity. Here, the authors combine molecular dynamics simulations, mutagenesis, and electrophysiology to provide mechanistic insights into how lipophilic molecules alter gating kinetics and K+ currents of hERG1.
Integrative pan cancer analysis reveals epigenomic variation in cancer type and cell specific chromatin domains
The NCI-60 cancer cell line panel covers multiple cancer types but has not been extensively investigated at the epigenetic level. Here, the authors present H3K4me3, H3K27ac, H3K9me3, and H4K20me3 ChIP-Seq analysis of the cell lines, and describe features of chromatin states and integrative analyses of expression, epigenetic and genetic mutation data.
Predictive learning as a network mechanism for extracting low-dimensional latent space representations
Neural networks trained using predictive models generate representations that recover the underlying low-dimensional latent structure in the data. Here, the authors demonstrate that a network trained on a spatial navigation task generates place-related neural activations similar to those observed in the hippocampus and show that these are related to the latent structure.
Immunogenicity of prime-boost protein subunit vaccine strategies against SARS-CoV-2 in mice and macaques
Current vaccine strategies for SARS-CoV-2 focus on eliciting neutralising antibodies to the spike protein (S), but differences in immunogenicity of full-length S versus receptor binding domain (RBD) only aren’t fully understood. Here, the authors show immunogenicity of different prime-boost strategies with S and/or RBD in mice and macaques.
Piwi deficiency results in sterility and is associated with transposon expression and genomic instability. Here the authors show that sterility of C. elegans Piwi prg-1 mutant is not associated with transposon-induced DNA damage but is associated with and is phenocopied by dysfunction of germ granules.
- Biological techniques
- Cell biology
- Chemical biology
- Computational biology and bioinformatics
- Developmental biology
- Drug discovery
- Molecular biology
- Plant sciences
- Stem cells
- Structural biology
- Systems biology
Inter- and intra-tumor heterogeneity of metastatic prostate cancer determined by digital spatial gene expression profiling
The inter- and intra-tumor heterogeneity of metastatic prostate cancer (mPC) is underexplored. Here the authors use Digital Spatial Profiling to study gene and protein expression heterogeneity in 27 mPC patients, finding variation in associated pathways and potential immunotherapy targets.
Minimally invasive delivery of therapeutic agents by hydrogel injection into the pericardial cavity for cardiac repair
Current routes to deliver therapeutics to the heart are normally invasive or difficult to perform. Here the authors develop intrapericardial injection as an efficient, easy-to-perform and minimally invasive method to deliver therapeutics for cardiac repair.
Antagonistic control of myofiber size and muscle protein quality control by the ubiquitin ligase UBR4 during aging
Sarcopenia is the age-associated functional decline and atrophy of muscle fibers, and it has been proposed that it might be counteracted by inducing myofiber hypertrophy. Here, the authors show that expression levels of the ubiquitin ligase UBR4 are increased with ageing, and that whilst its genetic ablation rescues muscle atrophy, it is also associated with reduced protein quality and impaired force production in Drosophila and mouse models.
T-cell CX3CR1 expression as a dynamic blood-based biomarker of response to immune checkpoint inhibitors
There is an urgent need to discover blood-based biomarkers to predict response to immune checkpoint inhibitors (ICI). Here the authors show that effective ICI therapy correlates with increased frequency of circulating CX3CR1+CD8+ T cells in preclinical tumor models and in a cohort of patients with non-small cell lung cancer treated with anti-PD-1.
Here, the authors determine seroprevalence of antibodies to SARS-CoV-2 in healthy blood donors in the cities of Wuhan, Shenzhen, and Shijiazhuang in China between January and April 2020. The age- and sex-standardized SARS-CoV-2 seroprevalence among 18–60 year-old adults is, with 2.66%, the highest in Wuhan.
The unprecedented cost of the 2018 eruption in Hawai’i reflects an intersection of disparate physical and social phenomena: widely spaced, highly destructive eruptions, and atypically high population growth. These were linked and the former indirectly drove the latter with unavoidable consequences.
Phase separation is familiar and useful, yet opportunities to manipulate it are surprisingly subtle and complex.
Single atom catalysis poised to transition from an academic curiosity to an industrially relevant technology
During the past decade, initial skepticism rapidly changed into widespread recognition of the role of single atoms in heterogeneous catalysts. The next decade could usher in the era of industrial applications as manufacturing of durable single atom catalysts is perfected.
Neural recording technologies increasingly enable simultaneous measurement of neural activity from multiple brain areas. To gain insight into distributed neural computations, a commensurate advance in experimental and analytical methods is necessary. We discuss two opportunities towards this end: the manipulation and modeling of neural population dynamics.
Writing in Nature communications, Zhu and collaborators reported the development of a genetically encoded sensor for the detection of formaldehyde in cells and tissues. This tool has great potential to transform formaldehyde research; illuminating a cellular metabolite that has remained elusive in live structures.
Many newly-discovered microbial phyla have been studied solely by cultivation-independent techniques such as metagenomics. Much of their biology thus remains elusive, because the organisms have not yet been isolated and grown in the lab. Katayama et al. lift the curtain on some intriguing biology by cultivating and studying bacteria from the elusive OP9 phylum (Atribacterota).