Bill Söderström et al.

Cell shape-independent FtsZ dynamics in bacteria

Latest Research

  • Article | | open

    The Cas12b family of CRISPR nucleases has been underutilized in mammalian cells due to the high temperature requirement of known members. Here the authors engineer BhCas12b to overcome this limitation for robust and specific genome editing applications in human cells.

    • Jonathan Strecker
    • , Sara Jones
    • , Balwina Koopal
    • , Jonathan Schmid-Burgk
    • , Bernd Zetsche
    • , Linyi Gao
    • , Kira S. Makarova
    • , Eugene V. Koonin
    •  & Feng Zhang
  • Article | | open

    While hydrogen offers a potential carbon neutral fuel, its production from water using earth-abundant, heterogeneous materials has proven challenging to understand. Here, authors present a series of molecular electrocatalysts based on molybdenum, sulphur, and oxygen for aqueous hydrogen evolution.

    • James McAllister
    • , Nuno A. G. Bandeira
    • , Jessica C. McGlynn
    • , Alexey Y. Ganin
    • , Yu-Fei Song
    • , Carles Bo
    •  & Haralampos N. Miras
  • Article | | open

    A computationally efficient description of ice-water systems at the mesoscopic scale is challenging due to system size and timescale limitations. Here the authors develop a machine-learned coarse-grained water model to elucidate the ice nucleation process much more efficiently than previous models.

    • Henry Chan
    • , Mathew J. Cherukara
    • , Badri Narayanan
    • , Troy D. Loeffler
    • , Chris Benmore
    • , Stephen K. Gray
    •  & Subramanian K. R. S. Sankaranarayanan
  • Article | | open

    The utility of UV vision for visualizing habitat structure is poorly known. Here, the authors use optical models and multispectral imaging to show that UV vision reveals sharp visual contrasts between leaf surfaces, potentially an advantage in navigating forest environments.

    • Cynthia Tedore
    •  & Dan-Eric Nilsson
  • Article | | open

    The mid-Pleistocene transition is recognized as a shift in paleoclimatic periodicity from 41- to 100-kyr cycles. Here the authors present a unique mid-Pleistocene transition of coupled monsoon-vegetation changes from 23- to 100-kyr cycles, which indicates varied sensitivity of past climate to astronomical and ice/CO2 forcing.

    • Youbin Sun
    • , Qiuzhen Yin
    • , Michel Crucifix
    • , Steven C. Clemens
    • , Pablo Araya-Melo
    • , Weiguo Liu
    • , Xiaoke Qiang
    • , Qingsong Liu
    • , Hui Zhao
    • , Lianji Liang
    • , Hongyun Chen
    • , Ying Li
    • , Li Zhang
    • , Guocheng Dong
    • , Ming Li
    • , Weijian Zhou
    • , Andre Berger
    •  & Zhisheng An
  • Article | | open

    Ocean warming contributes to the thinning of the Antarctic ice shelves, however, lack of observations has prevented a quantification of this contribution. Here the authors use geological records to show that 0.3–1.5 °C ocean warming has played a central role on regional ice shelf instability over the last 9000 years.

    • Johan Etourneau
    • , Giovanni Sgubin
    • , Xavier Crosta
    • , Didier Swingedouw
    • , Verónica Willmott
    • , Loïc Barbara
    • , Marie-Noëlle Houssais
    • , Stefan Schouten
    • , Jaap S. Sinninghe Damsté
    • , Hugues Goosse
    • , Carlota Escutia
    • , Julien Crespin
    • , Guillaume Massé
    •  & Jung-Hyun Kim
  • Article | | open

    Mutations in the mechanotransduction channel component TMC1/2 cause deafness. Here, the authors use a synthetic AAV to replace TMC1 and 2 in the inner ear and show restoration of cochlear and vestibular function, of neuronal reponses in the auditory cortex and of hearing and balance in mice.

    • Carl A. Nist-Lund
    • , Bifeng Pan
    • , Amy Patterson
    • , Yukako Asai
    • , Tianwen Chen
    • , Wu Zhou
    • , Hong Zhu
    • , Sandra Romero
    • , Jennifer Resnik
    • , Daniel B. Polley
    • , Gwenaelle S. Géléoc
    •  & Jeffrey R. Holt
  • Article | | open

    The Cas12b family of CRISPR nucleases has been underutilized in mammalian cells due to the high temperature requirement of known members. Here the authors engineer BhCas12b to overcome this limitation for robust and specific genome editing applications in human cells.

    • Jonathan Strecker
    • , Sara Jones
    • , Balwina Koopal
    • , Jonathan Schmid-Burgk
    • , Bernd Zetsche
    • , Linyi Gao
    • , Kira S. Makarova
    • , Eugene V. Koonin
    •  & Feng Zhang
  • Article | | open

    Plasmodium vivax biology is not well understood, due to a lack of in vitro culture systems and difficulties associated with studying clinical blood samples. Here, Kim et al. use gene expression profiles from P. vivax infected patient blood and show stage-specific chloroquine response and differential regulation of male and female gametocytes.

    • Adam Kim
    • , Jean Popovici
    • , Didier Menard
    •  & David Serre
  • Article | | open

    Mutations in the mechanotransduction channel component TMC1/2 cause deafness. Here, the authors use a synthetic AAV to replace TMC1 and 2 in the inner ear and show restoration of cochlear and vestibular function, of neuronal reponses in the auditory cortex and of hearing and balance in mice.

    • Carl A. Nist-Lund
    • , Bifeng Pan
    • , Amy Patterson
    • , Yukako Asai
    • , Tianwen Chen
    • , Wu Zhou
    • , Hong Zhu
    • , Sandra Romero
    • , Jennifer Resnik
    • , Daniel B. Polley
    • , Gwenaelle S. Géléoc
    •  & Jeffrey R. Holt
  • Article | | open

    GWAS have identified more than 500 genetic loci associated with blood lipid levels. Here, the authors report a genome-wide analysis of interactions between genetic markers and physical activity, and find that physical activity modifies the effects of four genetic loci on HDL or LDL cholesterol.

    • Tuomas O. Kilpeläinen
    • , Amy R. Bentley
    • , Raymond Noordam
    • , Yun Ju Sung
    • , Karen Schwander
    • , Thomas W. Winkler
    • , Hermina Jakupović
    • , Daniel I. Chasman
    • , Alisa Manning
    • , Ioanna Ntalla
    • , Hugues Aschard
    • , Michael R. Brown
    • , Lisa de las Fuentes
    • , Nora Franceschini
    • , Xiuqing Guo
    • , Dina Vojinovic
    • , Stella Aslibekyan
    • , Mary F. Feitosa
    • , Minjung Kho
    • , Solomon K. Musani
    • , Melissa Richard
    • , Heming Wang
    • , Zhe Wang
    • , Traci M. Bartz
    • , Lawrence F. Bielak
    • , Archie Campbell
    • , Rajkumar Dorajoo
    • , Virginia Fisher
    • , Fernando P. Hartwig
    • , Andrea R. V. R. Horimoto
    • , Changwei Li
    • , Kurt K. Lohman
    • , Jonathan Marten
    • , Xueling Sim
    • , Albert V. Smith
    • , Salman M. Tajuddin
    • , Maris Alver
    • , Marzyeh Amini
    • , Mathilde Boissel
    • , Jin Fang Chai
    • , Xu Chen
    • , Jasmin Divers
    • , Evangelos Evangelou
    • , Chuan Gao
    • , Mariaelisa Graff
    • , Sarah E. Harris
    • , Meian He
    • , Fang-Chi Hsu
    • , Anne U. Jackson
    • , Jing Hua Zhao
    • , Aldi T. Kraja
    • , Brigitte Kühnel
    • , Federica Laguzzi
    • , Leo-Pekka Lyytikäinen
    • , Ilja M. Nolte
    • , Rainer Rauramaa
    • , Muhammad Riaz
    • , Antonietta Robino
    • , Rico Rueedi
    • , Heather M. Stringham
    • , Fumihiko Takeuchi
    • , Peter J. van der Most
    • , Tibor V. Varga
    • , Niek Verweij
    • , Erin B. Ware
    • , Wanqing Wen
    • , Xiaoyin Li
    • , Lisa R. Yanek
    • , Najaf Amin
    • , Donna K. Arnett
    • , Eric Boerwinkle
    • , Marco Brumat
    • , Brian Cade
    • , Mickaël Canouil
    • , Yii-Der Ida Chen
    • , Maria Pina Concas
    • , John Connell
    • , Renée de Mutsert
    • , H. Janaka de Silva
    • , Paul S. de Vries
    • , Ayşe Demirkan
    • , Jingzhong Ding
    • , Charles B. Eaton
    • , Jessica D. Faul
    • , Yechiel Friedlander
    • , Kelley P. Gabriel
    • , Mohsen Ghanbari
    • , Franco Giulianini
    • , Chi Charles Gu
    • , Dongfeng Gu
    • , Tamara B. Harris
    • , Jiang He
    • , Sami Heikkinen
    • , Chew-Kiat Heng
    • , Steven C. Hunt
    • , M. Arfan Ikram
    • , Jost B. Jonas
    • , Woon-Puay Koh
    • , Pirjo Komulainen
    • , Jose E. Krieger
    • , Stephen B. Kritchevsky
    • , Zoltán Kutalik
    • , Johanna Kuusisto
    • , Carl D. Langefeld
    • , Claudia Langenberg
    • , Lenore J. Launer
    • , Karin Leander
    • , Rozenn N. Lemaitre
    • , Cora E. Lewis
    • , Jingjing Liang
    • , Behrooz Z. Alizadeh
    • , H. Marike Boezen
    • , Lude Franke
    • , Gerjan Navis
    • , Marianne Rots
    • , Morris Swertz
    • , Bruce H. R. Wolffenbuttel
    • , Cisca Wijmenga
    • , Jianjun Liu
    • , Reedik Mägi
    • , Ani Manichaikul
    • , Thomas Meitinger
    • , Andres Metspalu
    • , Yuri Milaneschi
    • , Karen L. Mohlke
    • , Thomas H. Mosley Jr.
    • , Alison D. Murray
    • , Mike A. Nalls
    • , Ei-Ei Khaing Nang
    • , Christopher P. Nelson
    • , Sotoodehnia Nona
    • , Jill M. Norris
    • , Chiamaka Vivian Nwuba
    • , Jeff O’Connell
    • , Nicholette D. Palmer
    • , George J. Papanicolau
    • , Raha Pazoki
    • , Nancy L. Pedersen
    • , Annette Peters
    • , Patricia A. Peyser
    • , Ozren Polasek
    • , David J. Porteous
    • , Alaitz Poveda
    • , Olli T. Raitakari
    • , Stephen S. Rich
    • , Neil Risch
    • , Jennifer G. Robinson
    • , Lynda M. Rose
    • , Igor Rudan
    • , Pamela J. Schreiner
    • , Robert A. Scott
    • , Stephen S. Sidney
    • , Mario Sims
    • , Jennifer A. Smith
    • , Harold Snieder
    • , Tamar Sofer
    • , John M. Starr
    • , Barbara Sternfeld
    • , Konstantin Strauch
    • , Hua Tang
    • , Kent D. Taylor
    • , Michael Y. Tsai
    • , Jaakko Tuomilehto
    • , André G. Uitterlinden
    • , M. Yldau van der Ende
    • , Diana van Heemst
    • , Trudy Voortman
    • , Melanie Waldenberger
    • , Patrik Wennberg
    • , Gregory Wilson
    • , Yong-Bing Xiang
    • , Jie Yao
    • , Caizheng Yu
    • , Jian-Min Yuan
    • , Wei Zhao
    • , Alan B. Zonderman
    • , Diane M. Becker
    • , Michael Boehnke
    • , Donald W. Bowden
    • , Ulf de Faire
    • , Ian J. Deary
    • , Paul Elliott
    • , Tõnu Esko
    • , Barry I. Freedman
    • , Philippe Froguel
    • , Paolo Gasparini
    • , Christian Gieger
    • , Norihiro Kato
    • , Markku Laakso
    • , Timo A. Lakka
    • , Terho Lehtimäki
    • , Patrik K. E. Magnusson
    • , Albertine J. Oldehinkel
    • , Brenda W. J. H. Penninx
    • , Nilesh J. Samani
    • , Xiao-Ou Shu
    • , Pim van der Harst
    • , Jana V. Van Vliet-Ostaptchouk
    • , Peter Vollenweider
    • , Lynne E. Wagenknecht
    • , Ya X. Wang
    • , Nicholas J. Wareham
    • , David R. Weir
    • , Tangchun Wu
    • , Wei Zheng
    • , Xiaofeng Zhu
    • , Michele K. Evans
    • , Paul W. Franks
    • , Vilmundur Gudnason
    • , Caroline Hayward
    • , Bernardo L. Horta
    • , Tanika N. Kelly
    • , Yongmei Liu
    • , Kari E. North
    • , Alexandre C. Pereira
    • , Paul M. Ridker
    • , E. Shyong Tai
    • , Rob M. van Dam
    • , Ervin R. Fox
    • , Sharon L. R. Kardia
    • , Ching-Ti Liu
    • , Dennis O. Mook-Kanamori
    • , Michael A. Province
    • , Susan Redline
    • , Cornelia M. van Duijn
    • , Jerome I. Rotter
    • , Charles B. Kooperberg
    • , W. James Gauderman
    • , Bruce M. Psaty
    • , Kenneth Rice
    • , Patricia B. Munroe
    • , Myriam Fornage
    • , L. Adrienne Cupples
    • , Charles N. Rotimi
    • , Alanna C. Morrison
    • , Dabeeru C. Rao
    •  & Ruth J. F. Loos
  • Article | | open

    Obesity is linked to increased cancer risk but the impact of body size versus weight distribution in determining the increased risk is unclear. Here the authors examined body mass index, waist circumference, and waist to hip ratio in relation to all-cancer incidence and incidence of seven individual cancers in a population of approximately 26,000 individual and conclude that central adiposity appears to be a stronger predictor of all-cancer risk than body size.

    • Amanda M. Barberio
    • , Asalah Alareeki
    • , Benjamin Viner
    • , Joy Pader
    • , Jennifer E. Vena
    • , Paul Arora
    • , Christine M. Friedenreich
    •  & Darren R. Brenner

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