Peter Boone, Lauren Rochelle et al.

A rainbow mouse model for visualizing clonal expansion of oncogenes in the intestine

Latest Research

Physical sciences

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  • Article
    | Open Access

    Though all-soft electronic devices with liquid metals are attractive due to the material’s compatibility with patterning methods, obtaining sub-micron patterns remains a challenge. Here, the authors report a hybrid lithography process to realize all-soft submicron-scale devices based on EGaIn.

    • Min-gu Kim
    • , Devin K. Brown
    •  & Oliver Brand
  • Article
    | Open Access

    Plasmons depend strongly on dimensionality. Here the authors show that plasmons in atomically thin metals are qualitatively different from those in a 2D electron gas or metal slab: they are dispersionless at large wavevectors and, in systems such as monolayer TaS2, long-lived enough to be observed experimentally as localized plasmon wave packets.

    • Felipe H. da Jornada
    • , Lede Xian
    • , Angel Rubio
    •  & Steven G. Louie
  • Article
    | Open Access

    Material interfaces are highly crucial to improve device performances. Here, the authors report interfacial reconstruction at the Au {001} substrate surface and the top MoS2 and WS2 monolayers due to the formation of a metastable interfacial Au4S4 phase. The reconstructed interface results in a p-type Schottky contact with reduced barrier height.

    • Ruichun Luo
    • , Wen Wu Xu
    • , Yongzheng Zhang
    • , Ziqian Wang
    • , Xiaodong Wang
    • , Yi Gao
    • , Pan Liu
    •  & Mingwei Chen

Earth and environmental sciences

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  • Article
    | Open Access

    Although there is extensive theory predicting the effects of population bottlenecks on mutation load, there is little empirical evidence from recent bottlenecks. Here, Grossen et al. compare the consequences of population bottlenecks in six ibex species for genome-wide variation and mutation load.

    • Christine Grossen
    • , Frédéric Guillaume
    • , Lukas F. Keller
    •  & Daniel Croll
  • Article
    | Open Access

    How the Asian monsoon, earth surface processes and human development interact is not well known. Here, a new record of dust storm intensity shows a relationship between the stability of dynasties and dust storm activity for the last ~2200 years, which argues for a strong human control of dust storms in East Asia over this time.

    • Fahu Chen
    • , Shengqian Chen
    • , Xu Zhang
    • , Jianhui Chen
    • , Xin Wang
    • , Evan J. Gowan
    • , Mingrui Qiang
    • , Guanghui Dong
    • , Zongli Wang
    • , Yuecong Li
    • , Qinghai Xu
    • , Yangyang Xu
    • , John P. Smol
    •  & Jianbao Liu
  • Article
    | Open Access

    The contributions of industrial parks towards addressing climate change remains unclear. Here, the authors studied the energy infrastructure of 1604 industrial parks in China and found that by decarbonizing energy infrastructure stocks in the industrial parks, the GHG mitigation potential will achieve 8%~16% relative to the GHG emissions in the baseline scenario with positive economic benefits, water savings and air pollutant emission reductions.

    • Yang Guo
    • , Jinping Tian
    •  & Lyujun Chen

Biological sciences

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  • Article
    | Open Access

    Loss ofMEN1 results in an inherited multiple endocrine neoplastic type 1 syndrome. Here, the authors generate an alveolar type II cell MEN1 knockout mouse model and show that on a Kras mutant background the mice develop lung tumors with features of neuroendocrine differentiation.

    • Huan Qiu
    • , Bang-Ming Jin
    • , Zhan-Feng Wang
    • , Bin Xu
    • , Qi-Fan Zheng
    • , Li Zhang
    • , Ling-Yu Zhu
    • , Shuang Shi
    • , Jun-Bo Yuan
    • , Xiao Lin
    • , Shu-Bin Gao
    •  & Guang-Hui Jin
  • Article
    | Open Access

    Curli amyloid fibers are important components of bacterial biofilms formed by E. coli and Salmonella. Here, Tursi et al. show that a human monoclonal antibody with pan-amyloid binding activity can disrupt biofilms formed by Salmonella Typhimurium in vitro and in vivo.

    • Sarah A. Tursi
    • , Rama Devudu Puligedda
    • , Paul Szabo
    • , Lauren K. Nicastro
    • , Amanda L. Miller
    • , Connie Qiu
    • , Stefania Gallucci
    • , Norman R. Relkin
    • , Bettina A. Buttaro
    • , Scott K. Dessain
    •  & Çagla Tükel
  • Article
    | Open Access

    Although there is extensive theory predicting the effects of population bottlenecks on mutation load, there is little empirical evidence from recent bottlenecks. Here, Grossen et al. compare the consequences of population bottlenecks in six ibex species for genome-wide variation and mutation load.

    • Christine Grossen
    • , Frédéric Guillaume
    • , Lukas F. Keller
    •  & Daniel Croll

Health sciences

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  • Article
    | Open Access

    Loss ofMEN1 results in an inherited multiple endocrine neoplastic type 1 syndrome. Here, the authors generate an alveolar type II cell MEN1 knockout mouse model and show that on a Kras mutant background the mice develop lung tumors with features of neuroendocrine differentiation.

    • Huan Qiu
    • , Bang-Ming Jin
    • , Zhan-Feng Wang
    • , Bin Xu
    • , Qi-Fan Zheng
    • , Li Zhang
    • , Ling-Yu Zhu
    • , Shuang Shi
    • , Jun-Bo Yuan
    • , Xiao Lin
    • , Shu-Bin Gao
    •  & Guang-Hui Jin
  • Article
    | Open Access

    Adult forms of inflammatory bowel disease (IBD) are of a polygenic nature, but paediatric and very early onset (VEO) IBD also occur as monogenic forms. Here, using whole exome sequencing, the authors explore both the monogenic and polygenic contribution to VEO-IBD and characterize a rare somatic mosaic VEO-IBD patient.

    • Eva Gonçalves Serra
    • , Tobias Schwerd
    • , Loukas Moutsianas
    • , Athena Cavounidis
    • , Laura Fachal
    • , Sumeet Pandey
    • , Jochen Kammermeier
    • , Nicholas M. Croft
    • , Carsten Posovszky
    • , Astor Rodrigues
    • , Richard K. Russell
    • , Farah Barakat
    • , Marcus K. H. Auth
    • , Robert Heuschkel
    • , Matthias Zilbauer
    • , Krzysztof Fyderek
    • , Christian Braegger
    • , Simon P. Travis
    • , Jack Satsangi
    • , Miles Parkes
    • , Nikhil Thapar
    • , Helen Ferry
    • , Julie C. Matte
    • , Kimberly C. Gilmour
    • , Andrzej Wedrychowicz
    • , Peter Sullivan
    • , Carmel Moore
    • , Jennifer Sambrook
    • , Willem Ouwehand
    • , David Roberts
    • , John Danesh
    • , Toni A. Baeumler
    • , Tudor A. Fulga
    • , Mohammad Karaminejadranjbar
    • , Ahmed Ahmed
    • , Rachel Wilson
    • , Jeffrey C. Barrett
    • , Abdul Elkadri
    • , Anne M. Griffiths
    • , Marlen Zurek
    • , Caterina Strisciuglio
    • , Mamoun Elawad
    • , Bernice Lo
    • , Carolina Arancibia-Carcamo
    • , Adam Bailey
    • , Ellie Barnes
    • , Elizabeth Louise Bird-Lieberman
    • , Oliver Brain
    • , Barbara Braden
    • , Jane Collier
    • , James East
    • , Lucy Howarth
    • , Satish Keshav
    • , Paul Klenerman
    • , Simon Leedham
    • , Rebecca Palmer
    • , Fiona Powrie
    • , Alison Simmons
    • , Matthew Walker
    • , Zoe Tolkien
    • , Stephen Kaptoge
    • , David Allen
    • , Susan Mehenny
    • , Jonathan Mant
    • , Emanuele Di Angelantonio
    • , Simon G. Thompson
    • , Bahtiyar Yilmaz
    • , Pascal Juillerat
    • , Markus Geuking
    • , Reiner Wiest
    • , Andrew J. Macpherson
    • , Francisco Damian Bravo
    • , Lukas Brügger
    • , Ove Carstens
    • , Ulrike Graf Bigler
    • , Benjamin Heimgartner
    • , Monica Rusticeanu
    • , Sybille Schmid (-Uebelhart)
    • , Bruno Strebel
    • , Aurora Tatu
    • , Radu Tutuian
    • , Reiner Wiest
    • , Ove Øyås
    • , Charlotte Ramon
    • , Jörg Stelling
    • , Yannick Franc
    • , Nicolas Fournier
    • , Valerie E. H. Pittet
    • , Bernard Burnand
    • , Mara Egger
    • , Yannick Franc
    • , Delphine Golay
    • , Astrid Marot
    • , Leilla Musso
    • , Valérie Pittet
    • , Jean-Benoît Rossel
    • , Vivianne Seematter
    • , Joachim Sommer
    • , Rachel Vulliamy
    • , Pierre Michetti
    • , Michel H. Maillard
    • , Céline Keller
    • , Michel H. Maillard
    • , Andreas Nydegger
    • , Alain Schoepfe
    • , Eva Archanioti
    • , Jessica Ezri
    • , Montserrat Fraga
    • , Alain Schoepfer
    • , Christoph Müller
    • , Gerhard Rogler
    • , Luc Biedermann
    • , Mirjam Blattmann
    • , Sabine Burk
    • , Barbara Dora
    • , Michael Fried
    • , Benjamin Misselwitz
    • , Beat Müllhaupt
    • , Nicole Obialo
    • , Daniel Pohl
    • , Nadia Raschle
    • , Gerhard Rogler
    • , Michael Scharl
    • , Stephan Vavricka
    • , Roland Von Känel
    • , Jonas Zeitz
    • , Karim Abdelrahman
    • , Gentiana Ademi
    • , Jan Borovicka
    • , Stephan Brand
    • , Remus Frei
    • , Johannes Haarer
    • , Christina Knellwolf (-Grieger)
    • , Claudia Krieger(-Grübel)
    • , Patrizia Künzler
    • , Christa Meyenberger
    • , Pamela Meyer
    • , Nina Röhrich
    • , Mikael Sawatzki
    • , Martin Schelling
    • , Gian-Marco Semadeni
    • , Michael Sulz
    • , Dorothee Zimmermann
    • , Patrick Aepli
    • , Dominique H. Criblez
    • , Cyrill Hess
    • , Jean-Pierre Richterich
    • , Johannes Spalinger
    • , Dominic Staudenmann
    • , Andreas Stulz
    • , Stefanie Wöhrle
    • , Amman Thomas
    • , Claudia Anderegg
    • , Henrik Köhler
    • , Rachel Kusche
    • , Anca-Teodora Antonino
    • , Eviano Arrigoni
    • , José M. Bengoa
    • , Sophie Cunningham
    • , Philippe de Saussure
    • , Laurent Girard
    • , Diana Bakker de Jong
    • , Polat Bastürk
    • , Simon Brunner
    • , Lukas Degen
    • , Petr Hruz
    • , Carolina Khalid-de Bakker
    • , Jan Niess
    • , Bruno Balsiger
    • , Janine Haldemann
    • , Gaby Saner
    • , Frank Seibold
    • , Peter Bauerfeind
    • , Andrea Becocci
    • , Dominique Belli
    • , Janek Binek
    • , Peter Hengstler
    • , Stephan Boehm
    • , Tujana Boldanov
    • , Patrick Bühr
    • , Rebekka Koller
    • , Vanessa Rueger
    • , Arne Senning
    • , Emanuel Burri
    • , Sophie Buyse
    • , Dahlia-Thao Cao
    • , Fabrizia D’Angelo
    • , Joakim Delarive
    • , Christopher Doerig
    • , Roxane Hessler
    • , Claudia Preissler
    • , Ronald Rentsch
    • , Branislav Risti
    • , Marc Alain Ritz
    • , Michael Steuerwald
    • , Jürg Vögtlin
    • , Markus Sagmeister
    • , Bernhard Sauter
    • , Susanne Schibli
    • , Christiane Sokollik
    • , Johannes Spalinger
    • , Hugo Schlauri
    • , Jean-François Schnegg
    • , Mariam Seirafi
    • , Holger Spangenberger
    • , Philippe Stadler
    • , Peter Staub
    • , Volker Stenz
    • , Michela Tempia-Caliera
    • , Joël Thorens
    • , Kaspar Truninger
    • , Patrick Urfer
    • , Francesco Viani
    • , Dominique Vouillamoz
    • , Silvan Zander
    • , Tina Wyli
    • , L. Jostins
    • , N. A. Kennedy
    • , T. Ahmad
    • , C. A. Lamb
    • , C. Edwards
    • , A. Hart
    • , C. Hawkey
    • , J. C. Mansfield
    • , C. Mowat
    • , W. G. Newman
    • , A. Simmons
    • , M. Tremelling
    • , J. C. Lee
    • , N. J. Prescott
    • , C. G. Mathew
    • , C. W. Lees
    • , D. P. B. McGovern
    • , S. R. Targan
    • , G. Botwin
    • , E. Mengesha
    • , P. Fleshner
    • , C. Landers
    • , D. Li
    • , J. D. Rioux
    • , A. Bitton
    • , J. Côté-Daigneault
    • , M. J. Daly
    • , R. Xavier
    • , K. Morris
    • , G. Boucher
    • , J. H. Cho
    • , C. Abraham
    • , M. Merad
    • , B. Sands
    • , I. Peter
    • , K. Hao
    • , Y. Itan
    • , R. H. Duerr
    • , L. Konnikova
    • , M. B. Schwartz
    • , S. Proksell
    • , E. Johnston
    • , V. Miladinova
    • , W. Chen
    • , S. R. Brant
    • , L. Datta
    • , M. S. Silverberg
    • , L. P. Schumm
    • , S. Birch
    • , M. Giri
    • , K. Gettler
    • , Y. Sharma
    • , C. Stevens
    • , M. Lazarev
    • , T. Haritunians
    • , Scott B. Snapper
    • , Neil Shah
    • , Aleixo M. Muise
    • , David C. Wilson
    • , Holm H. Uhlig
    •  & Carl A. Anderson
  • Article
    | Open Access

    In Mendelian randomization (MR) studies, one typically selects SNPs as instrumental variables that do not directly affect the outcome to avoid violation of MR assumptions. Here, Cho et al. present a framework, MR-TRYX, that leverages knowledge of such outliers of horizontal pleiotropy to identify putative causal relationships between exposure and outcome.

    • Yoonsu Cho
    • , Philip C. Haycock
    • , Eleanor Sanderson
    • , Tom R. Gaunt
    • , Jie Zheng
    • , Andrew P. Morris
    • , George Davey Smith
    •  & Gibran Hemani

News & Comment

  • Comment
    | Open Access

    While electrosynthesis represents a green and advantageous alternative to traditional synthetic methods, electrochemical reactions still suffer from some drawbacks that require further efforts in order to fully express the potential of electricity-driven transformations. In this Comment, we will briefly discuss both the advantages and limitations of electrosynthesis, especially when compared with the other traditional synthetic organic methods, and share some forward-looking thoughts on the future developments of electrochemical reactions.

    • Yong Yuan
    •  & Aiwen Lei
  • Comment
    | Open Access

    Skyrmions in chiral magnets are a particle-like texture that has been attracting growing interest due to their novel dynamics and possible applications. Here, we discuss the role of disorder and skyrmion-skyrmion interaction in governing their motion under an external drive.

    • C. Reichhardt
    •  & C. J. O. Reichhardt
  • Comment
    | Open Access

    A pharmaceutical industry viewpoint on how the fundamental laws of photochemistry are used to identify the parameters required to implement photochemistry from lab to scale. Parameters such as photon stoichiometry and light intensity are highlighted within to inform future publications.

    • Holly E. Bonfield
    • , Thomas Knauber
    • , François Lévesque
    • , Eric G. Moschetta
    • , Flavien Susanne
    •  & Lee J. Edwards
  • Comment
    | Open Access

    Can organic chemistry mimic nature in efficiency and sustainability? Not yet, but recent developments in photoredox catalysis animated the synthetic chemistry field, providing greener opportunities for industry and academia.

    • Giacomo E. M. Crisenza
    •  & Paolo Melchiorre
  • Comment
    | Open Access

    Understanding the cellular adaptation to oxygen deficiency -hypoxia- has a profound impact on our knowledge of the pathogenesis of several diseases. The elucidation of the molecular machinery that regulates response to hypoxia has been awarded the Nobel Prize in Physiology or Medicine.

    • José López-Barneo
    •  & M. Celeste Simon
  • Comment
    | Open Access

    Two complementary studies in Nature Communications define a critical role for the anti-apoptotic protein MCL-1 as a driver of adaptive survival in tumor cells treated with oncogene targeted therapies, providing a rationale for combining these agents with newly developed MCL-1 inhibitors in the clinic.

    • Kris C. Wood

Focus

Organic Chemistry and Chemical Biology

SEBASTIAN KAULITZKI/SCIENCE PHOTO LIBRARY/Getty

Organic Chemistry and Chemical Biology

Editors' Highlights: Each month our editors select a small number of Articles recently published in Nature Communications that they believe are particularly interesting or important.

Giovanni Bottari, Julia Eckhoff, Johannes Kreutzer and Prabhjot Saini