Peter Boone, Lauren Rochelle et al.

A rainbow mouse model for visualizing clonal expansion of oncogenes in the intestine

Latest Research

Physical sciences

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  • Article
    | Open Access

    Exploring correlations in strongly entangled quantum materials is of interest. Here the authors generate a tunable spin-, trajectory-, and energy-entangled neutron beam using a neutron spin-echo interferometer and show violations of Clauser-Horne-Shimony-Holt and Mermin contextuality inequalities with micron-scale trajectory separation.

    • J. Shen
    • , S. J. Kuhn
    • , R. M. Dalgliesh
    • , V. O. de Haan
    • , N. Geerits
    • , A. A. M. Irfan
    • , F. Li
    • , S. Lu
    • , S. R. Parnell
    • , J. Plomp
    • , A. A. van Well
    • , A. Washington
    • , D. V. Baxter
    • , G. Ortiz
    • , W. M. Snow
    •  & R. Pynn
  • Article
    | Open Access

    Long-standing radical species have raised noteworthy concerns in organic chemistry and but there remains a substantial challenge to produce long-standing radicals by light. Here, the authors demonstrate a stable dithienylethene derived photochromic radical for detection of peroxides and ozone.

    • Xuanying Chen
    • , Wandong Zhao
    • , Gleb Baryshnikov
    • , Michael L. Steigerwald
    • , Jian Gu
    • , Yunyun Zhou
    • , Hans Ågren
    • , Qi Zou
    • , Wenbo Chen
    •  & Liangliang Zhu

Earth and environmental sciences

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Biological sciences

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  • Article
    | Open Access

    HIV incidence among sex workers remains high in many settings. Here, the authors utilize individual-level data across ten countries in sub-Saharan Africa and suggest that increasingly punitive and non-protective laws are associated with HIV, and that stigmas and sex work laws may operate jointly in increasing HIV risk.

    • Carrie E. Lyons
    • , Sheree R. Schwartz
    • , Sarah M. Murray
    • , Kate Shannon
    • , Daouda Diouf
    • , Tampose Mothopeng
    • , Seni Kouanda
    • , Anato Simplice
    • , Abo Kouame
    • , Zandile Mnisi
    • , Ubald Tamoufe
    • , Nancy Phaswana-Mafuya
    • , Bai Cham
    • , Fatou M. Drame
    • , Mamadú Aliu Djaló
    •  & Stefan Baral
  • Article
    | Open Access

    It is unclear whether bird migration patterns are restricted to interglacial periods or are maintained during glacial maxima. Somveille et al. apply a global migration simulation model to climate reconstruction to show that the prevalence of this phenomenon has likely been largely maintained up to 50,000 years ago.

    • Marius Somveille
    • , Martin Wikelski
    • , Robert M. Beyer
    • , Ana S. L. Rodrigues
    • , Andrea Manica
    •  & Walter Jetz
  • Article
    | Open Access

    New design principles for bridging the photoluminescence and electroluminescence of colloidal quantum dots are needed. In this work, the authors report electrochemically-inert ligands as a general material-design strategy for realizing high-performance LEDs based on quantum dots.

    • Chaodan Pu
    • , Xingliang Dai
    • , Yufei Shu
    • , Meiyi Zhu
    • , Yunzhou Deng
    • , Yizheng Jin
    •  & Xiaogang Peng

Health sciences

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  • Article
    | Open Access

    HIV incidence among sex workers remains high in many settings. Here, the authors utilize individual-level data across ten countries in sub-Saharan Africa and suggest that increasingly punitive and non-protective laws are associated with HIV, and that stigmas and sex work laws may operate jointly in increasing HIV risk.

    • Carrie E. Lyons
    • , Sheree R. Schwartz
    • , Sarah M. Murray
    • , Kate Shannon
    • , Daouda Diouf
    • , Tampose Mothopeng
    • , Seni Kouanda
    • , Anato Simplice
    • , Abo Kouame
    • , Zandile Mnisi
    • , Ubald Tamoufe
    • , Nancy Phaswana-Mafuya
    • , Bai Cham
    • , Fatou M. Drame
    • , Mamadú Aliu Djaló
    •  & Stefan Baral
  • Article
    | Open Access

    Intermittent fasting (IF) has been shown beneficial in reducing metabolic diseases. Here, using a multi-omics approach in a T2D mouse model, the authors report that IF alters the composition of the gut microbiota and improves metabolic phenotypes that correlate with cognitive behavior.

    • Zhigang Liu
    • , Xiaoshuang Dai
    • , Hongbo Zhang
    • , Renjie Shi
    • , Yan Hui
    • , Xin Jin
    • , Wentong Zhang
    • , Luanfeng Wang
    • , Qianxu Wang
    • , Danna Wang
    • , Jia Wang
    • , Xintong Tan
    • , Bo Ren
    • , Xiaoning Liu
    • , Tong Zhao
    • , Jiamin Wang
    • , Junru Pan
    • , Tian Yuan
    • , Chuanqi Chu
    • , Lei Lan
    • , Fei Yin
    • , Enrique Cadenas
    • , Lin Shi
    • , Shancen Zhao
    •  & Xuebo Liu
  • Article
    | Open Access

    Autonomic dysfunction is a feature of some α-synucleinopathies, but there are no models of pure autonomic dysfunction associated with α-synuclein. Here the authors describe a mouse model of pure autonomic dysfunction without motor dysfunciton by injection of pre-formed fibrils of α-synuclein to the stellate and celiac ganglia.

    • Xue-Jing Wang
    • , Ming-Ming Ma
    • , Le-Bo Zhou
    • , Xiao-Yi Jiang
    • , Miao-Miao Hao
    • , Robert K. F. Teng
    • , Erxi Wu
    • , Bei-Sha Tang
    • , Jia-Yi Li
    • , Jun-Fang Teng
    •  & Xue-Bing Ding

News & Comment

  • Comment
    | Open Access

    While electrosynthesis represents a green and advantageous alternative to traditional synthetic methods, electrochemical reactions still suffer from some drawbacks that require further efforts in order to fully express the potential of electricity-driven transformations. In this Comment, we will briefly discuss both the advantages and limitations of electrosynthesis, especially when compared with the other traditional synthetic organic methods, and share some forward-looking thoughts on the future developments of electrochemical reactions.

    • Yong Yuan
    •  & Aiwen Lei
  • Comment
    | Open Access

    Skyrmions in chiral magnets are a particle-like texture that has been attracting growing interest due to their novel dynamics and possible applications. Here, we discuss the role of disorder and skyrmion-skyrmion interaction in governing their motion under an external drive.

    • C. Reichhardt
    •  & C. J. O. Reichhardt
  • Comment
    | Open Access

    A pharmaceutical industry viewpoint on how the fundamental laws of photochemistry are used to identify the parameters required to implement photochemistry from lab to scale. Parameters such as photon stoichiometry and light intensity are highlighted within to inform future publications.

    • Holly E. Bonfield
    • , Thomas Knauber
    • , François Lévesque
    • , Eric G. Moschetta
    • , Flavien Susanne
    •  & Lee J. Edwards
  • Comment
    | Open Access

    Can organic chemistry mimic nature in efficiency and sustainability? Not yet, but recent developments in photoredox catalysis animated the synthetic chemistry field, providing greener opportunities for industry and academia.

    • Giacomo E. M. Crisenza
    •  & Paolo Melchiorre
  • Comment
    | Open Access

    Understanding the cellular adaptation to oxygen deficiency -hypoxia- has a profound impact on our knowledge of the pathogenesis of several diseases. The elucidation of the molecular machinery that regulates response to hypoxia has been awarded the Nobel Prize in Physiology or Medicine.

    • José López-Barneo
    •  & M. Celeste Simon
  • Comment
    | Open Access

    Two complementary studies in Nature Communications define a critical role for the anti-apoptotic protein MCL-1 as a driver of adaptive survival in tumor cells treated with oncogene targeted therapies, providing a rationale for combining these agents with newly developed MCL-1 inhibitors in the clinic.

    • Kris C. Wood

Focus

Organic Chemistry and Chemical Biology

SEBASTIAN KAULITZKI/SCIENCE PHOTO LIBRARY/Getty

Organic Chemistry and Chemical Biology

Editors' Highlights: Each month our editors select a small number of Articles recently published in Nature Communications that they believe are particularly interesting or important.

Giovanni Bottari, Julia Eckhoff, Johannes Kreutzer and Prabhjot Saini

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